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Tdark Keratin-associated protein 5-7

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

 Comments

Property Summary

NCBI Gene PubMed Count 2
PubMed Score 0.11

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (1)

Disease Target Count P-value
psoriasis 6694 1.1e-04
diabetes mellitus 1728 1.1e-03

Expression

  Differential Expression (2)

Disease log2 FC p
diabetes mellitus 2.500 1.1e-03
psoriasis -1.200 1.1e-04

Synonym

Accession Q6L8G8 B2RNM3 Q701N5
Symbols KRTAP5-3
KRTAP5.7

Gene

KRTAP5-7

  Ortholog (1)

Species Source Disease
OMA EggNOG

 UniProt Keyword (4)

 GO Component (2)

 GO Process (1)

 Compartment GO Term (8)

 HCA RNA Cell Line (13)

See all...

Pathway (2)

AA Sequence 

MGCCGCSEGCGSGCGGCGSGCGGCGSGCGGCGSSCCVPVCCCKPVCCCVPACSCSSCGSCGGSKGGCGSC      1 - 70
GGSKGGCGSCGGSKGGCGSCGCSQCSCYKPCCCSSGCGSSCCQSSCCKPCCCQSSCCKPCCCSSGCGSSC     71 - 140
CQSSCCNPCCSQSSCCVPVCCQCKI                                                 141 - 165
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Text Mined References (3)

PMID Year Title