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Tdark Keratin-associated protein 26-1

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

 Comments

Property Summary

NCBI Gene PubMed Count 8
PubMed Score 1.50

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count P-value
psoriasis 6694 4.0e-04
diabetes mellitus 1728 1.3e-03
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.9

Expression

  Differential Expression (2)

Disease log2 FC p
diabetes mellitus 1.100 1.3e-03
psoriasis -1.200 4.0e-04

Synonym

Accession Q6PEX3 B0RZD3
Symbols

Gene

KRTAP26-1

PANTHER Protein Class (1)

  Ortholog (4)

Species Source Disease
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid EggNOG
OMA EggNOG

 UniProt Keyword (5)

 GO Component (2)

 GO Process (1)

 Compartment GO Term (22)

See all...

 HCA RNA Cell Line (1)

Pathway (2)

AA Sequence 

MSCPNYCSGNSNSGSLRTSRHIPLTSIDLCPTSVSCGDVLYLPTSSQDHTWVTDNCQETCGEPTSCQPVH      1 - 70
CETGNLETSCGSSTAYYVPRPCQGSSFLPASFFSSSCLPVSCRPQRYVSSGCRPLRPLLNSYQPIGDCVP     71 - 140
NAYRPQFCLSKSCQPQNLLTSGCQPSSCLAYRPQSLHVVSSSLRPLGPLFSGCQPLTHVFSTCRPSCSGL    141 - 210
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Text Mined References (9)

PMID Year Title