| Tbio | Keratin, type II cytoskeletal 74 |
Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This protein belongs to a family of keratins that are specifically expressed in the inner root sheath of hair follicles.[provided by RefSeq, Jun 2009]
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This protein belongs to a family of keratins that are specifically expressed in the inner root sheath of hair follicles.[provided by RefSeq, Jun 2009]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Hypotrichosis | 47 | 6.109 | 3.1 |
| ECTODERMAL DYSPLASIA 7, HAIR/NAIL TYPE | 1 | 0.0 | 0.0 |
| Woolly hair, autosomal dominant | 5 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Woolly hair, congenital | 5 |
| Wooly hair | 17 |
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 6.5e-09 |
| osteosarcoma | 7950 | 2.6e-06 |
| ovarian cancer | 8520 | 8.7e-06 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Keratosis | 37 | 6.325 | 3.2 |
| Monilethrix | 18 | 5.231 | 2.6 |
| Cardiomyopathy | 116 | 4.999 | 2.5 |
| LEOPARD syndrome | 20 | 4.467 | 2.2 |
| Mongolian spot | 4 | 4.249 | 2.1 |
| Middle lobe syndrome | 3 | 3.822 | 1.9 |
| Pachyonychia congenita | 10 | 3.608 | 1.8 |
| Photosensitive trichothiodystrophy | 30 | 3.547 | 1.8 |
| Cardiofaciocutaneous syndrome | 15 | 3.42 | 1.7 |
| Hereditary mucosal leukokeratosis | 7 | 3.105 | 1.6 |
| Tooth agenesis | 44 | 3.088 | 1.5 |
| Disease | Target Count |
|---|---|
| Ectodermal dysplasia, 'pure' hair-nail type | 3 |
| Hypotrichosis 3 | 6 |
| Disease | log2 FC | p |
|---|---|---|
| osteosarcoma | 1.234 | 2.6e-06 |
| ovarian cancer | -1.200 | 8.7e-06 |
| psoriasis | -1.400 | 6.5e-09 |
MSRQLNIKSSGDKGNFSVHSAVVPRKAVGSLASYCAAGRGAGAGFGSRSLYSLGGNRRISFNVAGGGVRA 1 - 70 GGYGFRPGSGYGGGRASGFAGSMFGSVALGPACLSVCPPGGIHQVTVNKSLLAPLNVELDPEIQKVRAQE 71 - 140 REQIKVLNDKFASFIDKVRFLEQQNQVLETKWELLQQLDLNNCKKNLEPILEGYISNLRKQLETLSGDRV 141 - 210 RLDSELRSMRDLVEDYKKRYEVEINRRTTAENEFVVLKKDADAAYAVKVELQAKVDSLDKEIKFLKCLYD 211 - 280 AEIAQIQTHASETSVILSMDNNRDLDLDSIIAEVRMHYEEIALKSKAEAEALYQTKIQELQLAASRHGDD 281 - 350 LKHTRSEMVELNRLIQRIRCEIGNVKKQRASLETAIADAEQRGDNALKDAQAKLDELEGALHQAKEELAR 351 - 420 MLREYQELMSLKLALDMEIATYRKLLEGEECRMSGENPSSVSISVISSSSYSYHHPSSAGVDLGASAVAG 421 - 490 SSGSTQSGQTKTTEARGGDLKDTQGKSTPASIPARKATR 491 - 529 //
