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Tdark KRAB domain-containing protein 4

This encodes a zinc finger protein with an N-terminal KRAB (Kruppel-associated) domain found in transcriptional repressors. This gene is located in a region of the X chromosome thought to be involved in nonsyndromic X-linked cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

 Comments

Property Summary

NCBI Gene PubMed Count 7
PubMed Score 1.03
PubTator Score 0.50

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (1)

Disease Target Count P-value
psoriasis 6694 1.3e-08
Pick disease 1894 8.6e-05
medulloblastoma, large-cell 6241 2.9e-04
osteosarcoma 7950 5.7e-03
lung cancer 4740 1.5e-02

Expression

  Differential Expression (5)

Disease log2 FC p
lung cancer -1.500 1.5e-02
medulloblastoma, large-cell -1.200 2.9e-04
osteosarcoma -1.438 5.7e-03
Pick disease -1.200 8.6e-05
psoriasis -1.100 1.3e-08

Synonym

Accession Q5JUW0 A8K0Y8 B3KU22 Q96EA3 Q9NXB1
Symbols ZNF673

Gene

KRBOX4

  Ortholog (1)

Species Source Disease
Macaque OMA EggNOG

 UniProt Keyword (3)

 GO Function (1)

 GO Component (1)

 GO Process (1)

 Compartment GO Term (2)

 HCA RNA Cell Line (56)

See all...

Pathway (3)

AA Sequence 

MAMSQESLTFKDVFVDFTLEEWQQLDSAQKNLYRDVMLENYSHLVSVGYLVAKPDVIFRLGPGEESWMAD      1 - 70
GGTPVRTCAGEDRPEVWQVDEQIDHYKESQDKLPWQAAFIGKETLKDESGQESRTCRKSIYLSTEFDSVR     71 - 140
QRLPKYYSWEKAFKTSFKLSWSKWKLCKKER                                           141 - 171
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Text Mined References (7)

PMID Year Title