| Tdark | Kelch-like protein 8 |
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7950 | 4.5e-06 |
| ependymoma | 4679 | 5.4e-06 |
| ulcerative colitis | 1819 | 7.8e-06 |
| pancreatic cancer | 2398 | 7.2e-04 |
| pancreatic carcinoma | 562 | 7.2e-04 |
| Rheumatoid arthritis | 1191 | 9.9e-03 |
| ovarian cancer | 8520 | 1.8e-02 |
| aldosterone-producing adenoma | 665 | 3.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Anorexia nervosa | 80 | 0.0 | 1.1 |
| Disease | log2 FC | p |
|---|---|---|
| aldosterone-producing adenoma | -1.005 | 3.8e-02 |
| ependymoma | -1.100 | 5.4e-06 |
| osteosarcoma | 2.075 | 4.5e-06 |
| ovarian cancer | 1.100 | 1.8e-02 |
| pancreatic cancer | 1.400 | 7.2e-04 |
| pancreatic carcinoma | 1.400 | 7.2e-04 |
| Rheumatoid arthritis | 2.100 | 9.9e-03 |
| ulcerative colitis | -1.200 | 7.8e-06 |
MASDSMSSKQARNHITKGKRQQQHQQIKNRSSISDGDGEDSFIFEANEAWKDFHGSLLRFYENGELCDVT 1 - 70 LKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPL 71 - 140 LYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSP 141 - 210 QHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNL 211 - 280 KCRDLLDEARNYHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGP 281 - 350 EMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGG 351 - 420 LDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEV 421 - 490 KEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVG 491 - 560 GHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVCSCLTSQIRDVGHGSNNVVDCM 561 - 620 //
