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Tbio Transmembrane protein 131-like

Isoform 1: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.

 Comments

Property Summary

NCBI Gene PubMed Count 8
PubMed Score 1.83
PubTator Score 1.80

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.9

Expression

  Differential Expression (17)

Disease log2 FC p
adrenocortical carcinoma 1.164 8.4e-05
adult high grade glioma 1.500 1.0e-04
Astrocytoma, Pilocytic 1.300 4.0e-06
atypical teratoid / rhabdoid tumor 1.800 5.8e-05
glioblastoma 1.600 1.0e-07
interstitial cystitis 1.700 1.8e-03
intraductal papillary-mucinous adenoma (... -2.500 2.5e-05
intraductal papillary-mucinous carcinoma... -2.500 5.1e-05
intraductal papillary-mucinous neoplasm ... -2.300 1.3e-03
lung cancer -1.400 9.1e-04
malignant mesothelioma -2.000 3.2e-07
medulloblastoma 1.400 1.7e-02
medulloblastoma, large-cell 1.400 4.4e-02
osteosarcoma -3.266 1.7e-05
ovarian cancer -1.500 6.4e-09
primitive neuroectodermal tumor 1.900 8.0e-04
ulcerative colitis 1.200 1.1e-02

Synonym

Accession A2VDJ0 B3KRV3 D3DP10 Q7LGA7 Q86Y92 Q8WU56 Q9H065 Q9Y2D7
Symbols KIAA0922

Gene

TMEM131L

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (14)

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 GO Component (4)

 GO Process (3)

 Compartment GO Term (21)

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 HCA RNA Cell Line (56)

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 CSPA Cell Line (2)

Gene RIF (4)

AA Sequence 

MAGLRRPQPGCYCRTAAAVNLLLGVFQVLLPCCRPGGAQGQAIEPLPNVVELWQAEEGELLLPTQGDSEE      1 - 70
GLEEPSQEQSFSDKLFSGKGLHFQPSVLDFGIQFLGHPVAKILHAYNPSRDSEVVVNSVFAAAGHFHVPP     71 - 140
VPCRVIPAMGKTSFRIIFLPTEEGSIESSLFINTSSYGVLSYHVSGIGTRRISTEGSAKQLPNAYFLLPK    141 - 210
VQSIQLSQMQAETTNTSLLQVQLECSLHNKVCQQLKGCYLESDDVLRLQMSIMVTMENFSKEFEENTQHL    211 - 280
LDHLSIVYVATDESETSDDSAVNMYILHSGNSLIWIQDIRHFSQRDALSLQFEPVLLPTSTTNFTKIASF    281 - 350
TCKATSCDSGIIEDVKKTTHTPTLKACLFSSVAQGYFRMDSSATQFHIETHENTSGLWSIWYRNHFDRSV    351 - 420
VLNDVFLSKETKHMLKILNFTGPLFLPPGCWNIFSLKLAVKDIAINLFTNVFLTTNIGAIFAIPLQIYSA    421 - 490
PTKEGSLGFEVIAHCGMHYFMGKSKAGNPNWNGSLSLDQSTWNVDSELANKLYERWKKYKNGDVCKRNVL    491 - 560
GTTRFAHLKKSKESESFVFFLPRLIAEPGLMLNFSATALRSRMIKYFVVQNPSSWPVSLQLLPLSLYPKP    561 - 630
EALVHLLHRWFGTDMQMINFTTGEFQLTEACPYLGTHSEESRFGILHLHLQPLEMKRVGVVFTPADYGKV    631 - 700
TSLILIRNNLTVIDMIGVEGFGARELLKVGGRLPGAGGSLRFKVPESTLMDCRRQLKDSKQILSITKNFK    701 - 770
VENIGPLPITVSSLKINGYNCQGYGFEVLDCHQFSLDPNTSRDISIVFTPDFTSSWVIRDLSLVTAADLE    771 - 840
FRFTLNVTLPHHLLPLCADVVPGPSWEESFWRLTVFFVSLSLLGVILIAFQQAQYILMEFMKTRQRQNAS    841 - 910
SSSQQNNGPMDVISPHSYKSNCKNFLDTYGPSDKGRGKNCLPVNTPQSRIQNAAKRSPATYGHSQKKHKC    911 - 980
SVYYSKHKTSTAAASSTSTTTEEKQTSPLGSSLPAAKEDICTDAMRENWISLRYASGINVNLQKNLTLPK    981 - 1050
NLLNKEENTLKNTIVFSNPSSECSMKEGIQTCMFPKETDIKTSENTAEFKERELCPLKTSKKLPENHLPR   1051 - 1120
NSPQYHQPDLPEISRKNNGNNQQVPVKNEVDHCENLKKVDTKPSSEKKIHKTSREDMFSEKQDIPFVEQE   1121 - 1190
DPYRKKKLQEKREGNLQNLNWSKSRTCRKNKKRGVAPVSRPPEQSDLKLVCSDFERSELSSDINVRSWCI   1191 - 1260
QESTREVCKADAEIASSLPAAQREAEGYYQKPEKKCVDKFCSDSSSDCGSSSGSVRASRGSWGSWSSTSS   1261 - 1330
SDGDKKPMVDAQHFLPAGDSVSQNDFPSEAPISLNLSHNICNPMTVNSLPQYAEPSCPSLPAGPTGVEED   1331 - 1400
KGLYSPGDLWPTPPVCVTSSLNCTLENGVPCVIQESAPVHNSFIDWSATCEGQFSSAYCPLELNDYNAFP   1401 - 1470
EENMNYANGFPCPADVQTDFIDHNSQSTWNTPPNMPAAWGHASFISSPPYLTSTRSLSPMSGLFGSIWAP   1471 - 1540
QSDVYENCCPINPTTEHSTHMENQAVVCKEYYPGFNPFRAYMNLDIWTTTANRNANFPLSRDSSYCGNV    1541 - 1609
//

Text Mined References (13)

PMID Year Title