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Tbio Transmembrane protein 131-like

Isoform 1: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.

 Comments

Property Summary

NCBI Gene PubMed Count 8
PubMed Score 1.83
PubTator Score 1.80

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.9

Expression

  Differential Expression (17)

Disease log2 FC p
adrenocortical carcinoma 1.164 8.4e-05
adult high grade glioma 1.500 1.0e-04
Astrocytoma, Pilocytic 1.300 4.0e-06
atypical teratoid / rhabdoid tumor 1.800 5.8e-05
glioblastoma 1.600 1.0e-07
interstitial cystitis 1.700 1.8e-03
intraductal papillary-mucinous adenoma (... -2.500 2.5e-05
intraductal papillary-mucinous carcinoma... -2.500 5.1e-05
intraductal papillary-mucinous neoplasm ... -2.300 1.3e-03
lung cancer -1.400 9.1e-04
malignant mesothelioma -2.000 3.2e-07
medulloblastoma 1.400 1.7e-02
medulloblastoma, large-cell 1.400 4.4e-02
osteosarcoma -3.266 1.7e-05
ovarian cancer -1.500 6.4e-09
primitive neuroectodermal tumor 1.900 8.0e-04
ulcerative colitis 1.200 1.1e-02

Synonym

Accession A2VDJ0 B3KRV3 D3DP10 Q7LGA7 Q86Y92 Q8WU56 Q9H065 Q9Y2D7
Symbols KIAA0922

Gene

TMEM131L

  Ortholog (12)

Species Source Disease
OMA EggNOG
OMA EggNOG
OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
OMA EggNOG
OMA EggNOG
OMA EggNOG

 UniProt Keyword (14)

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 GO Component (4)

 GO Process (3)

 Compartment GO Term (21)

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 HCA RNA Cell Line (56)

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 CSPA Cell Line (2)

Gene RIF (4)

AA Sequence 

MAGLRRPQPGCYCRTAAAVNLLLGVFQVLLPCCRPGGAQGQAIEPLPNVVELWQAEEGELLLPTQGDSEE      1 - 70
GLEEPSQEQSFSDKLFSGKGLHFQPSVLDFGIQFLGHPVAKILHAYNPSRDSEVVVNSVFAAAGHFHVPP     71 - 140
VPCRVIPAMGKTSFRIIFLPTEEGSIESSLFINTSSYGVLSYHVSGIGTRRISTEGSAKQLPNAYFLLPK    141 - 210
VQSIQLSQMQAETTNTSLLQVQLECSLHNKVCQQLKGCYLESDDVLRLQMSIMVTMENFSKEFEENTQHL    211 - 280
LDHLSIVYVATDESETSDDSAVNMYILHSGNSLIWIQDIRHFSQRDALSLQFEPVLLPTSTTNFTKIASF    281 - 350
TCKATSCDSGIIEDVKKTTHTPTLKACLFSSVAQGYFRMDSSATQFHIETHENTSGLWSIWYRNHFDRSV    351 - 420
VLNDVFLSKETKHMLKILNFTGPLFLPPGCWNIFSLKLAVKDIAINLFTNVFLTTNIGAIFAIPLQIYSA    421 - 490
PTKEGSLGFEVIAHCGMHYFMGKSKAGNPNWNGSLSLDQSTWNVDSELANKLYERWKKYKNGDVCKRNVL    491 - 560
GTTRFAHLKKSKESESFVFFLPRLIAEPGLMLNFSATALRSRMIKYFVVQNPSSWPVSLQLLPLSLYPKP    561 - 630
EALVHLLHRWFGTDMQMINFTTGEFQLTEACPYLGTHSEESRFGILHLHLQPLEMKRVGVVFTPADYGKV    631 - 700
TSLILIRNNLTVIDMIGVEGFGARELLKVGGRLPGAGGSLRFKVPESTLMDCRRQLKDSKQILSITKNFK    701 - 770
VENIGPLPITVSSLKINGYNCQGYGFEVLDCHQFSLDPNTSRDISIVFTPDFTSSWVIRDLSLVTAADLE    771 - 840
FRFTLNVTLPHHLLPLCADVVPGPSWEESFWRLTVFFVSLSLLGVILIAFQQAQYILMEFMKTRQRQNAS    841 - 910
SSSQQNNGPMDVISPHSYKSNCKNFLDTYGPSDKGRGKNCLPVNTPQSRIQNAAKRSPATYGHSQKKHKC    911 - 980
SVYYSKHKTSTAAASSTSTTTEEKQTSPLGSSLPAAKEDICTDAMRENWISLRYASGINVNLQKNLTLPK    981 - 1050
NLLNKEENTLKNTIVFSNPSSECSMKEGIQTCMFPKETDIKTSENTAEFKERELCPLKTSKKLPENHLPR   1051 - 1120
NSPQYHQPDLPEISRKNNGNNQQVPVKNEVDHCENLKKVDTKPSSEKKIHKTSREDMFSEKQDIPFVEQE   1121 - 1190
DPYRKKKLQEKREGNLQNLNWSKSRTCRKNKKRGVAPVSRPPEQSDLKLVCSDFERSELSSDINVRSWCI   1191 - 1260
QESTREVCKADAEIASSLPAAQREAEGYYQKPEKKCVDKFCSDSSSDCGSSSGSVRASRGSWGSWSSTSS   1261 - 1330
SDGDKKPMVDAQHFLPAGDSVSQNDFPSEAPISLNLSHNICNPMTVNSLPQYAEPSCPSLPAGPTGVEED   1331 - 1400
KGLYSPGDLWPTPPVCVTSSLNCTLENGVPCVIQESAPVHNSFIDWSATCEGQFSSAYCPLELNDYNAFP   1401 - 1470
EENMNYANGFPCPADVQTDFIDHNSQSTWNTPPNMPAAWGHASFISSPPYLTSTRSLSPMSGLFGSIWAP   1471 - 1540
QSDVYENCCPINPTTEHSTHMENQAVVCKEYYPGFNPFRAYMNLDIWTTTANRNANFPLSRDSSYCGNV    1541 - 1609
//

Text Mined References (13)

PMID Year Title