Property Summary

NCBI Gene PubMed Count 50
PubMed Score 52.62
PubTator Score 34.42

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (23)

Disease log2 FC p
Rheumatoid Arthritis 1.200 2.2e-02
hepatocellular carcinoma 1.700 4.0e-04
psoriasis -1.800 8.9e-05
osteosarcoma -1.972 9.8e-07
ependymoma 1.200 9.4e-10
glioblastoma 1.500 1.1e-04
medulloblastoma 1.800 2.8e-06
astrocytoma 1.700 1.6e-03
atypical teratoid / rhabdoid tumor 1.800 4.6e-06
medulloblastoma, large-cell 1.600 2.4e-04
primitive neuroectodermal tumor 1.500 8.6e-05
ulcerative colitis -1.082 5.0e-03
tuberculosis and treatment for 6 months -1.600 1.2e-04
pancreatic ductal adenocarcinoma liver m... 1.410 1.9e-02
intraductal papillary-mucinous adenoma (... 1.300 1.6e-03
intraductal papillary-mucinous carcinoma... 1.400 8.6e-04
intraductal papillary-mucinous neoplasm ... 1.100 2.1e-02
Breast cancer 2.700 4.7e-02
pediatric high grade glioma 1.500 4.6e-04
Alzheimer's disease 1.200 2.4e-02
Pick disease 2.300 3.8e-07
ovarian cancer 2.100 2.8e-07
dermatomyositis 1.100 1.3e-03

Gene RIF (29)

PMID Text
26645689 Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.
26566863 Treatment-induced temozolimide resistance in glioblastoma cells involves KDM5A mediated epigenetic mechanisms.
25686748 KDM5A is regulated by its reader domain through a positive-feedback mechanism
25575817 Data indicate that lysine (K)-specific demethylase 5A RBP2 (JARID1A; KDM5A) epigenetically downregulated micrRNA-21 (miR-21) in blast transformation of chronic myeloid leukemia (CML).
25190814 KDM5A and the NuRD complex cooperatively function to control developmentally regulated genes
25015565 RBP2 may link chronic inflammation to tumor development.
24716659 Overexpression of RBP2 and activation of VEGF might play important roles in human gastric cancer development and progression.
24582965 RBP2 is critical for breast cancer metastasis to the lung in multiple in vivo models. Mechanistically, RBP2 promotes metastasis as a pleiotropic positive regulator of many metastasis genes, including TNC.
24442343 Epigenetic changes mediated by JARID1A, SMYD3 and DNA methylation may be responsible, at least in part, for the functional progesterone withdrawal that precipitates human labour.
24376841 RBP2 down-regulated the expression of E-cadherin, up-regulated the expression of N-cadherin and snail, and induced epithelial-mesenchymal transition in non-small cell lung cancer cells.
24069348 JARID1A, JMY, and PTGER4 polymorphisms are related to ankylosing spondylitis in Chinese Han patients.
24068396 LSD1 is a more sensitive molecular marker than RBP2 on thyroid cancer diagnosis.
23922798 RBP2 is overexpressed in HCC and negatively regulated by hsa-miR-212. The hsa-miR-212-RBP2-CDKI pathway may be important in the pathogenesis of HCC.
23794145 MiR-212 directly regulates the expression of RBP2 and inhibits cell growth in gastric cancer, which may provide new clues to treatment.
23722541 our results establish an oncogenic role for RBP2 in lung tumorigenesis and progression and uncover novel RBP2 targets mediating this role.
23266085 High expression of KDM3B and KDM5A is associated with a better prognosis (no recurrence after mastectomy p=0.005 and response to docetaxel p=0.005)in breast cancer patients.
23093672 In terminally differentiated cells, common KDM5A and E2F4 gene targets were bound by the pRB-related protein p130, a DREAM complex component.
22615382 Jarid1a/b-mediated H3K4 demethylation contributes to silencing of retinoblastoma target genes in senescent cells, suggesting a mechanism by which retinoblastoma triggers gene silencing.
21935404 Evidence was provided that chronic drug exposure generated drug-tolerant cells via epigenetic mechanisms involving molecules such as CD44 and KDM5A.
21562575 JARID1A or a locus in strong linkage disequilibrium with it is a positional candidate for susceptibility to AS.
21348942 that H3K4 tri- and dimethylation play an important role and JARID1A is the histone-demethylating enzyme responsible for removal of this mark
19850045 RBP2 is overexpressed in gastric cancer, and its inhibition triggers senescence of malignant cells at least partially by derepressing its target genes cyclin-dependent kinase inhibitors.
19762557 Mad1 recruits RBP2 to the hTERT promoter that, in turn, demethylates H3-K4, thereby contributing to a stable repression of the hTERT gene in normal or differentiated malignant cells.
19430464 fusing an H3K4-trimethylation-binding PHD finger, such as the carboxy-terminal PHD finger of JARID1A, to a common fusion partner NUP98, generated potent oncoproteins that arrested haematopoietic differentiation and induced acute myeloid leukaemia
18722178 During differentiation, RBP2 exerts inhibitory effects on multiple genes through direct interaction with their promoters.
18270511 ARID is required for RBP2 demethylase activity in cells and that DNA recognition is essential to regulate transcription
17573780 RBP2 associates with MRG15 complex to maintain reduced H3K4 methylation at transcribed regions, which may ensure the transcriptional elongation state
17320161 Study shows that RBP2 is displaced from Hox genes during embryonic stem cell differentiation correlating with an increase of their di- and trimethylated histone 3 lysine 4 levels and expression.
16645588 that RBP2-H1 exerts a broad tumor-suppressive function partially mediated by pRb modulation

AA Sequence

MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPFACEVKSFRF      1 - 70
TPRVQRLNELEAMTRVRLDFLDQLAKFWELQGSTLKIPVVERKILDLYALSKIVASKGGFEMVTKEKKWS     71 - 140
KVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMGVQMPNLDLKEKVEPEVLSTDTQTSPEPGTR    141 - 210
MNILPKRTRRVKTQSESGDVSRNTELKKLQIFGAGPKVVGLAMGTKDKEDEVTRRRKVTNRSDAFNMQMR    211 - 280
QRKGTLSVNFVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPRE    281 - 350
AFGFEQAVREYTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGS    351 - 420
GFPVKDGRRKILPEEEEYALSGWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSY    421 - 490
SINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIMNPNVLMEHGVPVYRTNQCAG    491 - 560
EFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHEELIFKMAADPECLDVG    561 - 630
LAAMVCKELTLMTEEETRLRESVVQMGVLMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCL    631 - 700
YHPTDLCPCPMQKKCLRYRYPLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHKKDLIELRVMLEDA    701 - 770
EDRKYPENDLFRKLRDAVKEAETCASVAQLLLSKKQKHRQSPDSGRTRTKLTVEELKAFVQQLFSLPCVI    771 - 840
SQARQVKNLLDDVEEFHERAQEAMMDETPDSSKLQMLIDMGSSLYVELPELPRLKQELQQARWLDEVRLT    841 - 910
LSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAKVCLQARPRHSVASLESIVNE    911 - 980
AKNIPAFLPNVLSLKEALQKAREWTAKVEAIQSGSNYAYLEQLESLSAKGRPIPVRLEALPQVESQVAAA    981 - 1050
RAWRERTGRTFLKKNSSHTLLQVLSPRTDIGVYGSGKNRRKKVKELIEKEKEKDLDLEPLSDLEEGLEET   1051 - 1120
RDTAMVVAVFKEREQKEIEAMHSLRAANLAKMTMVDRIEEVKFCICRKTASGFMLQCELCKDWFHNSCVP   1121 - 1190
LPKSSSQKKGSSWQAKEVKFLCPLCMRSRRPRLETILSLLVSLQKLPVRLPEGEALQCLTERAMSWQDRA   1191 - 1260
RQALATDELSSALAKLSVLSQRMVEQAAREKTEKIISAELQKAAANPDLQGHLPSFQQSAFNRVVSSVSS   1261 - 1330
SPRQTMDYDDEETDSDEDIRETYGYDMKDTASVKSSSSLEPNLFCDEEIPIKSEEVVTHMWTAPSFCAEH   1331 - 1400
AYSSASKSCSQGSSTPRKQPRKSPLVPRSLEPPVLELSPGAKAQLEELMMVGDLLEVSLDETQHIWRILQ   1401 - 1470
ATHPPSEDRFLHIMEDDSMEEKPLKVKGKDSSEKKRKRKLEKVEQLFGEGKQKSKELKKMDKPRKKKLKL   1471 - 1540
GADKSKELNKLAKKLAKEEERKKKKEKAAAAKVELVKESTEKKREKKVLDIPSKYDWSGAEESDDENAVC   1541 - 1610
AAQNCQRPCKDKVDWVQCDGGCDEWFHQVCVGVSPEMAENEDYICINCAKKQGPVSPGPAPPPSFIMSYK   1611 - 1680
LPMEDLKETS                                                               1681 - 1690
//

Text Mined References (61)

PMID Year Title
26645689 2016 Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.
26566863 2015 The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma.
25686748 2015 Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism.
25575817 2015 Histone demethylase RBP2 decreases miR-21 in blast crisis of chronic myeloid leukemia.
25190814 2014 Physical and functional interactions between the histone H3K4 demethylase KDM5A and the nucleosome remodeling and deacetylase (NuRD) complex.
25015565 2014 Histone demethylase RBP2 induced by Helicobactor Pylori CagA participates in the malignant transformation of gastric epithelial cells.
24716659 2014 Critical role of histone demethylase RBP2 in human gastric cancer angiogenesis.
24582965 2014 Histone demethylase RBP2 is critical for breast cancer progression and metastasis.
24442343 2014 Increased progesterone receptor A expression in labouring human myometrium is associated with decreased promoter occupancy by the histone demethylase JARID1A.
24376841 2013 RBP2 induces epithelial-mesenchymal transition in non-small cell lung cancer.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24069348 2013 JARID1A, JMY, and PTGER4 polymorphisms are related to ankylosing spondylitis in Chinese Han patients: a case-control study.
24068396 2013 Immunohistochemical expression of RBP2 and LSD1 in papillary thyroid carcinoma.
23922798 2013 Histone demethylase retinoblastoma binding protein 2 is overexpressed in hepatocellular carcinoma and negatively regulated by hsa-miR-212.
23794145 2013 MicroRNA-212 inhibits proliferation of gastric cancer by directly repressing retinoblastoma binding protein 2.
23722541 2013 Histone demethylase RBP2 promotes lung tumorigenesis and cancer metastasis.
23266085 2013 Histone lysine demethylases in breast cancer.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23093672 2012 Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation.
22615382 2012 H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence.
21960634 2011 Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock.
21935404 2011 Drug-tolerant cancer cells show reduced tumor-initiating capacity: depletion of CD44 cells and evidence for epigenetic mechanisms.
21562575 2011 The histone demethylase JARID1A is associated with susceptibility to ankylosing spondylitis.
21348942 2011 The histone demethylase JARID1A regulates progesterone receptor expression.
20383146 2010 New loci associated with kidney function and chronic kidney disease.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
19850045 2010 The histone demethylase RBP2 Is overexpressed in gastric cancer and its inhibition triggers senescence of cancer cells.
19762557 2010 Chromatin remodeling: recruitment of histone demethylase RBP2 by Mad1 for transcriptional repression of a Myc target gene, telomerase reverse transcriptase.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19430464 2009 Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger.
18722178 2008 Genome-wide analysis of the H3K4 histone demethylase RBP2 reveals a transcriptional program controlling differentiation.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
18270511 2008 The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17573780 2007 RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation.
17320163 2007 The retinoblastoma binding protein RBP2 is an H3K4 demethylase.
17320161 2007 RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.
17320160 2007 The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.
17311883 2007 The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth.
17081983 2006 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
16645588 2006 Re-expression of the retinoblastoma-binding protein 2-homolog 1 reveals tumor-suppressive functions in highly metastatic melanoma cells.
16541399 2006 Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.
16541075 2006 The finished DNA sequence of human chromosome 12.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15949438 2005 Binding of pRB to the PHD protein RBP2 promotes cellular differentiation.
15640446 2005 DNA-binding properties of ARID family proteins.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15302935 2004 Large-scale characterization of HeLa cell nuclear phosphoproteins.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11445587 2001 A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH.
11358960 2001 Retinoblastoma-binding protein 2 (Rbp2) potentiates nuclear hormone receptor-mediated transcription.
9129143 1997 T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2.
9110174 1997 Large-scale concatenation cDNA sequencing.
8889549 1996 Generation and analysis of 280,000 human expressed sequence tags.
8619474 1996 A "double adaptor" method for improved shotgun library construction.
8530100 1995 Isolation and regional assignment of human chromosome 12p cDNAs.
8414517 1993 Characterization of the retinoblastoma binding proteins RBP1 and RBP2.
8125298 1994 Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
7935440 1994 Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein.
1857421 1991 Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product.