Tchem | Lysine-specific demethylase 4E |
The protein encoded by this intronless gene is a member of a large family of histone lysine demethylases, which use oxygen and 2-oxoglutarate to demethylate di- and trimethylated lys9 of histone H3. Derepression of genes by demethylases is sometimes involved in viral infection or carcinogenesis, so inhibitors of these enzymes are desired. [provided by RefSeq, Dec 2016]
Comments
CHEMBL3771198
pIC50 6.30
CHEMBL3771180
pIC50 6.30
CHEMBL3108958
pIC50 6.38
CHEMBL3769511
pIC50 6.40
CHEMBL3769724
pIC50 6.40
CHEMBL3621852
pIC50 6.40
CHEMBL51979
pIC50 6.40
CHEMBL1982368
pIC50 6.50
CHEMBL1230640
pIC50 6.50
CHEMBL2164246
pIC50 6.70
CHEMBL1615036
pIC50 6.75
CHEMBL3770740
pIC50 6.90
CHEMBL2169917
pIC50 6.96
CHEMBL3775889
pIC50 7.30
CHEMBL3775612
pIC50 7.40
CHEMBL3775237
pIC50 7.40
compound 6a [PMID: 18942826]
pIC50 5.85
ML324
pIC50 6.04
MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHQAGLAKVIPPKEWKARQMYDDIEDILIAT 1 - 70 PLQQVTSGQGGVFTQYHKKKKAMRVGQYRRLANSKKYQTPPHQNFADLEQRYWKSHPGNPPIYGADISGS 71 - 140 LFEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKTWY 141 - 210 VVPPEHGQHLERLARELFPDISRGCEAFLRHKVALISPTVLKENGIPFNCMTQEAGEFMVTFPYGYHAGF 211 - 280 NHGFNCAEAINFATPRWIDYGKMASQCSCGESTVTFSMDPFVRIVQPESYELWKHRQDLAIVEHTEPRVA 281 - 350 ESQELSNWRDDIVLRRAALGLRLLPNLTAQCPTQPVSSGHCYNPKGCGTDAVPGSAFQSSAYHTQTQSLT 351 - 420 LGMSARVLLPSTGSWGSGRGRGRGQGQGRGCSRGRGHGCCTRELGTEEPTVQPASKRRLLMGTRSRAQGH 421 - 490 RPQLPLANDLMTNLSL 491 - 506 //