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Tchem Lysine-specific demethylase 4E

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.

The protein encoded by this intronless gene is a member of a large family of histone lysine demethylases, which use oxygen and 2-oxoglutarate to demethylate di- and trimethylated lys9 of histone H3. Derepression of genes by demethylases is sometimes involved in viral infection or carcinogenesis, so inhibitors of these enzymes are desired. [provided by RefSeq, Dec 2016]

 Comments

Property Summary

Ligand Count 18
NCBI Gene PubMed Count 5
PubMed Score 5.72
PubTator Score 5.66

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (1)

Disease Target Count P-value
facioscapulohumeral dystrophy 288 6.7e-37

Expression

  Differential Expression (1)

Disease log2 FC p
facioscapulohumeral dystrophy 6.700 6.7e-37

Synonym

Accession B2RXH2
Symbols KDM5E
JMJD2E
KDM4DL

Gene

KDM4E

PANTHER Protein Class (2)

  Ortholog (1)

Species Source Disease
OMA EggNOG

 UniProt Keyword (13)

See all...

 GO Function (3)

 GO Component (1)

 GO Process (3)

 Compartment GO Term (11)

 HCA RNA Cell Line (9)

PDB (1)

Ligand (18)

Structure of CHEMBL3771198

CHEMBL3771198
pIC50 6.30

Structure of CHEMBL3771180

CHEMBL3771180
pIC50 6.30

Structure of CHEMBL3108958

CHEMBL3108958
pIC50 6.38

Structure of CHEMBL3769511

CHEMBL3769511
pIC50 6.40

Structure of CHEMBL3769724

CHEMBL3769724
pIC50 6.40

Structure of CHEMBL3621852

CHEMBL3621852
pIC50 6.40

Structure of CHEMBL51979

CHEMBL51979
pIC50 6.40

Structure of CHEMBL1982368

CHEMBL1982368
pIC50 6.50

Structure of CHEMBL1230640

CHEMBL1230640
pIC50 6.50

Structure of CHEMBL2164246

CHEMBL2164246
pIC50 6.70

Structure of CHEMBL1615036

CHEMBL1615036
pIC50 6.75

Structure of CHEMBL3770740

CHEMBL3770740
pIC50 6.90

Structure of CHEMBL2169917

CHEMBL2169917
pIC50 6.96

Structure of CHEMBL3775889

CHEMBL3775889
pIC50 7.30

Structure of CHEMBL3775612

CHEMBL3775612
pIC50 7.40

Structure of CHEMBL3775237

CHEMBL3775237
pIC50 7.40

Structure of compound 6a [PMID: 18942826]

compound 6a [PMID: 18942826]
pIC50 5.85

Structure of ML324

ML324
pIC50 6.04

Gene RIF (1)

AA Sequence 

MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHQAGLAKVIPPKEWKARQMYDDIEDILIAT      1 - 70
PLQQVTSGQGGVFTQYHKKKKAMRVGQYRRLANSKKYQTPPHQNFADLEQRYWKSHPGNPPIYGADISGS     71 - 140
LFEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKTWY    141 - 210
VVPPEHGQHLERLARELFPDISRGCEAFLRHKVALISPTVLKENGIPFNCMTQEAGEFMVTFPYGYHAGF    211 - 280
NHGFNCAEAINFATPRWIDYGKMASQCSCGESTVTFSMDPFVRIVQPESYELWKHRQDLAIVEHTEPRVA    281 - 350
ESQELSNWRDDIVLRRAALGLRLLPNLTAQCPTQPVSSGHCYNPKGCGTDAVPGSAFQSSAYHTQTQSLT    351 - 420
LGMSARVLLPSTGSWGSGRGRGRGQGQGRGCSRGRGHGCCTRELGTEEPTVQPASKRRLLMGTRSRAQGH    421 - 490
RPQLPLANDLMTNLSL                                                          491 - 506
//

Text Mined References (6)

PMID Year Title