Tclin | Tyrosine-protein kinase JAK3 |
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008]
Comments
Property Summary
Ligand Count | 656 |
NCBI Gene PubMed Count | 183 |
PubMed Score | 453.65 |
PubTator Score | 330.40 |
Disease | Target Count |
---|---|
Rheumatoid arthritis | 1191 |
Disease | Target Count | P-value |
---|---|---|
periodontitis | 293 | 2.7e-26 |
group 3 medulloblastoma | 4104 | 7.7e-07 |
osteosarcoma | 7950 | 1.0e-06 |
posterior fossa group B ependymoma | 416 | 7.7e-06 |
ulcerative colitis | 1819 | 7.8e-05 |
psoriasis | 6694 | 1.1e-04 |
medulloblastoma, large-cell | 6241 | 1.2e-04 |
lung adenocarcinoma | 2716 | 1.2e-04 |
ovarian cancer | 8520 | 1.4e-04 |
interstitial cystitis | 2312 | 2.1e-04 |
primitive neuroectodermal tumor | 3035 | 3.9e-04 |
head and neck cancer and chronic obstructive pulmonary disease | 239 | 1.7e-03 |
Atopic dermatitis | 952 | 2.0e-03 |
oligodendroglioma | 2850 | 1.3e-02 |
ductal carcinoma in situ | 1745 | 2.3e-02 |
Disease | log2 FC | p |
---|---|---|
Atopic dermatitis | 1.300 | 2.0e-03 |
ductal carcinoma in situ | 1.100 | 2.3e-02 |
group 3 medulloblastoma | -1.800 | 7.7e-07 |
head and neck cancer and chronic obstruc... | 1.400 | 1.7e-03 |
interstitial cystitis | 2.600 | 2.1e-04 |
lung adenocarcinoma | 1.200 | 1.2e-04 |
medulloblastoma, large-cell | -1.400 | 1.2e-04 |
oligodendroglioma | -1.100 | 1.3e-02 |
osteosarcoma | 1.283 | 1.0e-06 |
ovarian cancer | 1.200 | 1.4e-04 |
periodontitis | 1.100 | 2.7e-26 |
posterior fossa group B ependymoma | -1.100 | 7.7e-06 |
primitive neuroectodermal tumor | -1.500 | 3.9e-04 |
psoriasis | 1.200 | 1.1e-04 |
ulcerative colitis | 1.900 | 7.8e-05 |
Species | Source | Disease |
---|---|---|
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
OMA EggNOG | ||
OMA EggNOG |
CHEMBL1630795
pIC50 7.54
CHEMBL3642404
pIC50 7.54
CHEMBL3670397
pKi 7.54
CHEMBL3335678
pIC50 7.54
CHEMBL3114774
pIC50 7.54
CHEMBL3359914
pIC50 7.55
CHEMBL1081190
pIC50 7.55
CHEMBL1081377
pIC50 7.55
CHEMBL3593590
pIC50 7.55
CHEMBL3642411
pIC50 7.56
CHEMBL218439
pIC50 7.57
CHEMBL3357978
pIC50 7.57
CHEMBL3642262
pIC50 7.57
CHEMBL3593580
pIC50 7.57
CHEMBL1235315
pIC50 7.57
CHEMBL3764463
pIC50 7.57
CHEMBL323994
pIC50 7.57
CHEMBL234718
pIC50 7.57
CHEMBL3642340
pIC50 7.58
CHEMBL240429
pIC50 7.59
MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSL 1 - 70 FALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQ 71 - 140 HRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTR 141 - 210 RRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIA 211 - 280 WTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFR 281 - 350 LTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNP 351 - 420 LGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQR 421 - 490 GHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDA 491 - 560 KHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQ 561 - 630 LAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQ 631 - 700 TLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSF 701 - 770 RAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCR 771 - 840 YDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCL 841 - 910 RDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDY 911 - 980 YVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRL 981 - 1050 LELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHS 1051 - 1120 LSFS 1121 - 1124 //