Tbio ITM2C Integral membrane protein 2C

Protein Summary

Description

Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).

Uniprot Accession IDs

• Q9NQX7
• B3KPG4
• Q4G0A8
• Q53H84
• Q6IAE7
• Q86VK5
• Q8N288
• Q8TAW0
• Q9BUP8

Gene Name

• ITM2C

Ensembl ID

• ENST00000326407
• ENSP00000322100
• ENSG00000135916
• ENST00000326427
• ENSP00000322730
• ENST00000335005
• ENSP00000335121

Symbol

• BRI3
• E25
• BRI3
• E25C
• ITM3
• BRICD2C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.88
transcription factor perturbation	0.88
disease perturbation	0.87
molecular function	0.84
small molecule perturbation	0.82

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.69   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 131   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.69   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0