| Tchem | Integrin alpha-V |
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]
Comments
Property Summary
| Ligand Count | 35 |
| NCBI Gene PubMed Count | 522 |
| PubMed Score | 407.19 |
| PubTator Score | 468.15 |
| Disease | Target Count |
|---|---|
| Cerebrovascular accident | 63 |
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 5.0e-12 |
| tuberculosis | 2010 | 2.8e-08 |
| Astrocytoma, Pilocytic | 3081 | 1.5e-06 |
| acute quadriplegic myopathy | 1158 | 1.2e-04 |
| medulloblastoma, large-cell | 6241 | 2.8e-04 |
| ovarian cancer | 8520 | 9.7e-04 |
| nasopharyngeal carcinoma | 1058 | 1.8e-03 |
| osteosarcoma | 7950 | 2.8e-03 |
| hereditary spastic paraplegia | 318 | 3.0e-03 |
| diabetes mellitus | 1728 | 4.8e-03 |
| glioblastoma | 5792 | 2.9e-02 |
| Breast cancer | 3578 | 2.9e-02 |
| Rheumatoid arthritis | 1191 | 3.8e-02 |
| group 3 medulloblastoma | 4104 | 4.5e-02 |
| Disease | log2 FC | p |
|---|---|---|
| acute quadriplegic myopathy | 1.030 | 1.2e-04 |
| Astrocytoma, Pilocytic | 1.400 | 1.5e-06 |
| Breast cancer | 2.500 | 2.9e-02 |
| diabetes mellitus | -1.100 | 4.8e-03 |
| glioblastoma | 1.100 | 2.9e-02 |
| group 3 medulloblastoma | -1.100 | 4.5e-02 |
| hereditary spastic paraplegia | -1.161 | 3.0e-03 |
| medulloblastoma, large-cell | -2.200 | 2.8e-04 |
| nasopharyngeal carcinoma | 1.100 | 1.8e-03 |
| non-small cell lung cancer | 1.006 | 5.0e-12 |
| osteosarcoma | 2.002 | 2.8e-03 |
| ovarian cancer | -1.800 | 9.7e-04 |
| Rheumatoid arthritis | 1.200 | 3.8e-02 |
| tuberculosis | -2.600 | 2.8e-08 |
CHEMBL560927
pIC50 6.01
CHEMBL556845
pIC50 6.10
CHEMBL562068
pIC50 6.10
CHEMBL561270
pIC50 6.14
CHEMBL550395
pIC50 6.16
CHEMBL464399
pIC50 6.22
CHEMBL518086
pIC50 6.43
CHEMBL550320
pIC50 6.50
CHEMBL464400
pIC50 6.51
CHEMBL558520
pIC50 6.52
CHEMBL561126
pIC50 6.59
CHEMBL560670
pIC50 6.59
CHEMBL460622
pIC50 6.64
CHEMBL558939
pIC50 6.68
CHEMBL464398
pIC50 6.75
CHEMBL561737
pIC50 6.92
CHEMBL559740
pIC50 6.93
CHEMBL540432
pIC50 7.01
CHEMBL2372256
pIC50 7.07
CHEMBL562529
pIC50 7.09
MAFPPRRRLRLGPRGLPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGA 1 - 70 PKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAP 71 - 140 LYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQ 141 - 210 GQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTL 211 - 280 GMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQ 281 - 350 RASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQI 351 - 420 LEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKT 421 - 490 CSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRG 491 - 560 GLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDN 561 - 630 VCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAF 631 - 700 KTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLA 701 - 770 AVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLY 771 - 840 ILHYDIDGPMNCTSDMEINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLGCGVAQCL 841 - 910 KIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTTN 911 - 980 VTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRPPQEEQEREQLQPHENGEGNSET 981 - 1048 //
