| Tdark | Actin-binding protein IPP |
May play a role in organizing the actin cytoskeleton.
The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 50 amino acid repeat which interacts with actin. Transcript variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 50 amino acid repeat which interacts with actin. Transcript variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ependymoma | 2514 | 3.5e-15 |
| osteosarcoma | 7933 | 7.3e-08 |
| pilocytic astrocytoma | 3086 | 9.7e-08 |
| group 4 medulloblastoma | 1875 | 1.1e-07 |
| atypical teratoid / rhabdoid tumor | 4369 | 6.0e-06 |
| pediatric high grade glioma | 2712 | 7.6e-06 |
| medulloblastoma, large-cell | 6234 | 1.3e-04 |
| glioblastoma | 5572 | 3.6e-04 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2988 | 8.2e-03 |
| Disease | log2 FC | p |
|---|---|---|
| osteosarcoma | 2.851 | 7.3e-08 |
| ependymoma | 1.700 | 3.5e-15 |
| group 4 medulloblastoma | 1.700 | 1.1e-07 |
| atypical teratoid / rhabdoid tumor | 1.600 | 6.0e-06 |
| glioblastoma | 1.300 | 3.6e-04 |
| medulloblastoma, large-cell | 1.300 | 1.3e-04 |
| intraductal papillary-mucinous carcinoma... | 1.100 | 8.2e-03 |
| pediatric high grade glioma | 1.300 | 7.6e-06 |
| pilocytic astrocytoma | 1.100 | 9.7e-08 |
MANEDCPKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGM 1 - 70 KESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCI 71 - 140 GIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILK 141 - 210 DLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKV 211 - 280 RPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGG 281 - 350 EKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVV 351 - 420 GNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSV 421 - 490 GGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYN 491 - 560 PHSDTWTEIGNMITSRCEGGVAVL 561 - 584 //
| PMID | Year | Title | |
|---|---|---|---|
| 23676014 | 2013 | Update on the Kelch-like (KLHL) gene family. | |
| 16710414 | 2006 | The DNA sequence and biological annotation of human chromosome 1. | |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 11536049 | 2001 | Cloning and characterization of ectopically expressed transcripts for the actin-binding protein MIPP in mouse mammary carcinomas. | |
| 10072760 | 1999 | Isolation and characterization of IPP, a novel human gene encoding an actin-binding, kelch-like protein. | |
| 8432546 | 1993 | The IPP gene is assigned to human chromosome 1p32-1p22. | |
| 1906605 | 1991 | Identification of a novel murine IAP-promoted placenta-expressed gene. | |
| 1905535 | 1991 | Cell lineage-specific expression of the MIPP gene. |
