Property Summary

NCBI Gene PubMed Count 3,552
PubMed Score 28484.71
PubTator Score 22090.00

Knowledge Summary


No data available


  Disease (7)

Disease Target Count
Obesity 616
Atherosclerosis 275
Metabolic syndrome X 155
Pneumonia 133
Osteoporosis 259
psoriasis 6685
Schizophrenia 503
Cholestasis 93
Leishmaniasis 49
Hypercalcemia 37
Acute kidney injury 65
Albuminuria 20
Amnesia 17
Angiolymphoid hyperplasia 1
Arthritis, Experimental 39
Autistic Disorder 320
Autoimmune Diseases 33
Basal cell carcinoma 31
Berylliosis 28
Cachexia 10
Cardiomyopathies 90
Cerebrovascular accident 44
Cholangiocarcinoma 32
Colitis 46
Crohn Disease 97
Depressive disorder 48
Dermatitis, Atopic 45
Dermatologic disorders 65
Diabetes Mellitus, Experimental 106
Diabetes Mellitus, Non-Insulin-Dependent 161
Diaphragmatic Hernia 40
Drug-Induced Liver Injury 118
Edema 38
Entamoebiasis 6
Fever 34
Glomerulonephritis 36
HIV Wasting Syndrome 4
Headache 5
Heart failure 80
Heat Stroke 12
Hepatitis, Autoimmune 17
Hepatolenticular Degeneration 24
Hyperalgesia 71
Hyperoxaluria 5
Hyperparathyroidism, Secondary 5
Hypersensitivity 63
Hypoalbuminemia 3
Hypotension 53
Infarction, Middle Cerebral Artery 25
Inflammation 109
Inflammatory Bowel Diseases 87
Intracranial Arteriovenous Malformation 1
Ischemia 27
Kaposi Sarcoma 1
Kidney Failure, Chronic 45
Leishmaniasis, Visceral 13
Lichenoid Eruptions 2
Liver Cirrhosis 101
Liver Cirrhosis, Alcoholic 16
Liver carcinoma 217
Lung Injury 20
Lung Neoplasms 171
Lupus Erythematosus, Systemic 73
Mammary Neoplasms 410
Mitochondrial Myopathies 6
Multiple myeloma 1327
Myocardial Infarction 126
Myocardial Ischemia 169
Necrosis 51
Neoplasm Invasiveness 127
Neoplasm Metastasis 138
Neoplastic Cell Transformation 81
Neurodegenerative Disorders 37
Osteoporosis, Postmenopausal 7
Parkinson Disease 105
Peripheral Neuropathy 303
Pleurisy 18
Polymyositis 5
Pregnancy Complications, Cardiovascular 4
Premature Birth 9
Premature Obstetric Labor 2
Prostatic Neoplasms 471
Pulmonary Fibrosis 66
Renal Cell Carcinoma 199
Reperfusion Injury 84
Respiratory Hypersensitivity 18
Rheumatoid Arthritis 1170
Seizures 95
Shock, Hemorrhagic 7
Spontaneous abortion 108
Squamous cell carcinoma 96
Stomach Neoplasms 282
Thyroid Neoplasm 33
Ventricular Dysfunction, Left 15
chronic lymphocytic leukemia 244
hemolytic-uremic syndrome 28
ovarian neoplasm 97
Disease Target Count Z-score Confidence
Juvenile rheumatoid arthritis 105 0.0 5.0
Type 1 diabetes mellitus 104 0.0 5.0
Disease Target Count Z-score Confidence
Arthritis 248 6.896 3.4
Cancer 2346 6.776 3.4
diabetes mellitus 1663 6.115 3.1
Inflammatory bowel disease 142 5.98 3.0
Coronary artery disease 240 5.945 3.0
Hypersensitivity reaction type II disease 235 5.822 2.9
Kidney disease 397 5.781 2.9
periodontitis 269 5.637 2.8
Pancreatitis 97 5.373 2.7
Hypertension 293 5.364 2.7
Cerebrovascular disease 231 5.306 2.7
Heart disease 279 5.305 2.7
Liver disease 219 5.256 2.6
Chorioamnionitis 15 5.215 2.6
Peritonitis 37 5.164 2.6
Asthma 349 5.077 2.5
Anemia 252 5.03 2.5
Chronic obstructive pulmonary disease 147 4.97 2.5
Influenza 142 4.852 2.4
Multiple Sclerosis 498 4.832 2.4
Brain disease 84 4.752 2.4
Acquired immunodeficiency syndrome 164 4.705 2.4
Vasculitis 64 4.694 2.3
Alzheimer's disease 644 4.63 2.3
Hyperglycemia 120 4.607 2.3
Meningitis 46 4.605 2.3
Dermatitis 141 4.568 2.3
Respiratory failure 30 4.532 2.3
Synovitis 72 4.502 2.3
tuberculosis 1563 4.477 2.2
interstitial lung disease 292 4.459 2.2
Fatty liver disease 86 4.372 2.2
Leukopenia 42 4.361 2.2
Collagen disease 25 4.333 2.2
Lipid metabolism disorder 102 4.326 2.2
Uveitis 103 4.318 2.2
Endometriosis 535 4.286 2.1
Funisitis 8 4.259 2.1
Obstructive sleep apnea 28 4.23 2.1
Thrombocytopenia 105 4.192 2.1
Allergic hypersensitivity disease 123 4.17 2.1
Myopathy 128 4.099 2.0
Cystitis 16 4.089 2.0
Kawasaki disease 24 4.054 2.0
Malaria 140 3.977 2.0
Perinatal necrotizing enterocolitis 18 3.966 2.0
Dry eye syndrome 14 3.879 1.9
Dementia 129 3.851 1.9
Bacterial vaginosis 15 3.845 1.9
Major Depressive Disorder 106 3.842 1.9
Diarrhea 155 3.803 1.9
Aortic aneurysm 34 3.798 1.9
Toxic encephalopathy 131 3.792 1.9
Neuropathy 210 3.716 1.9
Toxic shock syndrome 28 3.702 1.9
Hepatitis B 103 3.685 1.8
cystic fibrosis 1670 3.681 1.8
Parasitic helminthiasis infectious disease 13 3.66 1.8
Keratitis 42 3.63 1.8
Pain agnosia 99 3.588 1.8
Exanthem 39 3.547 1.8
Diabetic Retinopathy 53 3.535 1.8
Common cold 63 3.531 1.8
Allergic rhinitis 92 3.53 1.8
Mastitis 48 3.515 1.8
Hepatitis C 90 3.514 1.8
Tetanus 66 3.496 1.7
Primary immunodeficiency disease 52 3.489 1.7
POEMS syndrome 6 3.428 1.7
Gingivitis 19 3.42 1.7
Peripheral vascular disease 90 3.413 1.7
Ankylosing spondylitis 138 3.398 1.7
Hemophagocytic lymphohistiocytosis 30 3.386 1.7
Arthropathy 34 3.385 1.7
Disseminated intravascular coagulation 32 3.381 1.7
Gastritis 44 3.354 1.7
Infertility 163 3.337 1.7
Otitis media 32 3.283 1.6
Candidiasis 48 3.271 1.6
Intestinal obstruction 16 3.266 1.6
Polycystic Ovary Syndrome 334 3.255 1.6
Psoriatic arthritis 85 3.25 1.6
Polyclonal hypergammaglobulinemia 5 3.248 1.6
Macular retinal edema 11 3.245 1.6
Parkinson's disease 364 3.218 1.6
Listeriosis 17 3.192 1.6
Cholangitis 20 3.188 1.6
Eosinophilia 65 3.185 1.6
Appendicitis 18 3.173 1.6
Lyme disease 23 3.161 1.6
Hyperinsulinism 63 3.156 1.6
Takayasu's arteritis 54 3.148 1.6
sarcoidosis 368 3.134 1.6
Bronchitis 44 3.123 1.6
Chronic fatigue syndrome 29 3.122 1.6
Prostatitis 15 3.101 1.6
Amyloidosis 68 3.072 1.5
Bacteriuria 13 3.067 1.5
Endometritis 21 3.057 1.5
Euthyroid sick syndrome 5 3.038 1.5
Degenerative disc disease 28 3.035 1.5


See source...

Protein-protein Interaction (8)

Gene RIF (3928)

27468568 Culture conditions affect Il6 secretion by stem cells to be used in treating myocardial infarction and may affect treatment outcome.
27296261 There was an association of the polymorphism G(-174)C of the IL-6 gene with the clinical features of Chronic Glomerulonephritis and a response to immunosuppressive therapy .
27049557 The results of this study indicated that IL-6 promoter -174 polymorphisms may play a role in susceptibility to stroke, but not stroke outcome.
27030742 Glioma stem cells, but not the bulk glioma cells, initiate microglial IL-6 secretion which regulates glioma growth.
27016501 Studies indicate that interleukin 6 (IL-6) is a central player in physiological neuronal and glial function as well as neuroinflammatory pathways observed in diseases of the central nervous system..
27012192 that the expression of ERG in prostate cancer is linked to the expression of IL-6 mediated by the prostanoid receptor EP2
27010153 The levels of ESM1, CLDN5, IL-1beta, IL-6, and TNF-alpha were significantly higher in the migraine attack group than in the control group
26960986 Presence of G allele or GG genotype at the -174 and the GG genotype at the -597 positions of the promoter region of the interleukin-6 gene constitute risk factors for developing febrile seizures in Egyptian children.
26945971 IL-6 is a contributing factor for multidrug resistance in cancer due to gp130/MAPK/STAT3 mediated activation of transcription factors, overexpression of p-glycoprotein, epithelial to mesenchymal transition and expansion of stem cells. [Review]
26911440 common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM10 exposure and diabetes
26907493 ANDV caused long-term elevated levels of eotaxin-1, IL-6, IL-8, IP-10, and VEGF-A that peaked 20-25 days after infection
26888535 Among recent lacunar stroke patients, IL-6 (and TNF receptor) concentrations predict risk of recurrent vascular events.
26881970 The results reveal that more severe inflammation, based on high levels of IL-6, is associated with lower expression of VPAC1 and, conversely, with increased expression of VPAC2.
26881918 Our results suggested that TNF-alpha may be an ideal biomarker for diagnosing the 3 forms of TB presentation, while the other factors (IL-6, IP-10, MCP-1, and IFN-gamma) can potentially facilitate differential diagnosis for the 3 TB presentation types
26876172 Tumor-driven, unremitting expression of Satb1 in activated Zbtb46+ inflammatory dendritic cells that infiltrate ovarian tumors results in an immunosuppressive phenotype characterized by increased secretion of tumor-promoting Galectin-1 and IL-6.
26858125 IL6/Notch3 signaling mediates hormone therapy resistance in metastatic breast cancer via self renewal of cancer stem cells.
26851119 IL6 is elevated and lung function is decreased in Ataxia-Telangiectasia
26850187 Patients aged >70 y undergoing cardiac operations generate more IL-6 during cardiopulmonary bypass.
26849353 The blood levels of IL-6 were significantly higher in women with polycystic ovary syndrome compared to BMI-matched controls.
26842302 GLP-1 secretion increased in response to inflammatory stimuli in humans, which was associated to parameters of glucose metabolism and best predicted by IL6.
26840977 The results show a protective effect of IL17 and IL6 polymorphisms on Pulmonary Tuberculosis outcome in Southern Brazilian population.
26840403 plasma IL-6 level is an independent and consistent predictor of AF in patients with CKD.
26799482 Ap-1 plays an essential role in the regulation of Il-1 beta induction of interleukin-6 in the developing enterocyte.
26790618 ERalpha decreased CCL5 and IL-6 expression in conditioned media that was collected from Cancer associated fibroblast cell.
26782575 The GG genotype of the -634C/G polymorphism in IL-6 appears to play a role in reducing bone mineral density, which affects normal bone metabolism and leads to osteoporosis. (Meta-analysis)
26781506 We have demonstrated an IL-6 -174 genotype dependent association between H. pylori infection and low serum HDL levels.
26780676 A prognostic model predicts the risk of distant metastasis and death for patients with nasopharyngeal carcinoma based on pre-treatment interleukin 6 and clinical stage
26775116 colorectal cancer cells secreting IL-6 via STAT3 phosphorylation can enhance the phagocytic capacity and migration of macrophages in the tumor microenvironment.
26775040 interaction of NHE1, NCX1 and CaM mediates the effects of IL6 on human hepatocellular carcinoma
26773775 Data suggest that overweight interacts with vitamin D deficiency to modulate inflammatory response, affecting plasma levels of adiponectin, sICAM1 (soluble intercellular adhesion molecule-1), and cytokines (interleukin 6, tumor necrosis factor-alpha).
26765465 high serum level associated with poor prognosis for colorectal cancer [review]
26765421 Interleukin 6 genetic polymorphism is associated with the development of hypertension.
26756931 B cells from relapsing-remitting multiple sclerosis patients produce TNFa and IL6, and present MBP85-99 peptide
26750536 Our data suggested that IL-6 mediates the singnal pathway of JAK-STAT3-VEGF-C promoting the growth, invasion and lymphangiogenesis in gastric cancer
26743937 Serum levels of IL-6 were significantly higher in subjects with lumbar intervertebral disc disease compared to control subjects.
26733302 no association was found for either polymorphism, suggesting that these genes are not implicated in the aetiology of Alzheimer's disease in all populations.
26728383 Data show that the expressions of interleukins IL-1 and IL-6 in the discs of discogenic low back pain (DLBP) patients were significantly elevated and negatively correlated with the Japanese Orthopedic Association (mJOA) scores of low back pain.
26722564 Il-6 CC genotype was more strongly associated with ischemic stroke than other two polymorphisms TNF-alpha and IL-10 in our population.
26714766 This is the first study to investigate the effects of functional two polymorphisms on IL-6 and IL-6R genes in a pediatric patient group with AA risk.
26711564 Concentrations of IL-6 (and IL-8) were found to be elevated in fibromyalgia patients.
26708270 The present study therefore indicated that IL-6 promoted the process of EMT in HIBECs as characterized by increased migration and invasion of HIBECs and the typical changes in mRNA and protein expression of the EMT markers E-cadherin and vimentin.
26702930 type 2 diabetes patients carrying the C allele of the IL-6 G(-174)C polymorphism have a significantly increased risk of cardiovascular diseases.
26700310 interleukin-6 and heme oxygenase-1 are involved in resistance to lenalidomide in multiple myeloma cells
26700208 we found no trend of increasing risk for primary dysmenorrhea in association with the number of putative high-risk genotypes of IL6 gene -597 G>A and -572 G>C and ESR1 gene XbaI polymorphisms.
26699882 High serum IL-6 levels were associated with Chronic Spontaneous Urticaria.
26681039 the results of this meta-analysis suggested that the IL-6 -572G/C polymorphism was not associated with an elevated risk of cancer.
26679059 In chronic cocaine abusers, serum levels of IL-6 were significantly increased compared to controls.
26673628 show the upregulation of the tumor-associated antigens CEACAM5/6 by trans-signaling of the pro-inflammatory cytokine IL-6
26671411 The SRF-IL6 axis is the critical mediator of YAP-induced stemness in mammary epithelial cells and breast cancer.
26662441 the CC genotype and C allele of the IL6 -174G/C (rs1800795) polymorphism are associated with an increased risk of cerebral infarction.
26662429 We did not observe a statistically significant association between IL-6 (-174 G>C) polymorphism and CD (P > 0.05).
26657940 The IL6 rs1818879 (GA) heterozygous genotype was associated with severe influenza A (H1N1) virus infection and two IL1B SNPs were associated with a decreased risk of infection
26640809 The functional IL-6 polymorphism rs1800795 is associated with intermediate uveitis but not with HLAB27 acute anterior uveitis.
26638215 Administration of E1 + P1 and E1 + P2 decreased the inhibitory effect of E1 on the IL-6 levels and AQP4 protein expression
26626206 tumour volume and mitotic index of tumours in nude mice co-injected with U266 and MSC transfected with IL-6 siRNA were significantly reduced compared to tumours of mice co-injected with control MSC
26623559 Data show that interleukin-6 (IL-6) promotes tumour self-seeding by circulating tumour cells (CTCs) in a nude mouse model.
26608499 Cerebrospinal fluid (CSF) levels of IL-6, IL-8, IL-10, MMP-2 and MMP-9 were significantly higher in patients with acute transverse myelitis; CSF IL-6 and IL-8 were significantly associated with severity of the disease
26605964 Data show that interleukin-6 (IL6) -174G>C substitution associated with lower grade of bladder cancer.
26600476 Articular cartilage tissues in knee OA patients have higher levels of MMP-9 and IL-6 expression, and these may play a synergistic role in OA pathogenesis.
26587801 Data show that monocytes from elderly denture wearers with Candida-related denture stomatitis produced lower levels of proinflammatory cytokines CXCL-8, IL-6 and MCP-1.
26581830 Data indicate that better cognitive control specifically following an emotional stressor is uniquely associated with less pronounced salivary IL-6 increase in response to such stress.
26580974 IL6 repressive effect on HBV replication is mediated by a loss of HNF1a and HNF4a binding to the cccDNA and a redistribution of STAT3 binding from the cccDNA to IL6 cellular target genes
26578807 This study points to a prominent contribution from promoter genetic variation in fibroblast IL-6 regulation, but not in other IL-6-producing cell types.
26572700 There was significant association between the genotype and allele frequencies of the IL6 -174 gene (rs1800795) and tinnitus among the elderly with history of exposure to occupational noise.
26559268 no role of rs1800796 in development of acute injury in rectal cancer patients treated with chemoradiotherapy
26558825 IL-6 gene variants previously found to associate among Indian children did not associate with risk of obesity or obesity-related quantitative measures among Caucasian children and juvenile men from Denmark.
26549519 these data indicate that IL-6 inhibits starvation-induced autophagy and that p-STAT3 mediates the signal transduction from IL-6 to downstream proteins including Bcl-2 and Beclin1
26549437 pimozide reduced the basal expression of phosphorylation STAT3 at tyrosine 705 and reversed the expression of phosphorylation of STAT3 induced by IL-6 addition, suggesting that pimozide can suppress cellular STAT3 activation
26535651 we suggest that the IL-6-572C>G (rs1800796) gene polymorphism influences the development of prostate cancer.
26535637 Our meta-analysis suggests that polymorphism rs1800796 within the IL6 gene may be a potential risk factor for cancer.
26535620 the meta-analysis results suggested that the IL6 -174 G/C polymorphism was not associated with an increased risk of ischemic stroke.
26530697 Our data suggest that chronic inflammation promotes the development of CRC by stimulating aerobic glycolysis and IL-6 is functioning, at least partly, through regulating PFKFB3 at early stage of colorectal cancer (CRC).
26526676 IL-6 promoter SNPs -597G > A (rs1800797), -572G > C (rs1800796) and -174G > C (rs1800795) were not associated with rheumatoid arthritis susceptibility.
26525581 PECs exhibited higher proliferation in response to IL-6/sIL-6R co-treatment compared with TECs in HCC via the up-regulation of gp130 /JAK2/STAT3.
26522057 These results showed that hybrid training system on a cycle ergometer (CE) was more efficient in stimulating acute increases in GH, lactate and IL-6 than CE at the same workload.
26518043 Inflammatory alterations associated with monocytes during HIV infection are different from those in aging individuals, mainly characterized by high levels of IL-6- and IL-10-producing monocytes.
26517210 the higher expression of IL-6 gene is an independent risk factor for cognitive decline among cognitive impairment no dementia individuals.
26515594 Data indicate the role of tropomyosin-related kinase-B (TrkB) in activation of the interleukin-6/Janus kinase 2/STAT3 transcription factor and PI3 kinase/c-AKT proto-oncogene protein pathway in breast cancer.
26513016 Up-regulation of IL-6 is associated with triple-negative breast cancer.
26512918 Describe a novel signaling network in which YB-1 regulates IL-6, and vice versa, creating a positive feed-forward loop driving EMT-like metastatic features during breast cancer progression.
26505399 we...investigate the genetic variants Interleukin-1beta(IL-1beta) +3953 C/T (rs1143634), IL-6 -174G/C (rs1800795), IL-8 -251T/A (rs4073), and IL-10 -1082A/G (rs1800896) and -819C/T (rs1800871) in the development of coronary artery disease
26494971 Prolonged low levels of plasma IL-6/-8 in pancreatic ductal carcinoma patients may be a prognostic marker for the clinical outcomes of chemoimmunotherapy.
26491227 IL-6 and the JAK-STAT signaling pathway have roles in myeloproliferative neoplasms
26486258 Patients with gastric cancer (GC) have significantly higher IL-6 levels, and lower IL-8 and IL-10 concentrations, in comparison to controls and patients with other gastric neoplasms
26474968 The mRNA expression of RORC, TNF-alpha and IL-6 was significantly high in CC patients
26472479 data suggest that, in neuromyelitis optica patients, IL-6 is related with severity of disease and this can be explained, at least in part, by the ability of this cytokine in favouring expansion of the corticoid-resistant Th17 phenotype
26463449 The GG genotype of rs1800796 predisposes to sepsis in chronic renal disease and to 28-day mortality by sepsis-unrelated cardiovascular phenomena.
26453329 The coupling between IL-6 and CRP requires increased adiposity, likely through release of IL-6 by visceral fat
26450708 miR-139-mediated downregulation of MCPIP1 promotes IL-6 expression in osteoarthritis.
26450567 Data show that microRNA-136 (miRNA-136) antagonized H5N1 influenza A virus replication, and as an interleukin 6 (IL-6) repressor, simultaneously as an immune trigger of retinoic acid-inducible gene 1 (RIG-I) signaling.
26447433 These results suggest that genetic predisposition to higher IL-6 production is associated with increased risk to HBV infection and hepatic inflammation, which might be due to C/EBPalpha-mediated regulatory effect on Th17 and Treg responses.
26429310 The results show an association between FcgRIIa, TNF-alpha and IL-6 gene single nucleotide polymorphisms and symptom persistence in Dengue patients.
26416274 Polarization of Monocytic Myeloid-Derived Suppressor Cells by Hepatitis B Surface Antigen Is Mediated via ERK/IL-6/STAT3 Signaling Feedback and Restrains the Activation of T Cells in Chronic Hepatitis B Virus Infection.
26408709 Results show significant post-operative increase in IL-6 concentration in patients with bone cancer.
26399395 Studied gene-specific regulation of hepatic selenoprotein expression by interleukin-6; by testing human hepatocytes in culture, found IL-6 reduced the concentrations of SePP mRNA and secreted SePP in a dose-dependent manner.
26385653 In CAD patients levels of TNF-alpha were higher, but IL-6 were not, and these cytokines might be flush out by lymphatic route
26385345 It is concluded that IL6 -174 G>C and IL1B +3954 C>T SNPs might be involved in the development of congenital Toxoplasma gondii infection.
26385127 These results indicate that certain SNPs of IL-6 gene at position -174 which located in promoter have association with predisposition of individuals to RAS.
26384383 Results show that IL-6 cytokine-induced lipolysis may be restricted to mesenteric white adipose tissue and that it contributes to hepatic insulin resistance and steatosis.
26381542 Data show that higher plasma levels of matrixmetalloproteinases 2/9 (MMP-2/MMP-9), osteopontin (OPN) and interleukin-6 (IL-6) were observed in Non-Hodgkin lymphomas (NHL) patients compared to controls.
26376825 Serum IL-6 levels correspond with severity of injury. However, within the first twelve hours after injury, these levels did not vary significantly with duration of injury.
26376467 IL-6 was expressed in normal epithelial cells, premalignant epithelial cells and malignant epithelial cells as well as in stromal cells
26363066 The IL-6 signaling complex is a hexamer, formed by the association of two IL-6.IL-6 receptor (IL-6R).gp130 trimers, with gp130 being the signal transducer inducing cis- and trans-mediated signaling via a membrane-bound or soluble form of the IL-6R.
26352938 IL-6 was involved in increasing free fatty acids, suggesting that the evening is more effective for exercise-induced lipolysis compared with the morning.
26345781 A comprehensive search was performed investigating the associations between IL-6 -174G>C polymorphism and COPD.
26345772 We conducted this case-control study to investigate the genetic role of IL-1beta+3954C/T, IL-6-174G/C, IL-6-572C/G, IL-10-1082A/G, and IL-10-819C/T in the development of coronary artery disease (CAD) in a Chinese population
26343270 The study presents the latest discoveries concerning the role of IL-6 in hepatitis B disease progression, and HBV entry and replication, and evaluate polymorphisms that are associated with the development of hepatitis B disease. [review]
26341097 IL-6 -174 G/C, IL-6 -634 G/C polymorphisms are associated with susceptibility to recurrent pregnancy loss.
26339896 Case Reports: IL-6 antagonism with tocilizumab in diffuse cutaneous systemic sclerosis was associated with an exacerbation of gastrointestinal symptoms.
26338965 Data show that tumor suppressor p16(INK4A) inhibits interleukin-6 (IL-6) expression in a microRNA miR-146b-5p-dependent manner.
26316317 The present study suggests that IL-6 of the tumor microenvironment has a critical role in oncogenic epithelial-to-mesenchymal transition
26316104 Significant associations were found between Crohn's disease (CD) and minor NOD2 variants, as well as TLR4 299Gly, TNF-alpha G-308A, IL-6 G-174C and IL-1RN VNTR A2 variants, while ulcerative colitis (UC) was associated only with IL-1RN VNTR A2 variants.
26315114 Data show that S100 calcium binding protein A9 (S100A9) mediated interleukin-6 (IL-6) release via the crosstalk of oral cancer cells with monocytes.
26313152 IL-6 signaling has a role in cisplatin resistance in non-small cell lung cancer via the up-regulation of anti-apoptotic and DNA repair associated molecules
26287468 Tet2 selectively mediates active repression of interleukin-6 (IL-6) transcription during inflammation resolution in innate myeloid cells, including dendritic cells and macrophages
26285873 IL6 was significantly greater in HIV/AIDS patients than in healthy controls.
26285213 174 G>C polymorphism is associated with severe Flu-Like Syndrome in Interferon Beta-1a Treated Multiple Sclerosis Patients.
26282935 Having the capability to predict the ascites formation, IL-6 might serve as a biomarker and a useful tool in epithelial ovarian cancer for monitoring purposes.
26279422 IL-6 secretion, TLR4 expression, and reactive oxygen species production, classical markers of inflammation, are down-regulated by moderate hypoxia.
26279115 IL-6 variability was positively associated with cognitive impairment and with greater decrease per year of gray matter volume of the hippocampus.
26276663 The incidence of polymorphic changes in IL-6 gene was in seen in seven (of the 62 patients) (11.3%), and in the 16 (20%) controls.
26270987 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
26266960 Increased soluble gp130 in older patients may inhibit IL-6 trans-signaling, impair barrier function, and decrease S100A8/ S100A9 production in elderly chronic rhinosinusitis patients with asthma and nasal polyps.
26252635 These findings support the feasibility of future efforts for diagnosis and gene therapy for prostate cancer that are based on IL-6, miR-21, and PDCD4.
26247025 RRV can infect human cholangiocytes resulting in the production of proinflammatory and profibrotic cytokines via the MAPK pathway. RRV-infected H69 cells could be a useful model system for investigating the viral hypothesis of BA.
26238017 Elevated IL-6 levels led to poorer 2-year progression-free survival rates in patients with ovarian clear cell carcinoma.
26233477 the polymorphism -572G/C IL6 is a protective factor for the presence and severity of hip and knee osteoarthritis in the elderly
26228109 High IL-6 expression is associated with Intrahepatic Cholangiocarcinoma.
26226212 results show that Gal-1 acts by inhibiting the stimulation of the LPS-induced IkappaBzeta expression, an NF-kappaB regulator involved in IL-6 gene transcription.
26215971 Data suggest that IL6 contributes to Ewing sarcoma tumor progression by increasing resistance to apoptosis in conditions of cellular stress, such as serum starvation, and by promotion of metastasis.
26209923 Data show that umbilical cord-derived mesenchymal stem cells (UCMSCs) transplantation promoted the expression of CD206 antigen and increased phagocytic activity of macrophages through interleukin-6 (IL-6) in systemic lupus erythematosus (SLE) patients.
26209639 Data show that interleukin-1 receptor type 2 (IL1R2) forms a complex with c-Fos proto-oncogene protein and activates the interleukin-6 (IL-6) and vascular endothelial growth factor A (VEGF-A) promoters.
26205261 Electrophysiological recordings reveal that increased Cav3.2 protein expression following IL-6 stimulation of LNCaP cells does not result in increased expression of functional channels in the membrane
26200663 obesity was a positive modulator of IL-6R and IL-6 expression in the adipose tissue which might be a contributory mechanism to induce metabolic inflammation.
26199858 a statistically significant association between the IL-6 (-174 G/C) functional polymorphism and susceptibility to idiopathic scoliosis, is reported.
26198920 Polymorphisms in IL-6 were not associated with the pathogenesis of schizophrenia in a Polish population.
26194504 In both arm and subumbilical skin biopsy of patients with idiopathic hirsutism, there was decreased IL6 mRNA expression.
26191329 The interactions of CX3CL1, LEPR and IL-6 genes might increase the risk of coronary artery disease in Chinese Han population.
26191285 The rs1800796 of IL-6 and rs679620 of MMP-3 were found significantly associated with increased susceptibility and severity of post-operative stiffness after rotator cuff repair
26189695 Intracellular signaling of IL-6 in response to receptor activation is through STAT-dependent and STAT-independent signaling modules, which are regulated by a complex regulatory network.
26174156 Association of interleukin-6 gene polymorphism with coronary artery disease: an updated systematic review and cumulative meta-analysis
26169021 indicates that the IL-1beta -511T/C polymorphism is associated with TB decreased risk in Africans, and IL-6 -174C/G polymorphism in Asians. Further well-designed, large scale studies are required to confirm this conclusion
26164540 Systemic inflammation and elevated values of IL-6 present in exacerbations and stabile chronic obstructive pulmonary disease might be responsible for the observed increased hepcidin level.
26163998 IL-6 trans-signaling is enhanced in pulmonary arterial hypertension [PAH]. Elevated concentration of sIL-6R suggests its potential unfavorable role in systemic amplification of IL-6 signaling in PAH.
26151690 Our results show that IL-17A, IL-17F and IL23R polymorphisms have no effect on expression of IL-6, IL-17, IL-21 and TGF-beta1 mRNAs expression in H. pylori-infected gastritis.
26148092 results suggest a potential role for PCT and IL-6 in predicting cancer in non-febrile patients
26134560 MCPIP1 and MCPIP4 form a complex but they act independently in regulation of IL-6 mRNA degradation.
26130650 Expression analysis revealed upregulation of IL6 and CD126 and GP130 in ALDH(hi) endometrial cancer ... targeted inhibition of the IL6 receptor and its downstream effectors JAK1 and STAT3 reduced tumor cell growth.
26125778 RPTS can significantly promote apoptosis in SW480 colorectal cancer cells. The mechanism may be that it suppresses the secretion of IL-6 and inhibits the IL-6/JAK-STAT3 protein signaling pathway.
26122176 IL-6 was found to be strongly associated with advanced serous EOC and could be used in combination with serum CA125 to discriminate benign and EOC
26120866 Therapeutic blockade of interleukin-6 by tocilizumab led to regression of amyloid deposits in patients with AA amyloidosis.
26107937 We conclude that IL-6 revealed the highest diagnostic and prognostic potential among studied biomarkers and was related to the fatal alcoholic liver disease course.
26096712 Long-term genetically-reduced circulating IL-6 might be causally associated with a lower risk of liver cancer.
26090964 This study showed that both IL6 and IL10 are upregulated during the late stage of sleeping sickness with a potential as adjunct stage biomarkers.
26090463 In donors significantly lower levels of IL-6, TNF-alpha, HGF, and TGF-beta were detected in portal blood compared to hepatic vein In patients with cirrhosis there were no significant differences of IL-6, TNF-alpha, and TGF-beta levels between portal and hepatic veins
26084218 Plasma ghrelin and interleukin-6 levels correlate with body mass index and arterial blood pressure in males with essential hypertension
26082435 Paracrine signaling by TNF-alpha secreted from a small subpopulation of "high-secreting" cells was necessary, but not sufficient, for the secretion of large amounts of IL-6 and IL-10 by the cell population.
26080030 serum zinc levels may be inversely related to inflammatory markers (IL-6, TNF-alpha, and CRP)
26080005 Data suggest that targeting interactions of interleukin-6 (IL6) and interleukin-6 receptors (IL6R) provides effective treatment in autoimmune diseases and cancers. [REVIEW]
26079504 For IL-6 gene -174 G/C polymorphism, no significant association was found between this variation and coronary artery disease risk.
26079381 Data show that interleukin 6 (IL-6) secretion and the percentage of CD71 antigen-positive T lymphocytes both uniquely predicted survival independent of papillomavirus infection status.
26075907 Differential signaling mechanism operates in HIV-1 Nef-mediated production of IL-6 and IL-8 in human astrocytes.
26075907 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
26073684 In conjunction with their major role in pathogenesis of SLE, baseline serum levels of IL-6 and IL-17 can be used as sensitive biomarkers for disease activity, as well as predictors of remission of lupus nephritis
26067576 Methylation levels at the IL-6 CpG sites -664, -628 and +13 at the first sampling time point (T1) and at -666 and -664 at the second sampling time point (T2) correlated negatively with initial body weight in the DMT2 group
26063187 Ox-LDL induces NF-kappaB activation and IL-6 expression via IGF2 activation in macrophages.
26048716 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
26048576 in prostate cancer patients, paracrine rather than autocrine IL6 production is likely associated with any role for the cytokine in disease progression.
26041742 Microenvironmental interleukin-6 suppresses TLR7 signaling in human leukemia cells through miR-17/19A.
26038346 The meta-analysis provides evidence of the association between the IL-6 polymorphism and the risk of SLE, hinting that the IL-6-174 G/C and IL-6-572 G/C polymorphisms may play a role in SLE susceptibility. [meta-analysis]
26038301 the S100A9-induced release of IL-6 and IL-8 from human periodontal ligament cells is dependent on TLR4, but not RAGE.
26036173 variation in inflammation related genes ALOX15 and IL6 was associated with bone microarchitecture and density in young adult women, but appears to be less important in the elderly
26026122 Interleukins IL-2, IL-6 and IL-10 are promising biomarkers of early-stage melanoma. IL-2 and IL-6 appear to be prognostic biomarkers.
26026087 The results of the present study show that TRAMP cells modified with H6 and H11 ( Hyper-IL-6 and Hyper-IL-11 )induce prostate tumor regression and increase mouse survival by stimulating the immune system.
26025192 Blood IL6 level is associated with the prevalence and severity of chronic kidney disease(CKD), independent from established CKD risk factors.
26025100 Results suggest that IL-6 allele variants are risk factors for septic shock induced by pneumonia.
26008736 This study identfied interleukin-6 signal pathway involved in major depressive disorder.
26006043 NAC may effectively suppress the MeHg-induced cytokine production through both, inhibition of reactive oxygen species as well as extracellular chelation of MeHg in astrocytes.
26001328 The combination of high TNF-alpha and high IL-6 ascites levels at primary surgery predicts worse PFS in patients with advanced EOC.
25998247 Data suggest lysophosphatidylcholine (LPC) up-regulates SREBP-2 (sterol regulatory element binding 2) and cholesterol efflux in vascular endothelium; 25-hydroxycholesterol (25HC) inhibits effects of LPC; both LPC/25HC up-regulate release of IL6/IL8.
25993353 the risk genotype of IL-6 rs2069845 gene is associated with the development of obesity in Brazilian children and adolescents.
25991421 using pre-storage and post-storage leukoreduction methods in erythrocyte transfusions did not change CRP or IL-6 levels, which are indicators of acute-phase response.
25990058 analysis of the decrease in CRP level without changes in TNF-alpha or IL-6 concentrations after the low-calorie diet and balneological treatment
25982844 study shows IL-6 levels are elevated in individuals infected with urogenital schistosomiasis; IL-6 also correlated with production of lectins in S. haematobium infection; a similar correlation between IL-6 and mannose-binding lectin was observed during visceral leishmaniasis
25977573 Interleukin-6 measured by electrochemiluminescence method is a promising marker for early differentiation between aseptic and bacterial meningitis
25970328 The assembly of EDC4 and Dcp1a into processing bodies is critical for the translational regulation of IL-6.
25968456 these findings indicate that constitutive IL6/STAT3 pathway activation is important in driving tumor growth and inflammatory cross-talk with myeloid cells within the Group A EPN microenvironment.
25966666 Mesenchymal Stem Cells Isolated From Human Gliomas Increase Proliferation and Maintain Stemness of Glioma Stem Cells Through the IL-6/gp130/STAT3 Pathway.
25966440 In patients with stable chest pain, low HDL cholesterol, low leptin and high IL-6 are independent predictors of high risk coronary anatomy as defined by an integrated CTA risk score.
25966252 Both PCIA and PCEA produced good analgesic effect, decreased postoperative level of serum IL-6, promoted release of anti-inflammatory factor IL-10, maintained balance in postoperative serum IL-6 level, and reduced the postoperative inflammatory response
25966134 Data show that metal nanoparticles AgNPs and AuNPs modified PMA/PHA/LPS induced cytokines IL-2, IL-6, and TNF-alpha production in Jurkat and U937 leukemic cells.
25966083 Data show that the interleukin 6 (IL-6 )-174 G>C polymorphism is correlated with coronary artery disease (CAD) risk.
25965334 Data suggest that NCL (nucleolin) is re-localized during lytic KSHV (Kaposi sarcoma-associated herpesvirus) infection and protects IL6 (interleukin-6) mRNA from SOX (KSHV cytoplasmic mRNA-specific endonuclease) degradation in cytoplasm.
25963492 Our results showed PCT as a valuable marker of bacterial infections in febrile patients. PCT was superior to CRP, IL-6 or SAA in the early identification of bacterial infection
25957466 Maternal blood IL-6 and CRP levels were elevated in women with subclinical intra-amniotic infection.
25943392 IL6 secreted by ovarian cancer cells may contribute to the refractoriness of these cells to tamoxifen via the crosstalk between ESR1 and IL6-mediated intracellular signal transduction cascades.
25942346 The present investigation revealed a significant association of the IL6 -174 G/C gene promoter polymorphism with NSCLC, and thus, the IL-6 -174G/C genotype can be considered as one of the biological markers in the etiology of NSCLC.
25941359 IL-6 blockade by the monoclonal anti-IL-6 receptor antibody, MR16-1, ameliorated hypoxia-induced pulmonary hypertension and prevented the hypoxia-induced accumulation of Th17 cells and M2 macrophages in the lungs.
25941031 Dkk-1 production was strongly suppressed by IL6 in the inflamed arthritic joint. IL6 levels were similar in synovial fluid of both rheumatoid arthritis and spondyloarthritis patients.
25939389 Study shows that pleiotropic cytokine IL-6 modulates epithelial-mesenchymal transition/mesenchymal-epithelial transition in an autocrine manner to facilitate adjustment of cells to an altered environment.
25931255 High serum IL-6 was related to advanced age, the presence of hepatic metastasis, large tumor burden in liver, severe fatigue, high carcinoembryonic antigen, high C-reactive protein, and anemia in patients with treatment-naive advanced PC.
25922060 Elevated concentrations of IL-6 were observed in patients with poorer response speed performance and perceived cognitive disturbances in breast cancer.
25921605 Findings suggest that aberrant DNA methylation of IL6 gene promoter may play an important role in the etiology and pathogenesis of obesity. IL6 methylation could be used as molecular biomarker for obesity risk assessment.
25917045 IL-6 -174 promoter polymorphism is a major genetic regulator in the etiology of early-onset preeclampsia
25895146 Hormone and Cytokine Responses to Repeated Endotoxin Exposures-No Evidence of Endotoxin Tolerance After 5 Weeks in Humans.
25894228 These findings shed light into the impact of IL-1beta on the inflammatory cytokine response and its molecular mechanisms in human sebocytes.
25892518 Endogenous PML suppresses interleukin (IL)-6-induced gene expression as well as phosphorylation and transcriptional activation of STAT3 in hepatoma cells.
25888065 erlotinib-resistant HNSCC cells display elevated IL-6 expression levels compared to erlotinib-sensitive HNSCC cells and blockade of the IL-6 signaling pathway may be an effective strategy to overcome resistance to erlotinib
25881039 High IL-6 expression is associated with breast cancer.
25879761 Report Il6 levels in synovial fluid from rheumatoid arthritis patients.
25879536 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
25873160 H2S inhibited the production of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in a concentration-dependent manner; it was most effective at the two highest concentrations used.
25872171 The use of lornoxicam at the onset of acute pancreatitis decreased TLR2 and TLR4 expression and the production of proinflammatory cytokine Il6, thereby reducing the risk of systemic complications and mortality.
25868978 Findings suggest a crucial roles for resistin, IL-6 and STAT3 in breast cancer racial disparity.
25867411 Data indicate there was no association between interleukin 6 (IL-6) -572C/G polymorphism and risk of cardiovascular events in patients receiving hemodialysis.
25862884 Interleukin-6 is up-regulated in colon cancer tissue at the transcriptional level and is significantly associated with increased risk of relapse.
25858261 Dengue patients treated with doxycycline showed lower mortality which may be associated with a reduction in IL-6/TNF levels.
25856395 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
25847297 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
25847223 These findings suggest that IL-6 blocking reduces the inflammatory mechanisms through the correction of STAT1 and STAT3 activation status.
25843793 NE is capable of inducing IL-6 generation in macrophages via beta-ADR-ROS-NF-kappaB signal pathway, which contributes to better understanding of the proinflammatory and proatherosclerotic actions of NE
25842551 Serum IL-6 was inversely associated with diabetic retinopathy in type 2 diabetes patients.
25841802 IL-6 serum levels were significantly increased in patients with ANCA-associated vasculitis as compared to controls
25839939 Genetic association studies show that IL-6, TNF-alpha and SDF-1 SNPs not only controlled serum cytokine levels but also affected various risk factors of diabetic foot ulcer.
25829425 Our data identify IL6 detection as a potential causal biomarker for MYC-driven metastasis after loss of PTEN and p53.
25827698 this study demonstrates a statistically significant association between the TNF-a -308 G/A and IL-6 -174 G/C polymorphism and IDCM in a Pakistani population.
25824337 Data show that calcitriol inhibited interleukin 6 (IL6) in association with an attenuation of STAT3 transcription factor activation.
25821796 Levels of anti-CCP and CRP are associated with increased cIMT and cardiovascular risk supporting a clinical role of the measurement of cIMT in RA in predicting and preventing cardiovascular events.
25815341 The C allele at the -174 locus of IL-6 gene is independently associated with the occurrence of metabolic syndrome, emphasizing the importance of inflammatory genetic background in the pathogenesis of visceral obesity and related cardiovascular burden.
25810377 Adiponectin and interleukin-6, but not adipose tissue, are associated with worse neurocognitive function in HIV-infected men.
25809226 Study reports that miR-9 is down-regulated in cervical adenocarcinoma due to its frequent promoter-hypermethylation and exerts its tumor suppressor role through inhibiting several novel target genes, including interleukin-6 (IL-6).
25797206 increased production by CD4 T cells from preterm cord blood in chorioamnionitis
25797190 A low serum IL-6 level is, in addition to low platelet count and low serum albumin level, an independent prognostic factor for disease-free survival in patients with hepatitis B virus (HBV)-related early hepatocellular carcinoma.
25788529 miR-634 mimics induced a proinflammatory phenotype in monocyte-derived macrophages, with enhanced expression and release of ADAM17 and IL-6 in Proteinase-3 ANCA-Associated Vasculitis
25787827 The Circulating Levels of Selenium, Zinc, Midkine, Some Inflammatory Cytokines, and Angiogenic Factors in Mitral Chordae Tendineae Rupture.
25787249 Studies indicate that long non-coding RNA MALAT1 regulates glucose-induced up-regulation of inflammatory mediators tumour necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) through activation of serum amyloid antigen 3 (SAA3).
25774595 study suggested that this risk model could identify patients at high risk of SR aGVHD with donor genotype of IL6 (rs1800797) and IFNG (rs2069727) along with gastrointestinal involvement of aGVHD.
25769924 a distinct activation of the IFN-stimulated gene signature with a substantial increase in the release of proinflammatory cytokines (IL-6) and chemokines (CXCL10 and CCL5).
25766682 an increased risk role of IL-6 -174 CC genotype in renal cancer susceptibility
25765005 Interleukin 6 inhibits HBV entry through downregulation of NTCP.
25754842 Data show that toll-like receptor 3/TRIF protein signalling regulates cytokines IL-32 and IFN-beta secretion by activation of receptor-interacting protein-1 (RIP-1) and tumour necrosis factor receptor-associated factor 6 (TRAF6) in cornea epithelial cells.
25753878 Up-regulation of miR-155 and miR-146b decreases H. pylori (cagA+)-introduced IL6 overexpression, which might weaken the cleanup of H. pylori (cagA+) and contributes to ulcer.
25750173 this study proposes the existence of an aberrant IL-6/STAT3/Fra-1 signaling axis leading to colorectal cancer aggressiveness through epithelial-mesenchymal transition induction
25749018 This study found that the mRNA and protein levels of TNF-alpha and IL-6, but not IL-1beta, were significantly increased in lymphocytes or plasma of schizophrenia patients compared with normal control subjects.
25748833 Reactive oxygen species increase the activity/levels of gelatinolytic matrix metalloproteinases, and stimulate cytokine secretion in human periodontal ligament fibroblast.
25740502 Elevation of RDW may be related with increased IL-6 and anemia-adjusted cardiovascular mortality in patients with ACHD.
25738867 The results of the current study demonstrated that pro-inflammatory cytokines, including TGF-beta1, IL-1beta and IL-6 exhibited increased expression in human vestibular schwannoma tissue compared with normal vestibular nerve samples
25735143 Combinations of cytokine gene network polymorphic markers as potential predictors of myocardial infarction
25734339 No statistically significant association has been found between IL-6-174G/C polymorphism and the risk of sepsis and mortality.
25730036 In the current study, we evaluated the effect of IL-1b +3954 C/T (rs1143634) and IL-1b -511 C/T (rs16944) and IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796) on the development of acute pancreatitis risk.
25729947 IL-6 gene -174G>C polymorphism was not associated with lung cancer.
25722296 Multiple factors affect inflammation in HIV and should be considered in studies of IL-6 as a biomarker of clinical outcomes.
25721917 IL-6 concentrations may be linked to adiposity traits and increased risk of insulin resistance.
25721605 Adipocytes revert to an immature and proliferative phenotype in the presence of breast cancer cells, and promote cancer cell migration via adipokines including IL-6 and MCP-1.
25708728 autophagy is required for Hepatitis B virus-induced NF-kappaB activation and release of IL-6, IL-8, and CXCL2 in Hepatocytes
25708204 IL-6 gene polymorphism is not associated with the risk of pneumonia.
25707877 A positive feedback loop involving sSema4D/IL-6 and TNFalpha/ADAMTS-4 may contribute to the pathogenesis of rheumatoid arthritis.
25704763 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
25697898 the expression of IL-6 was significantly higher in MBT-SCs. Additionally, the expression of STAT3 in MCF-7 cells increased slightly when they were co-cultured with malign breast tissue-derived stromal cells
25681343 Data indicate that plasmablast production of interleukin 6 (IL-6) induces CD4(+) T follicular helper (Tfh) cell differentiation.
25660311 HMGB1 Binds to Lipoteichoic Acid and Enhances TNF-alpha and IL-6 Production through HMGB1-Mediated Transfer of Lipoteichoic Acid to CD14 and TLR2.
25659766 The IL-6 -174G>C polymorphisms is candidate gene marker and risk factor for the prediction of ischemic stroke.
25653193 chronic lumbar radicular pain may be associated with a persistent increase of the pro-inflammatory substances IL-6 and IL-8 in serum after disc herniation.
25652640 IL6 increased significantly during short-term normobaric hypoxia.
25652333 In systemic lupus erythematosus and rheumatoid arthritis, variation in genes implicated in disease pathology is associated with serum IL-6 or TNFalpha concentration.
25650410 Cerebrospinal fluid soluble interleukin-1 Receptor II, but not log interleukin-6, levels were positively correlated with a composite measure of aggression.
25648033 Findings indicate that the IL-6 -572 allele G may be beneficial for spontaneous clearance of chronic hepatitis b virus infection.
25637022 The suppression-abrogating cytokine IL-6 augments GzmB expression by human CD4 T cells, and it inhibits Treg suppression via a nonapoptotic GzmB-mediated mechanism.
25635749 The variation of plasma CTRP-1 and IL-6 concentrations may play an important role in reflecting the degree of inflammation in CHD and the severity of coronary arterial atherosclerosis.
25634659 Results show no significant association was found between TNF-alpha (-308 G/A) and IL-1beta (-511 C/T) polymorphisms and polycystic ovary syndrome (PCOS) risk in the overall population or subgroup analysis under all genetic models; results indicate that the IL-6 (-174 G/C) polymorphism likely conveys a protective effect against PCOS.[Meta-analysis]
25634015 VEGF/CR and IL-6/CR have a role in glomerular pathological injury
25633035 EGR3 promotes excessive production of IL6 and IL8 observed during the progression of prostate cancer.
25625841 Study demonstrated that IL-6 played a pivotal role in colon cancer stem-like properties and chemoresistance via Notch 3 signaling rather than STAT3 signaling.
25625484 The 572G/C SNP in the promoter region of IL6 may predict the risk of venous thromboembolism in the Uyghur and Han populations.
25616107 IL-6 induction is potentiated by endogenous TNFalpha, which prolongs the synthesis of the IkappaBzeta co-activator and sustains C/EBPbeta recruitment and histone acetylation at IL-6 regulatory regions.
25613713 The main findings of this study are that, in acute stroke patients, levels of LBP, IL-10, IL-6 and CRP show a different time course in patients with and without post-stroke infection.
25611388 Phagocytosis-dependent IL-6 secretion may have significant regulatory function in the inflamed adipose tissue.
25609203 Paracrine SDF-1alpha signaling mediates the effects of pancreatic stellate cells on gemcitabine chemoresistance through an IL-6 autocrine loop in pancreatic cancer cells.
25604533 IL6 (rs2069837) was associated with Takayasu arteritis.
25603974 association between TGFB1 29 T --> C transition (rs1800470) and IL6 -572G --> C transversion (rs1800796) with developmental dysplasia of the hip (DDH) and a TGF-beta1 and IL-6 interaction in DDH pathogenesis.
25596176 -174G allele carriers at IL6 had fewer depressive symptoms following interpersonal stress, relative to C/C homozygotes with equal interpersonal stress exposure. IL6 genotype did not moderate the effects of non-interpersonal stress exposure on depression.
25595815 These data indicate that IL-1beta and IL-6 gene single nucleotide polymorphisms are associated with sickle cell anemia (SCA) complications among Brazilian patients and may act as genetic predictors of SCA clinical heterogeneity.
25589616 Blocking IL6 has demonstrated therapeutic efficacy with drug registration in Castleman disease and inflammatory diseases without major toxicity. In various cancers, in particular plasma cell cancers trials showed no efficacy of IL6 inhibitors.
25578228 Data show that the area under the curve for adult septic shock stratification and information technology (ASSIST) was greater than that of interleukin-6 (IL6) and procalcitonin (PCT).
25576892 IL-6-572G/C polymorphism was not an independent risk factor of low BMD or periodontitis, but may affect the relationship between the two diseases in postmenopausal Japanese women.
25575413 The study found increased IL-6 and TNF-alpha levels in patients with deep venous thrombosis.
25573292 IL6 is associated with EMTassociated markers, tumor differentiation, local invasion, TNM stage and survival rates in GBC.
25569375 data support strong association of reduced IL-10 and increased IL-6 levels with vaso-occlusive crisis (VOC) in sickle cell anemia, and their modulation of VOC-related parameters
25566963 IL-6 genetic variant (-174G/G and G/C) can be responsible for changes in prognosis of non-small cell cancer patients.
25565094 Combination of maternal characteristics and maternal serum IL-6 levels may provide effective first trimester screening for gestational diabetes mellitus.
25564959 increased serum levels positively correlates with diffuse large B-cell lymphoma in egyptions
25564572 The concurrent expression of OCT4/NANOG/IGFIR was mostly confined to hepatitis B virus (HBV)-related HCC (HBV-HCC) and was significantly correlated with early tumor recurrence.
25562992 The data conclude that IL-6 plays an important role in the pathogenesis of Vt-T1D patients and is likely to gain favour as a therapeutic target in these patients.
25560300 there was no association of SNPs in IL2 or IL6 and antipsychotic-induced weight gain
25548434 IL-6, TNF-alpha, and IL-1beta are involved in systemic lupus erythematosus in Indian patients
25547486 findings provide evidence that TLR1, TLR2, TLR4 and TLR8 gene expression induce downstream IL-6 and IL-8 gene expression; detection of these expression levels can serve as a colorectal cancer marker
25539898 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
25532786 Resting IL-6 was greater in osteoarthritis participants versus those without osteoarthritis, although this association was largely attributable to BMI
25530682 IL-6 and TNF-alpha in neonatal and adult blood is regulated by LPS and LTA in a pathway that involves MAPK and NFKB
25529283 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
25526459 genetic variation in the IL-6 promoter were established as significant independent risk factors for the survival of patients with three-vessel disease.
25523094 The functional polymorphism IL6 C-634G may affect serum AST and ALT levels, possibly through different IL-6 production.
25518708 B cell derived IL-10, IL-6 and TNF-alpha are down-regulated in MG, irrespective of different antibody productions. Ineffective cytokine production by B cells may be a susceptibility factor in dysregulation of autoimmune Aab production.
25514345 IL-6 inhibits Treg development, suggesting an opposing function of LIF and IL-6.
25514317 The coordinated expression of CD40-CD40L was critical for production and autocrine IL-6 in XG1 cells.
25510525 data suggest that VDR is a better predictor than serum 25OHD concentration of intramuscular IL-6 gene and protein expressions
25504688 The serum levels of il6 were found to be significantly higher in children with febrile seizures
25504436 signalings can reciprocally and positively regulate each other, leading to enhanced non-small cell lung cancer (NSCLC) cell proliferation and survival.
25500862 This study has found that the size, adhesion and nano-surface roughness of wear particles have medium strong to strong correlations with IL-6 and IL-8.
25492254 The parallel relationship with history of CVD and incident CV events of the -174 G/C polymorphism in the IL-6 gene suggests that IL-6 may be causally involved in the high CV risk in this population.
25483835 pre-treatment with IL-6 significantly abolishes the ability of hUC-MSCs to promote gastric epithelial cell proliferation and migration and provide new insight into the effects of the inflammatory cytokine, IL-6, on the tumor-promoting ability
25482841 lipopolysaccharide-stimulated interleukin-6 secretion in multiple myeloma cells is suppressed by bromodomain inhibition by JQ1
25481644 Our findings demonstrate that leptin-induced STAT3 is partially cross activated through SK1-mediated IL6 secretion and gp130 activation. Positive correlations in human tissues suggest the potential significance of this pathway in ER-negative breast cancer
25480923 Data suggest that hepatocytes respond to IL6 with down-regulation of mRNA for drug-metabolizing enzymes and drug transporter proteins; however, hepatocytes in primary culture exhibit significant interindividual donor variability.
25477266 The results provide evidence that the regulation of IL-6, IL-10, c-Jun, and STAT3 gene expression in Chronic lymphocytic leukemia B cells is clearly different from normal B lymphocytes.
25476497 This study indicates that obesity-associated systemic IL-6 indirectly enhances pre-adipocyte aromatase expression via increased breast cancer cell PGE2 production.
25470806 IL-6 gene SNPs didn't correlate with age in the Han Chinese population
25469832 Single-nucleotide polymorphism in IL-6 gene was associated with a high symptom burden in multiple myeloma.
25464926 interleukin-6 is expressed in saliva, venous and capillary plasma at different levels at rest and in response to exercise
25461668 IL6 signaling disrupts the nuclear localization of hMSH3 and DNA repair, leading to elevated microsatellite alterations at selected tetranucleotide repeats in cancer cell lines.
25458044 There were no significant differences in the distribution of IL-10 and IFN-gamma genotypes between different groups of control and oral precancerous lesions patients but the IL-6, TGF-beta1, and TNF-alpha gene polymorphisms may have a significant association.
25455350 Results show that IL-6, kynurenine and kynurenic acid are elevated in patients with chronic schizophrenia, strengthening the idea of brain immune activation in patients with this disease
25451609 Compared with healthy control subjects, unadjusted levels of IL-6 (p<0.05) and IL-18 (p<0.05) were elevated in manic/hypomanic bipolar disorder patients.
25450973 Placental mesenchymal-like adherent stromal cells -induced neuroprotection in ischemic PC12 cells may be partially explained by IL-6 and VEGF165 secretion.
25450715 Hepatic interleukin-6 (IL-6) expression was significantly elevated in Biliary atresia patients.
25436282 Report increased IL6 levels in inflammatory bowel diseases.
25436214 Data indicate the role of tumor necrosis factor-alpha (TNFalpha) in the Th17 cell differentiation in rheumatoid arthritis through interleukin-6 (IL-6) and interleukin-1 beta (IL-1beta) production.
25434497 IL-6 was commonly elevated in patients with central fat distribution, overweight, and moderate acute pancreatitis.
25433580 data indicate that 30-day supplementation with 112 mg/day CFB (CFB-1) resulted in a significant reduction of LDL, TG, TC, IL-1beta, IL-6, MCP-1, and CRP.
25432444 Our findings suggest that the IL-6-572C and IL-1A-889T alleles may contribute to the pathogenesis of acne in a Pakistani population.
25416216 For a complete analysis of our results on the reduction of the cytokines (IL-2, IL-6) content in patients with a stress in anamnesis, that will allow to identify the most effective ways to treat patients with this pathology
25415812 The single nucleotide polymorphisms of IL-6 do not appear to be associated with Behcet Disease reconstruction.
25412309 PKCeta promotes senescence through its ability to upregulate the expression of the cell cycle inhibitors p21Cip1 and p27Kip1 and enhance transcription and secretion of IL-6.
25411996 plasma IL-6 and serum CRP concentrations are more effective in predicting the severity of the clinical course in the early phase of LVAD therapy
25409241 association studies have revealed that TT genotype of IFN-gamma +874 T/A and GG genotype of IL-6-174 G/C were susceptible towards the CIU.
25398811 The combination of SLED and antibiotic therapy was unable to lower the initial high plasma IL6 concentrations, and high initial IL6 concentrations predicted in-hospital mortality.
25390649 von Willebrand factor and IL-6, but not P-selectin in the peripheral and cardiac radiofrequency catheter ablation of atrial fibrillation circulation are affected by
25384758 IL-6 serum level was a marker of synovial inflammation in rheumatoid arthritis.
25384728 Results suggest that IL6-174G>C may contribute to T1DM and increased albumin-to-creatinine ratio as well as to poor glycemic control and hyperlipidemia.
25382637 Results shed some light on the mechanisms promoted by EGFRvIII that contribute to the malignant microenvironment in glioblastoma and identified that C/EBPb increased IL-6-driven angiogenesis and thereby glioblastoma progression.
25371529 We postulate TNF-alpha and IL-6 play a key role in the systemic inflammatory response in CDI, and the plasma TNF-alpha level seems to act as a major factor of poor prognosis in patients infected with Clostridium difficile
25365225 these findings reveal that IKBKE-associated cytokine signaling promotes tumorigenicity of immune-driven TNBC and identify a potential therapeutic strategy using clinically available compounds.
25362566 miR26a maintains the Th17 and Treg cell balance in multiple sclerosis that involves repression of IL6 expression.
25360780 a highly relevant potential role for microRNA dysregulation in the control of IL-6 and IL-8 expression in asthma, was found.
25358651 we have identified the overexpression of additional secretory factors such as IL-6.
25357087 the IL6 -174G>C polymorphism can be a marker of susceptibility to psoriasis, with an almost twofold increased risk of the disease in individuals carrying the GG genotype
25351965 There was no significant difference in serum IL-6 between Kawasaki disease patients with or without pericardial effusion.
25350786 IL-6 gene expression was correlated strongly with DNMT1/3A/3B and EZH2 expression, highlighting a potential relationship between IL-6 and important epigenetic regulatory enzymes.
25345762 Our results did not show significant difference between the compared groups for MCP-1 and E-selectin genes, whereas a significant difference was reported for the IL-6 gene (P < .0001).
25336940 Report the mediation of cytokine IL-6 circulating levels on the effect of FEV1 upon walking performance in patients with COPD.
25329583 ). There was no statistically significant association between the primary outcome and baseline S-100B levels, baseline high-sensitivity C-reactive protein or interleukin-6 levels, or changes in high-sensitivity C-reactive protein or interleukin-6 levels.
25325233 SNP of rs1800796 in the IL-6 gene is related to IS and the SAO subtype using different statistical approaches. These findings could contribute to identifying individuals with a high IS risk.
25322977 no relation between polymorphism VEGF G-634C and pre-eclampsia was observed.
25318604 CCL2 greatly enhanced IL-6-induced EMT events mainly by upregulating the expression of Twist. Genetic or pharmacological inhibition of STAT3 disrupted STAT3-centered loop and markedly suppressed Twist expression as well as IL-6/CCL2-mediated EMT induction
25316129 study demonstrates that the methylome is stable, while discovering a novel link between exercise-induced increases in circulating IL-6 and the DNA methylation status of 11 individual genes.
25313020 Cultured human hepatocytes may represent a physiologically relevant experimental model for mechanistic investigation of the down-regulatory effects of inflammatory cytokine, Il6.
25312476 IL-6 -572G>C polymorphism may be linked with risk of CHD in a protective model
25304617 High IL-6 expression is associated with primary effusion lymphoma.
25303810 This study suggests there is an association of polymorphisms in the IL-6 gene at position - G174C with susceptibility to noise-induced hearing loss.
25301326 The study concluded that IL-6 expressions of both visceral and subcutaneous tissues may be associated with metabolic risk factors in postmenopausal Asian North Indian women.
25299090 results suggest that the IL-6 -572 C/C and IL-10 -819 T/T genotype polymorphisms are protective factors against PTB
25299085 did not find that the IL-6 572 CC and 597 AA genotypes were correlated with an increased risk of CAD. IL-6 174 G>C rs1800795 was associated with CAD risk in a Chinese population
25298068 serum values in bullous impetigo and staphylococcal scalded skin syndrome patients significantly higher than in healthy controls
25296733 there was positive correlation (p < 0.0001) between those biomarkers and the tumor grades. We also noticed an association between VEGF and IL-8 as well as CRP and IL-6.
25296499 GC genotype and G allele in IL-6 had significant correlation with hyperlipidimic CAD patients; however, G allele in IL-6 and IL-10 showed significant association with hypertension
25292079 Interleukin-6 gene polymorphisms are associated with the risk of bladder cancer.
25285632 results demonstrated that feedback activation of the IL6-STAT3 loop lead to acquired resistance to PI3K inhibitors by promoting EMT and CSC-like features
25281899 The data obtained allow suggesting that alpha7-specific antibody can provoke neuroinflammation within the brain by inducing IL-6 production via p38 MAPK in astrocytes.
25277211 miR-98 reduces melanoma metastasis and increases survival in part by reducing IL-6 levels.
25274950 The findings support an association between the IL-6 -572G/C polymorphism and idiopathic dilated cardiomyopathy(IDCM) risk.
25261668 there were no statistically significant differences regarding either the genotype or the allelic frequencies of the -174G/C il6 polymorphism between chronic lymphocytic (CLL), chronic myelogenous (CML) and acute myelogenous leukemia cases
25251588 Data suggest that serum levels of IL6 and C-terminal telopeptide are elevated at onset of acute Charcot foot (with/without diabetes); patients exhibit significant reduction in these markers at disease resolution (here by 3-month casting therapy).
25246282 Study supported that IL-6 -174G/C and -2954G/C polymorphisms were associated with an increased risk of recurrent pregnancy loss in Turkish patients.
25245339 In obese children and adolescents, insulin resistance is associated with elevated levels of IL-6 and diminished values of sIL-6R.
25240755 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
25239565 A novel IL-6/Stat3-miR-17-92 cluster-PTEN signaling axis is crucial for cholangiocarcinogenesis and tumor progression.
25238263 Il-6-induced recruitment of CD11b+ CD14+ HLA-DR- myeloid-derived suppressor cells is associated with progression and poor prognosis in squamous cell carcinoma of the esophagus.
25234193 Results suggest that piperine may exert at least part of its anti-cancer effect by controlling interleukin-6 (IL-6) expression through the suppression of p38 MAPK and STAT3 protein.
25233690 children who are heterozygous for the IL-6 G-174C/G-597A polymorphisms have a lower chance of developing Perthes disease than carriers of both homozygote genotypes
25231991 IL-6 has a major role in activating breast stromal fibroblasts through STAT3-dependent AUF1 induction
25231749 These results demonstrated that Gos induces apoptosis in MM cells not only through displacing BH3-only proteins from Bcl-2, but also through inhibiting IL-6 signaling, which leads to Bcl-2 dephosphorylation and Mcl-1 downregulation.
25227842 Patients with cervical cancer had a significantly higher frequency of the IL-6 -174 CC genotype, -572 CC genotype, and -174 C allele compared to controls.
25223243 Inflammation of the fetal side of the placenta was associated with elevated maternal and fetal IL6 at delivery.
25222779 IL-6 gene promotor single nucleotide polymorphisms play a prominent role in type 2 diabetes mellitus disease susceptibility in a population from north India.
25214388 IL6 -174G/C polymorphism does not influence IL-6 level, but is associated with the severity of positive symptoms in schizophrenia.
25213322 our findings established that SCCA1 contributes to tumorigenesis by promoting EMT and a UPR-dependent induction of NF-kappaB and IL6 autocrine signaling that promotes a protumorigenic inflammation.
25201048 These results demonstrated that S1P-induced COX-2 expression and PGE2 /IL-6 generation was mediated through S1PR1/3/c-Src/PYK2/p42/p44 MAPK- or JNK1/2- and S1PR1/3/c-Src/p38 MAPK-dependent AP-1 activation.
25193024 Hepatitis C virus genotype G1 and IL-6 and TNF-alpha polymorphisms have a clinically relevant influence on serum pro-inflammatory cytokine profile in hepatitis C patients.
25192658 Data show that oroxylin A inhibits the all-trans-Retinoic Acid (ATRA)-induced IL-6 production via downregulating transcription factor CHOP in leukemia cell lines, suggesting a therapeutic strategy for retinoic acid syndrome (RAS).
25185427 13q deletions are associated with increased production of IL-6 in multiple myeloma and could have a role in bad prognosis
25181692 Levels of IL6 in human hepatocellular carcinoma samples correlate with tumor stage and markers of carcinoma stem cells.
25181018 Interleukin-6(-174) locus polymorphism and serum IL-6 levels increase in normal tension glaucoma.
25176527 soluble IL-6R expression upregulated the levels of its own ligand, IL-6 and those of the pro-inflammatory cytokine IL-32.
25172494 these findings demonstrate that the production of sIL-6Ralpha from macrophages in the diseased lung contributes to IL-6 trans signaling that in turn influences events crucial in pulmonary fibrosis.
25158706 Interleukin-6 plays a pivotal role in inhibition of melanocytes.
25153416 serum procalcitonin, interleukin 6, and C-reactive protein levels according to non-specific surgical stimulation
25150002 an increase in the IL-6 levels, CXCR4 and CCR-5 receptors was observed in both women and men with all types of depression
25140780 IL-6-174 SNP is rare or not seen in the Han population in Guangzhou, so SNP at this locus cannot be selected for disease association analysis.
25139874 Chronic elevation of serum IL-6 was associated with the progression of atherosclerosis in patients with vascular risk factors
25136113 Gain-of-function and loss-of-function studies with cultured mouse and human basal cells suggest that IL-6/Stat3 signaling promotes ciliogenesis at multiple levels.
25135735 The results showed that the expression of SP and CGRP was significantly enhanced in the neurogenic SMSCs in response to IL-1beta, IL-6 and TNF-alpha, and the effect was remarkably inhibited by HA.
25132319 Higher IL-6 level was positively associated with the frail status in elderly men.
25130968 relationship between IL-6-643 (C/G) and IL-1beta-31 (C/T) polymorphisms and lung cancer risk among female non-smokers
25130545 sustained expression of Dll4 mediated by ADAM10 elicits an increased release of IL-6 suggesting a strong implication of the specific Dll4 signaling in this mechanism
25127106 Significant associations of genetic variants in TNFA and IL6 with the risk for autoimmune thyroid disease.
25126764 The blockage of CD44 expression by siRNA resulted in the attenuation of IL-6 and chemokines expression in low molecular weight hyaluronan treated normal human dermal fibroblasts.
25124963 IL-6 and IL-1RA polymorphisms as well as the overexpression of IL-6 might have significant implications in the pathogenesis of ID.
25121610 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
25114519 No direct association was observed for both IL-6 and IL-8 blood levels with the severity of COPD in ex-smokers.
25109623 IL-6 repression suppressed the effects of bradykinin on colorectal cancer cell invasion and migration.
25098998 For IL-6 (-597) frequency of genotype GA/AA and allele A was lower in CHPDM group, and for TNF-alpha -308 the frequency of genotype GA and allele A was higher in CHP subjects when compared with controls
25098666 Signatures related to TNFalpha, IL6, and TGFbeta activation pathways are induced within the first hour of retrodifferentiation of hepatocyte-like cells.
25092916 Data support a model in which EWS/FLI1 deficiency results in the secretion of soluble factors, such as IL6, which activate STAT3 in bystander cells that maintain EWS/FLI1 expression.
25091431 We aimed to quantify the association of blood interleukin-6 (IL-6) concentrations with poor outcome after stroke and its added predictive value over clinical information.
25081498 The IL-6-572 G allele was significantly associated with susceptibility to EV71 encephalitis in Chinese Han patients.
25078284 endothelial cell-secreted IL-6 defines the tumorigenic potential of cancer stem cells
25074527 BSF2 polymorphism did not play a major role in the progression of lung cancer.
25068427 sputum IL-6 and IL-8 may play a role in neutrophilic airway inflammation seen in patients undergoing HSCT.
25052265 IL6 and IL6R variants are not associated with metabolic syndrome or with any of its phenotypes.
25047843 ROS-mediated activation of JAK2 is required for Porphyromonas gingivalis-induced inflammatory cytokine production and the JNK/c-Jun signaling axis is involved in the ROS-dependent regulation of IL-1beta and IL-6 production.
25040935 PIM-1 is a direct target of IL-6/STAT3 signaling and mediates cytokine-induced cellular senescence.
25040543 Results suggest that SNPs in IL6 may have a role in the association between psoriasis and coronary calcinosis and the development of epicardial adiposity.
25038626 The genotype combinations GC/CC/GG/GG and GG/CT/GG/GG, corresponding to the respective polymorphisms DDX39B-22/DDX39B-348/TNF-308/IL6-176, were associated with a decreased or increased risk of complications of vivax malaria, respectively.
25036364 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
25030201 Rare IL-6 gene polymorphisms may associate with rheumatoid arthritis susceptibility in Han Chinese populations.
25027167 Genetic variants in IL-6 have a combined effect with smoking on incidence of coronary artery disease.
25023587 Malnutrition is more frequently associated in children with IL-6 174 G allele carriers (GG and CG genotypes), whereas IL-6 190 TT genotype has a protective function.
25022967 polymorphisms in IL_6 are significantly associated with radiographic hand osteoarthritis and hand osteoporosis related phenotypes in two samples having different ethnicity and lifestyle. Age x environment x genes interaction appears as an important factor of RHOA manifestation and progression
25011638 Elevated tracheal aspirate fluid (TAF) IL-6 levels at birth are strongly associated with funisitis. The TAF IL-6 concentration is a useful marker for detecting fetal inflammation in ventilated extremely low gestational age newborns.
25010770 Our clinical and experimental studies revealed that serum IL-6 is a surrogate marker for evaluating cachexia and the prognosis of patients with chemotherapy resistant metastatic lung cancer
25008924 HIV-1 gp120 activates the STAT3/interleukin-6 axis in primary human monocyte-derived dendritic cells.
25008924 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
25008917 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
25003325 IL-33 regulates the expression of IL-6 and sST2 in primary human endothelial cells.
25002079 In Wilson disease(WD) patients, antioxidants are reduced and MDA, cytokines and glutamate are increased which are more marked in symptomatic neurologic WD than asymptomatic patients.
24999042 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
24996572 There was a good correlation of IL-6 levels and community acquired pneumonia treatment failure.
24994460 IL-6 -174G>C polymorphism represents a potential modulator of risk for malignant disorders with ethnicity and site dependent trends. (Meta-analysis)
24991031 Elevated serum IL-6 but not C-reactive protein in midlife predicts cognitive decline.
24988892 Lung cancer cells upregulate IL-6 secretion by activating the p38/NF-kappaB pathway through treatment with cisplatin and camptothecin.
24987977 Interleukin 6 serum levels were significantly higher in patients with systemic lupus erythematosus than in healthy controls.
24986424 Studies indicate that the interleukin-6 (IL-6)/soluble forms of the IL-6R (sIL-6R)/soluble forms of glycoprotein 130 (sgp130) system as highly dynamic and regulated signal pathway.
24985590 this meta-analysis does not support the idea that IL-6 promoter -174G/C (rs1800795)genotype is associated with increased risk of knee osteoarthritis
24984610 The present meta-analysis suggested that there was no association between IL-6 rs1800796 polymorphism and lung cancer
24974143 two promotor variants in IL-6, especially rs1800795, were predisposing factors for AR with a negative heterosis pattern
24962479 This study is the first to show that dietary fat intake modulates the relationship between the IL-6 -174 G>C, IVS3 +281 G>T and IVS4 +869 A>G polymorphisms on obesity and serum lipids in black and white South African women.
24961464 Increased IL-6 mRNA expression in peripheral blood leukocytes from breast cancer patients.
24960621 plasma marker of odontogenic inflammation in chronic kidney disease patients
24956549 Plasma IL-6 was increased in obese women with PCOS compared to lean women with PCOS, which was increased compared to lean controls. IL-6 release from mononuclear cells after LPS exposure was increased in lean and obese women with PCOS and obese controls.
24953186 SHP-2/ERK/MAPK pathway regulates the expression of CDX2 in basal conditions
24952309 meta-analysis. Our results indicate that IL-6, IL-1A, and IL-1B genetic polymorphisms are statistically correlated with an increased risk of osteoarthritis under the allele and dominant models.
24951586 ASM knockdown or desipramine blunted p38 MAPK activation in response to TNFalpha, revealing a key role for ASM in activating p38, a signaling pathway known to regulate IL-6 induction.
24947242 suggest that targeting of the IL-6/JAK2/STAT3 signaling pathway and DNMT1 may become important strategies for treating lung cancer
24946088 The IL-6-STAT3 axis mediates a reciprocal crosstalk between cancer-derived mesenchymal stem cells and neutrophils to synergistically prompt gastric cancer progression.
24944154 TNF-alpha-308 G/A polymorphism is significantly associated with the development of postoperative sepsis and with increased expression of cytokines TNF-alpha, IL-6, and IL-8.
24943399 Monocyte-derived macrophages from CD patients stimulated with Escherichia coli were shown to release attenuated levels of tumour necrosis factor and interferon-gamma with normal secretion of interleukin-8 (IL-8), IL-10 and IL-6.
24939558 the level of IL-6 was higher in patients with Jaccoud's arthropathy secondary to systemic lupus erythematosus than in patients without Jaccoud's arthropathy.
24920818 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
24919524 Endogenous interleukin-6 amplifies interleukin-17 production and corticoid-resistance in peripheral T cells from patients with multiple sclerosis.
24913620 Antagonism of cannabinoid receptor 2 pathway suppresses IL-6-induced immunoglobulin IgM secretion.
24912675 interleukin-6 was differentially expressed in hepatocytes depending on cancerous malignancy and TM4SF5 expression.
24903966 The influence of IL-6 gene polymorphisms on IL-6 synthesis and the susceptibility to cerebral palsy is related to sex and gestational age.
24886605 Carriers of the rs1800795 ( IL-6, promoter) G/G and rs8192284 (IL-6R )C/C genotypes showed the worst overall survival
24885636 Tumor-associated macrophages participate in the metastasis of CRC induced by PRL-3 through secretion of IL-6 and IL-8 in a KCNN4 dependent manner.
24883303 IL-8 and CXCR2 expression was distinctly uncommon as opposed to IL-6, VEGF and SOCS-3, which were detected in the vast majority of cases.
24872191 these studies reveal that podocytes can negatively regulate neutrophil recruitment to inflamed GEnCs by modulating IL-6 signaling, identifying a potential novel anti-inflammatory role of IL-6 in renal glomeruli.
24868113 The HP (2)/HP (2) genotype is associated with elevated serum TNF and IL-6, but not with hsCRP, levels in obese subjects.
24861949 Il-6, IL-17, TNF-alpha and VEGF levels were measured in exhaled breath condensate and serum of 15 patients with stage I-IIA non-small cell lung cancer.
24856384 Over half of nonsurvivors of polytrauma had the SNP-174G/C polymorphism. No difference was found between survivors and nonsurvivors with heterozygous and homozygous gene IL-6 SNP-596G/A polymorphism.
24851609 Patients with poorly differentiated prostate cancer with Gleason score (GS) 4 + 3 = 7 and > 7 had significantly higher serum IL-6 levels than the patients with moderately differentiated prostate cancer.
24850720 Costimulation of human mesangial cells with M4 and galactose-deficient polymeric IgA1 resulted in a significant increase in IL-6 secretion compared with each stimulant alone.
24845415 leptin and IL6 levels in peritoneal fluid correlated in endometriosis
24841049 Preliminary findings indicate a potential role of IL-6(-572/-597) genotypes in HBV disease pathogenesis in an Indian population.
24840331 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
24837562 Methylation increased in PDK4, IL1 B, IL6, and TNF promoters 12 months after gastric bypass.
24836084 Blood levels of CRP, IL-6 and TNFalpha-R2 are not associated with incident depression.
24834995 This study supports the idea that Interleukin 6 SNPs play a role in the pathogenesis of Febrile Seizures.
24833103 High IL6 expression is associated with mesenchymal tumors.
24831174 Data indicate that interleukin-6 (IL-6) predicts systolic pulmonary artery pressure (sPAP) in advanced heart failure (HF).
24830311 IL6 levels in seminal plasma are correlated with other inflammatory cytokines and sperm quality, suggesting role in regulating inflammation of male reproductive system.
24823512 IL-6 levels were significantly elevated who have at least three visible lytic bone lesions and/or bone fracture in comparison to patients who have one or two visible or no visible lytic bone lesions (P 0.048).
24819026 results suggest that IL-10 may be a useful marker for CML prognosis and theGG genotype of the IL-6 gene may be associated with susceptibility
24807462 IL-6 was associated with increased odds of spontaneous preterm birth, defined by presentation of spontaneous preterm labor and/or preterm premature rupture of the membranes.
24806843 Study provides new insight into the regulation of Epithelial-mesenchymal transition by IL-6 via activation of Stat3 in human cervical carcinoma.
24801091 T-lymphocyte differentiation and IL-6 levels are increased in patients with advanced chronic heart failure.
24800252 Studied the associations between disease activity and levels of serum ferritin and cytokines; found IL-6, IL-8, and IL-10 to be associated with hyperferritinemia in rapidly progressive interstitial lung disease with polymyositis/dermatomyositis.
24800209 Elevated IL-6 values were associated with decreased muscle power but not with decreased muscle fibre size.
24787542 a "differential susceptibility" effect of rs1800795 in schizophrenia pathogenesis mediated through hippocampal volume deficit
24786212 IL-6, TNF-alpha and IL-10 gene polymorphisms all contribute in the association with ST-elevation of myocardial infarction
24782217 IL-6 rs1800796 and IL-1beta rs1864169 polymorphisms are associated with ischemic stroke risk in the Chinese population.
24771848 TLR costimulation causes oxidative stress with unbalance of proinflammatory and anti-inflammatory cytokine production.
24767621 This study provides evidence in humans for a circadian IL-6 rhythm in CSF and confirms prior observations reporting a plasma biphasic circadian pattern
24756455 interleukin-6 is involved in inflammation, innate immunity, and cardiac remodeling after myocardial infarction [review]
24752352 Pathway inhibition studies revealed that ADAMTS-2 upregulation by IL-6 was mediated by JNK pathway.
24746556 gene expression in monocytes and their progenitors is regulated by DNA methylation and controlling the chromatin structure
24743542 Differences in innate cytokine responses between European and African children.
24741587 Analysis of biomarker network suggests that IL-10 and IL-6 are a robust axis in malaria patients and that this interaction seems to be associated with the parasite load.
24740880 Obesity is most frequently associated in children with IL-6 174 C allele carriers and with IL-6 190 C allele carriers.
24738292 cagocel lead to an increase of IL-4 (p > 0.05), IL-2, IFN-gamma (p < 0.05) and decrease of TGF-beta and IL-12 (p < 0.05). At the same time basic therapy facilitated a significant increase of IL-5 and decrease of IL-6, IL-12, IFN-gamma.
24733087 NGF, but not BDNF or IL6, has a role in infant motor development in children of mothers with postpartum affective disorders
24730420 IL-6-mediated upregulation of SOCS1 is the mechanism by which umbilical cord mesenchymal stem cells regulate dendritic cell tolerogenic phenotypes.
24728031 This meta-analysis demonstrates that FCGR3A V allele carriers show a better response to rituximab, and individuals carrying the IL-6 -174 C allele show a poorer response to anti-TNF therapy for rheumatoid arthritis.
24725542 Data indicate that interleukin-6 (IL-6) may contribute to the increased matrix metalloproteinase (MMP)/tissue inhibitor of metalloproteinase-1 (TIMP) ratio during proliferative vitreoretinopathy (PVR).
24725540 Data indicate that interleukin 6 (IL6)-174 G/C gene polymorphism may contribute to susceptibility to community-acquired pneumonia in Egyptian children.
24722336 IL-6 and Hsp70 significantly interacted with multiple polycyclic aromatic hydrocarbon metabolites in relation to heart rate variability
24721042 numbers of lincRNAs regulated was higher due to TNF-alpha compared to IL-6. Interestingly, none of the identified lincRNAs was influenced by both, IL-6 and TNF-alpha
24719354 IL-6 modulates the expression of Sox2.
24712547 postulate that dynamic properties of the IL-6 AB-loop are responsible for inhibiting the interaction of IL-6 with gp130 in the absence of the IL-6R
24707478 The frequencies of both the T allele on the IL-4-590 and the C on the IL-6-174 were significantly increased in RA patients.
24705131 The presence of microbial invasion of the amniotic cavity, histological chorioamnionitis, or the coexistence of both was associated with higher amniotic fluid concentrations of IL-6.
24704835 Results show that RMP serves as a potent factor contributing to portal vein tumor thrombus by promoting IL-6 transcription.
24703990 increase in IL-6 level in Egyptian people with Behcet's disease is not associated with gene polymorphism
24703107 Findings suggest that nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (NFKB1)-94ins/del ATTG polymorphism was associated with population hashimoto thyroiditis (HT) disease by directly modulating interleukin 6 (IL-6) serum levels.
24702172 Data suggest that circulating IL6 is up-regulated by resistance exercise in well-controlled patients with type 1 diabetes.
24686488 Hypertension in obese type 2 diabetes patients is associated with increases in insulin resistance and IL-6 cytokine levels.
24676805 RANKL and IL-6 mediate direct paracrine-autocrine signaling between cells of the osteoblast lineage and cancer cells.
24673855 high concentrations of IL-6 during the glucose clamp may be limited to the atypical subgroup of patients with major depressive disorder
24671027 S100A7 also promotes secretion of IL-6 and IL-8.
24664372 results concluded that celastrol attenuates PC-3 cell proliferation via downregulation of IL-6 gene expression through the NF-kappaB-dependent pathway.
24664110 pneumococcal polysaccharide capsule and pneumolysin differentially affect CXCL8 and IL-6 release from cells of the upper and lower respiratory tract
24659862 IL-27 has a role in activating human trophoblasts to express IP-10 and IL-6 in preeclampsia
24659848 Fetal inflammatory response syndrome cases classified as acute stress presented higher expression of IL-6 and TNF.
24657340 PD-1 expression and serum IL-6 level correlate with exhaustion of cytomegalovirus-specific T cells after allogeneic hematopoietic stem cell transplantation.
24655147 Review on interleukin-6 and its possible biological roles during exercise.
24647663 IL-6 is a central mediator in chronic inflammatory human diseases and many autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and Crohn's disease. (Review)
24644001 Data indicate that metformin reverses epithelial-mesenchymal transition and decreases interleukin-6 signaling in EGFR-TKI-resistant lung cancer cells.
24633552 IL-6 regulates adipose deposition and homeostasis in lymphedema.
24632587 Serum IL-6 and IL-17 were inversely associated with T2DM retinopathy.
24631985 Complement activation, cytokine production, and related cellular responses are important factors during open-heart surgery.
24631773 P2Y2 receptor fails to repress IL-6 expression by valve interstitial cells through Akt in calcific aortic valve disease.
24630186 Il-6-174G>C polymorphism causes increased risk of atherosclerosis in individuals with chronic stress. In addition, individuals carrying the G allele of the Il-6-174G>C polymorphism may be more prone to adverse effects of psychosocial stress.
24628003 Data suggest that up-regulation of serum IL6 levels in women with polycystic ovary syndrome is dependent on weight status (that is, whether they are also overweight/obese) and on degree of hypertriglyceridemia (but not on degree of hyperandrogenism).
24627113 In this multiethnic cohort, when hsCRP-quartile was higher than IL-6 quartile, ischemic stroke risk was increased, and conversely when IL-6 quartiles were elevated relative to hsCRP, the risk was decreased.
24625985 URI may have an important role in the development of multiple myeloma and chemotherapeutic resistance through activation of the IL-6/STAT3 pathway.
24625912 Combat training inducing significant levels of stress, depression and anxiety is accompanied by evidence of increased blood-brain barrier permeability and by increases in systemic pro-inflammatory mediator IL-6.
24625449 Activated IL-6 signaling might be responsible to the induction of DNMT3b overexpression on oral cancer
24623002 Interleukin-6 contributes to the paracrine effects cardiosphere-derived cells.
24618929 essential in the initiation and progression of the atherosclerotic lesion [review]
24611887 detection of IL-6 -174 G/C polymorphisms may be a promising biomarker for the early detection of MI
24603891 Data suggested that IL-6 mainly promotes the cell migration and invasion of Nasopharyngeal carcinoma cells; the effect of IL-6 on cell migration and invasion may be mediated through regulation of the expression of MMP-2 and MMP-9.
24586496 Interleukin-6 in serum and in synovial fluid enhances the differentiation between periprosthetic joint infection and aseptic loosening.
24582558 IL-6 could directly stimulate endometrial cancer cell proliferation and an autocrine feedback loop increased its production even after the withdrawal of IL-6 from the medium.
24577500 In conclusion, here we show that STAT3 activation can be one of the molecular mechanisms leading to KSHV-mediated DC dysfunction, that might allow viral persistence and the onset of KSHV-associated malignancies.
24576911 These results suggest that both the up-regulation of ZIP14 and the down-regulation of ZnT10 by IL-6 might have enhanced the accumulation of manganese in SH-SY5Y cells.
24573491 IL-6 does not contribute to the development of postpartum thyroiditis.
24568505 IL6 overexpression is associated with obesity and with breast cancer.
24557990 Idiopathic large for gestational age-born children have significantly lower TNF-alpha and higher IL-6 levels than appropriate for gestational age-born children.
24557630 IL-17 induces the migration of neutrophils and monocytes/macrophages through the activation of synoviocytes, and enhances a positive feedback loop composed of proinflammatory cytokines IL-6 and IL-17, but not RANLK
24557363 1beta-stimulated HPDLCs. CONCLUSIONS: These data provide a novel mechanism through which genipin could be used to provide direct benefits in periodontal disease to inhibit IL-6 and CCL20 productions in periodontal lesions.
24554512 Effects of metformin or an oral contraceptive containing cyproterone acetate on serum c-reactive protein, interleukin-6 and soluble vascular cell adhesion molecule-1 concentrations in women with polycystic ovary syndrome.
24551293 IL-6/JAK/STAT3 signaling pathway is active and may play an important role in the mechanisms of epithelial hyper-proliferation responsible for cholesteatoma.
24551049 COX-2 expression in gingival tissues may be a marker of periodontal disease severity. COX-2 rs 6681231 may be associated with IL-6 local production in gingival tissues.
24550394 Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-beta (TGF-beta) signaling promoting SMAD3 activation and fibrosis via Gremlin protein.
24548412 TNF-alpha and IL-6 secreted from keratinocytes enhanced ST8SIA1 expression in melanocytes.
24548241 IL-6 plays a role in the acute phase response, zinc and tryptophan use, the erythron, HPA axis activation, oxidative stress, bacterial translocation, autoimmunity, neurodegeneration, and neuroprogression. Review.
24547612 Depressive symptoms and hopelessness are not independent predictors of IL-6 levels.
24533098 RhoC has a role in regulating cancer stem cells in head and neck squamous cell carcinoma through the over expression of IL-6 and phosphorylation of STAT3
24532142 patients with high serum IL-6 or TNF-alpha level demonstrated a significantly higher SOCS-1 methylation
24530755 Our results suggested that rs1800796 polymorphism of IL-6 gene was associated with susceptibility to HBV-related HCC in a male Chinese Han population.
24528956 There was not association between IL6 gene polymorphisms (rs2069827,rs1800795,rs2069840) and Henoch-Schonlein purpura in large series of spanish patients.
24525621 Cell wall associated Rv1808 protein manipulated the host cytokines via MAPK and NF-kappaB signaling pathways.
24515998 The present meta-analysis showed that two alleles of proinflammatory cytokines (IL-1alpha-889 and IL-1beta-511) in addition to the serum concentration of IL-6 were significantly associated with febrile seizures and epilepsy or both [review]
24513290 IL-6 production is elevated in rheumatoid arthritis synovial fibroblasts. Histone H3 acetylation is increased in the IL-6 promoter.
24495605 results suggest that IL-6 may be a biomarker for early psychotic symptoms.
24493366 interleukin-6 is elevated in endemic Burkitt lymphoma in Ghana
24492940 No significant publication bias was observed. In conclusion, we found that -634C>G and -174G>C polymorphisms in IL6 promoter region were not associated with lung cancer risk
24489445 PBMC from MM patients display a deregulated response related to CD38 activation pathway defects; CD38 may be functionally involved in the progression of this pathology via the secretion of high levels of IL-6 that protects neoplastic cells from apoptosis
24487064 eukaryotic elongation factor 1A1 (eEF1A1) was verified as the relevant target of HAK bioactivity. eEF1A1 forms complexes with STAT3 and PKCdelta, which are crucial for STAT3(S727) phosphorylation and for NF-kappaB/STAT3-enhanced interleukin-6 expression
24486505 IL-6-174G > C and -572C > G polymorphisms are associated with the risk of ischemic stroke.
24485227 Association is found in type 2 diabetes mellitus patients with IL-6 single nucleotide polymorphism (174G/C) and macrovascular complications.
24481949 We found that transforming growth factor-beta, in contrast to fibroblast growth factor-2 and interleukin-6, promotes human pulmonary pericyte differentiation into contractile smooth muscle-like cells.
24478088 These results support the key role of IL-6 in hepcidin regulation in response to a variety of infectious and inflammatory stimuli.
24474695 Meprin metalloproteases A and B inactivate interleukin 6
24473196 higher expression of miR-146b was positively correlated with patient survival in breast cancer subtypes with increased IL6 expression and STAT3 phosphorylation.
24472318 Deletion/mutagenesis of C/EBP-beta binding motif of DPP III promoter significantly increased its activity and abolished its responsiveness to IL-6 in glioblastoma cells.
24460857 Data indicate that all evaluated cytokines IFN-gamma, TNF-alpha, IL-4, IL-6 and IL-10 were elevated significantly in immune thrombocytopenic purpura (ITP) patients compared to controls.
24460320 IL-6-6331 is associated with decreased risk of gastric cancer
24451691 half- and full-marathon wheelchair races increased plasma IL-6, but not TNF-alpha and high-sensitivity C-reactive protein
24446297 SNP in IL-6 promoter was associated with increased risk of prostate cancer in the African-American set.
24445366 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
24434384 Short-term oral N-acetylcysteine treatment might result in the reduction of IL-6 and hs-CRP in patients who are on regular hemodialysis.
24429356 Tocilizumab targets IL-6 signaling in rheumatoid arthritis inducing apoptosis of Th1, Th17 and Treg cells and promoting the appearance of a Th2 response.
24420154 TERT rs2736100T/G polymorphism modulates IL-6 expression and may play a unique role in lung adenocarcinoma.
24418364 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
24416448 TL1A, together with IL-12, IL-15 and IL-18, directly induces the production of IL-6 and TNF-alpha from PLZF leukocytes.
24415767 Presented is the 2.55 A crystal structure of S low Off-rate Modified Aptamer SL1025 bound to human IL-6.
24410736 Dialysate IL-6 concentration increased with longer PD duration and was a significant, independent predictor of PSTR.
24409674 levels of IL-6 and IL-17 were elevated, and the levels of IL-21 were decreased in the acute group. The levels of IL-17 and IL-6 were positively correlated (r = 0.182, p = 0.03), and the levels of IL-17 and IL-21 were negatively correlated
24408019 meta-analysis suggested that IL6 -634C/G polymorphism was a risk factor for lung cancer
24405156 Network analysis suggested a central role of IL-6, confirmed by overexpression of IL-6 in tumor tissues as in sera of HPV-negative HNSCC compared with HPV-16-positive tumors
24402421 in patients with rheumatoid arthritis, insulin resistance is associated with higher, rather than the expected lower, concentrations of NT-proBNP and that this may be related to increased IL-6.
24401638 High IL-6 levels and inflammatory burden score were associated with mortality in a cohort of HIV-infected adults with alcohol problems.
24398988 Correlations between the pro-inflammatory interleukins IL-6 and IL-8 and the anthropometric measurements in malnourished vs. non-malnourished children, were evaluated.
24398033 S. aureus inhibits the terminal differentiation of keratinocytes by stimulating IL-6 secretion
24397394 Data suggest that plasma levels of interleukin-6 and galanin are up-regulated in second trimester in women with gestational diabetes (glucose intolerant/insulin resistant) as compared to normal pregnant women (with normal glucose/insulin tolerance).
24395296 We have observed that some evidence of interactions of the IL-6 polymorphism and have shown statistical significant association with elevated BMI, Lipid profile and total bilurubin in the study subjects.
24393164 results suggest that IL-6 -174GC gene polymorphism associated with susceptibility to SS. IL-6 polymorphism could influence lymphocytic infiltration of salivary glands and diminish lachrymal gland function.
24392029 Syndecan-1 modulates the cancer stem cell phenotype via regulation of the Wnt and IL-6/STAT3 signaling pathways
24390735 HAVCR/KIM-1 activates the IL-6/STAT-3/HIF-1A axis.
24383926 In summary, enriched HMGB1 in chronic hepatitis B patients shifts Treg/Th17 balance to Th17 dominance via the TLR4-IL-6 pathway, which exacerbates liver injury and inflammation.
24380782 SNP 174G/C related to an increased risk for obstructive sleep apnea in children
24374086 Acute coronary syndrome patients with moderate depressive symptoms who had higher IL-6 levels had higher levels of platelet microparticles.
24371367 The rs1800796 polymorphism is unlikely to contribute significantly to the progression of chronic hepatitis B virus infection.
24363620 serum IL-6 levels were increased in patients with coronary artery disease (CAD) compared with healthy controls and the IL-6 gene polymorphism at -174 was more prevalent in CAD cases
24359561 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
24356550 Diabetic nephropathy (DN) patients have significantly higher serum HBD-1 levels than non-DN patients, but there is no difference in beta-defensin (HBD)-2, (IL)-6, and tumor necrosis factor (TNF)-alpha profiles.
24355795 Patients with Paget's disease of bone presented higher levels of IL6 and reduced IL17, however, there were no significant differences when patients were compared according to disease activity or current treatment.
24347287 These studies showed that activation of a positive feedback loop, IL-6 stimulated by E2 in endometrial cancer cells induced aromatase expression in stromal cells, promoting enhanced intratumoral E2 synthesis.
24347177 The expression of vascular endothelial growth factor (VEGF), matrix metalloproteinase 2 (MMP2), tissue inhibitor of metalloproteinase 1 (TIMP1), interleukin 6 (IL-6), and interleukin 15 (IL-15).
24346288 Stromal fibroblasts isolated from colon cancer produced significant amounts of IL-6.
24340926 Body structure and serum concentration of adiponectin and cytokines (IL-6, -10 and TNF-alpha) in rheumatoid arthritis combined with obesity
24339057 The role of elevated IL-6 in Paget's disease of bone, was examined.
24338120 Elevated cord blood IL6 was associated with preterm birth <32 wks gestational age, respiratory distress syndrome, and chronic lung disease.
24328460 The IL-6-174G/C polymorphism may be a risk factor for the development of Multiple sclerosis in Asians.[meta analysis]
24328421 Study of adiponectin, interleukin-6, and endothelin-1 and how they correlate with modifiable cardiometabolic risk factors in overweight/obese men.
24318992 IL-6-174 G/C, but not -572 G/C polymorphism could be a candidate for susceptibility to hepatocellular carcinoma (Meta-Analysis)
24314919 Il-6 levels in menstrual effluents is a significant predictor of chronic endometritis.
24314052 Strong association of cerebral palsy with an extended 7-SNP haplotype containing the functional promoter SNP rs1800795 in a recessive model of disease inheritance.
24312369 report pre-ART IL-6 and LBP levels as well as IL-6, LBP and I-FABP levels during IRIS-event as potential biomarkers in TB-IRIS
24308758 TNF-alpha and IL-6 gene polymorphisms were associated with endometriosis in Asians. [review]
24308236 IL-6 - 174 single nucleotide polymorphism (SNP) distribution may differ between various ethnic groups and that a single cytokine gene polymorphism has probably just a minor effect on prostate cancer susceptibility.
24299316 Our findings suggest that the coexpression of these two cytokines (serum interleukin-6 (IL-6) and tumor necrosis factor-a (TNF-a) could be used clinically as a useful tumor marker for the extension and the outcome of the disease.
24297684 All of the studied primary epithelial cells expressed CCL26, IL-6 and IL-8 after IL-4 or IL-13 stimulation.
24294778 Serum TNF-alpha and IL-6 have predictive value for development of inflammation and fibrosis in patients with AH and can be used as non-invasive markers of fibrosis.
24287883 Keratinocytes produce IL-6 in response to desmoglein 1 cleavage by Staphylococcus aureus exfoliative toxin A.
24286242 Data show that IL-29 enhances Il-6 and Il-8 proinflammatory cytokines production in the synovial fibroblasts from rheumatoid arthritis via upregulation of Toll-like receptors TLR2, 3 and 4.
24266503 Bereaved respondents had higher levels of inflammatory biomarkers IL-6 and sE-selectin, but not CRP and sICAM-I than the non-bereaved.
24265545 Aqueous humor concentrations of the cytokines (IL-1 alpha, IL-1 beta, IL-6, FasL, and TNF- alpha) in patients with open angle glaucoma, were measured using multiplex bead analysis.
24256045 low levels in cholesteatoma
24254894 When the patients with overt and nonovert DIC were compared, the PrC level was lower, and PCT, PAI-1, IL-6, and IL-10 levels were higher in the patients with overt DIC.
24252021 Serum IL-6 levels may predict the prognosis of clinically amyopathic dermatomyositispatients with rapidly progressive interstitial lung disease
24247794 IL-6 acts as a pro-inflammatory cytokine during early-stage acute T-cell-mediated renal rejection, and plays an anti-inflammatory role during later stages post-transplantation.
24246233 cord blood level elevated in funisitis
24244348 TNF-alpha-induced activation of NF-kappaB is sufficient to induce IL-6 expression, activate STAT3, and elevate STAT3 target gene expression in GBM cell lines and human GBM xenografts in vitro.
24243972 Although Delta1 activates signal transducer and activator of transcription 3 signaling similarly to the gp130-activating cytokine interleukin-6 (IL-6), it has opposite effects on myeloid cell production.
24243775 IL6 plasma levels correlate both with clinical and ultrasound measures of arthritis disease activity in systemic lupus erythematosus
24243751 The results suggest that idiopathic cardiac arrhythmias of unknown origin in children are not associated with selected pro-inflammatory markers of infections i.e. elevated IL-6, CRP or -174 G>C IL-6 polymorphism.
24242046 IL-6-induced suppression of PPARalpha expression by inducing STAT1 and STAT3 phosphorylation and subsequent down-regulation of PPARalpha mRNA expression.
24242026 study indicated that inflammatory response as presented by local IL-6 levels was associated with slow flow/microvascular dysfunction in patients with ST-elevation AMI after successful primary PCI.
24239840 One common variant (rs11265611; P = 1.70 x 10(-6)) intronic to IL6R (interleukin-6 receptor gene) was significantly associated with AF.
24238294 Data indicate that reproductive epithelial cell culture showed considerable variation in IL-6 response to Chlamydia or chlamydial proteins.
24223608 this is the first study to evaluate the association of -174G/C and -572G/C polymorphisms of the IL-6 gene with RA in Mexican mestizo patients.
24217195 Plasma advanced glycation end products (AGEs), receptors for AGEs and their correlation with inflammatory markers in middle school-age children.
24204677 Data suggest that SNP IL-6-174 G>C may be a useful marker for neuroblastoma prognosis.
24200066 Let-7a is down-regulated and IL-6 is overexpressed in esophageal squamous cell carcinom
24189439 IL-6 secreted by ovarian cancer cells may contribute to the refractoriness of these cells to tamoxifen via the estrogen receptor alpha isoform and SRC-1 (NCOA1).
24189370 elderly women classified as high response experienced greater serum response to eccentric resistance exercise
24187466 SNPs of IL-6 gene may be associated with susceptibility to chronic HBV infection in the Han Chinese population.
24186266 Exposure to follicular fluid transiently increased the transcript levels of IL8 and PTGS2, and decreased the expression of SOD2, GPX3, DAB2, and NR3C1. TNF and IL6 levels were also decreased while those of NAMPT were unaffected.
24175805 There was a significant decrease in the serum level of IL-6 in glioma patients compared to healthy controls. Lower levels of IL6 was correlated with increased age in glioma patients.
24164541 Underscore the importance of DUOX1 and DUOX2 in vesicant-induced IL-6 secretion in human airway epithelial cells.
24162780 P. gingivalis induced IL-6, IL-8, and VCAM-1 expression in hGFs and hPDLCs through NOD1/2-mediated NF-kappaB and ERK1/2 signaling pathways.
24155968 The kinetics of IL-6 production instead of elevated IL-6 levels defines the T effector cell responsiveness in early T regulatory-T cell communication in multiple sclerosis.
24152848 Upon activation by thrombin or calcium ionophore A23187, but not by ADP, the IL-6R-alpha is released in soluble form, while cangrelor, the specific inhibitor of P2Y12 receptor, can partially inhibit sIL-6R release
24151609 multiple myeloma patients with advanced aggressive disease had significantly higher levels of IL-6 and TNFalpha than those with multiple myeloma in plateau phase
24150223 IL6 was not significantly associated with development of manic symptoms in depressed patients. IL6 was higher in depressed patients, with or without manic symptoms, than in controls.
24143215 multiple miRs are involved in the molecular regulation of TLR2-mediated responses in the trophoblast towards gram-positive bacterial components
24141626 Thus, the pretreatment cytokine profile, particularly serum levels of IL-6 and IL-2R, may be used to identify patients with cHL at high risk for early-disease relapse.
24140476 Data indicate that carriers of variations in the IL6, IL12B and absence of HLA-Cw6 as having decreased risk for psoriasis.
24140302 Results showed that BDNF levels positively associated with IL-6 levels in patients suffering from major depressive disorder.
24139871 Higher parasitemia levels were observed in IL6-174C carriers
24136650 We identified interleukin-6 (IL-6) as a crucial cervical cancer cell-derived mediator
24136333 Plasma IL-6 has a role in survival in pulmonary arterial hypertension
24128993 A relevant relationship exists between epilepsy, inflammatory cytokine IL-6, and iron regulation and metabolism, linked as acute phase and antioxidant markers.
24128872 Data indicate that the upper 95th percentile reference limit for IL-6, TNF-alpha, and IL17-A was 4.45, 2.53, and 1.93pg/mL, respectively.
24120137 Unlike early hepatocarcinogenesis, which depends on paracrine IL-6 production by inflammatory cells, due to upregulation of LIN28 expression, hepatocellular carcinoma progenitor cells had acquired autocrine IL-6 signaling that stimulates their in vivo growth and malignant progression.
24119107 TNF a and EGF were significantly altered in VCP disease as compared to control. No significant differences were observed in IL-4 and IL-6.
24118442 IL-6 G/G and MBL AA gene polymorphisms are potential risk factors and that the IL-6 G/C and MBL AB polymorphisms are a protective factor for occurrence and recurrence of CA.
24116074 Increased IL-6-induced activation of STAT3 was observed in neoplastic gastric tissue, which positively correlated with tumor progression.
24114793 Human metapneumovirus interrupted the IL-6-induced JAK/STAT pathway by blocking the phosphorylation of JAK2.
24106887 findings support the participation of IL-6, IL-8 and IFN-gamma in the events linked to fatal outcome in infective prosthetic valve endocarditis
24106699 Our results indicate that IL-6 -174G/C polymorphism might be associated with the susceptibility to SLE especially in women
24102240 the -174 G>C polymorphism of the IL-6 gene is an independent risk factor for Diabetic nephropathy in Turkish type 2 diabetes mellitus patients
24101193 data suggested that IL16 rs11556218 T/G polymorphism was associated with increased susceptibility to nasopharyngeal carcinoma
24096654 CGRP promotes SAA synthesis through activation of IL-6 in human hepatocytes
24095158 Increased circulating inflammatory factor IL-6 is associated with greater risk of atrial fibrillation in the general population and among patients who underwent coronary artery bypass grafting (CABG) surgery procedure or catheter ablation.
24094983 Data (from in vitro studies) suggest that pre-treatment of placental explants with calcium (suggestive of dietary calcium supplementation) inhibits activation of vascular endothelium in response to IL6 (as found in preeclamptic sera).
24086566 Stimulation of OASFs with leptin induced IL-6 expression.
24086545 High basal expression of IL-1beta by monocytes predicted high IL-6 levels.
24083740 High serum IL6 levels are associated with advanced stages of non-small cell lung cancer.
24081898 IL-6 produced from IL-1beta-stimulated human periodontal ligament cells could increase CCL20 production.
24078775 palmitic acid can stimulate IL-6, TNF- alpha, and IL-1 beta production and cell proliferation in HaCaT keratinocytes
24077340 Inflammatory gene polymorphisms were not associated with arterial stiffness.
24073214 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
24072654 There were no significant associations between IL-1beta, IL-6 and IL-10 gene polymorphisms and acute pancreatitis risk.
24072607 Estimate the circulating levels of CRP and IL-6 and also study the IL-6 -174G>C gene polymorphism in the context of coronary artery disease in patients, first degree relatives and healthy controls.
24061634 Genetic variation in IL-16 miRNA target site and time to prostate cancer diagnosis in African-American men.
24059848 The IL-6 promoter, receptor and signal transducer SNPs can modify disease susceptibility. [Meta-analysis]
24057184 individuals having a haplotype combination of AA, GG and CA for IL-6, TNF-alpha and IL-10 gene polymorphisms will have higher susceptibility and be at greater risk of developing T2DM.
24053561 This suggests that there are modest effects of the -634C/G and -174G/C polymorphisms on BMD.
24051540 Interleukin-6-induced Twist and N-cadherin have roles in melanoma cell metastasis
24051251 TNF-alpha promoter polymorphisms as well as IL-6 gene polymorphisms are associated with chronic idiopathic urticarial in Iranian patients.
24051035 IL-6 -598/-572/-174 (AGC) haplotype has a low prevalence among first-degree relatives of subjects with type 2 diabetes. Our results suggest that this haplotype is associated with decreased risk of type 2 diabetes in Mexican subjects with FHT2D.
24044867 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
24044580 the -174G/C polymorphism in the IL-6 gene is not significantly associated with circulating IL-6 levels in a normal population
24043886 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
24043651 Having a high interleukin-6 level twice over the 5-year exposure period was associated with nearly halved odds of successful aging at the 10-year follow-up and increased risk of future cardiovascular events and noncardiovascular death.
24037855 Gankyrin is crucial for cholangiocarcinoma carcinogenesis and metastasis by activating IL-6/STAT3 signaling pathway through down-regulating Rb protein.
24037056 The objective of this study is to investigate the possible role of inflammatory mediators such as IL-6, IL-1beta, and TNF-alpha in Kashin-Beck disease (KBD) children and rats fed with T-2 toxin under a selenium-deficient nutrition.
24032723 IL-6 plays a role in spontaneous miscarriage irrespectively of its type, however, no correlation between circulating IL-6 and IL6 gene polymorphism, as well as IL-6 and IL-6R polymorphisms associations with spontaneous miscarriage were revealed.
24029665 Data indicate that the substitution levels from G to A and from G to C in the TNF-alpha and IL-6 genes, respectively, were significantly higher in the infertile subjects as compared to that of control group.
24026137 Norepinephrine and adenosine-5'-triphosphate synergistically induced release of IL-6 by a human dermal microvascular endothelial cell line
24015240 Cerebrospinal fluid interleukin-6 levels help differentiate multiple sclerosis (MS) from diseases that may mimic MS.
24013670 Review/Meta-analysis: IL-6 -174 G/C and -572 G/C polymorphisms could be candidates for susceptibility to systemic lupus erythematosus.
24012192 Polymorphism in cytokine genes may explain sleep disturbances in patients diagnosed with breast cancer.
23999825 These data indicated that IL-1Ra, IL-6, IL-8, and TNF-alpha were associated with increased risk of Osteosarcoma, in which IL-8 and TNF-alpha may be further correlated with the progression of this disease
23999600 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
23993981 Our meta-analysis suggested that IL-6 promoter polymorphisms (-174G/C and -572G/C) were associated with intracranial aneurysms.
23991193 IL6 may lead to individual differences in tacrolimus metabolism mainly by affecting liver function
23991153 results demonstrate the role of IL-6-STAT3 signaling in ACS through increased Th17 cell differentiation
23987834 IL-6 and activin A may provide prognostic information on cardiovascular events and mortality in type 2 diabetics.
23982631 genetic polymorphism is associated with recurrent aphthous stomatitis in a cohort of Turkish population
23981903 influence of IL-6 -174G/C polymorphism on acute IL-6 and creatine kinase response to eccentric resistance exercise in elderly obese women, indicating possible muscle damage without exacerbating IL-6 and CK for the GG genotype
23977098 The downregulation of let-7 by cancer-associated mesenchymal stem cells upregulates IL-6 expression.
23968978 Our data highlight the strong connection between the circulating inflammatory biomarkers CRP and IL-6 and platelet gene expression, adjusting for cardiovascular disease risk factors.
23954871 The present meta-analysis suggests that the IL-6 gene -174G C polymorphism is associated with the susceptibility to AS. [meta-analysis]
23954444 These results strongly suggest that the combined stimulation of IL-6 and glucocorticoids induces the activation of both Reg and HGF genes.
23953866 elevated levels of IL-6 and MMP-8 in amniotic fluid at mid-trimester are predictive of preterm delivery
23953057 Data indicate a mechanism that fibroblast senescence promotes cervical cancer development through high-risk HPV16 and HPV18 E6-activated IL-6/STAT3 signalling in tumour microenvironment.
23936495 Extracellular vesicles are potent stimulators of MMP-9, IL-6, TGF-beta1 and induce the secretion of extracellular EMMPRIN
23933386 Upregulation of IL-6 gene is not responsible for the development of acquired oxaliplatin resistance in gastric carcinoma.
23932860 Levels of IL-6 and C-reactive protein are independently associated with right ventricular morphology and function in a multi-ethnic population.
23929842 Lymphocyte deficiency alters basal and inflammatory IL-6 in immune-mediated liver disease.
23928667 IL-6 and CRH are both secreted in a pulsatile fashion during the active phase of human labor. The time-integrated concentrations of the two hormones are positively correlated, with IL-6 leading CRH secretion.
23924795 Data indicate that anti-CD115 monoclonal antibody H27K15 exerts partial inhibitory effects on CD115 signaling, but inhibits monocyte chemotactic protein-1 secretion and reduces interleukin-6 production.
23921153 A role for IL-6 in suppressing olfactory receptor neuron regeneration was not found following 2,6-dichlorobenzonitrile.
23918902 found that -786CC in eNOS was associated with lower levels of IL-6
23917204 TIS21 decreased interleukin-6 (IL-6) expression in human dermal fibroblast.
23916117 Data show that in 12 invasive cancer nipple aspirate fluids (NAF) samples, a significant positive linear correlation was found among aluminium, carbonyls and pro-inflammatory IL-6 cytokine as well as monocyte chemoattractant MCP-1 cytokine.
23913484 IL6 is an inducer of IRF9 expression in prostate cancer and a sensitizer for the antiproliferative effects of IFNalpha2.
23910616 Studies show IL-6 and CRP are important in systemic sclerosis both in pathogenesis and clinical manifestations and may be useful indicators of disease activity, severity, and poor prognosis.
23898208 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
23897063 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
23894088 cyclic strain increased the expression of vascular endothelial growth factor (VEGF) and interleukin (IL)-6, which are critical to wound healing
23893709 Studied significance of interleukin 6 gene polymorphism -174 in gastric cancer risk; results show interleukin 6 -174 GG & GC genotypes increase risk of diffuse type gastric carcinoma, but not intestinal type gastric carcinoma or precursor conditions.
23892696 Data indicate that serum highest TNF-alpha and IL-6 and higher ferritin are among those with intense steatosis.
23889749 novel activated signaling pathways that drive the expression of IL6
23887901 Respiratory muscles contribute to exercise-induced increases in plasma IL-6 concentration in the absence of diaphragm fatigue. Inspiratory muscle training can reduce the magnitude of the response to exercise.
23884823 Decreased expression of the cytokines TNF-alpha and IL-6 may be responsible for the development of a more severe clinical picture in patients with varicella-zoster virus infection.
23884764 Based on a meta-analysis,IL6 174G>C polymorphism is not asociate with colorectal cancer.
23871133 Type 2 diabetes mellitus patients with the Il6 GC genotype tended to have more frequently nephropathy than those with the GG or the CC.
23867565 Data indicate that pro-inflammatory cytokines such as IL6 or OSM could activate pathways associated with prostate cancer progression and synergize with cell-autonomous oncogenic events to promote aggressive malignancy.
23862741 Elevated expression of IL-6 and IL-8 induced by IL-17 may be involved in the mechanisms of rheumatoid arthritis via the Act1 pathway.
23860887 The results indicate a positive association between -174 GC of IL-6 genotype and the risk of hypertensive disorders of pregnancy.
23856918 that severe hemorrhage in patients without brain injury is associated with increased serum levels of S100B, which correlates with IL-6 and tissue hypoperfusion.
23851938 Synthesis of IL-6 was significantly reduced by 1 % STS and stimulated by 10 % STS
23844163 Data indicate that a PKCa-independent mechanism of IL6 gene activation is very sensitive to physical forces in thyroid cells cultured in vitro as monolayers.
23832741 High Interleukin-6 expression is associated with invasiveness in glioma.
23828679 Determining soluble IL6 in children after cardiosurgical operations at 2 hrs after the procedure constitutes a good, yet not a perfect marker of acute kidney injury risk development.
23821953 Association between IL1B, IL6, and IL8 gene polymorphisms and risk of recurrent erosion development in patients with hereditary corneal stromal dystrophies.
23819403 In this study we have shown that there is no increase in lL-6 levels in patients undergoing preterm labor without clinical or biochemical infection signs.
23815191 may have a role in the diagnosis of ovarian torsion [review]
23815102 lung tissue immunostaining demonstrated an increased intima and adventitia distribution of IL-6 in individuals who died of schistosomiasis-associated pulmonary arterial hypertension
23813968 Plasma IL-6 levels might be another biological marker for the human depressive state.
23807226 Photo-oxidative tumor cells and the upregulation of IL-6-facilitated tumor cell death underpin the association of certain primary apoptotic mediators with inhibition of tumor growth.
23792529 carriage of IL-6 high producer/Fas low producer genotype has a protective effect against renal graft function loss
23791019 Our results revealed a novel role of Epstein-Barr virus encoded small non-cdoing RNAs (EBERs) in the coordination of IL-6-STAT3 signaling pathway to chemoresistance and cellular migration in cancer cells.
23785756 Statistically significant differences in infected women (groups 1 and 2) in comparison with uninfected women (group 3) were detected: d) IL-6 concentration in vaginal washings increased in mixed infection in group 1.
23784949 The results indicate that higher serum levels of IL-6 are associated with increased hepatocellular carcinoma risk
23782174 up-regulated in late onset severe pre-eclampsia
23777202 genetic polymorphism is associated with end stage renal disease and malnutrition inflammation syndrome in India
23776669 Oral but not intravenous glucose acutely decreases circulating interleukin-6 concentrations in overweight individuals.
23774701 Data indicate that in response to pancreatitis-associated ascitic fluid (PAAF), overexpression of TNF-alpha and IL-6 mRNA was found in THP-1 cells.
23770252 genetic polymorphism of the promoter region is associated witgh SLE susceptibility in Brazil
23766379 Significant inverse correlations emerged between education and IL-6, and between anger control and IL-6.
23765061 Expression of IL-6 in nasal epithelial cells was higher in nasal polyps compared to control mucosa.
23763486 These results show that acrolein stimulates the synthesis of IL-6 and CRP, which function as protecting factors against acrolein toxicity.
23762858 The effects of interleukin-6 on the regulation of epithelial-mesenchymal transitions and the expressions of the MASPIN, NDRG1, and KAI1 genes attribute to the modulation of tumorigenesis in human bladder carcinoma cells.
23762476 Galpha12 drives oral squamous cell carcinoma invasion through the up-regulation of IL-6 and IL-8 cytokines.
23761639 interleukin-6 expression was increased after bed rest
23760743 the CC genotype of IL-6 G-174C polymorphism may be associated with high bone mineral density (BMD)at femoral neck and distal radius and decreased risk of osteoporosis in the Caucasian population whereas G-634C polymorphism was associated with distal radius BMD in Asians
23756867 in colorectal cancer, tumour necrosis, independent of T stage, is associated with elevated circulating IL-6 concentrations modulating both local and systemic inflammatory responses including angiogenesis that, in turn, may promote tumour progression and metastases
23754245 In this early rheumatoid arthritis cohort, we demonstrated a significant reduction of plasma IL-6, but not TNF-alpha, during methotrexate treatment. The post-treatment IL-6 level was a strong indicator of radiographic progression.
23748363 Urinary IL-6 can be used as a biomarker for the early recognition of ongoing renal damage in patients with posterior urethral valves.
23747799 Blockade of endogenous IL-1 or IL-6 restricts or favors hippocampal-dependent memory.
23746176 The aim of this study was to determine the salivary concentrations of tumour necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) in patients with premalignant and malignant lesions.
23743311 Increasing IP-10 and IL-6 production by bronchoalveolar lavage cells is associated with non-cavitary tuberculosis in patients who present with radiographically advanced TB
23737648 H1N1 virus infection induces an early and significant upregulation of both interleukins IL1 beta and IL-6 plasma expressions.
23735697 IL-6 is a potent inducer of energy dependent neutrophil extracellular traps formation.
23728617 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
23701120 Up-regulation of IL-6 expression by C-terminal Haptoglobin fragment in THP-1 monocytic cells.
23674845 Review: discuss role of Il6 SNPs in chronic liver diseases and hepatocellular carcinoma.
23666170 The promoter region of the IL-6 gene exerts an effect through gene linkage in Alzheimer's disease.
23665320 Positive expression rate of IL-6/STAT3 was 39.7% (23/58)/29.3% (17/58) in primary Wilms' tumor tissues, while 61.1% (11/18)/33.3% (6/18) in associated invasive/metastatic tissues.
23658720 IL-6R overexpression, coupled with enhanced IL-6/STAT3 signaling may facilitate the malignant transformation of EBV-infected epithelial cells.
23657600 The IL-6 -174 G/C polymorphism may confer susceptibility to periodontitis in Brazilians, and the IL-6 -572 G/C polymorphism may be associated with susceptibility to periodontitis in Europeans, and chronic periodontitis.
23654074 A significant increase in the frequency of the G allele and GG genotype at position -174 of IL6 was found in patients with AD, thus suggesting that production of this cytokine is greater in atopic patients.
23651237 Data indicate that IL-6 -597 did not show any disease association with oral lichen planus in the study population.
23648135 These findings strongly suggest that ATF3 is involved in suppressing IL-6 cytokine expression during gonococcal infection.
23648010 Increased CD16(+ ) NK cells were associated with IL-6 and VEGF deficiency in a high proportion of UI-IF(unexplained infertility with implantation failure) patients.
23647063 Findings suggest that elevated hepcidin levels and inadequate erythropoietin response are frequent in diffuse large B-cell lymphoma (DLBCL), but elevated interleukin-6 (IL-6) plays the major role for the development of anemia.
23639700 Solar simulted radiation-induced Il-6 may be involved in the photoaging-induced loss of facial subcutaneous fat.
23638863 TNF-alpha-308GA and IL-6 -174CC gene polymorphisms are involved in susceptibility to Graves disease in Turkish population.
23637926 The data revealed that IL-6 was overexpressed in the bladder cancer specimens compared with non-malignant tissues at both mRNA and protein levels.
23637318 Measurement of serum IL-6 in rheumatoid arthritis before treatment may be useful to estimate residual disease activity after tocilzumab treatment and to predict responsiveness to tocilzumab treatment.
23634964 temporal profile of total and high molecular weight (HMW) adiponectin and interleukin-6 (IL-6) in 15 critically ill patients
23633491 A Cox multivariable analysis of patient specimens revealed that IL-6 and IL-8 expression predicted patient survival times in triple-negative breast cancer.
23633489 An interaction between neuroblastoma cells and their microenvironment is mediatwed by the IL-6-STAT3 pathway.
23632023 a causal connection between MMP-8 activity and the IL-6/IL-8 network, with an acute response to MMP-8 involving induction of the proinflammatory mediators, which may in part serve to compensate for the deleterious effects of MMP-8 on breast cancer
23630220 Both lonelier healthy adults, and lonlier breast cancer survivors exposed to acute stress exhibited greater synthesis of IL-6 by peripheral blood mononuclear cells stimulated with lipopolysaccharide than their less lonely counterparts.
23625043 Exposure of human coronary artery endothelial cells to constant high glucose induces expression of IL-6, TNF-alpha and ICAM-1, and the production of these proinflammatory cytokines is further enhanced in periodic high glucose.
23622344 Leptin may be one of the proinflammatory cytokines that up-regulates IL-6 production in rheumatoid synovial fibroblasts via activation of JAK2/STAT3.
23619188 MRP8 has a crucial role in stimulating IL-6 expression by rheumatoid arthritis fibroblast-like synoviocytes.
23617681 IL6 SNP rs1800795 genotype CC is protective against preterm birth in women of European descent. It is not significant in other heterogeneous or admixed populations, or in fetal genotype analysis.[Meta-analysis]
23616277 Results show that interferon regulatory factor-5 (IRF-5) and NF-kappaB p50 are key co-regulators of IFN-beta and IL-6 expression following TLR9-mediated activation of human plasmacytoid dendritic cells
23604117 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
23601344 This meta-analysis suggests that the IL-6 -174 polymorphism might not confer susceptibility to rheumatoid arthritis and type 1 diabetes mellitus.
23601055 IL-6 was strongly and significantly associated with liver fibrosis in a cohort of HIV-infected patients with alcohol problems.
23593346 These results suggest the importance of IL-6 mediated stromal-epithelial cell interaction in gastric tumorigenesis.
23593036 Our findings elucidate the regulation of IL-6 signaling by IL-6R, which is causally relevant to several complex diseases, identify mechanisms for new approaches to target the IL-6/IL-6R axis.
23591770 The IL-6/STAT3 signalling loop and platelet-derived growth factor-BB (PDGF-BB)/PDGF receptor (PDGFR) pathway were important for CM-induced cell migration and invasion.
23582716 IL-6 and soluble interleukin-6 receptor are associated with acute myocardial infarction and cardiac injury.
23582441 Image-guided thermal ablation of tumors increases plasma levels of IL-6 and IL-10.
23571152 Genetic variations in the IL-6 gene increase the risk of IFN-induced depression and anxiety. The IL-6 polymorphism was associated with fatigue rates in patients with chronic hepatitis C before treatment.
23569034 IL6-572 CG genotype may be related to protection from acute rejection following liver transplant in Han Chinese patients.
23567762 Plasma ghrelin levels were increased, and TNF-a and IL-6 were decreased in obstructive sleep apnea patients with and without coronary heart disease.
23564789 Overexpression of IL-6 by gene transfer stimulates IL-8-mediated invasiveness of esophageal carcinoma.
23564454 a dual role of the IL-6R stalk region in IL-6 signaling.
23561329 IL-6 was significantly associated with poor prognosis in patients with esophageal cancer.
23559389 Th1 chemokines CXCL11 and CXCL10 may be involved in the pathogenesis of mixed cryoglobulinemia; IL-6 and CCL2 may be involved in regulating their elevation
23555719 HCMV activated the IL-6-JAK-STAT3 pathway in PHH and HepG2 cells
23555579 When patients were classified according to sputum IgE levels, it appeared that IL-5, IL-6, IL-17 and TNF-alpha sputum supernatant levels were raised in the "IgE high" asthmatics when compared to "IgE low" asthmatics
23554973 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
23553197 IL-6 concentrations were significantly higher in peritoneal fluid of endometriosis patients than in controls.
23545836 Serum IL-6 with a threshold of 15.4 pg/ml was found to be able to diagnose minimal to mild endometriosis with 89.5 % sensitivity and 82.5 % specificity.
23538947 binding of sphingosine-1-phosphate to sphingosine-1-phosphate receptor 2 activates multiple Rho GTPases-dependent pathways that coordinate with PI3K pathway for secretion of IL-6 in BeWo cells.
23536722 important roles of endothelial cells within the prostate cancer microenvironment to promote the prostate cancer metastasis and provide new potential targets of IL-6-->AR-->TGFbeta-->MMP-9 signals to battle the prostate cancer metastasis
23525184 leptin and IL-6 levels were demonstrated to be associated with the severity of chronic obstructive pulmonary disease.
23524623 Chronic higher levels of IL-6 might affect functions of neural regions related to decision making, and thus can modulate rejection of unfair offers.
23517877 the expression of HIF-1alpha is closely correlated with IL-6 expression (r = 0.61 and p = 0.005), suggesting a close interaction of HIF-1alpha and IL-6 in the psoriasis immuno-microenvironment.
23510983 Data suggest that signal transduction between two cytokines, IL-6 and IL-13, and their respective receptors, IL6R and IL13R, results in rapid phosphorylation of two STAT transcription factors, STAT3 and STAT6, in pancreatic beta-cells.
23510010 This meta-analysis suggested that the -174G/C polymorphism of IL-6 gene would be a protective risk factor for Alzheimer disease in Asians.
23509207 Measurement of serum IL-6 level in overweight boys may help to identify subjects who need specific exercise formats to achieve maximal beneficial health effects and to reduce their risk for the development of type 2 diabetes and atherosclerosis.
23506572 carrying the IL-6 -572G allele is likely to increase an individual's susceptibility to in-stent restenosis by promoting serum IL-6 levels
23505291 An IL-6-specific weighted allele score explained 2% of the variance of log IL-6 levels in Whitehall II and 1% in British Women's Heart and Health Studies.
23498057 The combination of glutamine and alanine did not influence significantly IL-6 and IL-8 expression in monocytes during endotoxemia, however strongly reduced TNF-alpha production.
23497639 Circulating levels of IL6 and heart-type fatty acid binding protein were predictive for clinical outcome in acute cerebral infarction.
23490413 The results of the present study support a model in which the GG and CC genotypes, respectively for IL-6-174 G > C and MMP-9-1562 C > T polymorphisms, are associated with a risk of deep vein thrombosis in cancer patients.
23490068 A significant relationship was found between IL-6 and MuRF-1 expression after incubation with PGE2
23489698 Effect on the induction of IL-6 or TNF by erythropoietin or high-mobility group-box 1 protein (HMGB1) or by necrotic cells, was investigated.
23487197 The results of this study showed that no linkage interleukin 6 gene polymorphisms with paranoid schizophrenia in a Polish population.
23484124 the expression of resistin, TNF- alpha , IL-6, and IL-1 beta from human mononuclear cells, might be enhanced by the hyperinsulinemia and hyperleptinemia and possibly by the hyperglycemia in metabolic diseases as obesity, type 2 diabetes, and atherosclerosis.
23482714 Findings provide preliminary evidence of subgroups of individuals with distinct trajectories of attentional function and of a genetic association with an IL6 promoter polymorphism
23480455 A low-cervical IL-6 concentration can accurately identify symptomatic women with a very low chance to progress to preterm birth within 2-7 days.
23478175 IL-6 and IL-8 are HIF2alpha controlled cytokines for angiogenesis particularly in endothelial cells.
23470916 The data suggest that the G allele of the IL6 gene could be one of the factors influencing the power-orientated sport performance.
23470607 IL-6 level was the same in schizophrenic exacerbation compared to remission. IL-6 was higher in patients in both exacerbation and remission compared to controls. IL-6 level were positively correlated with age of onset and duration of untreated psychosis.
23461851 P2Y11 receptor mediates interferon gamma-induced IL-6 production in human keratinocytes
23461479 The presence of the IL-6 -174 G allele influences levels of IL-6 and increases the risk of coronary artery disease in South African Indians.
23446881 IL-6 was associated with vegetative depressive symptoms in terminally ill cancer patients but not with affective depressive symptoms, suggesting possible differences in the pathophysiological mechanisms between these sets of symptoms.
23445133 IL6 serum level is significantly increased in intrauterine growth restriction
23444260 GKN1 expression induced production of inflammatory cytokines including IL-8 and -17A, but decreased expression of IL-6 and -10.
23441314 The IL-6 74 GG genotype was found more frequently in all inflammatory groups than in controls. This genotype could influence nasal polyposis and asthma, and seems to be more important in the latter.
23433353 Our results suggest that the IL-6 polymorphism may contribute to genetic susceptibility to chronic periodontitis in Northwestern Chinese Han population
23430759 Elderly women with a combination of genotypes associated with an anti-inflammatory profile (low TNF-alpha and IL-6 production, high IL-10 production) showed better physical performance independent of exercise modality
23428306 Serum IL6 (interleukin 6), sIL6R (soluble interleukin 6 receptor), and sGP130 (soluble interleukin 6 signal transducer) are elevated in metabolic syndrome and are associated with markers of endothelial dysfunction/arterial stiffness/atherosclerosis.
23426918 IL-6 expression levels were increased in the plasma of patients with cerebral AVM and this correlated with the activated MMP-9 levels of cerebral arteriovenous malformation tissues.
23426900 The peak concentrations of TNF-alpha and IL-6 were shown to be in concordance with the rhythm of melatonin secretion. The circadian rhythm of melatonin secretion and circadian gene expression were altered in the early stages of sepsis
23425215 The systemic inflammatory process, evaluated by IL-6, seems to be persistent, progressive and associated with mortality and worse physical performance in COPD patients. TRIAL REGISTRATION: No.:NCT00605540.
23423626 An elevated serum IL-6 level may be useful as an early marker of fat embolism syndrome in patients with isolated skeletal trauma.
23421536 Data indicate that thrombin-induced IL-1ss and IL-6 cytokine release in naive PBMCs is PAR-1-dependent.
23415255 Genetic variation of the IL6 gene may influence susceptibility to spastic tetraplegia in males.
23411129 Functional polymorphisms in the CYP1A1, ACE, and IL-6 genes contribute to susceptibility to community-acquired and nosocomial pneumonia.
23408619 Interaction of IL-6 mRNA with the AU-rich element (ARE) binding proteins AUF1 and HuR prevents its degradation by SOX of human herpesvirus 8.
23401019 High IL-6 expression is associated with rectal cancer recurrence.
23399848 This study demonstrated a significant increase in plasma IL-6 levels immediately after the wheelchair basketball game in individuals with spinal cord injuries
23396843 The IL-6 amplifier in the epithelial cells of grafts is involved in chronic rejection after lung transplantation, suggesting that the amplifier may be a valuable therapeutic target to prevent chronic rejection after lung transplantation.
23392112 Dysregulated IL-6 signaling as a consequence of aging contributes to the blunted muscle stem cell response.
23389820 Urinary IL-8 level was higher in children with pyelonephritis with later renal scarring than in those without renal scarring. Urinary IL-6 and IL-8 were increased in children with urinary tract infection compared to those with fever of other origin.
23383108 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
23380741 Data indicate that circulatory hepcidin levels associated with the levels of its regulatory cytokine interleukin-6 and of the anti-inflammatory cytokine inerleukin-10 in childhood malaria.
23378460 in scleroderma-associated interstitial lung disease, serum IL-6 levels appear to be predictive of early disease progression
23378274 Data indicate that galectin-4 elicits tumor promotion in vitro and in vivo through activation of IL-6/NF-kappaB/STAT3 signaling.
23377045 The frequency of the genotype IL-6 174GG and allele G was different between healthy and ill groups, therefore, this genotype may be a common risk factor for both CP and PID in Brazilian populations.
23375410 This review also provides a strong basis for carrying out multiple experimental studies with IL-6 inhibitors to further elucidate the specific pathways by which IL-6 may promote PCO as well as to better determine what role inflammation may play. [review]
23371411 study concludes elevated IL-6 concentration is associated with diabetes-related variables which could accelerate progression of microvascular complications in type 1 diabetes patients
23369187 After IL6 receptor antagonism, OCC infiltration was significantly decreased, mostly in regions rich in MSCs, indicating that recruitment and tridimensional invasion of OCC was dependent of IL6 secretion
23364322 IL-6 associated with cognitive decline among older participants in this racially/ethnically diverse sample independent of other vascular risk factors and C-reactive protein.
23363979 Enhanced IL-6R signaling through pSTAT3, in some cases through increased IL-6Ralpha expression, contributed to T(eff) resistance in active relapsing-remitting multiple sclerosis.
23363559 The polymorphisms studied in the promoter regions of IL-1beta and IL-6 genes did not reveal a strong association with urolithiasis
23357300 the aim of the present study was to assess the association of NFKB1, IL6 and TNF-alpha gene polymorphisms with left ventricular dysfunction in coronary artery disease (CAD) patients.
23357299 An aberrant production of the pro-inflammatory cytokines IL-6 and TNF-alpha and the anti-inflammatory cytokine IL-10 is observed in acute myeloid leukemia patients.
23350952 increased serum levels are associated with progression of hepatitis C to hepatocellular carcinoma
23350010 Down-regulation of Parkin in macrophages resulted in a consistent and specific decrease in interleukin-6 (IL-6) and monocyte chemoattractant protein 1 (MCP-1/CCL2) production in response to mycobacteria or lipopolysaccharides.
23349310 through constitutive production of interleukin-6, multipotent stromal cells prevent the differentiation of monocytes towards antigen-presenting immunogenic cells and skew differentiation towards an anti-inflammatory interleukin-10-producing cell type.
23349093 metal particles induced higher amounts of IL-6 and IL-1 but very low amounts of TNF-alpha. T-lymphocyte activation was evaluated by the quantification of IL-2 and IFN-gamma levels
23348396 Our findings provide insight into the biologic effects of IL-6 trans-signaling in ovarian hyperstimulation and highlight that IL-6 trans-signaling can induce vascular leakage in this disease.
23347173 In a dose-dependent manner, recombinant Staphylococcus aureus haemolysin A induced secretion of IL-8 in A549-, 16HBE14o- and S9 cells, but IL-6 release only in 16HBE14o- and S9 cells.
23344094 IL-6, VCAM-1, and SOD are highly recommended to be used as biomarkers of the oxidative stress and inflammatory status in cardiovascular risk
23343403 CCN4 activates signalling pathways in osteoarthritis synovial fibroblasts leading to up-regulation of IL-6 production
23336844 the genotypes related with a lower production of IL-6 may be associated with the occurrence of TR.
23332218 The high expression of IL-6 is an important factor in chronic periodontitis, but was not associated with methylation status or the -174 (G/C) genetic polymorphism, suggesting that other mechanisms are involved in this gene transcriptional regulation.
23326472 Blood IL-6 and TNF-alpha concentrations of 5 subjects estimated from the microchip data were compared with results obtained by the conventional method, good correlations were observed between the methods according to linear regression analysis.
23322904 Studies indicate that interleukin-1 (IL-1), IL-6, IL-17, and tumor necrosis factor are critical for the pathogenesis of inflammation in specific brain disorders.
23322593 Not only is transgenic cerebellar IL-6 production and leakage into the peripheral compartment the dominating factor controlling transgenic autoimmune encephalomyelitis: it facilitates induction of autoimmunity in the absence of normal IL-6 production.
23322270 IL-6 inhibited the differentiation of mesenchymal stem cells into chondrocytes in the dose-dependence manner.
23320781 Expression of M. tuberculosis-induced suppressor of cytokine signaling (SOCS) 1, SOCS3, FoxP3 and secretion of IL-6 associates with differing clinical severity of tuberculosis.
23311694 A higher fetal inflammatory response mediated by umbilical cord blood IL-6 is identified when both microbial invasion of the amniotic cavity and histological chorioamnionitis are detected in preterm prelabor rupture of membranes.
23303450 IL-6 trans-signaling-STAT3 pathway may have an integral role in hypertrophic scar pathogenesis.
23300019 High serum IL-6 is associated with head and neck squamous cell carcinoma.
23298711 Results indicate that the crosstalk between IL-6 and TGF-beta1 is associated with malignant features, including epithelial-mesenchymal transition (EMT), and Smad4 works in a dominant manner to promote these features.
23289913 present meta-analysis suggests a significant association between the IL-6 gene -572 G allele and increased risk of type 2 diabetes mellitus
23281720 These results showed that sleep restriction increases the proinflammatory cytokine, GH, and testosterone concentrations after physical exercise but did not affect the cortisol responses.
23276701 IL-6-174C investigated. A higher number of pro-inflammatory cytokine risk alleles were independently associated with both prevalent depression at baseline and persistent depression at one year follow-up.
23276493 The serum levels of IL-6 and IL-18 in patients with systemic juvenile idiopathic arthritis, were analyzed.
23272057 CDF, a curcumin derivative, increases expression of VEGF, IL-6 and miR-21 and hypoxia-induced aggressiveness of pancreatic cancer cells
23269580 Serum IL-6 and IL-8 levels were significantly higher in patients with laryngeal squamous cell cancer compared to healthy controls
23265967 promoter single nucleotide polymorphisms of IL-6 (-174 G>C) and TNF-alpha (-238 G>A) genes have been studied to evaluate whether these variants contribute to schizophrenia susceptibility in Indian Bengalee population.
23262029 results indicate that MVNP decreases FoxO3/Sirt1 signaling to enhance the levels of IL-6, which in part mediate MVNP's contribution to the development of Paget's disease
23257175 IL-6 augments mechanical strain-induced CRP synthesis in vessels via the stretch-activated channel-NF-kappaB pathway.
23255681 Measured the levels of endothelial microparticles (EMPs), IL-6, and TNF-a in patients with Kawasaki disease (KD). EMPs and IL-6 were elevated in KD, the level of TNF-a in KD was not different from disease controls, but higher than healthy controls.
23251686 Gp120 and MA affect IL-6 but not IL-8 in a synergistic manner.
23251686 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
23250823 findings show bFGF enhances IL-6 production in LNCaP and PC3-PSMA prostate cancer cells; the effect of bFGF on stimulating IL-6 secretion was greater in LNCaP than in PC3-PSMA cells
23246692 The IL-6 gene -174 G/C polymorphism is not associated with T1DM risk. [Meta-analysis]
23242654 the association between the IL-6 gene and CAD risk was mild and moderate for the -174 G/C and -572 G/C polymorphisms. However, this relationship requires additional investigation through well-designed studies with larger sample sizes.
23236659 IL-6 is a reliable parameter and sign for intra uterus infection in cases with preterm birth.
23233117 Rheumatoid arthritis patients with an IL-6 -174GG genotype respond to etanercept better than patients with GC or CC genotype
23232337 HIV-induced T helper cell type 1 (Th1), Th2 and Th17 cytokine changes in the sera of treatment naive individuals, were determined.
23227240 CTGF increased IL-6 production in osteoarthritic synovial fibroblasts via the alphavbeta5 integrin, ASK1, p38/JNK, and AP-1/NF-kappaB signaling pathways.
23225885 Blocking or deleting A2BAR adenosine receptor inhibits T helper (Th)17 cell differentiation by blocking IL-6 production from antigen-presenting cells such as dendritic cells.
23224211 Differences in intravitreal cytokine levels in DRP, RVO and ARMD could be demonstrated.
23219526 These results indicate that IL-6 activation occurs through ASK1 and p38, which in turn activates AP-1, resulting in the activation of VEGF expression.
23215766 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
23207068 Cowpox virus but not Vaccinia virus induces secretion of CXCL1, IL-8 and IL-6 and chemotaxis of monocytes in vitro.
23206933 Data suggest that targeting multiple cytokines, interleukin-6 (IL-6) may be effective in improving cartilage repair in symptomatic cartilage defects and osteoarthritis.
23206733 Syndecan-1, a target of miR-10b, inhibits epithelial endometriotic cell invasiveness through down-regulation of metalloproteinase activity and interleukin-6.
23204162 TNF-alpha, IL-6, and IL-8 production capacity was significantly decreased in pediatric ICU infants with severe Respiratory Syncytial virus bronchiolitis compared with both floor patients and healthy controls.
23202972 The -572 C allele showed a significant correlation with the MS severity score, suggesting a possible role in disease progression.
23199226 Increased IL-6 in anorexia nervosa (AN) seems to be compensated by the changes in sIL-6R and sgp130, which are directed towards inhibition of IL-6 action. The balance between these factors might play a role in the regulation of energy expenditure in AN.
23198942 show that the presence of TFF3 isolated from milk strongly correlates with downregulation of IL8 and IL6 in human intestinal epithelial cells
23197841 NEO Five-Factor Inventory openness was negatively associated with IL-6.
23195133 The IL-16 gene polymorphisms is associated with coronary artery disease in Chinese Han population.
23190742 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
23190106 Stress-induced elevation in the levels of IL-6 may play a key role in the etiology of a heterogeneous family of hyperexcitable central conditions including epilepsy, schizophrenic psychoses, anxiety and disorders of the autistic spectrum.
23185547 In male oral squamous cell carcinoma patients, high IL6 expression in tumor cells was associated with poor prognosis.
23180271 The IL6-rs2069837 SNP may be a marker for susceptibility to cervical cancer in Eastern Chinese women by a possible mechanism of altering the IL6 protein expression.
23178494 roles for p53 and IKKalpha/IKKbeta in non-canonical Notch signaling and IL-6 as a novel non-canonical Notch target gene
23177780 The increased expression of VEGF in adenoid tissues suggests a possible role of the IL-6/VEGF axis in the pathogenesis of hypertrophied adenoids in children.
23175672 IL-6 levels were independently associated with cerebrovascular events and could improve reclassification in those with silent lacunar infarction.
23168996 CSF IL-6 levels did not differ between suicide attempters and healthy controls.
23168096 Rheumatic heart disease patients and ethnically matched controls were screened for TNF-alpha(-308)G/A, IL-10(-1082) G/A, IL-6(-174) G/C and a variable number of tandem repeats (VNTRs) polymorphism of the IL-1Ra gene.
23166328 The dynamic genome-wide transcriptional responses were nearly identical at early time points following stimulation (when STAT3 is active in response to both IL-6 and IL-10) but divergent at later times (when STAT3 is active only in response to IL-10).
23161179 Our findings suggest that the functional IL-6-174G>C polymorphism itself is unlikely a major risk factor for primary open-angle glaucoma (POAG).
23159283 This paper investigates serum levels of IL-10 and IL-6 in patients with chronic hepatitis C genotype, the relation of each with clinical and virological characteristics and their relation with the IL28B polymorphisms rs12979860.
23159256 Plasma levels of CRP and IL-6 were higher in women reporting sexual abuse in adolescence compared to those reporting no abuse (p=0.04 and 0.03, respectively) in analyses adjusted for confounders including age and childhood adiposity
23158132 Data found that venous thromboembolism was associated with IL-6 and CRP levels, and there was an association of IL-6 and its promoter polymorphism at -572G/C with the risk of VTE.
23154434 High interleukin 6 is associated with renal cell carcinoma progression.
23151405 Plasma IL-6 and C-reactive protein (CRP) are prospectively associated with new-onset fatigue, supporting the hypothesis that low-grade inflammation has a role in the development of fatigue.
23142265 Genotypes of the IL6(-597/-572/-174) polymorphisms are associated with obesity and hyperglycemia in Mexican adolescents
23136556 The role of IL-6 in asthma and other lung diseases is discussed. [review]
23136554 The function of IL-6 in the central nervous system and CNS diseases is discussed. [review]
23136553 The molecular mechanisms and possible therapeutic targets involved in IL-6 signaling in colorectal cancer are discussed. [review]
23135962 The IL6 -174G>C and CD14 -260C>T polymorphisms are likely to be associated with a pro-atherogenic profile but not with increased inflammatory markers and endothelial dysfunction in young AMI patients.
23124693 Serum CRP levels were higher in FMS and significantly correlated with body mass index, erythrocyte sedimentation rate, IL-8, and IL-6 levels, suggesting that inflammation may contribute to the symptoms.
23124416 IL-6 blood level was strongly correlated with the severity of symptoms of depression, cancer activity (progressive disease) and to a lesser extent to the symptoms of anxiety in breast cancer patients.
23118848 Cytokine production by SGE cells from SS patients showed a skewed balance compared with normal controls, with increased IL-6 and decreased TGFbeta secretion
23117246 High IL-6 expression is associated with progression of gastric carcinoma.
23116190 In an African American sample, predatory self interest, as measured by the Cook Medley Hostility Scale, was significantly associated with greater IL-6 levels
23100065 Single-base changes in the TNFA and IL6 alleles correlated with occurrance of lung cancers in the Han ethnic group.
23097096 IL-6 release is an important biological marker in patients treated with bilateral knee replacement and hydrocortison therapy.
23092922 IL-6 induction results from an increase in steady state IL-6 mRNA, and is mediated through Akt and NF-kappaB activation. Circulating CD40(+)CD45(+)Col1(+) fibrocytes are far more frequent in vivo in donors with TAO compared with healthy subjects.
23088295 Data indicate that plasma adrenomedullin (ADM) levels are related to the single nucleotide polymorphisms (SNPs) rs17147230 in interleukin-6 (IL6) gene.
23087143 Inhibited Ang II- and IL-6-induced expression of CRP both in protein and mRNA levels.
23086036 IL-6 appears to play a differential role in regulating metabolism in type 2 diabetic patients compared with normal glucose tolerant subjects.
23078984 No significant changes in cortisol level were noted between the mindfulness intervention group and controls.
23078005 No association with mastocytosis was found for the IL6-174G/C polymorphism, however, it may influence the effect of IL6R polymorphism.
23073774 There was no significant association between IL-6 -174 G>C polymorphism and PCa increased risk. Nevertheless, the presence of allele C and the CC genotype were statistically significantly associated with decreased PCa risk.
23071313 The production of lipopolysaccharides-induced TNF-alpha, IL-6, and IL-12p40 is increased significantly when miR-187 expression is silenced.
23065424 Up-regulation of hepcidin during infection is thought to serve as a host defense strategy; data suggest that interleukin-6 down-regulates expression of hepcidin in hepatocytes.
23062767 A high simvastatin dose or the combination of a low-dose simvastatin with ezetimibe reduce to a similar extent TLR2, TLR4 membrane expression and LPS-induced IL-6 and IL-1beta production in monocytes of hypercholesterolemic patients.
23058031 Report Il6 levels in patients with differing grade/duration of alopecia areata.
23058014 After 24 h of culture in presence of polished and unpolished resins a spontaneous release was present of pro-inflammatory cytokines such as IL-6, which was higher in unpolished resins.
23052692 This is the first evidence of identifying an IL-6 promoter haplotype (CC) associated with increased risk of lung cancer.
23052480 we present cIAP-2 as a novel inducer of platinum resistance in ovarian carcinoma cells, and suggest an axis beginning with an encounter between cisplatin and these cells, mediated sequentially by IL-6 and cIAP-2, resulting in cisplatin resistance
23044206 Polymorphism of the IL-6 promoter -572 loci may be associated with hepatocellular carcinoma occurrence in men.
23043537 Upregulation of IL-6, IL-8 and CXCL-1 production in dermal fibroblasts by normal/malignant epithelial cells in vitro: Immunohistochemical and transcriptomic analyses.
23038213 These preclinical and clinical results support a role of NF-kappaB and IL-6 in the resistance to docetaxel in castration resistant prostate cancer.
23036532 HepG2 cell gamma' fibrinogen is disproportionately up-regulated by inflammatory responses induced by interleukin-6.
23034889 High serum IL6 is associated with advanced nonsmall cell lung cancer.
23027890 Our results suggest that the IL6 gene may influence the development of systemic sclerosis and its progression.
23027872 Conservation of functional sites on interleukin-6 and implications for evolution of signaling complex assembly and therapeutic intervention.
23025692 A potential role of this interleukin in mediating the link between abdominal obesity and venous thromboembolism.
23022409 IL-6 significantly downregulated P4Halpha1 expression in aortic smooth muscle cells
23019398 The IL-6 -634 G allele appears with greater frequently in patients with end-stage renal disease and may be associated with vascular access dysfunction in non-diabetic hemodialysis patients.
23018032 RPA and ELISA data showed that alloferon decreased the production of UVB-induced pro-inflammatory cytokines, such as IL-1alpha, IL-1beta, IL-6 and IL-18, both on the mRNA and protein level.
23013513 Simvastatin decreases the pro-inflammatory marker IL-6 while ezetimibe monotherapy or the combination with simvastatin has no effect.
23013217 No association between polymorphisms in IL-10, IL-6, and IL-1Ra and PE in Mexican-Mestizo and Maya-Mestizo women
23011405 We observed that the serum IL-6 concentration was inversely correlated with miR-26a expression in cancerous tissues. These results indicate that miR-26a reduction in hepatocellular carcinoma might be due to IL-6 upregulation.
23009764 This study aimed to examine interleukin-6 (IL-6), interferon-gamma (IFN-gamma) and interleukin-17A (IL-17A) production in patients with cystic echinococcosis.
22990627 Exercise duration is of importance in IL-6 regulation in marathon/half-marathon runners.
22986484 In sera of patients with Parkinson's disease, a differential increase in autoantibody titers to alpha-synuclein is associated with boosted levels of pro-interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha but a decrease in interferon (IFN)-gamma concentration.
22984233 IL-6 blood level change is an indicator of osteopathic manipulation therapy in patients with chronic low back pain.
22984080 Tolerance is disrupted in transgenic mice when IL-6 and soluble CD40L fail to spatially restrict p-ERK kinase and fail to repress TLR4-induced autoantibody secretion.
22983646 Sequential monitoring of serum IL-6, TNF-alpha, and IFN-gamma levels in a CAEBV patient treated by plasma exchange and immunochemotherapy
22982189 Loss of TIMP-3 may increase IL-6 production via the tumor necrosis factor alpha/nuclear factor kappaB axis, thereby promoting tumor malignancy.
22977658 The proteasome inhibitor MG132 could inhibit IL-6/TGF-beta-mediated downregulation of FOXP3 protein, which reveals a potential pathway for modulating Treg activity.
22977256 Native glycodelin-A binds to peripheral blood monocytes inducing interleukin-6 secretion through L-selectin.
22976070 We found that elevated interleukin-6 levels were associated with higher severity of dVRS in basal ganglia, suggesting that inflammation might be associated with the burden of dilated Virchow Robin spaces in the elderly.
22968454 our study identifies IL-6 as a key cytokine for Mantle cell lymphoma growth and survival
22964303 Data suggest that the signaling elements IL-6, IL-8, OPN, TLN1, and CTGF are involved with NF-kappaB p65 in random positioning machine (RPM)-dependent thyroid carcinoma cell spheroid formation.
22956742 Mastitic milk contains higher IL-6 levels than milk from the healthy breast. This difference is larger if accompanied by systemic symptoms of mastitis (fever/malaise).
22948743 The release of IL-6 and IL-21 by polyclonally activated CD4+ T cells directly correlates with neurological disability in neuromyelitis optica (NMO) patients.
22931953 The simultaneous elevation of IL-6 and IL-10 levels distinguishes ST elevation myocardial infarct patients with worse clinical outcomes from other STEMI patients.
22927445 the intracellular interaction of IL-32alpha with PKCepsilon and STAT3 promotes STAT3 binding to the IL-6 promoter by enforcing STAT3 phosphorylation, which results in increased production of IL-6.
22924939 findings suggest that the IL-6 -634C/G polymorphism is associated with atrial fibrillation (AF), and the G allele has increased risk of AF in elderly Han Chinese patients with essential hypertension
22923236 increased expression levels of IL-6 contribute to multidrug resistance in human breast cancer cells
22923190 The study suggested for the first time a role for epigenetic modifications in the regulation of the expression of IL1B, IL6, and IL8.
22921280 data demonstrates no significant difference in levels of IL-6 between early onset and late onset preeclampsia, although IL-6 levels in both groups were significantly higher than healthy pregnant women; results suggest excessive maternal inflammatory response in preeclampsia
22914813 results suggest that IL-6 -634C/G polymorphism is associated with thrombus and severe spontaneous echocontrast, and the G allele is an independent risk for thrombus and severe spontaneous echocontrast in Han Chinese patients with atrial fibrillation
22908985 Higher levels of positive relationships may be associated with lower IL-6 in women only, whereas moderate levels of autonomy may be associated with higher IL-6 in males only, particularly among older adults.
22906998 results showed that IL-6 and CRP are implicated in both cancer characteristics and hepatic reserve and thus remain a useful prognostic indicator for hepatocellular carcinoma survival
22904305 IL-6 is a reliable marker of inflammation, with no direct role in an inflammasome-mediated mouse model of Muckle-Wells syndrome.
22895491 The results show that chromatin structure is likely to have an important role in the way IL6 regulatory polymorphisms show their effect.
22894740 Vitamins can exert an antioxidant or a pro-oxidant effect depending on concentration, and could be an inductor of an inflammatory process via IL-6 secretion.
22889273 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
22883518 There is a significant association between genetic susceptibility to endometriosis and the combination polymorphisms of TNF-alpha -1031T/C and IL-6 -634C/G.
22883217 Interleukin-6 levels were significantly higher in patient with hepatic encephalopathy and minimal hepatic encephalopathy as compared to patients without minimal hepatic encephalopathy and healthy controls.
22872134 Il-6 upregulates the expression of GDF-15 in prostate carcinoma cells
22869038 This study demonistrated that IL-6 is changed in the dorsolateral prefrontal cortex of individuals with schizophrenia
22867712 Rheumatoid and pyrophosphate arthritis synovial fibroblasts induce osteoclastogenesis independently of RANKL, TNF and IL-6.
22849850 data demonstrated that 25-HC augments the release of IL-8 and IL-6 via NF-kappaB signalling pathway and enhances the release of IL-8 and IFN-beta after stimulation of TLR3 in airway epithelial cells.
22843899 levels of HGF and IL-6 in serum could be useful prognostic indicators of the survival of patients with stage III NSCLC undergoing surgery and chemotherapy
22843654 Serum CRP, IL-6 levels and the ratio CRP/IL-6 are associated with descending aortic aneurysmal dimensions.
22836752 we report that malignant angiosarcoma is associated with high levels of RelA/NF-kappaB and IL-6
22819759 there is compelling evidence indicating altered systemic IL6 trans-signalling in women prone to recurrent miscarriage, with excessive IL6 bioavailability potentially inhibiting generation of CD4+ T regulatory cells required for pregnancy tolerance.
22819326 Long term trastuzumab treatment generates highly enriched CSCs which display an EMT phenotype secreting over 100-fold more IL6 than parental cells.
22819248 Ovarian endometrioma but not deep infiltrating endometriosis is associated with increased serum levels of interleukin-8 and interleukin-6.
22818022 Data indicate that IL-1beta [+3954 C>T (rs1143634)], IL-6 [-174 G>C (rs1800795)] and IL-10 [-1082 A>G (rs1800896)] were associated with breast cancer risk.
22814515 We confirmed a significant role of IL6, IFNgamma, and IL-17A in the local inflammatory response in sarcoidosis.
22814248 Data indicate that concomitant treatment with gp120 reduced the levels of IFN-alpha, IFN-beta, TNF-alpha, IL-6, and IP-10 induced by CpG-A in plasmacytoid dendritic cells.
22814248 Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1)
22810465 Data suggest that plasma levels of IL6 and TNFa (tumor necrosis factor-alpha) can be controlled by dietary factors; following high-fat meal, both IL6 and TNFa significantly increase reaching maximum concentrations 8 hours after meal consumption.
22808178 The model demonstrated significant effects of physical activity on IL-6 both directly and through body composition.
22796263 In healthy young adults, salivary IL-6 levels peaked at awakening, gradually declined from morning to noon, and peaked again at midnight, before participants went to sleep. IL-6 levels exhibited moderate to high stability over 2 days of sample collection.
22782910 study implicates IL-6 promoter variant 6331T>C with prostate cancer risk and poor survival
22773460 Our study did not show any associations between the IL-6 -174 G>C polymorphism and the occurrence of stroke
22769440 findings suggest Porphyromonas gingivalis gingivalis HmuY may be associated with increased IL-6 production during chronic periodontitis; patients with periodontitis and individuals with higher HmuY-induced production of IL-6 show a high frequency of the G allele at position -174
22763101 The results suggest a role for IL-6, IL-8, and CXCR1 in the pathophysiology of tubal ectopic gestation.