Tbio HSPBAP1 HSPB1-associated protein 1

Protein Summary

Description

May play a role in cellular stress response. This gene encodes a protein that binds to one of the small heat shock proteins, specifically hsp27. Hsp27 is involved with cell growth and differentiation. This encoded protein was found to be abnormally expressed in patients with intractable epilepsy, although how brain function is affected remains unknown. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• Q96EW2
• Q6P476
• Q8N8J4
• Q8NHH6
• Q8WWF0

Gene Name

• HSPBAP1

Ensembl ID

• ENST00000306103
• ENSP00000302562
• ENSG00000169087

Symbol

• PASS1
• PASS1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.83
kinase perturbation	0.76
transcription factor	0.75
tissue sample	0.7
cell type or tissue	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.8   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 210   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.8   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0