| Tchem | Heat shock protein beta-1 |
This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]
Comments
Property Summary
| Ligand Count | 7 |
| NCBI Gene PubMed Count | 417 |
| PubMed Score | 974.92 |
| PubTator Score | 1299.22 |
| Disease | Target Count | P-value |
|---|---|---|
| lung adenocarcinoma | 2716 | 1.5e-06 |
| ulcerative colitis | 1819 | 1.7e-06 |
| cystic fibrosis | 1696 | 4.5e-06 |
| Breast cancer | 3578 | 3.4e-05 |
| ependymoma | 4679 | 4.7e-05 |
| adrenocortical carcinoma | 1428 | 1.3e-03 |
| group 4 medulloblastoma | 1855 | 2.3e-03 |
| diabetes mellitus | 1728 | 2.9e-03 |
| pancreatic cancer | 2398 | 4.4e-03 |
| ovarian cancer | 8520 | 7.2e-03 |
| Rheumatoid arthritis | 1191 | 1.1e-02 |
| glioblastoma | 5792 | 1.2e-02 |
| colon cancer | 1478 | 1.9e-02 |
| esophageal adenocarcinoma | 737 | 2.0e-02 |
| active Crohn's disease | 922 | 2.5e-02 |
| subependymal giant cell astrocytoma | 2287 | 3.3e-02 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 4.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Neurodegenerative disease | 414 | 3.675 | 1.8 |
| Charcot-Marie-Tooth disease | 62 | 0.0 | 4.0 |
| Disease | Target Count |
|---|---|
| CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2F | 1 |
| Neuronopathy, Distal Hereditary Motor, Type 2B | 1 |
| Disease | log2 FC | p |
|---|---|---|
| active Crohn's disease | -1.644 | 2.5e-02 |
| adrenocortical carcinoma | 1.233 | 1.3e-03 |
| Breast cancer | 1.500 | 3.4e-05 |
| colon cancer | -1.300 | 1.9e-02 |
| cystic fibrosis | -1.706 | 4.5e-06 |
| diabetes mellitus | -1.100 | 2.9e-03 |
| ependymoma | 1.100 | 4.7e-05 |
| esophageal adenocarcinoma | -1.800 | 2.0e-02 |
| glioblastoma | 1.900 | 1.2e-02 |
| group 4 medulloblastoma | -1.600 | 2.3e-03 |
| lung adenocarcinoma | 1.458 | 1.5e-06 |
| ovarian cancer | -1.200 | 7.2e-03 |
| pancreatic cancer | 1.400 | 4.4e-03 |
| pancreatic ductal adenocarcinoma liver m... | 1.657 | 4.8e-02 |
| Rheumatoid arthritis | -1.100 | 1.1e-02 |
| subependymal giant cell astrocytoma | 1.898 | 3.3e-02 |
| ulcerative colitis | -1.400 | 1.7e-06 |
CHEMBL1935538
pIC50 6.70
CHEMBL95692
pIC50 6.80
CHEMBL477583
pIC50 7.06
CHEMBL103667
pIC50 7.24
CHEMBL478649
pIC50 7.28
CHEMBL476351
pIC50 7.57
CHEMBL476141
pIC50 8.22
