| Tclin | Histamine H3 receptor |
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| Ligand Count | 2,232 |
| NCBI Gene PubMed Count | 49 |
| PubMed Score | 570.24 |
| PubTator Score | 334.43 |
| Disease | Target Count |
|---|---|
| Hypertensive disease | 292 |
| Disease | Target Count |
|---|---|
| Narcolepsy | 72 |
| Meniere's disease | 24 |
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 2.4e-89 |
| astrocytoma | 1146 | 6.5e-16 |
| ovarian cancer | 8520 | 9.7e-11 |
| osteosarcoma | 7950 | 7.7e-06 |
| glioblastoma | 5792 | 1.0e-05 |
| pituitary cancer | 1972 | 1.1e-05 |
| Astrocytoma, Pilocytic | 3081 | 1.4e-05 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.5e-05 |
| group 3 medulloblastoma | 4104 | 2.5e-03 |
| adult high grade glioma | 3801 | 6.0e-03 |
| ependymoma | 4679 | 1.7e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.500 | 6.0e-03 |
| astrocytoma | -1.200 | 6.5e-16 |
| Astrocytoma, Pilocytic | -1.900 | 1.4e-05 |
| atypical teratoid / rhabdoid tumor | -1.300 | 1.5e-05 |
| ependymoma | -1.200 | 1.7e-02 |
| glioblastoma | -1.600 | 1.0e-05 |
| group 3 medulloblastoma | -2.400 | 2.5e-03 |
| osteosarcoma | 1.374 | 7.7e-06 |
| ovarian cancer | 1.100 | 9.7e-11 |
| pituitary cancer | 1.100 | 1.1e-05 |
| psoriasis | 4.000 | 2.4e-89 |
CHEMBL1923530
pKi 7.00
CHEMBL473928
pKi 7.00
CHEMBL180061
pKi 7.00
CHEMBL1170580
pKi 7.00
CHEMBL204615
pKi 7.00
CHEMBL423070
pKi 7.00
CHEMBL597879
pKi 7.00
CHEMBL560358
pKi 7.00
CHEMBL503733
pKi 7.00
CHEMBL403736
pKi 7.00
CHEMBL158518
pKi 7.00
CHEMBL361355
pKi 7.00
CHEMBL1951056
pKi 7.00
CHEMBL12160
pKd 7.00
CHEMBL351671
pKi 7.01
CHEMBL3127680
pKi 7.01
CHEMBL1688973
pKi 7.01
CHEMBL1935573
pKi 7.01
CHEMBL260374
pEC50 7.01
CHEMBL1958156
pKi 7.02
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNN 1 - 70 FFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAV 71 - 140 SYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTP 141 - 210 FLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEA 211 - 280 AVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRL 281 - 350 SRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR 351 - 420 RAFTKLLCPQKLKIQPHSSLEHCWK 421 - 445 //
