| Tbio | Homeobox protein Hox-B2 |
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer. [provided by RefSeq, Jul 2008]
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 9.5e-18 |
| malignant mesothelioma | 3232 | 3.4e-06 |
| ovarian cancer | 8520 | 5.5e-05 |
| osteosarcoma | 7950 | 1.1e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 1.4e-04 |
| atypical teratoid / rhabdoid tumor | 5112 | 7.9e-04 |
| active Crohn's disease | 922 | 4.1e-03 |
| ependymoma | 4679 | 5.7e-03 |
| Astrocytoma, Pilocytic | 3081 | 5.9e-03 |
| medulloblastoma, large-cell | 6241 | 7.2e-03 |
| glioblastoma | 5792 | 1.2e-02 |
| primitive neuroectodermal tumor | 3035 | 1.4e-02 |
| primary pancreatic ductal adenocarcinoma | 1109 | 1.4e-02 |
| adult high grade glioma | 3801 | 1.5e-02 |
| psoriasis | 6694 | 1.6e-02 |
| pancreatic cancer | 2398 | 1.9e-02 |
| medulloblastoma | 720 | 4.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Bamforth-Lazarus syndrome | 4 | 4.39 | 2.2 |
| Disease | log2 FC | p |
|---|---|---|
| active Crohn's disease | -1.176 | 4.1e-03 |
| adult high grade glioma | 1.300 | 1.5e-02 |
| Astrocytoma, Pilocytic | 1.300 | 5.9e-03 |
| atypical teratoid / rhabdoid tumor | 1.300 | 7.9e-04 |
| ependymoma | 1.400 | 5.7e-03 |
| glioblastoma | 1.400 | 1.2e-02 |
| intraductal papillary-mucinous adenoma (... | -1.500 | 1.4e-04 |
| lung carcinoma | 2.300 | 9.5e-18 |
| malignant mesothelioma | -1.400 | 3.4e-06 |
| medulloblastoma | 1.300 | 4.8e-02 |
| medulloblastoma, large-cell | 1.800 | 7.2e-03 |
| osteosarcoma | 1.526 | 1.1e-04 |
| ovarian cancer | 2.600 | 5.5e-05 |
| pancreatic cancer | 1.700 | 1.9e-02 |
| primary pancreatic ductal adenocarcinoma | 1.856 | 1.4e-02 |
| primitive neuroectodermal tumor | 2.100 | 1.4e-02 |
| psoriasis | 1.200 | 1.6e-02 |
MNFEFEREIGFINSQPSLAECLTSFPAVLETFQTSSIKESTLIPPPPPFEQTFPSLQPGASTLQRPRSQK 1 - 70 RAEDGPALPPPPPPPLPAAPPAPEFPWMKEKKSAKKPSQSATSPSPAASAVPASGVGSPADGLGLPEAGG 71 - 140 GGARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQHREPPDG 141 - 210 EPACPGALEDICDPAEEPAASPGGPSASRAAWEACCHPPEVVPGALSADPRPLAVRLEGAGASSPGCALR 211 - 280 GAGGLEPGPLPEDVFSGRQDSPFLPDLNFFAADSCLQLSGGLSPSLQGSLDSPVPFSEEELDFFTSTLCA 281 - 350 IDLQFP 351 - 356 //
