| Tchem | Glutamine synthetase |
The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Comments
Property Summary
| Ligand Count | 11 |
| NCBI Gene PubMed Count | 74 |
| PubMed Score | 845.25 |
| PubTator Score | 511.55 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Hepatic encephalopathy | 27 | 3.725 | 1.9 |
| Brain Diseases, Metabolic, Inborn | 4 | 0.0 | 0.0 |
| Carcinoma, Hepatocellular | 228 | 0.0 | 0.0 |
| Glutamine deficiency, congenital | 1 | 0.0 | 0.0 |
| Liver Neoplasms, Experimental | 59 | 0.0 | 0.0 |
| Obesity | 678 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 2.4e-22 |
| ependymoma | 4679 | 2.0e-10 |
| Breast cancer | 3578 | 8.7e-08 |
| lung adenocarcinoma | 2716 | 3.1e-06 |
| ovarian cancer | 8520 | 1.1e-04 |
| primitive neuroectodermal tumor | 3035 | 3.5e-04 |
| medulloblastoma, large-cell | 6241 | 6.0e-04 |
| glioblastoma | 5792 | 6.5e-04 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.4e-03 |
| Down syndrome | 499 | 1.9e-03 |
| Astrocytoma, Pilocytic | 3081 | 2.0e-03 |
| osteosarcoma | 7950 | 3.8e-03 |
| cutaneous lupus erythematosus | 1057 | 3.9e-03 |
| dermatomyositis | 966 | 5.3e-03 |
| adrenocortical carcinoma | 1428 | 5.9e-03 |
| active Crohn's disease | 922 | 8.0e-03 |
| group 3 medulloblastoma | 4104 | 9.0e-03 |
| astrocytic glioma | 2597 | 2.0e-02 |
| esophageal adenocarcinoma | 737 | 2.0e-02 |
| Gaucher disease type 1 | 180 | 2.1e-02 |
| adult high grade glioma | 3801 | 2.2e-02 |
| Multiple myeloma | 1332 | 3.9e-02 |
| chronic rhinosinusitis | 512 | 4.9e-02 |
| gastric cancer | 459 | 5.0e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| hepatocellular carcinoma | 547 | 4.463 | 2.2 |
| Adenoma | 167 | 3.994 | 2.0 |
| Toxic encephalopathy | 141 | 3.983 | 2.0 |
| Eye disease | 62 | 3.718 | 1.9 |
| Griscelli syndrome type 2 | 12 | 3.577 | 1.8 |
| Disease | Target Count |
|---|---|
| Congenital brain dysgenesis due to glutamine synthetase deficiency | 1 |
| Disease | log2 FC | p |
|---|---|---|
| active Crohn's disease | 1.350 | 8.0e-03 |
| adrenocortical carcinoma | -1.103 | 5.9e-03 |
| adult high grade glioma | -1.200 | 2.2e-02 |
| astrocytic glioma | -1.400 | 2.0e-02 |
| Astrocytoma, Pilocytic | -1.500 | 2.0e-03 |
| atypical teratoid / rhabdoid tumor | -1.400 | 1.4e-03 |
| Breast cancer | 1.600 | 8.7e-08 |
| chronic rhinosinusitis | -1.316 | 4.9e-02 |
| cutaneous lupus erythematosus | 1.600 | 3.9e-03 |
| dermatomyositis | 1.200 | 5.3e-03 |
| Down syndrome | 2.000 | 1.9e-03 |
| ependymoma | -2.400 | 2.0e-10 |
| esophageal adenocarcinoma | -1.900 | 2.0e-02 |
| gastric cancer | -1.500 | 5.0e-02 |
| Gaucher disease type 1 | -1.800 | 2.1e-02 |
| glioblastoma | -1.600 | 6.5e-04 |
| group 3 medulloblastoma | -1.800 | 9.0e-03 |
| lung adenocarcinoma | -1.100 | 3.1e-06 |
| lung carcinoma | -1.300 | 2.4e-22 |
| medulloblastoma, large-cell | -1.300 | 6.0e-04 |
| Multiple myeloma | 1.946 | 3.9e-02 |
| osteosarcoma | -1.310 | 3.8e-03 |
| ovarian cancer | -1.300 | 1.1e-04 |
| primitive neuroectodermal tumor | -1.500 | 3.5e-04 |
| psoriasis | 1.700 | 9.4e-05 |
| ulcerative colitis | 1.100 | 6.7e-03 |
CHEMBL3142429
pKi 6.07
CHEMBL312041
pEC50 6.74
CHEMBL311662
pEC50 6.89
CHEMBL309243
pEC50 7.18
CHEMBL312399
pEC50 7.18
CHEMBL82546
pEC50 7.27
CHEMBL83110
pEC50 7.42
CHEMBL310570
pEC50 7.85
MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSEPKCVEELPEWNFDGSSTLQS 1 - 70 EGSNSDMYLVPAAMFRDPFRKDPNKLVLCEVFKYNRRPAETNLRHTCKRIMDMVSNQHPWFGMEQEYTLM 71 - 140 GTDGHPFGWPSNGFPGPQGPYYCGVGADRAYGRDIVEAHYRACLYAGVKIAGTNAEVMPAQWEFQIGPCE 141 - 210 GISMGDHLWVARFILHRVCEDFGVIATFDPKPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAIEKLSKR 211 - 280 HQYHIRAYDPKGGLDNARRLTGFHETSNINDFSAGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFS 281 - 350 VTEALIRTCLLNETGDEPFQYKN 351 - 373 //
