| Tchem | Alpha-(1,3)-fucosyltransferase 6 |
Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates.
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 1.5e-13 |
| medulloblastoma, large-cell | 6241 | 4.1e-05 |
| psoriasis | 6694 | 1.1e-04 |
| osteosarcoma | 7950 | 2.7e-04 |
| pancreatic cancer | 2398 | 3.0e-04 |
| diabetes mellitus | 1728 | 1.0e-03 |
| nephrosclerosis | 333 | 3.6e-03 |
| esophageal adenocarcinoma | 737 | 3.3e-02 |
| spina bifida | 1074 | 4.1e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Leukocyte adhesion deficiency | 16 | 3.287 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| diabetes mellitus | 1.100 | 1.0e-03 |
| esophageal adenocarcinoma | -1.700 | 3.3e-02 |
| medulloblastoma, large-cell | 1.100 | 4.1e-05 |
| nephrosclerosis | -1.161 | 3.6e-03 |
| osteosarcoma | 1.053 | 2.7e-04 |
| ovarian cancer | 1.400 | 1.5e-13 |
| pancreatic cancer | 1.300 | 3.0e-04 |
| psoriasis | 1.600 | 1.1e-04 |
| spina bifida | -1.849 | 4.1e-02 |
MDPLGPAKPQWSWRCCLTTLLFQLLMAVCFFSYLRVSQDDPTVYPNGSRFPDSTGTPAHSIPLILLWTWP 1 - 70 FNKPIALPRCSEMVPGTADCNITADRKVYPQADAVIVHHREVMYNPSAQLPRSPRRQGQRWIWFSMESPS 71 - 140 HCWQLKAMDGYFNLTMSYRSDSDIFTPYGWLEPWSGQPAHPPLNLSAKTELVAWAVSNWGPNSARVRYYQ 141 - 210 SLQAHLKVDVYGRSHKPLPQGTMMETLSRYKFYLAFENSLHPDYITEKLWRNALEAWAVPVVLGPSRSNY 211 - 280 ERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALAFCKACWKLQEESRYQ 281 - 350 TRGIAAWFT 351 - 359 //
