| Tdark | Flt3-interacting zinc finger protein 1 |
May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity).
This gene encodes zinc finger protein, which interacts with a receptor tyrosine kinase involved in the regulation of hematopoietic and lymphoid cells. This gene product also interacts with a transcription factor that regulates the expression of rod-specific genes in retina. [provided by RefSeq, Jul 2008]
This gene encodes zinc finger protein, which interacts with a receptor tyrosine kinase involved in the regulation of hematopoietic and lymphoid cells. This gene product also interacts with a transcription factor that regulates the expression of rod-specific genes in retina. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8491 | 1.4e-08 |
| atypical teratoid / rhabdoid tumor | 4369 | 4.2e-08 |
| glioblastoma | 5572 | 5.7e-08 |
| osteosarcoma | 7933 | 6.0e-08 |
| medulloblastoma, large-cell | 6234 | 2.6e-06 |
| group 4 medulloblastoma | 1875 | 1.1e-04 |
| Disease | log2 FC | p |
|---|---|---|
| osteosarcoma | 1.919 | 6.0e-08 |
| atypical teratoid / rhabdoid tumor | 1.400 | 4.2e-08 |
| glioblastoma | 1.300 | 5.7e-08 |
| medulloblastoma, large-cell | 1.400 | 2.6e-06 |
| group 4 medulloblastoma | 1.100 | 1.1e-04 |
| ovarian cancer | 1.100 | 1.4e-08 |
| PMID | Text | |
|---|---|---|
| 24956037 | Signal transducer/transcription factor FIZ1 regulated signaling pathways are implicated in regulation of the balance between proliferation and differentiation in keratinocytes. | |
| 17141759 | Activators of the Rhodopsin gene are present before activation of the gene. FIZ1 expression rises at this time and it can synergize with NRL and CRX at the Rho and PDE6B promoters. FIZ1 may syncronize the onset of maturation related gene expression. | |
| 12566383 | Homologous to mouse and bovine Fiz1 (flt-3 interacting zinc finger). Interacts with NRL (neural retina leucine zipper). Antibody detects protein in human, mouse, bovine retina. Possible role for Fiz1 as a transcriptional repressor. |
MDDVPAPTPAPAPPAAAAPRVPFHCSECGKSFRYRSDLRRHFARHTALKPHACPRCGKGFKHSFNLANHL 1 - 70 RSHTGERPYRCSACPKGFRDSTGLLHHQVVHTGEKPYCCLVCELRFSSRSSLGRHLKRQHRGVLPSPLQP 71 - 140 GPGLPALSAPCSVCCNVGPCSVCGGSGAGGGEGPEGAGAGLGSWGLAEAAAAAAASLPPFACGACARRFD 141 - 210 HGRELAAHWAAHTDVKPFKCPRCERDFNAPALLERHKLTHDLQGPGAPPAQAWAAGPGAGPETAGEGTAA 211 - 280 EAGDAPLASDRRLLLGPAGGGVPKLGGLLPEGGGEAPAPAAAAEPSEDTLYQCDCGTFFASAAALASHLE 281 - 350 AHSGPATYGCGHCGALYAALAALEEHRRVSHGEGGGEEAATAAREREPASGEPPSGSGRGKKIFGCSECE 351 - 420 KLFRSPRDLERHVLVHTGEKPFPCLECGKFFRHECYLKRHRLLHGTERPFPCHICGKGFITLSNLSRHLK 421 - 490 LHRGMD 491 - 496 //
| PMID | Year | Title | |
|---|---|---|---|
| 24956037 | 2014 | Dissection of a novel autocrine signaling pathway via quantitative secretome and interactome mapping. | |
| 24024966 | 2013 | Genome-wide association study of chronic periodontitis in a general German population. | |
| 22814378 | 2012 | N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. | |
| 17141759 | 2007 | FIZ1 is expressed during photoreceptor maturation, and synergizes with NRL and CRX at rod-specific promoters in vitro. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 15057824 | 2004 | The DNA sequence and biology of human chromosome 19. | |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | |
| 12566383 | 2003 | Interaction of retinal bZIP transcription factor NRL with Flt3-interacting zinc-finger protein Fiz1: possible role of Fiz1 as a transcriptional repressor. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 10409713 | 1999 | Fiz1, a novel zinc finger protein interacting with the receptor tyrosine kinase Flt3. |
