Tbio | F-box only protein 31 |
Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor.
This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Comments
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Mental Retardation, Autosomal Recessive 45 | 1 | 0.0 | 0.0 |
Disease | Target Count | P-value |
---|---|---|
posterior fossa group A ependymoma | 468 | 2.2e-09 |
ovarian cancer | 8520 | 2.5e-08 |
atypical teratoid / rhabdoid tumor | 5112 | 1.3e-07 |
pituitary cancer | 1972 | 3.9e-06 |
medulloblastoma, large-cell | 6241 | 1.3e-04 |
pediatric high grade glioma | 1064 | 9.6e-04 |
glioblastoma | 5792 | 1.5e-03 |
subependymal giant cell astrocytoma | 2287 | 9.7e-03 |
gastric carcinoma | 807 | 1.6e-02 |
Breast cancer | 3578 | 2.6e-02 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Intellectual disability | 1016 | 0.0 | 4.0 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Mast cell neoplasm | 8 | 3.138 | 1.6 |
Disease | log2 FC | p |
---|---|---|
atypical teratoid / rhabdoid tumor | -1.100 | 1.3e-07 |
Breast cancer | -3.200 | 2.6e-02 |
gastric carcinoma | 1.100 | 1.6e-02 |
glioblastoma | -1.300 | 1.5e-03 |
medulloblastoma, large-cell | -1.100 | 1.3e-04 |
ovarian cancer | -1.500 | 2.5e-08 |
pediatric high grade glioma | -1.200 | 9.6e-04 |
pituitary cancer | -1.600 | 3.9e-06 |
posterior fossa group A ependymoma | -1.500 | 2.2e-09 |
subependymal giant cell astrocytoma | -1.285 | 9.7e-03 |
Species | Source | Disease |
---|---|---|
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG |
MAVCARLCGVGPSRGCRRRQQRRGPAETAAADSEPDTDPEEERIEASAGVGGGLCAGPSPPPPRCSLLEL 1 - 70 PPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIWRRRCREEYGVCENLRKLEITGVSCRDVYAKLLH 71 - 140 RYRHILGLWQPDIGPYGGLLNVVVDGLFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKAATVECMYGH 141 - 210 KGPHHGHIQIVKKDEFSTKCNQTDHHRMSGGRQEEFRTWLREEWGRTLEDIFHEHMQELILMKFIYTSQY 211 - 280 DNCLTYRRIYLPPSRPDDLIKPGLFKGTYGSHGLEIVMLSFHGRRARGTKITGDPNIPAGQQTVEIDLRH 281 - 350 RIQLPDLENQRNFNELSRIVLEVRERVRQEQQEGGHEAGEGRGRQGPRESQPSPAQPRAEAPSKGPDGTP 351 - 420 GEDGGEPGDAVAAAEQPAQCGQGQPFVLPVGVSSRNEDYPRTCRMCFYGTGLIAGHGFTSPERTPGVFIL 421 - 490 FDEDRFGFVWLELKSFSLYSRVQATFRNADAPSPQAFDEMLKNIQSLTS 491 - 539 //