Property Summary

NCBI Gene PubMed Count 2,476
PubMed Score 8119.16
PubTator Score 11099.47

Knowledge Summary

Patent (299,825)


  Disease (6)


  Differential Expression (14)

Disease log2 FC p
malignant mesothelioma -1.300 1.1e-04
psoriasis -1.200 7.8e-16
osteosarcoma -2.199 1.9e-03
Atopic dermatitis -1.300 8.8e-04
adrenocortical carcinoma -1.332 1.8e-03
intraductal papillary-mucinous adenoma (... -1.600 4.4e-03
intraductal papillary-mucinous carcinoma... -1.800 2.7e-03
intraductal papillary-mucinous neoplasm ... -1.800 1.9e-02
lung cancer -2.700 4.3e-04
breast carcinoma 2.000 2.2e-04
interstitial cystitis -1.200 4.8e-02
cystic fibrosis 1.100 4.9e-04
Breast cancer -1.800 1.1e-07
pituitary cancer -3.200 5.1e-06


Accession P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 ER
Symbols ER



1A52   1AKF   1ERE   1ERR   1G50   1GWQ   1GWR   1HCP   1HCQ   1L2I   1PCG   1QKT   1QKU   1R5K   1SJ0   1UOM   1X7E   1X7R   1XP1   1XP6   1XP9   1XPC   1XQC   1YIM   1YIN   1ZKY   2AYR   2B1V   2B1Z   2B23   2BJ4   2FAI   2G44   2G5O   2I0J   2IOG   2IOK   2JF9   2JFA   2LLO   2LLQ   2OCF   2OUZ   2P15   2POG   2Q6J   2Q70   2QA6   2QA8   2QAB   2QE4   2QGT   2QGW   2QH6   2QR9   2QSE   2QXM   2QXS   2QZO   2R6W   2R6Y   2YAT   2YJA   3CBM   3CBO   3CBP   3DT3   3ERD   3ERT   3HLV   3HM1   3L03   3OS8   3OS9   3OSA   3Q95   3Q97   3UU7   3UUA   3UUC   3UUD   4AA6   4DMA   4IU7   4IUI   4IV2   4IV4   4IVW   4IVY   4IW6   4IW8   4IWC   4IWF   4JC3   4JDD   4MG5   4MG6   4MG7   4MG8   4MG9   4MGA   4MGB   4MGC   4MGD   4O6F   4PP6   4PPP   4PPS   4PXM   4Q13   4Q50   4TUZ   4TV1   4XI3   4ZN7   4ZN9   4ZNH   4ZNS   4ZNT   4ZNU   4ZNV   4ZNW   4ZUB   4ZUC   4ZWH   4ZWK   5AAU   5AAV   5ACC   5AK2   5BNU   5BP6   5BPR   5BQ4   5DI7   5DID   5DIE   5DIG   5DK9   5DKB   5DKE   5DKG   5DKS   5DL4   5DLR   5DMC   5DMF   5DP0   5DRJ   5DRM   5DTV   5DU5   5DUE   5DUG   5DUH   5DVS   5DVV   5DWE   5DWG   5DWI   5DWJ   5DX3   5DXB   5DXE   5DXG   5DXK   5DXM   5DXP   5DXQ   5DXR   5DY8   5DYB   5DYD   5DZ0   5DZ1   5DZ3   5DZH   5DZI   5E0W   5E0X   5E14   5E15   5E19   5E1C   5EGV   5EHJ   5EI1   5EIT   5FQP   5FQR   5FQS   5FQT   5FQV   5HYR  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

Protein-protein Interaction (10)

MLP Assay (23)

AID Type Active / Inconclusive / Inactive Description
1078 confirmatory 2 / 0 / 22 Estrogen Receptor-alpha Coactivator Binding Inhibitors Reporter Gene Dose Response
1211 screening 71 / 0 / 751 Estrogen Receptor (alpha) binding: Primary Screen
1223 confirmatory 17 / 0 / 46 Estrogen Receptor (alpha) binding: Dose Response of Primary Screen Assay
1226 screening 4 / 2 / 6 Functional assay for estrogen-mediated translocation of PIP3: Secondary Assay for Estrogen receptor alpha
1788 other 0 / 0 / 0 Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Ancillary Activity
1921 other 2 / 0 / 0 Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator: Ancillary Activity
2277 screening 14 / 0 / 0 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors.
504934 other 1 / 0 / 0 Late stage assay provider results from the probe development effort to identify inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors
602169 other 10 / 0 / 23 Late stage assay provider counterscreen for the probe development effort to identify activators of the Aryl Hydrocarbon Receptor (AHR): Luminescence-based Human Ovarian Carcinoma (BG1Luc4E2) Cell-based assay to identify inhibitors of Estrogen Receptor-Dependent Gene Expression
624355 other 0 / 0 / 0 Late stage results from the probe development efforts to identify dual inhibitors of signal transducer and activator of transcription 3 (STAT3) and nuclear factor NF-kappa-B (NF-kB): Cell-based radioligand binding assay to determine the binding affinities for selected transporters, receptors, and GPCRs

Gene RIF (2555)

27434945 ESR1 and VKORC1 single nucleotide polymorphisms were used to determine the vitamin K dosage in patients with ulcer-related hemorrhage.
27174898 Among the proteins reported here, some well-known breast cancer markers (e.g., annexin A1, annexin A2 and vimentin) were identified in the MDA-MB-231 cell line and thus we were able to distinguish both cell lines sufficiently.
27107895 Enhanced KLF17 expression sensitizes ERalpha-positive breast cancer cells to endocrine therapy.KLF17-ERalpha interaction plays a potential role in inhibition of ERalpha-dependent breast cancer progression.
27070141 Three SNPs of the ESR1 gene were not associated with increased BC risk.
27035664 rapid signaling through ERalpha is essential for many of the transcriptional and physiological responses of ECs to E2, and that ERalpha rapid signaling in ECs, in vivo, may be critical for the vasculoprotective and anti-inflammatory effects of estrogen
26960573 Along with the PHF20/MOF complex, G9a links the crosstalk between ERalpha methylation and histone acetylation that governs the epigenetic regulation of hormonal gene expression.
26939421 There was no difference in distribution of polymorphic genes ESR1 and VKORC1 in peptic ulcer hemorrhage patients of both sexes, with the exception of A/A VKORC1 genotype found in women.
26928228 Expression of ESR1, RMND1 and CCDC170 associated with variants in separate enhancer elements predisposing breast cancer. [meta-analysis]
26911590 Genetic variation at the WLS and CCDC170/ESR1 loci were found to be significantly associated with bone mineral density
26846986 In the setting of highly sensitive and robust IHC methodology, cutoffs for ER status determination and subsequent systemic therapy should be revisited.
26829108 the MapQuanttrade mark assay, based on mRNA expression assay, provides an objective and quantitative assessment of Estrogen receptor, Progesterone receptor and HER2 status in invasive breast cancer.
26826253 A review of ESR1 mediated mechanisms in the context of the female reproductive system. [review]
26820652 TargetPrint ER had a positive agreement of 98 %, and a negative agreement of 95 % with central pathology. Corresponding figures for PgR were 85 and 94 % and for HER-2 72 and 99 %. Agreement of mRNA versus central protein was not different when the same or a different portion of the tumor tissue was analyzed or when DCIS and/or normal tissue was included in the sample subjected to mRNA assays
26790618 ERalpha decreased CCL5 and IL-6 expression in conditioned media that was collected from Cancer associated fibroblast cell.
26768368 These findings expand our understanding of hormone responsiveness in the tumor microenvironment; however, additional in-depth studies are required to elucidate the detailed mechanisms of TSA-induced ERalpha regulation under hypoxia.
26742628 the results indicate that there is a crosstalk between ERalpha and ERbeta to regulate the expression of each other, and suggest the involvement of other receptors, such as ER-alpha36, in the rapid ERK1/2 activation by E2.
26728382 Data show that Cyclin D1 has a higher expression in breast cancer, positively correlated with estrogen receptors (ER) and better prognosis.
26723394 miR-26b-3p played an important role in the regulation ofHuman umbilical cord-derived mesenchymal stem cells proliferation in vitro by targeting the ESR-CCND1 pathway.
26703694 Protein kinase CK2 expression predicts relapse survival in ERalpha dependent breast cancer, and modulates ERalpha expression in vitro.
26700933 We found that elevated levels of estradiol and SHBG in HT [Hormone therapy] users were associated with elevated levels of CRP and lower levels of TFPI, both of which may be related to a prothrombotic milieu in HT [Hormone therapy ]users.
26700208 we found no trend of increasing risk for primary dysmenorrhea in association with the number of putative high-risk genotypes of IL6 gene -597 G>A and -572 G>C and ESR1 gene XbaI polymorphisms.
26695360 expressed in prolactinomas, especially among men and post-menopausal women
26688601 homozygote (XX) genotype of ER-alpha gene XbaI polymorphism, but not PvuII mutation, may increase the risk of chronic periodontitis, specifically in the Chinese Han female population.
26674964 ER-alpha regulates the osteoblast differentiation through modulation of Dlx3 expression and/or interaction with Dlx3.
26669013 it is concluded that the ESR1 haplotypes may influence the Th2 cytokine profile and susceptibility to SLE among the South Indians
26639757 the genomic amplification of ESRRA causes its upregulation in a subset of oral squamous cell carcinoma tumor samples.
26634548 ESR1 may be associated with low mineral osseous densitometry, while CYP17 and COMT gene polymorphisms were not associated with mineral osseous densitometry.
26620113 Our study offers evidence that the catechol-O-methyltransferase and estrogen receptor alpha genes may also play a role in the susceptibility to depressive mood in postmenopausal women.
26598706 findings define, for the first time to our knowledge, a direct regulatory pathway between ERalpha and HIF-1alpha, which might modulate hormone response in treatment
26592768 Activation of ERalpha but not ERbeta increases ADAM9 expression in cultured human neuronal cells.
26575018 Inhibition of ERalpha signaling in prostate cancer cells may be a novel therapeutic strategy to inhibit the osteoblastic lesion development as well as lung metastasis in patients with advanced prostate cancer.
26560360 ESR1 mutations can be robustly identified with circulating DNA analysis and predict for resistance to aromatase inhibitors therapy.
26550991 Estrogen receptor, progesterone receptor or human epidermal growth factor receptor 2 samples with high-methylation risk score had the worst 5-year survival rate and overall survival time.
26535709 Our meta-analysis results strongly suggest that the ESR1 gene polymorphisms PvuII (rs2234693T>C) and XbaI (rs9340799A>G) are not associated with CVD risk.
26530297 For key genes ERBB2 and ESR1, we demonstrate that overexpression is linked to the production of highly modified and truncated splice variants in tumours, but not controls, correlated with tumour subtype
26529820 a G2014A SNP genotype in exon 8 of the estrogen receptor was associated with postmenopausal women who had osteoporotic hip fracture.
26529545 ERa mRNA and protein levels of in multiple leiomyomas were significantly lower than those of solitary leiomyomas, whereas ERb mRNA and protein levels in multiple leiomyomas were significantly higher than those in solitary leiomyomas.
26522827 Cells traditionally considered as being deprived of estrogen receptor are able to respond to hormonal stimulation via the ERalpha36 receptor. [Review]
26506594 Studies indicate that prostate cancer stem cells lack the androgen receptor, and express classical alpha and/or beta and GPR30 estrogen receptors.
26503703 Inhibition of MTA1 by ERalpha contributes to protection hepatocellular carcinoma from tumor proliferation and metastasis
26488768 Knockdown of METTL17 reduces transcriptional activities of ESR1 and ESR2 in breast cancer cells.
26485345 A Lower PBMC Estrogen Receptor alpha Gene Expression in Chronic Hepatitis B Is Associated with a Sustained Virological Response to Pegylated Interferon
26484775 Our results thus demonstrated that ER-alpha36 is involved in neuroprotective activities mediated by both estrogen and tamoxifen.
26469385 HIV-1 MA upregulates ESR1 mRNA expression in HepG2 cells
26456481 Results of the meta-analysis revealed a potential benefit of positive ESR1 mRNA expression in survival in patients with NSCLC, especially in those of advanced stage. No statistically significant association was found between ESR2 mRNA expression and NSCLC patients' prognosis.
26434778 ESR1 PvuII, XbaI, and P325P polymorphisms are associated with breast cancer susceptibility [meta-analysis]
26434753 ddPCR technique could be a promising tool for the next-generation sequencing-free precise detection of ESR1 mutations in endocrine therapy resistant cases and may assist in determining the treatment strategy
26428028 Expression of seven ERalpha splice variants, total progesterone receptor (PR) and of five PR transcript isoforms was found to be significantly decreased in endometrial cancer
26424167 Uni- and multivariate analyses included age, tumor size, grade, ER, and Her2; in multivariate analysis, MammaPrint reached near-significance (HR 3.01; p 0.08).
26411678 APOBEC3B is required for regulation of gene expression by ERalpha and acts by causing C-to-U deamination at ERalpha binding regions.
26406593 Results show that genetic variants in the oestrogen receptor alpha and the oxytocin receptor may be associated with an increased risk of oesophageal adenocarcinoma and Barrett's oesophagus.
26394816 In estradiol-treated monocytes, there is a direct physical interaction of ligand-activated estrogen receptor-alpha 36-kDa splice variant with NF-kB p65 component in the nucleus. This is not changed during differentiation into macrophages or dendritic cells.
26393498 Data suggest 17beta-estradiol stimulates odontoblastic differentiation of dental pulp via coordinated regulation of estrogen receptor alpha, c-Src, and MAP kinase signaling pathways, which may play key role in calcification/regeneration of dentin.
26389696 Collectively, the results demonstrate a novel ligand-dependent action of ERalpha that stimulates the activity of an E3 ligase.
26383254 This study demonstrates that ER-alpha36-mediated rapid estrogen signaling is involved in the neuroprotection activity of estrogen against oxidative toxicity.
26374855 AMPK-alpha-2 binds to ER-alpha, as well as ER-beta.
26370976 our results show the involvement of the variants of ESR1, LPL and CETP genes in metabolic events related to MetS or some of its features.
26348925 The ESR1 ubiquitin binding surface contributes to the modulation of estradiol-induced ESR1-mediated cell proliferation.
26345870 the ESR1 PvuII polymorphism is associated with AD susceptibility in males, and that ESR1 XbaI polymorphism is associated with AD risk in the Japanese population. the PP/XX haplotype is associated with AD susceptibility in the Chinese population.
26334887 ESR1 gene polymorphisms may have major contributions to the pathogenesis of migraine in Caucasian populations.
26334217 Data indicate that high proto-oncogene protein HER-2 (HER2) and low estrogen receptor alpha (ESR1) mRNA levels are required for achieving trastuzumab response.
26318038 Nuclear ERalpha expression is an independent predictor of recurrence in pT1a lung adenocarcinomas and correlates with poor prognostic immune microenvironments.
26299756 the conformational dynamics of ERalpha36 in the absence and presence of Hsp90 and gammaSyn, is reported.
26299454 ER-alpha status of endometrioid adenocarcinomas could restrict eventual proapoptotic or anti-apoptotic impact of aberrantly expressed Cx43 and Cx26 in these tumors.
26280373 TLX has a role in regulating growth and invasion in ERalpha-negative breast cancer cells
26261103 ESR1 mutations can occur at a high frequency in human breast cancer.
26252518 the morphological features and ER-alpha/PRA/p53 immunohistochemical expression of a sample of 45 endometrial endometrioid carcinoma metastases compared to matched primary tumors, were evaluated.
26251204 ESR2 rs4986938 AG and AG + AA genotypes were associated with significantly decreased risk of prostate cancer (PCa). However, there was no significant association between ESR1 rs2234693 and PCa risk.
26244666 Results suggest that expression levels of protease activated receptors 1 and 2 (PAR-1 and PAR-2) associate with breast cancer outcome in an estrogen receptor (ER)-dependent manner.
26186972 ESR1 directly interacts with TRAF3 and promotes K48-linked proteasomal degradation of TRAF3.
26183887 Functional roles of ESR1 mutations in breast cancer (review).
26183824 PARP regulates estradiol-mediated cell growth by controlling the ER/IGF-1R/PDZK1 axis.
26180042 HOXB7 Is an ERalpha Cofactor in the Activation of HER2 and Multiple ER Target Genes Leading to Endocrine Resistance
26179105 Tissue factor isoform and estrogen signaling share downstream targets in BrCa; the concomitant presence of asTF and estrogen signaling is required to promote BrCa cell proliferation.
26169989 Our findings support the hypothesis that estrogen receptor polymorphisms influence risk for major depression.
26166704 condensin complexes exhibit an unexpected, dramatic estrogen-induced recruitment to estrogen receptor alpha (ER-alpha)-bound eRNA(+) active enhancers in interphase breast cancer cells, exhibiting non-canonical interaction with ER-alpha via its DNA-binding domain
26166202 HAND2-mediated proteolysis negatively regulates the function of estrogen receptor alpha.
26165414 ESR1 polymorphisms, PvuII and XbaI and VDR polymorphisms (TaqI, ApaI) did not significantly influence fractional calcium absorption
26161666 The ER-/PgR+ phenotype is associated with higher grade with HER2 overexpression/amplification and occurs more commonly in younger women.
26160085 10.7% of this Pakistani breast cancer cohort were estrogen receptor positive only, though 51% were ER and PR positive.
26158518 This newly described ERa-mediated and estrogen response element (ERE)-independent non-canonical autophagy pathway, which involves the function of BAG3 and provides stress resistance in our model systems.
26153859 PR functions as a molecular rheostat to control ERalpha chromatin binding and transcriptional activity, which has important implications for prognosis and therapeutic interventions in breast cancer
26148232 ERa-dependent expression of LRIG1 dampens ErbB3 signaling in luminal breast cancer cells, and by blocking ERa activity with fulvestrant, LRIG1 is decreased thus permitting ErbB3 accumulation, enhanced ErbB3 signaling to cell survival pathways
26131816 ERalpha36 expression is valuable for differential diagnosis of malignant renal tumors from benign ones.
26122181 the contribution of ESR1 mutations to the development of acquired resistance to endocrine therapy in breast cancer patients (Review)
26122040 By investigating the role of ERa in the ETS-1 activity regulation, we demonstrated that ERalpha may be a novel ETS-1 co-activator and thus a potential therapeutic target in human neuroblastoma treatment
26100352 Results show that ESR1 and ERBB2 were found to modulate the most numbers of gene pairs in breast neoplasm and they share complex interplay between each other suggesting a role in breast cancer pathogenesis through gene regulation.
26056290 results indicate that estrogen signaling in cervical cancer has dramatic differences from ERalpha+ breast cancers, and imply that estrogen signaling increasingly proceeds indirectly through ERalpha in tumor-associated stromal fibroblasts
26049107 results show that PHB2 binds to the ligand binding domain of ERalpha with a conformational change in the helix 12 of ERalpha
26043844 Coordinate pattern of Rb1+ and ER+ in HGSC and LGSC is 19 and 50%, respectively. Rb1 and P16 show inverse expression pattern according to tumor grade with more frequent Rb1 in low grade vs. more frequent P16 in grade 3 tumors
26036718 ESR1 XbaI and PvuII polymorphisms are associated with precocious puberty susceptibility (meta-analysis).
26036714 The expression of ERalpha and ERbeta was inversely correlated with menopausal age. No significant association was observed between ERs or PR expression and benign or malignant endometrial pathology.
26033249 Data show that ESR1 promotes obesity and metabolic dysfunction in animal model; its tissue-specific actions control feeding, physical activity and insulin sensitivity. [review]
26029980 Trp383 in hERalpha and Trp335 in hERbeta interact with the NR-box motif of the H12 helix.
26023734 ERalpha inhibits epithelial-mesenchymal transition and stemness through the downregulation of Bmi1 in breast cancer
26023053 Data suggest that differential transactivation of ESR1 and ESR2 is exhibited by the various isoflavone phytoestrogens present in soy versus red clover commercial dietary supplements available on the German market as capsules.
26022099 This study illustrates for the first time that, in contrast to hepatic and adipose tissue, estrogen induces SCD-1 expression and activity in breast carcinoma cells. These results support SCD-1 as a therapeutic target in estrogen-sensitive breast cancer.
26006730 Conclude that not only ERalpha, but also basal activities of EGFR and Src kinase are essential for Cd-induced signal transduction and activation of MAPK/ERK pathway for breast cancer cell proliferation.
26001094 genetic association study in population of postmenopausal women in southern China: Data suggest that a positive association between hip bone mineral density and dietary phytoestrogen intake exists in women with xx genotype in intron 1 of ESR1.
25994408 Digital PCR results showed mutations in ESR1 gene significantly associated with aromatase inhibitor resistant metastatic breast neoplasm.
25991817 SERD- or SSH-palbociclib combination has therapeutic potential in breast tumors resistant to endocrine therapies or those expressing ESR1 mutations
25981900 Our study suggests that ESR1 gene amplification is an early event in breast pathology and might be a helpful predictive marker to identify patients at high risk of developing breast cancer.
25979597 The loss of heterozygosity in the regulatory regions of ESRa, ESRb, and AR genes is an early genetic alteration in breast carcinoma and has possibly synergistic effects on tumor proliferation, histological aggressiveness and down-regulation of these genes in tumor samples.
25970543 In localized colorectal cancer carriers, mRNA-based CD3Z/CD8 profiling of tumor immune response may have stage, site and tissue-specific prognostic significance, along with ESR1 expression.
25955393 miR-18a expression suppression led to a decrease in trophoblast cell invasion and an increase in trophoblast cell apoptosis, by inducing estrogen receptor - alpha expression.
25944846 The present results indicate that the estrogen-ERalpha-H19 signaling axis plays a role in regulating the proliferation and differentiation potentials of the normal luminal progenitor which may also be important in the development of ER(+) breast cancer tumors
25943392 IL6 secreted by ovarian cancer cells may contribute to the refractoriness of these cells to tamoxifen via the crosstalk between ESR1 and IL6-mediated intracellular signal transduction cascades.
25928859 SNAI2/SLUG is prognostic of patients' outcome. The strong inverse correlation with ESR1 indicates a significant impact of estrogen receptor pathway regarding these malignant features.
25928204 ESR1 mutations in advanced, endocrine therapy-resistant breast cancers(Review)
25927974 Intragenic methylation levels correlate with ESR1 expression in homogenous cell populations but not in heterogeneous tumor biopsies, highlighting the significant differences between the in vivo tumor microenvironment and individual homogenous cell types.
25923108 Estrogen deprivation induced a cluster of noncoding RNAs that defined a large chromatin domain containing the ESR1 locus.
25917453 Data shows that ERA36 is a novel ERA that is expressed in breast neoplasm and confers tamoxifen resistance. It is localized in the cytoplasm and plasma membrane and seems playing a role in breast cancer stem cells. [review]
25908555 Regardless of methodology, basal-like cases seldom expressed ER/ESR1 or PR/PGR and were associated with the lowest expression level of HER2/ERBB2 relative to other subtypes.
25907805 demonstrates that miR-135b regulates ERalpha, AR and HIF1AN protein levels through interaction with their 3'UTR regions, and proliferation in ERalpha-positive BCa and AR-positive PCa cells
25904752 Prediction of breast cancer prognosis and treatment response was improved by combining AR and ER status
25901081 Our findings shed new light on the mechanisms underlying the progression of ER(+) breast cancer and indicate the potential of novel therapies targeting CCL2 and CCL5 pathways.
25892216 The present meta-analysis suggests that the rs2234693 polymorphism is associated with an increased knee osteoarthritis risk
25890275 This study suggested that interactions among impulsiveness, testosterone, sex hormone binding globulin and androgen receptor gene CAG repeat length
25887457 Review/Meta-analysis: suggest a weak relationship between the ERalpha XbaI polymorphism and osteoarthritis in Europeans.
25884832 Among women with breast cancer, those who were highly obese, but not mildly obese, around breast cancer diagnosis were more likely to have breast tumors with greater expression of proliferation genes and lesser expression of ESR1
25884434 Results showed that HNRNPG and HTRA2-BETA1 were specific antagonistic regulators of ERa exon7 splicing and increased HNRNPG levels were associated with improved clinical outcome of endometrial cancer through up-regulation of ERaD7 expression.
25866209 Pin1 has a role in allosteric regulation of ERalpha function
25864647 The anticancer activity of triptolide against MCF-7 cells is partially mediated by downregulation of the ERalpha-mediated signaling pathway.
25860340 Many membrane trafficking proteins contribute to the regulation of ESR1 degradation, thus unraveling the contribution of endocytic proteins in estradiol:ESR1 signaling.
25859975 we describe a TR-FRET assay that monitors the interaction of the estrogen receptor (ER) alpha ligand binding domain (labeled with a terbium chelate via a streptavidin-biotin interaction) with a sequence of coactivator protein SRC3
25857231 Suggest that OATP2B1 is involved in cell proliferation by increasing the amount of estrogen in ER1-positive breast cancer cells.
25851346 this study demonstrated that a celecoxib and luteolin combination treatment yielded synergistic effects in four different breast cancer cell lines and suppressed triple-negative (ER-negative and HER-2 negative) breast tumor growth in vivo
25849766 Data suggest that ESR1 agonists (here endocrine disruptors 2,4-dihydroxybenzophenone or nonylphenol) alter gene expression, stimulate cell proliferation, and induce cell migration/metastasis in adenocarcinoma breast cancer cells (MCF-7 cells).
25846769 These results suggest that H19 is an estrogen-inducible gene and plays a key role in cell survival and in estrogen-induced cell proliferation in MCF-7 cells, indicating that H19 lncRNA may serve as a biomarker for breast cancer diagnosis and progression
25845386 negative-ER ,negative-PR ,positive-p53 and higher Ki-67 expressions were related to a higher mtDNA copy ratio. In addition, advanced T-status (p=0.019) and negative-HER-2/neu expression (p=0.061) were associated with mtDNA D310 mutations
25836047 ERalpha XbaI AA polymorphism may intensify the beneficial effect of estradiol on the distribution of fatty tissue after menopause; XbaI GG and PuvII TC genotypes may intensify the beneficial effect of estradiol on HDL level.
25828708 rs2077647 polymorphism may be a risk factor for prostate cancer, while rs3798577 polymorphism could be a promoting factor in combination with other polymorphisms in estrogen receptor alpha contributing to development of high-grade carcinomas.
25825714 Data suggest that targeting therapy-resistant estrogen receptor alpha (ERalpha)-positive cancer cells by converting the unfolded protein response (UPR) from cytoprotective to cytotoxic may hold significant therapeutic promise.
25823469 cells. These results suggest that adipocytes can modify breast cancer cell ER gene expression through hypoxia and also can promote EMT processes in breast cancer cells, supporting an important role of obesity in aggressive breast cancer development.
25822021 MEL-18 loss in luminal breast cancer cells resulted in the downregulation of expression and activity of ER-alpha and the progesterone receptor, MEL-18 overexpression restored ER-alpha expression in triple-negative breast cancer cells.
25802405 HER2 status was highly concordant between the paired primary and brain tumors, whereas changes of ER and PR status occurred in a substantial proportion of the patients
25801958 S6K1, overexpressed in many breast cancers, controls HDAC1-dependent transcriptional regulation of ESR1 levels upon mitogenic stimuli.
25788266 H4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible transcription
25778331 Review/Meta-analysis: ESR1 genetic variation may be risk factor for HCC, prostate cancer and gallbladder cancer.
25769926 These results demonstrate that estradiol upregulates REA expression and recruits REA via ERalpha to the EREs on the RORgammaT promoter region, thus inhibiting RORgammaT expression and Th17 differentiation.
25766326 Our study revealed novel molecular mechanisms underlying the regulation of ERa protein and provided insights in understanding the relationship between SPOP mutations and the development of endometrial cancer.
25752574 TNFalpha signaling causes redistribution of NF-kappaB and FoxA1 binding sites across the genome, creates latent ERalpha binding sites that underlie altered patterns of gene expression and clinically relevant cellular responses.
25740706 FOXK2 might act as a negative regulator of ERalpha, and its association with both ERalpha and BRCA1/BARD1 could lead to the down-regulation of ERalpha transcriptional activity, effectively regulating the function of ERalpha.
25736863 ER positivity was increased in BRCA2 breast cancers compared to non-BRCA familial and BRCA1 breast cancers.
25730068 ESR1 gene PvuII polymorphism may not be associated with fracture risk in postmenopausal women [meta-analysis]
25728938 Data show that loss of ERalpha in breast cancer cells results in a potent epithelial to mesenchymal transition characterized by changes in the expression profile of matrix effectors suggesting their potential role in breast cancer endocrine resistance.
25728767 ER-alpha, SRC-3, and p300 form an active protein complex on estrogen response element-DNA.
25720568 At the molecular level, estrogen upregulated hepatic SHP expression through binding to its proximal promoter. In addition, the roles of estrogen were largely blunted in mice with SHP deficiency.
25701261 estrogen receptor activation under chronic hyperinsulinemic condition increases breast cancer growth through the modulation of cell cycle and apoptotic factors and nutrient metabolism.
25693206 It is shown that there is a connection between the PvuII-gene polymorphism EsRalpha with the degree of proliferation (chi2=43,142; p<0,0001) and the expression level EsRalpha (chi2=51,041; p<0,0001) in breast tissue at BBD in patients
25683269 c-MYC expression is up-regulated through the cross-talk between ER and HER2 in aromatase inhibitor resistant breast cancer cells.
25666264 Has no impact on the prognosis of patients with ER-negative tumors.
25663546 these data show that DC-SCRIPT acts as a novel regulator of CDKN2B and induces cell cycle arrest in ESR1-positive breast cancer cells.
25655200 Report substituted benzopyran targeting refractory prostate cancer cells behaving as ESR1 antagonist/ESR2 agonist.
25652255 Study shows the ability of Slug to bind E-boxes of ERalpha promoter region, and thereby to suppress de novo ERalpha synthesis contributing to tumor progression in breast and prostate neoplasm and drug resistance as well.
25643697 our results suggest that ERalpha and ERRalpha cooperate to promote endocrine resistance, and they provide a rationale for the exploration of ERRalpha as a candidate drug target to treat endocrine-resistant breast cancer
25632198 Combined expression of estrogen receptor 1 and VEGF-A is a potential prognostic marker for gallbladder carcinoma patients.
25626180 None of the four polymorphisms studied in ESR1 and ESR2 were associated with increased risk for cataract.
25617525 No association between the ESR1 gene polymorphisms and the presence of PCOS was observed.
25604459 The identification of cytoplasmic proteins interacting with estrogen receptor alpha in breast cancer cells
25603724 ESR1 mRNA expression was significantly lower on granulosa cells of PCOS patients compared to controls.
25597633 Data identified phosphorylation sites in ESR1 that direct its temporal recruitment to specific genes. Disruption of some of them in breast cancer cells elicit unique gene expression related to cell proliferation, morphology and migration. [review]
25595040 This study investigetes the functional properties and subcellular localization of alpha human and rainbow trout estrogen receptors.
25594859 ERalpha contributes to the growth of papillary thyroid carcinoma (PTC) by enhancing an important prosurvival catabolic process, autophagy, in PTC cells.
25582774 roles of ESR1-mediated transactivation and transrepression in the regulation of invasiveness of ESR1+/HER2+ breast cancer cells by E2
25576212 High ESR1 expression is associated with lymph node metastasis and recurrence in Thyroid cancer.
25561399 Data suggest that, in vaginal agenesis following modified Abbe-McIndoe neovaginoplasty using regenerated oxidised cellulose, expression of ESR1 is low in neovaginal tissue resulting in local hypo-estrogenism and thus vaginal trophism (vaginal atrophy).
25542856 Our data indicates that cohesin is not a universal facilitator of estrogen receptor alpha-induced transcription and can even restrict enhancer-promoter communication.
25534852 ERalpha regulates chromosome alignment and spindle dynamics by stabilizing microtubules during mitosis.
25531331 Mir-873 inhibits ESR1 activity and cell growth via targeting CDK3.
25526766 ESR1/2 gene polymorphisms are associated with the results of controlled ovarian hyperstimulation.
25524554 low ERb1 expression and high ERb2 expression are markers for identification of AET-treated ERa-positive breast carcinoma patients at risk of early and late relapse, respectively.
25522625 Data indicate that carnosol could significantly increase estrogen receptors ERalpha and ERbeta expressions of T47D cells, and remarkably increase ERalpha/ERbeta ratio.
25512541 ERRalpha is needed for the efficient production of cytomegalovirus progeny, and we propose that the nuclear receptor contributes importantly to the induction of a metabolic environment that supports optimal cytomegalovirus replication.
25503779 after administration of abexinostat for three consecutive days, we did not observe any induction of ESR1 or ESR1-related genes and ERalpha protein expression
25500588 Data indicate that the mRNA level for forkhead box P1 (FOXP1) and estrogen receptor beta (ERbeta) in ovarian carcinoma tissues decreased, while the expression level of estrogen receptor alpha (ERalpha) mRNA increased.
25490392 REGgamma expression is positively correlated with ERalpha status and poor clinical prognosis in ERalpha positive breast cancer patients
25483016 Study show that miR-221 is upregulated in HBV-related hepatocellular carcinoma (HCC) and modulates cell proliferation by suppressing ERalpha, functioning as a tumor promoter.
25463985 ESR1 single nucleotide polymorphisms and haplotypes influence the risk of hypospadias in white and Hispanic subjects
25445105 No significant differences in ESR1-397C>T and -351A>G polymorphisms were was found between the patients with premature ovarian failure and controls
25433206 Data shows that lobular breast neoplasm expresses high levels of both ESR1 and ESR2. No tumor infiltrating leucocytes express ESR1. [review]
25428437 ESR1 gene PvuII polymorphism is significantly associated with an increased risk of premature ovarian failure.ESR1 gene XbaI polymorphism is significantly association with risk of premature ovarian failure in Asian population.
25423566 Our investigation identified miR-219-5p as a negative regulator of papillary thyroid carcinoma development through targeting of ERalpha.
25418858 Results show FOXO3a and FOXM1, two transcription factors with antagonistic roles in cancer and DNA damage response, mediating signaling and repair as well as for senescence, cell cycle and cell death control. [review]
25416214 a polymorphic variant of A-351G gene ESR1 estrogen can be considered as a marker of premenstrual syndrome. Pathological variant GG genotype was significantly associated with the presence of edematous and severe forms of the disease
25415230 ERalpha is overexpressed in a significant number of prostate cancer cohorts.
25385317 The ratios of IGF-I/IGFBP-3 were increased in postmenopausal Taiwanese women with breast cancer, irrespective of their ages, ER and PR statuses, and HER2 expression.
25381338 Circulating tumor cells expression of ER, BCL-2, HER2, and Ki67 can be reproducibly measured with high analytical validity using the CellSearch System.
25375021 upon exposure to E2, ERalpha rapidly localizes to mitochondria, in which it interacts with HSD17B10 to modulate the expression of mitochondrial RNA transcripts.
25370037 Data suggest that rs2046210 SNPs located in the region of C6ORF97 (CCDC170)-estrogen receptor alpha (ESR1) might have substantial roles not only in carcinogenesis but also in progression toward a more aggressive phenotype in breast cancer patients.
25356941 Immunohistochemical profile of breast cancer with respect to estrogen receptor and HER2 status.
25347744 Studies indicate that activated CDC42 kinase 1 (ACK1) interacts with the estrogen receptor (ER) and (AR) regulates the activity of androgen receptor (AR) to promote the growth of breast cancer and prostate cancer.
25339659 role in TLR7 signaling in plasmacytoid dendritic cells
25338681 This study contributes to elucidating the intrinsic relations among breast cancer subgroups defined by ER, PR and HER2 expression via integrating mRNA and miRNA expression
25325995 The ESR1 rs9340799 polymorphism might be associated with the risk of osteoarthritis. [Meta-analysis]
25323936 Data show that estrogen receptor 1 (ESR1) rs2881766 polymorphism increased breast cancer risk and rs3798377 decreased the risk in Korean women.
25307539 Data show that recruitment of MLL1 (mixed lineage leukaemia histone methylase 1) to the homeobox-containing gene HOXA10 EREs (estrogen response elements) is mediated via ERalpha (estrogen receptor alpha).
25303530 Study reports a signature of the functionally active estrogen-regulated enhancers, particularly the 1,333 most active ERalpha enhancers linked to target coding gene activation; signature of these MegaTrans enhancers is the selective recruitment in trans of an apparent complex of other transcription factors, including RARalpha/gamma, GATA3, AP2gamma, STAT1, AP1, and FoxA1.
25299774 Neuroglobin player role in estrogen receptor alpha-positive cancer cell viability.
25287328 Data indicate that serine/threonine-protein kinase D1 (PKD1) stimulates estrogen receptor alpha (ERalpha) expression in breast cancer MCF-7 cells.
25284587 Data show that odulation of RNA helicase DDX18 directly affects growth of tamoxifen-resistant cells, suggesting that it may be a critical downstream effector of the estrogen receptors (ERs) and high mobility group box 2 (HMGB2) complex.
25283589 The association between body mass index (BMI) and the risk of developing breast cancer according to the menstruation status and age, and the correlation between BMI and expression of estrogen receptor, was examined.
25283550 miRNA mediated alterations in mTOR and ERalpha signaling establishes a new mechanism for altered estrogen responses independent of growth factor stimulation.
25283475 In colorectal carcinoma, pERalpha(Ser167) score was a significant prognostic factor for both disease-free interval and overall survival, independent of sex, age, glucose levels, tumor stage, bowel obstruction/perforation, or adjuvant chemotherapy.
25281901 mRNA expression profile of runx2 mirrored that of ERalpha36 and showed a degree subcellular co-localisation with ERalpha36. This study suggests that ERalpha36 is involved in the process of osteogenesis in BMSCs
25277204 ERalpha plays a protective role in bladder cancer initiation and growth at least partly via modulating the INPP4B/Akt pathway.
25275589 GPR30 activation inhibits proliferation of estrogen receptor-negative breast cancer cells.
25270093 The ERalpha mRNA levels in tumor tissue were upregulated.
25263449 Data show that estrogen, acting via estrogen receptor alpha (ERalpha), induces rapid anticipatory activation of the unfolded protein response (UPR).
25258361 At clinically effective concentrations, phenytoin is a strong ERalpha cell antagonist but a many-fold weaker agonist, via interactions with helix 12.
25258321 ASH2L enhances ERalpha expression as a coactivator of GATA3 in breast cancers
25231129 SGC7901 cells with high levels of ER-a36 expression exhibited estrogen hypersensitivity, high growth rate and high levels of Cyclin D1 expression while SGC7901 cells with knocked-down levels of ER-a36 expression were insensitive to estrogen stimulation
25228414 Single-nucleotide polymorphism in the ESR1 gene is associated with racial differences in breast cancer.
25222219 This review focuses on the new advances made in understanding the complex and important interface between ERRalpha and mitochondrial physiology. [review]
25218501 In breast cancer cells, GSTP1 inhibits the expression of RIP140, a negative regulator of estrogen receptor alpha transcription, at both mRNA and protein levels.
25218234 The potential utility of serum DNA methylation of ERalpha gene promoter.
25217304 ESR1 is strongly expressed in rectosigmoid endometriosis tissue.
25203051 Elevated expression of the ER-alpha36-EGFR/HER2 loops is one of the mechanisms by which ER-positive breast cancer cells escape tamoxifen therapy.
25201024 In the coronary intima from surgically repaired congenital heart disease patients there was a reduction in ESRA expression.
25200861 The results indicated that ESR1 rs1801132 (C>G) was associated with cancer risk in Caucasian populations
25198130 SERPINA6-rs1998056 regulated by FOXA/ERalpha might be associated with female HCC risk
25195863 ESR1 and maternal sensitivity are both associated with age of menarche.
25178548 There was a higher number of pxpx and pxPX genotypes in the DJD+ samples compared to the DJD- group, which suggests the presence of polymorphism possibly modulates the ER-alpha activity in bone and contributes to the degenerative process in the TMJ.
25178514 Androgen receptor collaborates with estrogen receptor alpha to promote resistance to aromatase inhibitors in breast cancer cells.
25175082 The two compounds inhibited cell growth, reduced expression of total estrogen receptor alpha (ER), Ser118-phosphorylated ER, FOXA1 and AIB1 and resensitized tamoxifenresistant cells to tamoxifen
25158023 ERa variant ERa36 mediates antiestrogen resistance in ER-positive breast cancer stem/progenitor cells
25154549 Nuclear p-Ser(167) -ERalpha was significantly positively correlated with p-MAPK and p-S6K1, and with significantly shorter relapse-free survival in endometrioid endometrial cancer (EEC).
25152917 These results suggest that ERalpha genotype may influence the relationship between habitual exercise and bone density.
25145671 data suggest that RIP140 plays an important role in ERalpha-mediated transcriptional regulation in breast cancer and response to tamoxifen treatment
25135164 Epigenetic marks in estrogen receptor alpha CpG island correlate with some reproductive risk factors in breast cancer.
25128001 Data from case-control genetic association studies suggest that SNPs in ERA/ESR1 (rs2234693C; rs9340799) and ERB (rs1256049GA; not rs4986938) are associated with male infertility. [META-ANALYSIS]
25113640 expression and localization of estrogen receptor in human breast cancer and its clinical significance
25113249 High expression of ER-alpha is associated with lymphatic metastasis and vaginal recurrence in cervical adenocarcinoma.
25101695 findings suggest that TSC may have therapeutic effects on ERalpha positive breast cancers and moreover that TSC may suppress breast epithelial cell proliferation by inhibiting the estrogen pathway
25099679 ESR1-CCDC170 rearrangements are found in an aggressive subset of estrogen receptor-positive breast cancers
25077953 ESR1 XbaI and G894T NOS3 polymorphisms may be useful in accessing insulin resistance and type 2 diabetes risks in all women, even before menopause and occurrence of metabolic disease
25077943 examined in isolation, rs9340799 polymorphism does not appear to be a likely susceptibility variant for adolescent idiopathic scoliosis predisposition. rs9340799 may be associated with adolescent idiopathic scoliosis severity, progression and treatment.
25061285 Based on this meta-analysis, we conclude that the ESR1 PvuII polymorphism might be a risk factor in Alzheimer's disease in Caucasians.
25060183 Therefore, we studied expression of ERalpha and ERbeta protein in the trigeminal mesencephalic nucleus of ten human brains (five female/five male).
25051172 estrogen receptor binding and p300 redistribution have a role in a squelching mechanism for estradiol-repressed genes
25044212 CCNB1 is a biomarker for the prognosis of ER+ breast cancer and monitoring of hormone therapy efficacy
25030786 These results suggested that both CYP17A1 and ESR1 polymorphisms may modulate the effects of phthalate exposure on the development of leiomyoma.
25027393 Data suggest that estrogen receptor (ER) subtypes (ERalpha and ERbeta) might play different roles in the development of breast cancer.
25014269 We conclude that the CC genotype of PvuII in ESR1 is associated with an increased risk of CHB, HBV-related LC and HCC in Guangxi Zhuang populations.
25011585 Peroxiredoxin-1 protects estrogen receptor alpha from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer.
25004254 Estradiol regulates TNF-alpha expression and secretion in ERalpha-positive breast cancer cells.
25003667 Provide additional prognostic information when evaluating clinical features of ER(+), HER2(-) early breast cancer.
24992175 Oncotype DX RT-qPCR assay for ER and PR correlation with IHC: a study of 3 different clones.
24975878 Mutations of p53 increase the stability of the protein, which in turn promotes the biogenesis of miR-18a and decrease the expression of ESR1.
24971610 SMRT enhances cell growth of estrogen receptor-alpha-positive breast cancer cells by promotion of cell cycle progression and inhibition of apoptosis.
24962896 ERalpha expression highly correlates with ZNF217 in lysates from breast tumors.
24961754 ERalpha Xbal and ERalpha PvuII polymorphisms are not obviously associated with risk of idiopathic scoliosis.
24960263 Med25 is identified as a new coactivator of ERalpha that is required for ERalpha-mediated regulation of CYP2C9 expression
24947674 Nongenomic activities of ESR1 are unable to mediate proliferative changes or the transcriptional profile following estradiol exposure.
24945100 Data suggest expression of ESR1 (but not ESR2) in endometrium in women with endometriosis may be biomarker for subsequent fertility; ESR1 levels in normal range or down-regulated are indicative of fertility following medical or surgical treatment.
24934762 TRPS1 gene expressionis associated with different epithelial mesenchymal transformation markers in ERalpha-positive and ERalpha-negative breast cancers.
24928730 ERalpha36 had a high expression mainly in adenocarcinoma and the high expression of ERalpha36 was strongly correlated with more advanced regional lymph node metastasis and poor survival in lung adenocarcinoma
24928087 The ERS1 P allele is a novel sporadic breast cancer biomarker whereas p and x alleles enhanced chemotherapy responsiveness.
24908329 In low-grade ovarian carcinoma and in ovarian tumors of low malignant potential, methylation of the ESR1 promoter inversely correlated with survival (p = 0.031).
24885022 Aminoflavone mediates growth inhibition effects in ERalpha-positive and negative breast cancer cells.
24884830 estrogen-activated ERa may mediate stimulatory effects on papillary thyroid cancergrowth and progression whereas ERb1 has some inhibitory actions
24878609 MCP-1 was shown to have a role in activation of the ER1 by phosphorylating Ser167 via the PI3K/Akt/mTORC1 signaling pathway
24861435 Data indicate that estrogen receptors alpha (ERalpha) promoter unmethylation occurred more frequently in systemic lupus erythematosus (SLE) and rheumatoid arthritis(RA) than in controls.
24859835 ESR1 rs9340799 polymorphism was associated with prostate cancer risk in overall populations
24857745 the PvuII variant was negatively associated with Alzheimer disease in the Caucasian population
24851606 The loss of both hormone receptors in carcinoma cells and loss of PGR in the myometrium was a predictor of a more aggressive type of endometrial cancer and a poor prognosis.
24848085 there is an independent positive association between burden comorbidity and breast cancer with estrogen receptor expression
24833090 strong associations between ERalpha/ERbeta methylation and ER, PR, and HER2 status, tumor size, clinical stage, and triple negative tumors.
24829062 The x allele of rs9340799 might have a protective effect on the risk of Alzheimer disease (AD) in Asia and in patients with sporadic AD (SAD). In addition, the p allele of rs2234693 might decrease the risk of patients with SAD. [Meta-Analysis]
24828673 MiR-4728-3p regulates expression of estrogen receptor alpha.
24825747 Oral squamous cell carcinoma cells expressed functional ERa whose Ser118 phosphorylation and transcriptional activity were enhanced by FAK/AKT signaling, leading to promoted cell growth
24824712 Association of ESR1 gene polymorphism with preterm rupture of fetal membranes.
24823458 The ESR1 rs9340799 genotype may modify the ischemic arterial disease risk related to high endogenous estrogens levels in older postmenopausal women.
24818995 Insulin-induced apoptotic commitment depended on the down-regulation of Erk-1, insulin growth factor-1 receptor (IGF-1R), and fibroblast growth factor receptor-1 (FGFR-1)-mediated signaling.
24815444 methylation of promoter sites of ESR1 and PGR is a relatively uncommon event in ductal and lobular breast cancer, the determination of epigenetic states of ESR1 and PGR could represent an alternative or complement to histopathological expression analysis
24789043 E2 promoted the binding of ERalpha to the EREs (estrogen-response elements) of CLOCK promoter, thereby up-regulating the transcription of CLOCK
24786296 Our data strongly demonstrated that ER1 was able to increase drug resistance of breast cancer cells through activating MDR1 transcription.
24785095 Both OPG and progesterone receptor are independently associated with good prognosis in ER positive breast cancer.
24772998 ESR1 genetic polymorphisms may contribute to the development of cerebral infarction, especially in the female population. [Meta-analysis]
24772413 ESR1 gene is considerably associated with knee Osteoarthritis etiology in the Chinese Han population.
24768427 Estrogen receptor expression and vessel density in the vagina wall in postmenopausal women with prolapse.
24758408 This may have profound implications for the anti-estrogen treatment of ER-positive breast cancers that have increased levels of EGFR.
24756215 ESR1 amplification is not a key genetic abnormality in the tumorigenesis of breast cancer in Taiwan.
24755315 We conclude that ER expression can be understood as a Darwinian process and linked to variations in estrogen delivery by temporal and spatial heterogeneity in blood flow
24742914 PRMT6 specifically interacts with ERalpha at its ligand-binding domain.
24737323 TTP acts as a bona fide ERalpha corepressor and suggest that this protein may be a contributing factor in the development of E2-dependent tumors in breast cancer.
24732579 ESR1 polymorphisms affect age of onset of AD in women, and risk alleles vary by ethnicity.
24725156 ESR1 intramolecular interactions in agonist and antagonist conformations have been elucidated.
24705910 ERalpha and ERbeta genetic variants were associated with ovarian response to standard gonadotropin stimulation of women undergoing in-vitro fertilization affecting mainly the follicular growth.
24684970 The ratio of ER-alpha and PR-A expression in the epithelial glands and the stroma of endometrioid carcinoma biopsies may serve as an additional parameter in the histological evaluation.
24680642 Results indicate a combination of decreased expression of ERs, AR and SRC-3 but not SRC-1 may be involved in the tumorigenesis of gliomas, ERalpha/SRC-3 axis may play central role in the regulation these tumors.
24674832 estrogen receptor expression was positively correlated with lymphovascular space invasion in high-grade serous ovarian carcinoma. This study emphasizes the importance of estrogen pathway in promoting lymphatic or vascular spread of ovarian neoplasms.
24667714 CONCLUSION: TargetPrint and local assessment of ER, PgR, and HER2 show high concordance with central assessment in the first 800 MINDACT patients.
24647635 Polymorphisms in the ESR1 gene may have differential roles in the predisposition to male infertility according to the different ethnic backgrounds.
24639548 unliganded ERalpha participates, together with other factors, in the maintenance of the luminal-specific cistrome in breast cancer cells.
24619425 Data indicate that Fe65 is a positive estrogen receptor alpha (ERalpha) transcriptional regulator.
24615515 The associations between LKB1 expression and the methylated form of ERalpha (metERalpha), Src and PI3K, have been analyzed both in cultured cells and in 154 primary breast tumor samples.
24614816 ER-alpha-related bioinformatic data was integrated at different levels to systematically explore the mechanistic and therapeutic implications of ER-alpha.
24607813 ERalphaA87 mutation reduces the transactivation efficiency of ERalpha on an ERE reporter gene.
24603706 In response to the elevated levels of Estrogen, the ERa signaling was accentuated in the ovarian epithelial cells of ERalphad/d mice, triggering increased ERa-dependent gene expression, abnormal cell proliferation, and tumorigenesis
24601884 Data suggest that expression of ESR1 in omental adipose tissue (collected at term Cesarean section) is down-regulated in subjects with gestational diabetes mellitus; expression of MIRN222 is up-regulated in these tissue samples.
24601830 the results implicate the XbaI and PvuII polymorphisms of the ESR1 gene as possible disease-modifying factors in dermatomyositis in relation to the clinical manifestations.
24599688 A meta-analysis suggests that the ESR1 PvuII polymorphism has an important role in coronary artery disease susceptibility.
24594358 Data indicate that irect estrogen receptor alpha (ERalpha) methylation by histone methyltransferase SMYD2 regulates estrogen signaling.
24586459 ERalpha intracellular concentration is an important target through which endocrine disruptors hamper the hormonal milieu of E2 target cells driving cells to different outcomes or mimicking E2.
24584714 meta-analysis revealed that the G allele in the XbaI polymorphism of estrogen receptor alpha was associated with a statistically significant increase in the risk of prostate cancer
24577825 Our results indicate that a greater number of dinucleotide repeats in the promoter region of ESR1 is associated with a significantly increased likelihood of lone atrial fibrillation in men.
24570392 PR frequently prevails over ER in pulmonary lymphangioleiomyomatosis
24568551 Estrogen receptor 1 gene PvuII and XbaI polymorphisms were associated with unexplained recurrent spontaneous abortion in a Chinese Han population.
24567374 Trim21, an estrogen receptor coactivator, induces MYC oncogene by removing repressive CoAA through E2-dependent degradation of CoAA.
24565681 There are comparable levels of EESR1, total ERK1/2 and active ERK1/2 in the stroma and epithelium of proliferative phase endometrium.
24558373 ER-alpha36-mediated rapid estrogen signaling plays an important role in regulation and maintenance of ER-positive breast cancer stem/progenitor cells
24550401 IQGAP1 binds to ERalpha and modulates its transcriptional function
24523574 TT variant of estrogen receptor alpha polymorphism may be associated with enhanced inflammatory response
24508513 Estren and ginsenoside Rg1 activate ESR1 via phosphorylation at Serine 118 in a ligand-independent manner.
24502950 Data show that erythropoietin receptor (EPOR) protein is expressed in breast cancer cells, where it appears to promote proliferation by an EPO-independent mechanism in estrogen receptor alpha (ERalpha) expressing breast cancer cells.
24498137 miR-222-3p plays a significant role in the regulation of ERalpha expression and could be potential targets for restoring ERalpha expression and responding to antiestrogen therapy in a subset of ECs.
24495356 Silencing, by methylation, of the promoter region of the ESR1 affects the expression of the estrogen receptor protein in tumors of breast cancer patients; high methylation of ESR1-DNA is associated with estrogen receptor negative status which.
24495253 Impairment of ERalpha signal-mediated OLFM4 expression promoted the malignant progression of endometrioid adenocarcinoma.
24486245 ERbeta and CXCL12/CXCR4 expression in lung adenocarcinoma depends on sex and hormonal status, which may partly explain the sex and hormonal differences in lung cancer behavior.
24485503 [review] Estrogen resistance due to mutations in the estrogen receptor alpha (ESR1) gene have been described. Their clinical presentations are similar to that of aromatase-deficient men and women.
24482673 ESR1 PvuII T allele may increase the risk of hip fracture and that the XbaI polymorphism is not associated with hip fracture
24481879 Our findings suggest that ESR1 and C6orf97 gene polymorphism is associated with fracture and vertebral fracture risk in Chinese postmenopausal women.
24481237 The present study aimed to gain further insight into the DNA methylation patterns of alternative promoters of the steroid receptor genes ESR1, ESR2 and PGR in intestinal deep endometriosis.
24475282 Immune escape mechanisms in ERalpha breast cancer may be facilitated through an ERalpha suppressive mechanism on IFN-gamma signaling.
24471565 PKM2 acts as a transcriptional coactivator for ERalpha and small-molecule PKM2 activators inhibit ERalpha transcriptional activity and reduce E2-induced cell proliferation.
24464625 Overexpression of DNMT1/3a was correlated with promoter hypermethylation and reduced expression of estrogen receptor-alpha and BRCA1.
24452315 FOXA1 is a tumor suppressor in endometrial cancer and has a possible interaction with estrogen receptor alpha.
24449868 The data show a clear difference in ER expression between lobular and ductal breast cancer.
24449583 Regulation of TRIM-21 expression occurs through an ERalpha-dependent mechanism, a pathway that was observed to be overactive in SLE patients.
24442344 Results demonstrate that degradation of proteins such as ESRa expressed in activated blastocysts is involved in successful implantation.
24441044 SUPT6H is a new epigenetic regulator of ERalpha activity and cellular differentiation.
24441041 RNF31, via stabilizing ESR1 levels, controls the transcription of estrogen-dependent genes linked to breast cancer cell proliferation.
24434785 Methylation status of DNA sequences at ERalpha binding sites is tightly coupled with ERalpha activity.
24430361 SNPs in ESR1 (rs2234693), ESR2 (rs2987983), CYP17A1 (rs743572), and CYP19A1 (rs700519) indeed contribute to breast cancer susceptibility among North Indian women.
24427778 An association between ESR1 rs9340799 polymorphism and infertile women with endometriosis.
24422630 ESR1 repression by SENP2 is independent of its SUMO protease activity.
24416430 In aP2-Cre/ERalpha(flox/flox) mice, increased serum estrogen levels cause over-stimulation in the uterus.
24414486 meta-analysis indicated elected PvuII polymorphism of ER-alpha was a risk factor for prostate cancer development
24413532 MTA1-TFAP2C or the MTA1-IFI16 complex may contribute to the epigenetic regulation of ESR1 expression.
24410765 Letrozole was effective for ovarian cancers with abundant expression of ERalpha. Inhibition of angiogenesis and of ascites production appeared to contribute to prolongation of the survival period.
24398991 The values and the distribution of the ER and PR taken from the biopsies made in the patients with mammary carcinoma are influenced by the age and menopausal status.
24398047 we show evidence for the temporal selection of functional ESR1 mutations as potential drivers of endocrine resistance during the progression of ER(+) breast cancer.
24395301 Authors first report that these SNPs (rs2077647, rs9340799, rs2234693, rs1801132 and rs2228480) in estrogen receptor alpha can influence the outcomes of hepatitis C in a high-risk Chinese population.
24395109 ALTTO ineligibility did not change when HER2 testing was performed ... a dual antibody ER assay had fewer false-negative test results than an assay with a single antibody.
24389498 Rs9340799 of ESR1 and one haplotype formed by the two polymorphisms of the ESR1 were significantly associated with bone mineral density in postmenopausal Mexican-mestizo women.
24380700 ESR1-positive epithelial ovarian cancer tissues had lower expression of lnRNAs compared to ESR1-negative tissues.
24377599 ESR1 polymorphisms are associated with susceptibility to breast cancer.
24376711 PHB lies downstream of ERalpha and mediates estrogen-dependent Paclitaxel resistance signaling cascades
24376209 PES1 may play important role in the progression of ovarian cancer by inversely regulating the ERalpha and ERbeta expression.
24375531 genistein treatment produces cell cycle arrest and an improvement of mitochondrial functionality in T47D cells with a low ERa/ERb ratio, but not in MCF-7
24374826 Estrogen receptor alpha in cancer-associated fibroblasts suppresses prostate cancer invasion via modulation of thrombospondin 2 and matrix metalloproteinase 3.
24372587 ER and HER2 are useful markers in core needle biopsies, providing a reliable base for preoperative decisions in neoadjuvant chemotherapy, and may be omitted on surgical specimens with certain precautions and exceptions.
24366551 PRKCA activity suppresses the level of ER-alpha expression by inhibiting c-JUN phosphorylation.
24366110 Overexpression of estrogen receptor alpha and beta enhances endometrial carcinoma cell migration, invasion and proliferation.
24340027 results demonstrate that, while ER signaling acts synergistically with Wnt3A in promoting osteogenic differentiation, Wnt3A may crosstalk with ER signaling by up-regulating ERalpha expression and down-regulating ERbeta expression in MPCs.
24335662 ER-alpha expression in uterine serous carcinoma is associated with advanced stage tumors and a significantly worse prognosis
24335340 Adiponectin modulates breast cancer cell growth, providing evidences on the cell-type dependency of adiponectin action in relationship to ERalpha status.
24322303 serum ERalpha-mediated bioactivity is associated with increased breast cancer risk in post-menopausal women
24322014 calretinin immunoexpression and the hormonal status for estrogen receptors (ER), progesterone receptors (PR), and ERRB2, in 33 cases of cutaneous metastases of ductal breast carcinoma, as well as in seven primary cutaneous apocrine tumors, were studied
24304549 NCOA3 is a selective co-activator of estrogen receptor alpha-mediated transactivation of PLAC1.
24283290 Data suggest that ESR1 (estrogen receptor 1) regulates cell cycle by suppressing expression of p53/p21 (tumor protein p53/cyclin-dependent kinase inhibitor 1A protein) and up-regulating proliferating cell nuclear antigen (PCNA).
24282178 Neither the haplotype nor the three ESR1 SNPs were associated with EDs, BN, AN, or restricting type AN.
24269135 Studies indicate that changes in oestrogen receptor (ER), progesterone receptor (PgR) and epidermal growth factor receptor 2 (HER2) expression may occur during the natural history of breast cancer.
24266697 Variations in the ERalpha gene affected the BMI in women with High breast density, who already are at increased risk for Breast Cancer.
24228243 The potential association of spontaneous abortion with the ESR1 gene variations (PvuII and XbaI) in fetal tissue, was studied.
24227889 These studies thus identified PTPH1 as a novel ER phosphatase and further demonstrate a therapeutic potential of enhancing breast cancer sensitivity to antiestrogens through dephosphorylating ER by PTPH1.
24223909 Data indicate that the Cyclopia extracts displayed estrogen receptor alpha (ERalpha) antagonism and estrogen receptor beta (ERbeta) agonism when ER subtypes were expressed separately, however, when co-expressed only agonism was uniformly observed.
24223763 NgBR is highly associated with ESR1-positive/HER2-negative breast cancer.
24217905 The expression of both ERalpha and ERbeta in human fetal brown adipose tissue suggests a role for estrogen in its development, primarily via ERalpha.
24217577 Experiments in breast cancer cells indicated constitutive, ligand-independent transcriptional activity of the D538G estrogen receptor, and overexpression of it enhanced proliferation and conferred resistance to tamoxifen.
24192230 This study provides a deeper understanding of ERbeta's role in breast tumors that coexpress both ERbeta and ERalpha and supports an emerging bi-faceted role of ERbeta.
24189439 IL-6 secreted by ovarian cancer cells may contribute to the refractoriness of these cells to tamoxifen via the estrogen receptor alpha isoform and SRC-1 (NCOA1).
24188405 The discovery of sub-isoforms of ER alpha and beta has further complicated our understanding of how the interaction between ERs and its ligands contribute to the development of disease
24185512 Ligand-binding domain mutant forms of ESR1 mediate clinical resistance to hormonal therapy.
24185510 Activating mutations in ESR1 are a key mechanism in acquired endocrine resistance in breast cancer therapy.
24174373 Data show that estrogen receptor 1 (ESR1) mRNA as assessed by qPCR represents a reliable method for detecting ESR1 expression in non-small cell lung cancer (NSCLS) and that ESR1 expression is an independent prognostic factor in metastatic NSCLC.
24166501 Aurora-A represents a prognostic marker in ESR1-positive tumor and a critical therapeutic target in tamoxifen-resistant breast cancer.
24162602 It mediates direct and indirect regulations in bone metabolism.(review)
24162264 marker of main subtypes of invasive breast cancer in China
24162262 Immunohistochemical expression of ERalpha, ERbeta, and TFF1 in type I and II ovarian tumors.
24155906 No association was found between ESR1 XbaI or ESR1 PvuII single nucleoptide polymorphism and idiopathic scoliosis in Caucasian females.
24150894 A significant effect of ESR1 genotypes was observed for the donepezil-treated alzheimer patients, among which those carrying at least one copy of P and X alleles showed a significantly lower cognitive decline than the noncarriers.
24142535 It was concluded that estrogenic signals exert malignant transformation capacity of cancer cells, exclusively through non-genomic regulation in female germ cell tumors.
24140101 Genetic variants in ERalpha were not associated with metabolic syndrome or its components, in a group of 250 Lebanese Caucasian elderly participants, a group with a high prevalence of metabolic syndrome.
24133901 ERalpha XbaI polymorphism is associated with an increased risk of Alzheimer's disease in Chinese population
24127041 Our results provide additional insights into the opposing roles of the ESR1 and FLJ43663 genes in breast cancer onset and progression.
24126791 the present study demonstrated that both ERa and ERbeta were sufficient to inhibit PPARgama and provide a valuable therapeutic option for the treatment of Hepatocellular carcinoma patients.
24125069 Hbo1 modulated transcription by estrogen receptor-alpha. Hbo1 contributes to degradation of ER-alpha by ubiquitination through lysine 48.
24121066 Estradiol mediated phosphorylation of ESR1 is mechanism to potentiate transcription from an estrogen response element.
24114857 Progesterone receptor and estrogen receptor alpha expression are discordant in different distant breast cancer metastases.
24106242 Meta-analytically combined evidence from the present genotyping and the literature showed that rs2295193 polymorphism in ESR1 is not a major genetic susceptibility factor in Anorexia Nervosa.
24103020 similarly to the situation for the ovary, a diagnostic panel of HNF-1beta and ER may be considered for separating clear cell carcinoma from endometrioid and serous carcinoma of the endometrium
24101509 Data suggest that SMYD2-mediated estrogen receptor alpha (ERalpha) protein methylation and p300/cAMP response element-binding protein-binding protein-dependent ERalpha acetylation play an important role in the estrogen-induced gene expression profiles.
24101215 Our results demonstrate the predictive value of the RS for clinical response to neoadjuvant exemestane therapy in postmenopausal women with estrogen receptor-positive breast cancer.
24101172 ERalpha and ERbeta levels were inversely correlated, and the downregulation of ERalpha and upregulation of ERbeta may indicate unfavorable prognosis of esophageal squamous cell carcinoma
24099775 these results demonstrate that knockdown of HOXA7 in MCF7 cells significantly decreased cell proliferation and ERa expression.
24096540 RhoA and RhoC play different, but clear, roles in ERalpha signaling in breast cancer cells.
24086615 Mutations of putative estrogen receptor alpha and/or nuclear factor Y binding sites markedly reduced promoter activity.
24062311 The loss of TBK1 expression parallels the loss of ERalpha expression, in turn helping drive an aggressive breast cancer phenotype.
24058649 CTCs frequently lack ER expression in metastatic breast cancer patients with ER-positive primary tumors and show a considerable intra-patient heterogeneity, which may reflect a mechanism to escape endocrine therapy.
24058548 anti-ERalpha antibody serum immunoreactivity was detected in 42% of patients with systemic sclerosis.
24055055 Estrogen-receptor-positive PDXs were associated with ESR1 ligand-binding-domain mutations, gene amplification, or an ESR1/YAP1 translocation.
24054032 Did not find any significant correlation between ER-alpha expression and histopathological and biochemical findings in chronic hepatitis C patients.
24053619 data suggest that signal peptide CUB domain (SCUBE2), like in breast cancer, associates with estrogen receptor alpha and might have a potential as prognostic or predictive marker in endometrial cancer
24051224 The GFP-GRER exhibited cytoplasmic localization in the absence of ERalpha ligands and translocated to the nucleus in response to stimulation with ERalpha agonists and antagonists
24047697 The estrogen receptor alpha is the key regulator of the bifunctional role of FoxO3a in breast cancer motility and invasiveness.
24045439 Knockdown of TFAP2C or RET inhibited activation of ERK and AKT in MCF-7 cells. Knockdown of TFAP2C, which controls ESR1 (estrogen receptor) and RET, had a greater effect on cell growth than either RET or ESR1 alone.
24023309 ESR1 amplification is independent of known clinicopathological factors related to poor prognosis and PTEN, p53, HER2, MLH1, and ARID1A protein expression, suggesting ESR1 amplification may be an early event in endometrial carcinoma development.
24021827 The expression of the estrogen receptor was found in 18% of salivary duct carcinoma patients.
24015958 Expression of HER4 JM-a/CYT2 isoform relate to survival of bladder cancer patients only if the tumors do not express ESR1.
24015267 chronic cadmium exposure stimulates the expression of SDF-1 by altering the molecular interactions between ERalpha, c-jun and c-fos.
24009311 Findings suggest a novel pathway in which ERalpha signaling regulates miR-190a expression, causing inhibition of PAR-1 expression, correlated with inhibition of cancer metastasis in breast cancer.
23996526 Significantly increased estrogen receptor level was found in patients with juvenile angiofibromas.
23991038 Data indicate that ZNF703 overexpression in MCF-7 breast cancer cells activated the Akt/mTOR signaling pathway, downregulated ERalpha, and reduced the antitumor effect of tamoxifen.
23977306 1p11-rs11249433 polymorphism is involved in breast cancer susceptibility and confer its effect primarily in estrogen receptor-positive and progesterone receptor-positive tumors.
23951298 ESR1 gene dosage in the entire group of breast cancer patients correlated with higher T stage and lymph node involvement.
23950888 MEK5/ERK5 signaling suppresses estrogen receptor expression and promotes hormone-independent tumorigenesis.
23932494 ESR1 rs2234693 and rs9340799 were not significantly associated with the risk of decline on any of the cognitive tasks.
23925045 motivate a cooperation model of ESR1 and SP1 in regulating cell cycle arrest, and a hypothesis that their overactivation in non-hyperdiploid multiple myeloma disrupts proper regulation of cell cycle arrest
23923078 the results show that the cervical malignant cells tend to loss the ER-alpha but maintain the ER-beta actively expressed
23923010 ESR1 gene deletion and amplification do not constitute per se prognostic markers, instead they can be classified to distinct prognostic groups according to their protein-mediated functional status.
23917948 Our results support a role for ESR1 in the etiology of PPD, possibly through the modulation of serotonin signaling.
23915851 Genotypes of these single nucleotide polymorphisms of ESR1 and RANKL may help us predict the osteoporosis risk in menopausal women.
23913373 Results suggest a possible role of ERalpha in male infertility.
23874775 Transcription factor Ets1 cooperates with estrogen receptor alpha to stimulate estradiol-dependent growth in breast cancer cells and tumors.
23873111 Data indicate that receptors (ERs) ERalpha and ERbeta showed significantly decreased mRNA and protein expression levels in endometrial carcinoma as compared to normal endometrium.
23868472 Retinoic acid receptor alpha may be a novel therapeutic target and a predictive factor for estrogen receptor alpha-positive breast cancer patients treated with adjuvant tamoxifen.
23867501 LXRbeta has nonnuclear function in endothelial cell caveolae/lipid rafts that entails crosstalk with estrogen receptor alpha.
23867117 study suggest that SNPs in sex steroid related genes, known to affect gene expression (rs2747648 in ESR1) and enzymatic activity (Leu89Val in SRD5A2), seem to be associated with ALTs in a general population.
23861392 Mediator of ERBB2-driven cell motility (MEMO) promotes extranuclear estrogen receptor signaling involving the growth factor receptors IGF1R and ERBB2.
23860318 Specific binding of ER (alpha and/or beta) to ERETTR was demonstrated by EMSA and supershift assays confirmed the binding to ERalpha and/or ERbeta
23859042 Pumpkin seed extract downregulates ER-alpha and upregulates progesterone receptor in the MCF-7 breast cancer cell line.
23843035 ERalpha overexpression significantly inhibited cell growth and proliferation, blocked cell entry into the G1/G0 phase and promoted cell apoptosis.
23829397 Glucose-regulated protein 94 is a downstream effector of ER-alpha36-mediated oestrogen signalling, and may be involved in ER-alpha36 function during gastric carcinogenesis.
23825704 the expression of ERalpha prevents cells from apoptosis
23822672 Frequencies of p and x alleles in ER-alpha gene PvuII and XbaI polymorphisms were more prevalent among fertile men compared with infertile oligoasthenoteratozoospermic men.
23821363 These results clarify the relationship between ER-alpha and PDZK1, propose a direct relationship between PDZK1 and IGF1R, and identify a novel oncogenic activity for PDZK1 in breast cancer.
23814048 The recruitment of GR to ERalpha-binding regions (EBRs) requires assistance from ERalpha and FOXA1 and is facilitated by AP1 binding within the EBRs.
23812730 Data indicate that in breast cancers with no lymphatic metastasis, the expression of HtrA3 was lower in patients with estrogen receptor (ER)- and progesterone receptor (PR)-positive tumors.
23810008 Data suggest that FOXP1 (forkhead box P1) and FOXA1 (forkhead box A1) are primary ESR1 target genes and critical transcription factors that regulate ESR1 activity in breast cancer. [REVIEW]
23810005 Data suggest that ESRA activity is modulated in breast cancer via various mechanisms: transcriptional regulation, microRNA deregulation, and posttranslational modifications.
23809427 A significant difference in the allele frequencies of XbaI.
23805834 The two ESR1 SNPs, Pvu II and Xba I, are not commonly associated with premature ovarian failure in Serbian women and may not contribute to the genetic basis of the condition.
23774759 Estrogen receptors alpha and beta and their key coregulators, SRC3 and RIP140, generate overlapping as well as unique chromatin-binding and transcription-regulating modules.
23770852 This work not only identifies these late-activated genes as bona fide ERalpha targets but describes a novel mechanism for their periodic activation.
23763623 There was no association between the PvuII polymorphism and stroke severity and short-term outcome in the studied female stroke population.
23762395 AIB1 exerted its effect on epithelial mesenchymal transition through its interaction with ERalpha, which could directly bind to the ERalpha-binding site on the SNAI1 promoter.
23749764 Estrogen receptor alpha expression is upregulated in the surrounding ovarian tissues of patients with endometrioma compared to controls.
23749503 The PvuII polymorphism in the ESR1 gene may be a risk factor for uterine leiomyoma. [Meta-analysis]
23747343 Estrogen receptor-alpha mediates multidrug resistance associated protein 3 expression following 17alpha-ethynylestradiol administration.
23741969 The risk factors for breast cancer were more prevalent in women with high breast density but without significant associations with ESR1 polymorphisms.
23737135 The aim of this study was to evaluate the effect of two polymorphisms in the estrogen receptor alpha, PvuII and XbaI, on the development of prostate cancer within Slovak population.
23733894 overexpression of ERalpha mediates apoptosis in ERalpha-negative Hep3B cells by the binding of ERalpha to SP1 protein.
23714156 show gender-specific transcriptional control of UGT1A genes in jejunum and colon, which is repressed by ERalpha and the recruitment of HDCA 1 and 2 to the UGT1A promoter sequence in females
23709055 Negative estrogen receptor status was strongly associated with locoregional recurrence after accelerated partial breast irradiation in early-stage invasive breast cancer.
23707549 Hepatic nuclear ER-alpha expression percentage (staining index) is lower in patients with nonalcoholic steatohepatitis when compared to simple steatosis and normal liver.
23704881 Estradiol and IGF-I induced the rapid association of ER to IGF-IR.
23695389 The ESR1 gene was identified as a candidate tumor suppressor gene in HCC and further validation is warranted.
23690166 Lower expression of ER-alpha66 is associated with the development of endometrial hyperplasia in polycystic ovarian syndrome patients.
23687977 Data show that the expressions of ER-alpha, PR, LIF, VEGF, iNOS and CB1 in fallopian tube and chorionic villi of tubal pregnancy were not altered by exposure to levonorgestrel emergency contraception.
23681011 Studies indicate that the biosensing strategy is based on the protection of DNA duplex from exonuclease III (Exo III)-mediated digestion by specific binding of estrogen receptor (ER) to its DNA response element.
23678541 Expression of JMJD2A in infiltrating duct carcinoma is higher than in fibroadenoma, and is associated with ARHI, p53 and ER
23676274 Mutation of the penultimate Threonine of ERalpha (T594) strongly enhances estradiol-dependent dimerization and transactivation.
23674830 A total of 10 markers in the ESR1 gene show association with migraine in a Norfolk Island pedigree.
23668054 Expression of the progesterone and Estrogen Receptors can significantly affect therapeutic decisions in selected patients with endometroioid endometrial cancer.
23666105 ERalpha gene XbaI polymorphism may modify individual susceptibility for breast cancer in a Portuguese population.
23665993 Data indicate that the menstrual cyclic expression of bcl-2 could be controlled by either direct binding of estrogen receptor alpha (ERalpha) to estrogen-responsive element (ERE) in the c-Jun promoter or the interaction of ERalpha with c-Jun.
23644255 Variants in ESR1 and PARP1 modify effect of passive smoking on breast cancer risk.
23636943 ESR1 can bind to genomic locations with closed chromatin, inducing chromatin opening in an estradiol-dependent manner.
23625281 ER, COX-2 and aromatase are expressed in endometrial neoplasms, suggesting their involvement in tumor development and progression
23620292 The results suggest that the G-quadruplex formation in the coding region of the hERalpha mRNA impacts folding and proteolysis of hERalpha protein by slowing down or temporarily stalling the translation elongation.
23614677 Results suggest that the polymorphisms of ESR1, ESR2 and FSHR genes did not result in differences in the genotype distribution when obese non-polycystic ovary syndrome population were compared with the non-obese population
23609470 these findings demonstrate that ERalpha is a major driver of growth in tamoxifen-resistant breast cancer cells
23593326 PvuII (C>T) and rs3020314 (C>T) polymorphisms in estrogen receptor 1 may be risk factors for endometrial cancer
23591816 Impairment of ERalpha association to ubiquitinated species strongly affects E2-induced ERalpha transcriptional activity.
23585209 The scanning and typing of ERalpha polymorphism in girls with precocious puberty has uncovered several potentially meaningful polymorphisms.
23584859 Findings suggest that estradiol and T regulate arginine-vasopressin (AVP) expression in SH-SY5Y cells through ERs, exerting a stimulatory action via ERalpha and an inhibitory action via ERbeta.
23583297 Study provides further evidence of functional interplay among NRF2, AHR and ERalpha signaling pathways through altered p300 recruitment to NRF2-regulated target genes.
23580588 ERa and pAR210 are differentially expressed in hormone-naive (HN) and castration-resistant prostate cancers and that high levels of AR, ERb and pAR210 in HN prostate cancer correlate with a poor clinical outcome.
23580323 findings show ESR1 is an independent positive prognostic factor for survival in early-stage non-small cell lung cancer patients; patients with ESR1 high tumors did not benefit from adjuvant chemotherapy
23576398 Wanted to identify estrogen receptor alpha (ERalpha) interacting proteins in Tamoxifen treated MCF7 cells. Using a GST-pull down assay with ERalpha ligand-binding domain and MS-based proteomics approach we identified Profilin1 as a novel ERalpha interacting protein.
23570281 ER+ /PR+ /TFF3+ /IMP3- immunoprofile distinguishes endometrioid from serous and clear cell carcinomas of the endometrium.
23567436 study showed association between ESR polymorphisms and cognitive decline or specific areas in cognitive profile.
23559367 present study reveals that neither PvuII nor XbaI polymorphisms in the estrogen receptor alpha gene are associated with onset and progression of puberty
23546602 Data suggest that 17 beta-estradiol enhances the the glucose uptake, activates PI3K/Akt signaling pathway, leading to translocation of glucose transporter 4 to the plasma membrane in an ERalpha-dependent manner.
23546601 Results indicate that elevated ER-alpha36, a variant of ER-alpha, concentration is one of the mechanisms by which ER-positive breast cancer cells escape tamoxifen (TAM) therapy.
23546553 an intronic variant in ESR1 (rs9322336) was associated with increased risk of musculoskeletal toxicity-related exemestane discontinuation in breast cancer treatment
23542176 As Pin1 impacts both ERalpha protein levels and transactivation function, these data implicate Pin1 as a potential surrogate marker for predicting outcome of ERalpha-positive breast cancer
23526455 Estrogen receptor alpha regulatory mechanisms in breast cancer gene expression.
23525242 Data suggest that the ERalpha status of mammary cells dictates whether KISS1R may be a novel clinical target for treating breast cancer metastasis.
23524984 ligand dynamics directs unique signaling pathways and reveals a new role of the DBD in allosteric control of ERalpha-mediated signaling
23522078 PvuII polymorphism (rs2334693) is associated with diminished ovarian reserve.
23515291 IGFBP-2 not only modulates IGFs and directly regulates PTEN but also has a role in maintaining ER-alpha expression.
23506158 ESR1 single nucleotide polymorphism is a predictor of diabetes mellitus, type 2 in hypogonadal men.
23499841 Glutathione peroxidase, Complex V, Complex III, Complex II, Complex IV, AKT, SAPK, and ERalpha were significantly and positively correlated with ERalpha/ERbeta ratio
23499324 MCF-7/tamoxifen resistant cells possess overexpressed ER-alpha 36 and EGFR, but down-regulated ER-alpha 66.
23497414 Haplotypes consisting of these two polymorphisms in ESRalpha may be strongly associated with schizophrenia
23494590 There is an association between ESR1 polymorphisms and some ART parameters such as the level of E2 on the day of hCG administration and the quality of the embryos.
23493373 In female mice, perinatal exposure to low dose of BPA resulted in increased ERalpha mRNA expression and high fat diet resulted in elevated ERalpha expression among females that were exposed to the high dose of BPA early in life. There were no changes in males.
23474223 ER alpha and ER alpha-isophorm 36 estrogenic transcriptional effects are opposite.
23471591 meta-analysis of 10 studies involving Chinese Han population suggests the CC genotype of the ESR1 rs2234693 polymorphism is significantly associated with increased risk of coronary heart disease(CHD)in males only; there was no evidence of a significant association between the ESR1 rs9340799 polymorphism and CHD risk
23468243 ESR1 is associated with a distinct tumor subtype defined by estrogen receptor-negative status in male breast cancer patients in Italy.
23467929 The suppression of ERalpha by the upregulation of let-7 expression may be a promising strategy.
23463097 Data show that ER-alpha (nuclear) was detected in only 4 (9 %) of patients and not statistically significant, and presence of ER-beta (nuclear) was associated with favourable survival, whereas the presence of ER-beta (cytoplasm) was associated with a poor survival.
23450473 polymorphisms of rs3798759 may be a risk factor for female patients with schizophrenia, and haplotypes C-A-G and C-G-G may be risk factors for schizophrenia.
23437920 In this study ribosome display has been used to reassess the estrogen receptor alpha and beta for new and enlarged peptide recognition motifs, leading to the discovery of a potent and highly evolved PXLXXLLXXP binding consensus.
23403054 ERalpha is a positive regulator of Runx2-I transcription.
23402757 HDAC3 is necessary for ERalpha mRNA stability, and is involved in the estrogen-dependent proliferation of ERalpha-positive tumors.
23397283 our results suggest that the detection of ESR1/PGR/ERBB2 mRNA levels by RT-QPCR is a better approach for subtyping breast cancer and predicting the prognosis.
23391338 Response to trastuzumab is correlated to HER2 mRNA levels only in ESR1-positive tumors. This study adds further evidence to the different biology of both subsets within the HER2-positive group.
23390529 The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor alpha in breast cancer.
23362266 Estrogen receptor alpha mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor beta
23350368 The article reviews the relationship between polymorphism of sex hormone-related genes (CYP17, CYP19, CYP1A1, COMPT, ERalpha, ERbeta and others).
23342282 Moreover, subgrouping of Luminal A-type breast cancer samples according to ERE activity revealed that ERalpha mRNA expression correlated with ER target gene mRNA expression in the high-, but not the low-, ERE-activity group.
23342072 The study indicates a positive link between hNIS and ER expression in breast cancer.
23339407 Taken together, our findings offer evidence that in human breast cancer RhoB acts as a positive function to promote expression of ERa and PR in a manner correlated with cell proliferation.
23338998 Genetic predispositions and the short- and long-term effects of hormonal therapy on bone mineral density in girls with functional hypothalamic amenorrhoea.
23328702 Short-term folate supplementation in physiological doses decreases plasma homocysteine but has no effect on ESR1 and MLH1 methylation in colonic mucosa of individuals with adenoma.
23324193 The expression of ER protein in superficial and deep ectopic tissues was significantly lower than in eutopic tissues of adenomyosis.
23322423 Epigallocatechin gallate downregulates ER-alpha and explains the inhibitory action of EGCG on the proliferation of ER+ PR+ cancer cells tested.
23319822 Lack of estrogen receptor-alpha is associated with epithelial-mesenchymal transition and PI3K activations resulting in endometrial carcinoma.
23307470 WNT10B/beta-catenin signalling induces HMGA2 and proliferation in metastatic breast cancer tumours devoid of ERalpha, PR and HER2 expression.
23305873 Data indicate that the prognostic value of Akt2 increases with higher oestrogen receptor (ER) expression, motivating further mechanistic studies on the role of Akt2 in ER+ breast cancer.
23285017 The expression of deltaEF1 is up-regulated by 17beta-estradiol (E2) in MCF-7 cells in an ER-alpha-dependent manner.
23277184 the first immunohistochemical study of the MIER1alpha protein expression pattern in human tissues, is reported.
23273711 ESR1 gene and insulin resistance remission are associated with serum uric acid decline for severely obese patients undergoing bariatric surgery
23272245 Our results provide strong evidence to support that the common polymorphism near the ESR1 gene, rs2046210, is associated with an increased risk of breast cancer in Asian and European populations but not in Africans.
23271418 we identified Caspase 3, BAG1 and BAG3 as key targets of ERalpha in neuronal cells that may play a role in ERalpha-mediated neuroprotection.
23268322 The frequency of ESR1 amplification in breast cancer is low when measured by FISH in large sections. ESR1 gain and amplification in breast cancer may be associated with older age and poorer outcomes.
23267128 Identifying novel kinases which modulate Estrogen Receptor alpha activity is relevant to therapeutics. LATS2 modulates Estrogen Receptor alpha-regulated gene transcription, through direct and/or indirect interactions with Estrogen Receptor alpha.
23257935 Estrogen receptor-alpha36 may be an important biomarker for diagnosis, prognostication, and treatment choice in endometrial carcinoma.
23250869 The findings reveal a tumor suppressive role of hsa-miR-196a2 through regulation of TP63 by ERalpha and/or ERK2 signaling.
23248117 Data indicate there was a HIF-1alpha-dependent cancer stem cell (CSC) increase in ER-alpha-positive cancers following hypoxic exposure.
23245353 genetic association studies in population of women in Brazil: Data suggest that 2 SNPs in ESR1 (454-397T>C, rs2234693; 454-351A>G, rs9340799) are not associated with response of heart rate variability to oral contraceptives (estrogens/progestins).
23244119 ESR1 PvuII (C>T) polymorphism places pre-menopausal breast cancer women at risk for breast cancer.
23242705 Point mutants in the estrogen receptor alpha GalphaI-binding domain provide genetic segregation of nonnuclear from nuclear function.
23242655 mutant p53 protein binds to the promoter of ESR1 through direct interaction with HDAC1 and indirect interaction with DNMT1, MeCP2 proteins in the ER-negative MDA-MB-468 cells.
23206990 ESPR1 polymorphisms are associated with adolescent behavior styles.
23202974 ESR1 variants have no effect on cardiorespiratory and metabolic variables, while HRV indices are influenced by aerobic capacity and lipids in healthy women.
23199240 Data indicate that estrogen receptor alpha, estrogen receptor beta, progesterone receptor and androgen receptor may be partly involved in gastric carcinogenesis but their clinicopathological and prognostic significance appears to be limited.
23178685 Data suggest that CAC1 (cullin domain-containing protein 1), in association with LSD1 (lysine-specific histone demethylase 1), functions as an ERalpha corepressor and may be involved in drug resistance in breast cancer.
23177411 The ESR1 polymorphism rs3798573 A/G was associated with risk of endometriosis and infertile endometriosis in Han women from central China.
23159625 these data suggest that ZNF131 inhibits estrogen signaling by acting as an ERalpha-co-repressor.
23150099 In Brazilian population evaluated results have demonstrated that the genetic variation in ESR1 gene (PvuII polymorphism) is associated to POF risk.
23145106 these results demonstrate a novel role for cohesin in estrogen-mediated regulation of MYC and the first evidence that cohesin plays a role in ERalpha binding
23137636 the polymorphic genotypes of BGLAP, ER1, Col1A1 and CALCR are not found to be associated with osteoporosis in a single form but found to be associated in combined forms.
23133636 DOX could modulate the expression of GCS through the Sp1 site of GCS promoter in ERalpha-positive breast cancer cells
23131391 Breast cancer mRNA levels of ESR1 and HER2 predict response to neoadjuvant chemotherapy and are significantly associated with long-term outcome.
23128795 p allele of the ESR1 Pvu II polymorphism is a potential biomarker of logical memory decline among aging women.
23116284 genetic association study in population in China: Data suggest that 2 SNPs in ESR1 (rs2234693, -397T/C, PvuII; rs9340799, -351A/G, XbaI) are associated with premature ovarian failure (POF); heterozygotes are at higher risk of POF than homozygotes.
23098699 Study sequence rules of estrogen receptor alpha-DNA interactions using dual polarization interferometry and computational modeling.
23098526 findings show that ERalpha methylation is correlated with poor prognosis subtypes of breast tumors in Iranian patients and may play an important role in pathogenesis of the more aggressive breast tumors
23098495 Variants on ESR1 gene is associated with prostate cancer.
23088992 Interaction between genetic and environmental factors may help to explain nonreplication in genetic studies of hypospadias.
23078272 the XBAI polymorphism in the estrogen receptor alpha gene was observed at a higher mutated homozygous frequency in women with dense breasts
23074960 Polymorphic variants of ESR1 gene with TA-repeats could be related to dysfunction of the ovaries and infertility, which requires additional studies.
23074152 Analyses of femoral neck BMD also supported association with SNPs in WNT16 and ESR1/C6orf97
23071688 ERalpha binds to the DEK promoter.
23060440 Estrogen receptor alpha signaling regulates breast tumor-initiating cells by down-regulating miR-140 which targets the transcription factor SOX2
23056236 Data suggest that 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene [MBP] has key contacts with amino acids in estrogen receptors ERalpha and ERbeta.
23056216 Data suggest a role for the ERalpha, ERbeta and GPER in the estrogenic disruption of acinar formation.
23051957 The relationship between ERRgamma and ERalpha status could be a predictive marker for the treatment of uterine endometrial cancer.
23042805 Estrogen receptor-alpha, RBCK1, and protein kinase C beta 1 cooperate to regulate estrogen receptor-alpha gene expression.
23042285 The presence of ERalpha in Sertoli and Leydig cells in normal human testis demonstrated in this study suggests that estrogens may affect testicular function.
23032375 the 5'-UTRs of the E isoforms post-transcriptionally control ERalpha expression mainly through translational repression
23030067 Data indicate that the persistent organic pollutants (POPs)-related receptors estrogen-, androgen- and aryl hydrocarbon-receptortransactivities can be used as effect biomarkers.
23024189 Immunohistochemistry revealed very low expression of ERalpha, whereas all informative tumors expressed ERbeta1 and ERbeta2 in parathyroid adenomas.
23023562 The genomic and transcriptional cross talk between AR and ERalpha signaling in a luminal breast cancer cell line, was investigated.
23018357 The aim of this study was to assess the expression of estrogen receptors alpha and beta in paratesticular tissues in a group of boys with and without cryptorchidism.
22982060 Data suggest that estradiol counters oxidized LDL by restoring dimethylargininase activity and preventing loss of eNOS (nitric oxide synthase 3) in arterial endothelium acting through ERalpha (but not ERbeta or G protein-coupled estrogen receptor).
22978347 Immunohistochemical evaluation of TRAP1 together with ERalpha provides significant prognostic information. TRAP1 alone is significantly associated with chemotherapy response and overall survival.
22976807 Overexpression of antizyme (AZ), an ornithine decarboxylase (ODC) inhibitory protein, suppressed ERalpha expression, suggesting that ODC plays an important role in regulation of ERalpha expression.
22972951 The predictive capacity of 32 genome wide association studies-detected common variants for breast cancer risk, alone and in combination with classical risk factors, and for tumours with different hormone receptor status, was investigated.
22971276 Expression of ER-a is positively correlated with positive rates of AMA-M2 antibody, Sp100 and gP210 in tissues of primary biliary cirrhosis patients.
22970307 findings unveil a potential tumor-suppressor role of ERbeta in ovarian carcinogenesis, which could be of potential clinical relevance for the selection of the most appropriate treatment for patients
22962310 Characterize an estradiol-regulated interaction of NPPA with ERalpha in cardiomyocytes.
22936801 ASPP 049 from C. comosa induced osteoblastic cell proliferation and differentiation through ERalpha-, Akt-, and GSK-3beta-dependent activation of beta-catenin signaling.
22927007 These experiments further define the molecular mechanism of estrogen's bone-protective effects by inducing osteoclast apoptosis through upregulation of MMP3 and FasL cleavage.
22921477 interaction of Delta(5)-androstenediol with ERalpha and ERbeta
22908231 Both ACTN4 (full length) and ACTN4 (Iso) potentiate basal transcription activity and directly interact with estrogen receptor alpha, although ACTN4 (Iso) binds ERalpha more strongly.
22907427 Activation of the PKA signaling pathway alters the transcriptome by redirecting ERalpha to new transcriptional start sites, resulting in altered transcription and tamoxifen resistance.
22902633 These results suggest that ERalpha is a critical regulator of chondrocyte proliferation and maturation during skeletal development, mediating longitudinal bone growth in vivo.
22890138 Estrogen receptor-alpha gene PvuII (T/C) and XbaI (A/G) polymorphisms are not associated with endometriosis risk.
22884659 Estrogen receptor alpha mRNA/protein expression levels were increased in ectopic tissue in peritoneal endometriosis.
22882944 The XbaI polymorphism is correlated to BMD at diverse skeletal sites. PP had a protective role for the lumbar spine but might be a risk factor for the femoral neck.
22865929 ERalpha phosphorylation at Y537 by Src triggers E6-AP-ERalpha binding, ERalpha ubiquitylation, promoter occupancy, and target gene expression.
22853951 17beta-estradiol stimulation induces the recruitment of PAD2 to target promoters by ERalpha, whereby PAD2 then citrullinates H3R26, which leads to local chromatin decondensation and transcriptional activation.
22850893 BCA2 is therefore a newly identified transcriptional target of estrogen receptor.
22820289 expression of PES1 correlated positively with ERalpha expression and negatively with ERbeta expression and predicted good clinical outcome in breast cancer
22819972 testable hypotheses regarding a role of genetic variants in ESR1 in dysfunctional human maternal parenting.
22810499 The results indicates that there appears to be an influence of ESR1 codon 594 genotypes on genetic susceptibility to breast cancer.
22808109 The associations of 6 selected polymorphisms in three genes: ESR1 (rs2234693, rs9340799, rs1801132), ESR2 (rs1271572, rs1256049) and PGR (rs1042838) with gallbladder cancer risk, were examined.
22807578 Increased TRPV6 expression is a feature of estrogen receptor (ER)-negative breast tumors.
22806965 This study found a significant effect of estrogen receptor alpha (ESR1) TA microsatellite repeat number on left hand 2nd:4th digit ratio, but no effect on right hand digit ratio. There is also an effect of ESR1 polymorphism on aggressive behavior.
22800951 ERalpha gene polymorphism is correlated with the pathogenesis of missed abortion. Alleles P and X may be susceptibility genes.
22799738 The XbaI polymorphism was clearly associated with a reduction in endometrial thickness in women with breast cancer treated with aromatase inhibitors.
22792352 The microsatellite ESR1_TA in the ESR1 gene seems to have no association with breast cancer among African American or Nigerian women.
22791811 show that c-Fos and ERalpha can cooperate in regulating E2F1 gene expression by binding to regulatory elements in the E2F1 promoter
22787161 an insight into a feedback loop between ERalpha and p53 and a biological role of p53 in the DNA damage response in ER-positive breast cancers.
22784973 Differences in uterine immunoexpression of PR, ERalpha and OTR when comparing prostaglandin- to progestagen-based protocols for ovine estrus synchronization.
22784503 Presence of membrane-bound ERalpha expression together with EGFR mutation was found to be an independent prognostic factor for survival in patients with lung adenocarcinoma, suggesting cross-talk between membrane-bound ERalpha and EGFR mutation.
22760258 ESR1 454-397T>C mutation is significantly associated with increased risk of ischemic stroke. [Meta-analysis]
22759734 Estrogen receptor alpha gene polymorphism was related to unknown thin endometrium, in which P allele may be the risk and X allele may be its guard factor. The expression of estrogen receptor alpha was decreased in thin endometrium.
22749220 The ESR1-PvuII polymorphism emerges as a potential candidate for the early prediction of infertility due to premature ovarian aging.
22733972 attenuated phosphorylation of ERalpha at S118 and S167 significantly affected cellular physiology and behavior in MCF-7 breast cancer cells, resulting in increased growth, migration/invasion, an altered gene expression patterns.
22727021 Estrogen receptor alpha gene polymorphisms has a role in risk of HBV-related acute liver failure in the Chinese population
22669764 that hinge domain phosphorylation patterns uniquely inform on the various ER alpha activation mechanisms thought to underlie the biologic and clinical diversity of hormone-dependent breast cancers
22668753 Estrogen receptor (ER)alpha gene polymorphism using XbaI restriction enzyme influences the perception of back pain in patients with degenerative spondylolisthesis.
22632162 HIV-1 MA upregulates ESR1 mRNA expression in HepG2 cells
22626971 Major variations in estrogen receptor (ER) measured by ligand binding assay and immunohistochemistry are observed within all ESR1 copy number subgroups and other mechanisms than gene copy number seem to contribute to the ER protein content in the tumors.
22622808 A novel mechanism by which overexpression of estrogen receptor (ER) beta through NCoR is able to down regulate ER alpha gene expression, thus blocking ER alpha's driving role on breast cancer cell growth.
22615145 17beta-estradiol treatment increased the proliferation of MCF-7 cells with a higher ERalpha/ERbeta ratio.
22613997 Estrogen receptor positive (ER+)BRCA1-related breast cancers show several morphologic and immunophenotypic differences from ER+ sporadic breast cancers.
22606272 measurement of ESR1 mRNA levels may be predictive of response to endocrine therapy in a manner that is different from the predictive value of ER
22590818 The epithelial component demonstrated the expression for ER-alpha (45.6%, 36 of 79), ER-beta (37.2%, 29 of 78), PR (91.1%, 72 of 79), and AR (10.1%, 8 of 79).
22580535 There were no statistically significant associations of ESR1 and ESR2 gene polymorphisms with response to treatment.
22580007 A consistent enrichment of PR transcripts, relative to estrogen receptor transcripts, in the bipotent progenitor subfraction in the normal human breast, is reported.
22569715 The mechanism of estrogen-promoted ovarian cancer metastasis may due to the up-regulation of survivin conducted through the ERalpha signalling pathway.
22564243 CAV-1 affected cell growth of lung cancer NCI-H446 cell through the interactions with p-ERK1/2, estrogen receptor and progestin receptor
22562654 Data show that HEK293T cells transfected with estrogen receptor alpha (ERalpha)+/-Galpha(o) revealed that Galpha(o) stimulated phosphorylation of ERK MAP kinases ERK 1/2 and subsequently increased the phosphorylation of ERalpha on serine 118.
22550166 study establishes a role for AIB1 in aromatase inhibitor-resistant breast cancer and describes a new mechanism of ER-alpha/AIB1 gene regulation which could contribute to the development of an aggressive tumor phenotype
22549810 The ER-CXCL12-CXCR4 signaling axis may represent a promising target for development of therapeutics for ER+ ovarian cancers.
22547449 increased expression is associated with improved overall survival in patients with adenocarcinoma that underwent surgical resection
22543272 divergent effects of coregulators on the stable association of estrogen receptor alpha with estrogen response elements associated with the TFF1 and progesterone receptor promoters
22531679 ERalpha positivity, ERbeta negativity, and AR expressions are associated with a more aggressive phenotype of differentiated thyroid cancer.
22524805 Aberrant hypermethylation of ER gene is associated with invasive ductal cell carcinoma of the breast.
22521644 these data suggest that TTF-2 may modulate the function of ERalpha as a corepressor and play a role in ER-dependent proliferation of mammary cells.
22509838 Based on a limited selection of gene variants, no involvement of SRD5A1, SRD5A2, ESR1, ESR2 or PGR in female pattern hair loss is evident.
22508765 AR and ESR1 have distinct modes of interaction with chromatin and that DNase I hypersensitivity dynamics provides a general approach for predicting cell-type specific cistromes.
22463081 Data indicate that estrogen receptor (ER)alpha and ERbeta immunoreactivity was detected in the nuclei of esophageal squamous cell (41.1 and 97.8%, respectively).
22460789 Her2-tumor-initiating cells-enriched signature was specific to HER2(+):ERalpha(-) tumors, a previously reported stroma-derived signature was predictive for HER2(+):ERalpha(+) breast cancer.
22457607 TWIST expression was inversely correlated with ERalpha expression in both breast cancer cell lines and human breast ductal carcinomas.
22446104 Data suggest that lack of palmitoylation renders ERalpha more susceptible to estradiol-dependent degradation, blocks phosphorylation of ERalpha at Ser118, and prevents estradiol-induced ERalpha estrogen-response element occupancy.
22446103 Data suggest that ERalpha colocalizes with activated/phosphorylated JNK1 (c-Jun N-terminal kinase 1) at many target gene promoters in nuclei of breast cancer cells exposed to estrogens.
22426783 results indicate that in ER-negative breast cancer cells Src functions as a switch in ERalpha36-mediated biphasic estrogen signaling through the EGFR/STAT5 pathway
22415229 GPER status adds clinically relevant information to ERalpha status in endometrial carcinoma and suggest a potential for new inhibitors in the treatment of metastatic endometrial cancers with ERalpha expression and GPER loss.
22414972 68.3% of patients were ER-positive, and 71.5% were PR-positive. Among the 28.3% of HER2-positive tumors, the majority (19.2%) stained +++. Almost 50% of the tumors were ER+ PR+ HER2-, which makes this the predominant tumor type.
22404101 This meta-analysis provides evidence that PvuII polymorphisms in the ESR1 gene, which encodes for estrogen receptor-alpha, could modify the susceptibility to endometrial cancer.
22402113 ER-alpha36 expression was significantly higher in ER-negative tumors than in ER-positive tumors
22399296 phosphorylation at Ser-118 is required for ER to bind both p38gamma and c-Jun, thereby promoting ER relocation from ERE to AP-1 promoter sites.
22394363 EGFR overexpression relates to triple negative profile (ER-/PR-/HER2-) and poor prognosis in breast cancer patients in Tunisia
22389694 In the female bipolar disorder a significant association result was found for rs6023059, a single nucleotide polymorphism (SNP) placed downstream of the gene coding for transglutaminase 2 (TGM2).
22382029 PIMT may act as a co-activator in ERalpha-mediated transcription of TFF1 through its recruitment to the promoter via interacting with ERalpha.
22375075 HADHB is a functional molecular target of estrogen receptor alpha in the mitochondria, and the interaction may play an important role in the estrogen-mediated lipid metabolism in animals and humans.
22374427 In clinical practice, besides routine detection of ER-alpha and PR in invasive luminal subtype breast cancers, immunohistochemical staining of ER-Beta1 and ER-Beta2 should be considered in order to achieve more useful information.
22362381 epigenetic silencing of the estrogen receptor (ER) by hypermethylation of the ESR1 promoter is seen predominantly in triple-negative breast cancers in Indian women
22359603 in ER-positive breast cancer cells, LRH-1 promotes cell proliferation by enhancing ERalpha mediated transcription of target genes such as GREB-1
22347418 ERalpha/beta heterodimers are growth inhibitory in breast and prostate cells which co-express the two ER isoforms
22344619 The regulation of estrogen receptor alpha signaling by target proteins of SSX2 may explain the metastatic potential of breast cancer cells.
22342729 ERalpha25p is a new CaM-binding ligand.
22336175 Our results indicated that expressions of ERalpha and ERbeta correlate with each other and with less aggressive phenotypical features of invasive breast ductal carcinoma.
22328528 Binding of the ERalpha and ARNT1 AF2 domains to exon 21 of the SRC1 isoform SRC1e is essential for estrogen- and dioxin-transcription.
22328322 Significant increases in osteoporosis risk with minor alleles of rs2077647 located in the first exon and rs2234693 located in the first intron
22326682 Data show that 7alpha, 6-hexanyl derivatives of estradiol (compound 13) functions as a mixed agonist/antagonist, inducing only weak estrogen receptos (ER) transcriptional activity while preventing coactivator recruitment and stabilizing ER expression.
22324545 genetic association studies in Brazilian women: Data suggest that an SNP in ESR1 (rs2813544) influences LDL cholesterol level in postmenopausal women undergoing estrogen replacement therapy; hypercholesterolemia may be adverse effect of estrogens.
22311091 The presence of the APOE epsilon4 allele, and not the alleles of ER SNPs, is a risk factor for MCIa. Furthermore, APOE genotype seems to predict the conversion from MCIa to AD.
22311020 The estrogen receptor alpha PvuII/XbaI and vitamin D receptor FokI polymorphisms may contribute to the determination of bone mineral density in Turkish postmenopausal women.
22310000 These results provide new evidence of the mechanisms whereby estradiol regulates leptin expression in placenta and support the importance of leptin in placental physiology.
22296324 genetic association studies in population of Greek women: No differences in distribution of ERalpha or ERbeta SNPs were found between women with PCOS and healthy controls; however, some associations with insulin resistance/circulating FSH were found.
22295107 a role of non-genomic signaling through the activation of p-ERK1/2 in the hormonal dependence of inflammatory breast cancer by a combination of estrogen receptors
22295098 reduced microRNA-152 can lose an inhibitory effect on DNA methyltransferase, which leads to hypermethylation of the ERalpha gene and a decrease of ERalpha level
22291950 PRSS23 is upregulated by estrogen receptor alpha in breast cancer cells.
22291085 Among the 1% to 9%, 10%, and more than 10% ER IHC-positive patients, 24%, 67%, and 92% were also positive by ESR1 mRNA expression. The average ESR1 expression was higher in the >/= 10% ER-positive cohorts compared with the 1% to 9% or ER-negative cohort.
22290394 ER/PR and HER2 statuses between primary and liver metastatic lesions of breast carcinoma can be modified after treatment but are stable in most cases during the natural metastatic process.
22286763 S6K1 directly phosphorylates and regulates ligand-independent activity of ERalpha, while ERalpha upregulates S6K1 expression.
22284250 The ERa PvuII polymorphism is associated with the increased risk of CAD in men of a Chinese population.
22283119 This study suggested that there was a modest but statistically significant association between the PvuII pp genotype of the ESR1 gene and vertebral fracture in Chinese patients.
22277987 ERbeta AluI A allele presence was the most important independent predictor of hormone therapy-induced increase in flow-mediated dilation while ERalpha XbaI A allele was the only independent predictor of decrease in sCD40L.
22275375 CaM binds two molecules of ER-alpha in a 1:2 complex and stabilizes ER-alpha dimerization.
22273809 Results indicate that the 2,4- and 2,5-dimethyl derivatives of phenyl vinyl estradiols had the highest relative binding affinity with estrogen alpha receptor.
22271294 discussion of role of ERalpha/ERbeta in cardiovascular adaptations of uterus during pregnancy; structural basis for functional diversity of ERalpha/ERbeta subtype selectivity of estrogens; and genetic/epigenetic regulation in endothelium [REVIEW]
22271290 discussion of tissue-specific regulation of gene expression involving ERalpha and ERbeta, ER agonists, estrogen response elements, and epigenetic modification of ER genes; discussion of molecular targeted anticancer therapy with ER agonists [REVIEW]
22266976 None or very small amounts of ERbeta were detected, and ERalpha and ERbeta2 mRNA were elevated in the Puumala virus infection patient group.
22266866 RASSF1A has a key role in suppressing the transformation of human breast epithelial cells and estrogen receptor alpha positive breast cancer initiation.
22266331 Data show that phosphorylation of serine 212 enabled estrogen receptor alpha (ERalpha) to regulate a unique set of genes and cellular functions.
22247547 presence of an ERalpha splice variant, ERalpha36, in ERalpha-positive MCF7 and ERalpha-negative HCC38 breast cancer cells, which localized to plasma membranes and rapidly activated PKC in response to E(2)
22245602 The results suggest that polymorphisms in ESR1, ESR2 and LHCGR contribute to the risk of developing testicular germ cell cancer, histological subtype, and risk to metastasis.
22240483 Estrogen can repress transcription of HBV genes by up-regulating ER-alpha, which interacts with and alters binding of HNF-4alpha to the HBV enhancer I.
22228197 In the Iranian population, genetic polymorphisms of the ER-alpha and ER-beta genes may be involved in the etiology of prostate cancer
22228098 identified a locus on 6q25 associated with breast cancer risk in US Latinas; the peak of the 6q25 signal includes the estrogen receptor 1 (ESR1) gene and 5' region, a locus previously implicated in breast cancer
22226967 ERalpha repressively modulates the expression of LKB1 at the transcriptional level.
22222969 The findings in this pilot study suggest that estrogen receptor 1 (ESR1) gene polymorphisms do not contribute to endometriosis susceptibibility in women.
22216287 siRNA-mediated knockdown of Noxa resulted in cell cycle arrest following E2 treatment, indicating that Noxa expression is required for cell cycle progression in ER-positive breast cancer cells.
22213398 OD extracts enhance the tumor suppressor p53 expression as a result of an increased binding of ERalpha/Sp1 complex to the p53 promoter region.
22207717 We have determined the estrogen receptor alpha cistrome defined by a novel method to study DNA-protein interactions in vivo.
22203942 The predictive value is amplified when the ER status is correlated with the PR status.
22201220 ER-alpha intrinsic DNA binding free energy is identical to that of progesterone receptor B (PR-B) isoform, as expected; this ability serves as a framework for regulating receptor-specific promoter occupancy and thus receptor-specific gene regulation.
22199306 p27KIP1 has a role in node-negative breast cancer, but the interaction with ER and PR is only significant in T1a/b stage
22199302 SNPs (HSD17B1 (rs2010750, rs598126 and rs676387), COMT (rs4680), UGT1A1 (rs8175347) and ESR1 (rs9340799)) seem to be related to mammographic density in the same direction of their associations with breast cancer risk
22198466 Expression of the newly identified estrogen receptor alpha-36 is not limited within breast cancer epithelium, but is equally identified in tumor vasculature, peritumoral fat tissue, lymphocytic infiltrate and stromal fibroblasts.
22193044 Our findings suggest that estrogen signaling could be affected not only in estrogen receptor alpha (ER A)-negative breast cancer, but also in ER A-positive breast cancer due to lack of circadian availability of ER A.
22174013 NR2E3 regulates ESR1 via direct binding to the ESR1 promoter with concomitant recruitment of PIAS3 to the promoter in breast cancer cells, and is essential for physiological cellular activity of ESR1 in estrogen receptor (ER)-positive breast cancer cells
22170254 Amplification of ESR1 in breast carcinoma occurs as low-level amplification.
22142990 Results demonstrate that estradiol induces growth of human astrocytoma cell lines through ERalpha and its interaction with SRC-1 and SRC-3 and also suggest differential roles of ERalpha on cell growth depending on astrocytoma grade.
22141363 ER gene PvuII and XbaI polymorphisms have no major influence on bone mineral density in our group of postmenopausal women.
22139072 It was shown that cocaine- and amphetamine-regulated transcript protein (CART) increases the transcriptional activity of estrogen receptor alpha and that CART stimulates an autocrine/paracrine loop within tumor cells to amplify the CART signal.
22138413 Colocalization of estrogen receptor alpha 36 isoform with cytoskeleton microfilaments suggests a role of estrogens in cell motility.
22132110 Thyroid hormone is shown to induce human lung cancer cell proliferation via crosstalk between integrin alphavbeta3 and ERalpha.
22125492 PBX1 is a novel pioneer factor defining aggressive ERalpha-positive breast tumors, as it guides ERalpha genomic activity to unique genomic regions promoting a transcriptional program favorable to breast cancer progression
22119825 Invasive ductal mammary carcinoma type was analyzed for comparative investigation of hormonal receptors (estrogen receptor ER and progesterone receptor PR) and Her2/neu oncoprotein expression.
22107784 The prognostic impact of Akt (Akt1) phosphorylated at threonine308 and serine473, Akt2, Akt3, PI3K and PTEN, alone and in coexpression with ER and PgR in non-gastrointestinal stromal tumor soft tissue sarcomas.
22102068 ER-alpha and PR may be useful markers predicting therapy response in endometrial hyperplasia.
22092403 Expression of PR and ESR1 defines a subgroup of ovarian carcinomas with a favourable prognosis.
22086303 Genetic variants in ESR1 does not contribute to the development of Lynch syndrome.
22083956 NF-kappaappaB, acting through two response elements, is required for ER recruitment to an adjacent estrogen response element in the BIRC3 promoter.
22074947 a small increase in the expression of p23 amplifies ER-binding genome wide and, in combination with ER, elicits an invasive phenotype in breast cancer
22071320 Highlight the importance of cross-regulation between AhR and ERalpha and a novel mechanism by which AhR controls, through modulating the recruitment of RIP140 to ERalpha-binding sites, the kinetics and magnitude of ERalpha-mediated gene stimulation.
22068927 Data indicate that in myometrium in pregnancy, ER1 and GPR30 mRNA are expressed; ER2 mRNA is undetectable; ER1 protein is undetectable unless 26S proteasome activity is inhibited; estradiol acts via ER1 and activation of ERK/MAPK pathway.
22064478 Estrogen receptor alpha unstructured transactivation domain (AF1) activity is regulated by S118 phosphorylation-dependent recruitment of PIN1.
22056872 regulation of ER by Twist could be an underlying mechanism for the loss of ER activity observed in breast tumors, and may contribute to the generation of hormone-resistant, ER-negative breast cancer
22056872 In breast cancer, estrogen receptor alpha is downregulated by TWIST1 (Twist) through interactions with DNA methyltransferase 3B (DNMT3B) and histone deacetylase 1 (HDAC1).
22052998 our study has identified novel aspects of ligand-mediated estrogen receptor alpha and beta interactions underlying the diversity of estrogen-mediated regulation of different cellular functions mediated by ligands of different biocharacter
22049316 Chromatin immunoprecipitation identified ERalpha genomic binding activity in estrogen-deprived cells.
22038234 Data suggest that pelvic organ prolapse is associated with higher expression of ERalpha/ERbeta in the pelvic floor of both pre- and post-menopausal women.
22022496 Gene expression signatures comprising 24, 51 and 14 genes predictive of ER, PR and ERBB2 status respectively, were investigated.
22014058 Gastrointestinal stromal tumours do not show immunopositivity for ERa or HMB45.
22012767 analysis did not reveal any association between the ER1 genetic variant and postmenopausal breast cancer risk, either ER-positive or ER-negative disease
22009847 A combination of CALM1 and ER1 gene polymorphisms might be related to double curve in patients with AIS.
22004841 Reduced estrogen receptor is associated with recurrent breast cancer.
22001950 ERalpha gene polymorphisms may be associated with the pathogenesis of schizophrenia in Korean patients.
21986093 When combined with HER2, ESR1 may be prognostic but should not be used for endocrine treatment selection in postmenopausal women with endocrine-responsive early breast cancer.
21984905 XAP2 exerts a negative effect on ERalpha transcriptional activity and may thus prevent ERalpha-dependent events.
21984528 There is little involvement of genetic variation of the ESR1 gene in modifying risk of coronary artery disease.
21983130 aberrantly expressed miRNA-206 may be associated with the development of ERalpha-positive endometrioid adenocarcinoma (EEC).
21980607 1 of 8 in: Anal Quant Cytol Histol. 2011 Apr;33(2) Differential expression of estrogen receptors in endometrial polyps and adjacent endometrium in postmenopausal women
21972702 The median time of survival in patients with lung cancer depending on the expression of ER alpha was 31 months, while for ER beta was 73 months.
21966761 There was no compelling evidence of an association between variant alleles of genotypes estrogen receptors alpha and breast density.
21951066 ERalpha has a role in regulating tyrosine hydroxylase and alpha-synuclein expression; the extent to which oysterol 27-hydroxycholesterol utilizes their pathways to modulate expression levels of these two proteins is characterized.
21947828 Data suggest that the low-level expression of ESR1 is associated with tamoxifen resistance in ER-positive breast cancer.
21946067 14-3-3beta has oncogenic potential in breast cancer via binding to ERalpha and activation of the transcriptional activity of ERalpha.
21943781 We propose that different variants of IVS1-397 estrogen receptor alpha polymorphism may become additional genetic factor that influences regulatory conditions during diabetes type 1 in females.
21937726 total internal reflection fluorescence microscopy in endothelial cells illustrates that ER46 can topologically conform to a type I transmembrane protein structure
21934279 the A allele of SNP12 of ESRa may increase the risk of hypospadias or cryptorchidism.
21924251 This study described the generation of two isogenic breast cancer cell lines, Hs578T-ERalphaLuc and Hs578T-ERbetaLuc, with stable integration of an estrogen responsive luciferase reporter gene.
21922275 Epigenetic alteration of ERalpha gene may play an important role in the pathogenesis of familial breast cancer
21920899 ERalpha physically interacted and functionally cooperated with SIRT1 in breast cancer cells. ERalpha also bound to the promoter for SIRT1 and increased its transcription.
21907803 demonstrated that ER-alpha36 positively regulates HER2 expression and the population of ALDH1 positive breast cancer cells, and suggested that non-genomic estrogen signaling mediated by ER-alpha36 is involved in maintenance of breast cancer stem cells
21907792 These results suggest a novel negative regulation of estrogen receptor alpha activity and protein by JAK2 in breast cancer cells and indicate a potential new cross-talk
21901395 Data show that hierarchical clustering based on mRNA expression of estrogen receptors, progesterone receptor and neu receptor by quantitative RT-PCR identified patient groups that were comparable to the subtypes identified by immunohistochemistry.
21888973 summarizes recent studies on the structure and function of ER-alpha36 and the relationship of ER-alpha36 with cancer, with special emphasis on its function in the resistance of breast cancer to endocrine therapy
21880074 common single-nucleotide polymorphisms inside ER are related to the clinical outcomes of androgen-deprivation therapy in men with prostate cancer
21878914 All the enhanceosome components comprising estrogen receptor alpha (ERalpha), FOXA1, and GATA3 are necessary for the full repertoire of cancer-associated effects of the ERalpha.
21868451 These studies identify PITX1 as a new ERalpha transcriptional target.
21866462 We conclude that Reed-Sternberg cells in classical Hodgkin lymphoma in children seem to be mainly ERbeta positive and ERalpha negative.
21858728 Data from material procured by laser capture microdissection suggest that coordinated expression of ESR1 and XBP1 in breast carcinoma is due to their co-expression in carcinoma cells rather than in the surrounding stromal cells.
21842124 The allele of estrogen receptor-alpha identified by XbaI (X) restriction was detected less frequently in the study group compared to the control group.
21841772 H3K27 demethylation by JMJD3 at a poised enhancer of anti-apoptotic gene BCL2 determines ERalpha ligand dependency
21840910 analysis of Aurora A and B kinases, Ki-67 and the estrogen and progesterone receptors from an endometriosis tissue microarray model
21840388 Annonacin induced growth arrest and apoptosis via ERalpha-related pathways in MCF-7 cells.
21840040 We confirmed evidence that discordance of ER/Her2 expression between primary and metastatic breast carcinoma does occur.
21837769 A polymorphism of the ESR1 gene is a novel c.453-397C allele-specific and c-myb-dependent enhancer-like cis-acting regulatory variation and could be part of the genetic variations underlying the susceptibility to hepatitis B virus-related liver cirrhosis.
21837403 the ER1 polymorphisms might associate with type 2 diabetes and fasting glucose among Iranian male subjects.
21835891 These results demonstrate a novel pathway of estrogen regulation of gene expression by cooperation between ER and AP-1 at the distal enhancer element and that AP-1 is involved in estrogen induction of the c-myc oncogene.
21826373 These results suggested a novel regulatory mechanism of let-7 miRNAs on ER-alpha36 mediated nongenomic estrogen signal pathways.
21823190 Results found that in the Brazilian male population, genetic variations in both estrogen receptors alpha (PvuII and XbaI) and beta (AluI and RsaI) were not relevant to idiopathic infertility.
21784129 TNF-alpha activates ER signaling in endometrial epithelial cells.
21781458 Different expression patterns of androgen receptor and ER alpha mRNAs in malignant tissues of oral mucosa suggest an involvement of these sexual hormones in oral cancer
21762477 Data show that triple-negative breast cancer (TNBC) are larger in size compared with other subtypes and almost all grade 3.
21762042 The age at disease diagnosis was lower in carriers of the ESR1 rs9340799 A allele compared with GG homozygotes as well as in patients with ESR1 rs2234693 TT and CT genotypes compared with CC homozygotes.
21761367 Sata support the relevance of phosphorylation at p-Y537-ERalpha in breast cancers and add further support to the presence of a phosphorylation code for ERalpha in human breast cancer in vivo.
21761362 microRNAs actively control some of the most distinguishing characteristics of the breast cancer subtypes, such as ERalpha itself, Dicer, and growth factor receptor levels
21761334 Aurora-A phosphorylation of p53 sequesters the protein in the cytoplasm and enhances its interaction with ERalpha in a ternary complex comprising of the three proteins
21760950 These data replicate previous associations found between single nucleotide polymorphisms in the 6q25 locus and bone mineral density [BMD(a)] at the hip.
21757754 the nongenomic PI3K signaling pathway plays a role in estrogen/hERalpha-stimulated hSlo1 gene expression; whereas c-Src activity leads to hSlo1 gene tonic repression independently of estrogen, likely through ERK activation.
21749714 Data show that the triple-negative and HER2 subtypes were associated with poorer outcomes compared with the luminal A subtype.
21747171 pancreatic Stat3 has a role in ER-mediated suppression of lipid synthesis
21741601 AR is enriched in ER- breast tumors that overexpress HER2.
21736840 ER and PR do not appear to have a role in how dietary folate and vitamin B6 intakes are inversely associated with breast cancer risk
21734414 Our data suggest that polymorphisms of the ER alpha and ER beta genes may influence tumor growth, particularly in the passage from in situ to invasive melanoma.
21720911 The genetic variants in the ESR, FTO, and UCP2 genes may be considered as a screening tool prior to bariatric surgery to help clinicians predict weight loss or glycemic control outcomes for severely obese patients.
21713035 Data suggest that estrogen receptor loss in estrogen/antiestrogen sensitive cells triggers loss of endocrine dependence and onset of events that change the cell from an epithelial to a mesenchymal type.
21707866 ER-alpha might have an important role in human papillary thyroid carcinoma, and its overexpression can be studied in routine needle aspirate as a possible marker of malignancy.
21706051 Consistent with its ability to regulate the levels of ERalpha, expression of RUNX3 inversely correlates with the expression of ERalpha in breast cancer cell lines, human breast cancer tissues and Runx3(+/-) mouse mammary tumors
21703046 ER-alpha XbaI and VDR BsmI genetic polymorphisms had a significant association with the risk of prostate cancer.
21700719 The molecular signaling set off by ERalpha and CrkL association may have a central role in pregnancy and cancer.
21699784 Estrogen regulates human DBS, which could reduce the risk for duodenal ulcer in women and contribute to sex differences in the prevalence of duodenal ulcer.
21695903 After calcium supplementation, bone mineral density increased in lactating women with some estrogen receptor genotypes.
21691043 associations between PvuII-XbaI haplotype 2 polymorphism and body fat mass in girls were found in recent cohort, non-carriers of this polymorphism are likely to be more vulnerable to fat accumulation in today's obesity promoting environment, than carriers
21684697 The menopausal women having heterozygous and homozygous mutants of PvuII or XbaI genotypes were strongly correlated with breast cancer (P<0.01).
21680658 17beta-estradiol induces the expression of KCNK5 via ERalpha(+) in breast cancer cells, and this channel plays a role in regulating proliferation in these cell lines.
21673408 single nucleotide polymorphisms in the ESR1 or ESR2 genes do not seem to play a major role in the genetic susceptibility of Alzheimer's disease
21658000 Studying each locus alone, no significant results were drawn for ESR1 and ESR2 genes.
21655654 The prognostic value of the correlations between the expression of estrogen and progesterone receptors, Ki67 expression and the histological stage, tumor stage, the degree of myometrial and vascular invasion, was investigated.
21644229 CYP17 gene and ERalpha gene may not be genetic risk factors for endometriosis among southern women in China
21642474 This study established WBP2 as a tyrosine phosphorylation target of estrogen signaling via EGFR crosstalk.
21640622 Two ER subtypes exhibit different expression patterns in spinal trigeminal nucleus, with higher expression levels of ERalpha than ERbeta, suggesting that estrogens may directly affect trigeminal neuron excitability in humans.
21632819 ERalpha and ERbeta may act in opposite directions to regulate the Slug-E-cadherin pathway and to affect invasiveness of nonfunctional pituitary adenoma
21625942 The ERalpha methylation status in basal-like breast cancer was significantly higher than in sporadic non-basal-like breast cancer
21623207 determined the status of ERalpha and ERbeta in the myometrium and leiomyomas, atypical leiomyomas and leiomyosarcomas, concomitantly with the expression of NTS/NTS receptor 1 in these tumors
21610700 ER-alpha, which is regulated by miR-26a, is important for liver tumor cell growth.
21607585 Devised a novel flow cytometric method to quantify the expression of ERalpha, HER2, and the activation of ERK1/2 simultaneously in single cells.
21607583 Expression of TLR9 isoforms A and B can be detected in clinical breast cancer specimens. The ERalpha and sex steroid hormones regulate TLR9 expression and invasive effects in the breast cancer cells.
21597315 Differential expression of estrogen receptor alpha and beta transcripts in tissues and in primary culture cells from pubertal gynecomastia.
21572391 AP-2gamma is a novel collaborative factor in ERalpha-mediated transcription.
21570196 An association between ESR1 and global anxiety in older women, however these associations varied depending on the anxiety syndrome and the use of hormone treatment.
21552322 ESR1 expression is correlated with three open reading frames on chromosome 6 in tumours.
21536917 TLE1, is a necessary transcriptional component of the ER complex, where it facilitates ER-chromatin interactions.
21523370 homocysteine promoted hypermethylation of the promoter A region of the estrogen receptor-alpha gene, which may be an important mechanism for the pathogenesis of postmenopausal osteoporosis
21520258 no association of rs9340799 with adolescent idiopathic scoliosis predisposition or curve severity
21509526 Combination of Src kinase inhibitor KX-01 with tamoxifen may present a promising new strategy for clinical management of ERalpha positive breast cancer.
21506659 Significant elevation of ERalpha and MTCYB transcript levels in premenopausal leiomyomas and its association with ERalpha, -397 CC genotype suggests the mitochondrial-mediated role of estrogen as the promoter of leiomyoma tumorigenesis.
21505052 ERalpha phosphorylation at serine 118 affects recruitment of unique protein complexes at gene-specific promoters.
21491087 analysis of estrogen and progesterone receptor expression in HPV-positive and HPV-negative cervical carcinomas
21487104 Studies suggest that the development of ERbeta-based therapies may lead to improved drug efficacy.
21486948 Upon IMS stress, overproduction of reactive oxygen species (ROS) and phosphorylation of AKT triggers estrogen receptor (ER) activity, which further upregulates the transcription of the mitochondrial regulator NRF1 and the IMS protease HTRA2.
21480391 Results suggest that co-targeting c-ABL and ERalpha as a combinatory approach may have therapeutic potential for breast cancer.
21468554 These results suggest that ERalpha induces the down-regulation of PTEN through PI3K activation in breast cancer cells.
21463834 Overexpression of ERalpha gene and enhanced activation of calcineurin in response to estrogen in peripheral blood lymphocytes may contribute to the pathogenesis of female dominant in systemic lupus erythematosus.
21458421 these observations show that hypoxia-stabilized HIF-1a induces the repression of the ESR1 gene, which may facilitate hormone insensitivity in the tumor microenvironment.
21445546 ERalpha gene CG haplotype could be associated with a reduced risk of primary knee osteoarthritis in Mexican mestizo population.
21445275 JMJD2B is recruited to ERalpha target sites, demethylates H3K9me3 and facilitates transcription of ER responsive genes including MYB, MYC and CCND1
21444077 ESR1 expression did change through the menstrual cycle or in uteri with adenomyosis.
21437249 A comprehensive immunohistochemical study was performed to investigate the protein expression of eight CT genes in 454 invasive ductal carcinomas, including 225 ER/PR/HER2-negative (triple-negative) carcinomas.
21427057 CYP17A knockdown in H295R cells resulted in less production of both 17alpha hydroxyprogesterone and androstenedione.
21423915 The results indicate that the PvuII and the XbaI polymorphisms of ESR1 gene are associated with bone mineral density in premenopausal women with GD and may help to estimate the risk of bone loss particularly at lumbar spine.
21422801 ERalpha and some growth factors may be involved in the tumorigenesis of prolactinoma. ERalpha could potentially be an effective therapy target for treating prolactinoma.
21410323 in breast cancer cells, IGF-2 activates ER-alpha and ER-beta, and modulates their translocation to nucleus, membrane organelles and mitochondria; IGF-2 actions are mediated by the IGF-1R and the insulin receptor
21397694 Differential expression of 4 out of 5 genes related to estrogen metabolism and action (ESR1, ESR2, PGR and BGN) was confirmed in endometriosis.
21378170 histone modifications governing TFF1 transcription are mediated by estrogen receptor
21367855 gen up-regulates ATBF1 transcription but causes its protein degradation in estrogen receptor-alpha-positive breast cancer cells
21356307 an inherent role for monoubiquitination in estrogen receptor alpha signaling and physiological function of receptor monoubiquitination in the regulation of estrogen induced cell proliferation
21351528 ERalpha expression was reduced in in Sertoli, myoid and Leydig cells of infertile men.
21348637 This observation suggests that a switch from ERalpha66 to a predominant expression of ERalpha36 may be associated with development and/or progression of human HCC.
21344398 Estrogen receptor alpha/beta influence sperm metabolism and may be involved in the pathophysiology of varicocele-associated male infertility.
21330404 ER-alpha recruitment in the tethering pathway is dependent on the ligand-induced formation of transcription factor complexes that involves interplay between the proteins from different transcription factor families.
21323952 Results showed that changes in both ERalpha and ERbeta expression characterize the transition from normal epithelium to cancer in patients with vulvar squamous cell carcinoma
21309471 Estrogen receptor-alpha polymorphism is associated with fracture.
21308739 Results demonstrate that ROSC negatively affects the functional status of ER-alpha, making it potentially useful in the treatment of estrogen-dependent breast cancer cells.
21304949 estrogen receptor alpha mediates gene expression changes and growth responses induced by 25 HC in breast and ovarian cancer cells
21300759 Data show that the L858R mutation of EGFR is associated with SNP of estrogen biosynthesis and metabolism genes CYP17, CYP19A1, ERalpha, and COMT in never-smoking female lung adenocarcinoma patients.
21295396 The interaction between ERalpha and Akt plays a crucial role in the regulation of proliferative activity in postmenopausal endometrium.
21292820 Data show that that bortezomib enhances the fulvestrant-mediated aggregation of the ER in the cytoplasm without blocking the degradation of the ER in the nucleus.
21285458 The studies reveal the sequence(s) in the ERalpha hinge region that are involved in tethered-mediated actions as well as nuclear localization and attribute important functionality to this region of the receptor
21282336 Findings suggest that coexpression of CARM1 and ERalpha may provide a better biomarker of well-differentiated breast cancer.
21273576 Lower ER alpha expression is associated with tamoxifen-resistance in breast cancer.
21271213 Estrogen Receptor positivity in non gastrointestinal soft tissue sarcoma was a significant favourable indicator for disease specific survival in women
21269613 The higher PR-A and ER-alpha gene expression in granulosa cells in patients with endometriosis, compared with patients with tubal infertility, might be a leading cause of ovarian dysfunction due to endometriosis
21269226 lower in endometrium of polycystic ovary syndrome group compared to controls
21266162 these findings offer new insights into the regulation o