Tbio BICC1 Protein bicaudal C homolog 1

Protein Summary

Description

Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development. This gene encodes an RNA-binding protein that is active in regulating gene expression by modulating protein translation during embryonic development. Mouse studies identified the corresponding protein to be under strict control during cell differentiation and to be a maternally provided gene product. [provided by RefSeq, Apr 2009]

Uniprot Accession IDs

• Q9H694
• Bic-C

Gene Name

• BICC1

Ensembl ID

• ENST00000373886
• ENSP00000362993
• ENSG00000122870

Symbol

• BICC
• CYSRD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.74
transcription factor perturbation	0.74
protein domain	0.73
cell type or tissue	0.69
tissue sample	0.66

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Apolipoprotein / Protein Bicaudal C Homolog 1

Protein / Nucleic Acid Binding / Rna Binding Protein / Protein Bicaudal C Homolog 1

DTO Classes

Protein / Transporter / Apolipoprotein / Protein Bicaudal C Homolog 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.56   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 158   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.56   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0