| Tbio | Embryonal Fyn-associated substrate |
Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES (By similarity).
The longest protein isoform encoded by this gene contains an SH3 domain, which is known to be important in intracellular signal transduction. The protein encoded by a similiar gene in mice was shown to bind to SH3 domains of protein-tyrosine kinases. The function of this gene is unknown. Three alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2013]
The longest protein isoform encoded by this gene contains an SH3 domain, which is known to be important in intracellular signal transduction. The protein encoded by a similiar gene in mice was shown to bind to SH3 domains of protein-tyrosine kinases. The function of this gene is unknown. Three alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2013]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 8.3e-08 |
| glioblastoma | 5792 | 5.6e-07 |
| ependymoma | 4679 | 3.2e-06 |
| primitive neuroectodermal tumor | 3035 | 1.8e-05 |
| cystic fibrosis | 1696 | 6.9e-05 |
| ovarian cancer | 8520 | 1.2e-04 |
| Astrocytoma, Pilocytic | 3081 | 1.5e-04 |
| psoriasis | 6694 | 5.6e-04 |
| lung cancer | 4740 | 8.6e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 8.6e-04 |
| medulloblastoma, large-cell | 6241 | 1.2e-03 |
| interstitial cystitis | 2312 | 1.4e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 2.0e-03 |
| adult high grade glioma | 3801 | 2.4e-03 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.6e-03 |
| oligodendroglioma | 2850 | 8.1e-03 |
| astrocytoma | 1146 | 9.7e-03 |
| pituitary cancer | 1972 | 1.4e-02 |
| colon cancer | 1478 | 1.4e-02 |
| esophageal adenocarcinoma | 737 | 1.8e-02 |
| group 3 medulloblastoma | 4104 | 2.4e-02 |
| cutaneous lupus erythematosus | 1057 | 3.7e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Attention deficit hyperactivity disorder | 278 | 5.432 | 2.7 |
| Heart disease | 306 | 4.239 | 2.1 |
| Oppositional defiant disorder | 17 | 3.894 | 1.9 |
| Conduct disorder | 33 | 3.737 | 1.9 |
| Coronary artery disease | 268 | 3.552 | 1.8 |
| Ocular hyperemia | 2 | 3.088 | 1.5 |
| Phenylketonuria | 20 | 3.079 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 1.900 | 2.4e-03 |
| astrocytoma | 2.000 | 9.7e-03 |
| Astrocytoma, Pilocytic | 2.100 | 1.5e-04 |
| atypical teratoid / rhabdoid tumor | 1.100 | 2.6e-03 |
| colon cancer | -2.900 | 1.4e-02 |
| cutaneous lupus erythematosus | -1.200 | 3.7e-02 |
| cystic fibrosis | -1.165 | 6.9e-05 |
| ependymoma | 1.600 | 3.2e-06 |
| esophageal adenocarcinoma | -2.400 | 1.8e-02 |
| glioblastoma | 2.000 | 5.6e-07 |
| group 3 medulloblastoma | 1.800 | 2.4e-02 |
| interstitial cystitis | -1.200 | 1.4e-03 |
| intraductal papillary-mucinous adenoma (... | -1.200 | 8.6e-04 |
| intraductal papillary-mucinous carcinoma... | -1.100 | 2.0e-03 |
| lung cancer | -2.200 | 8.6e-04 |
| medulloblastoma, large-cell | 2.000 | 1.2e-03 |
| non-small cell lung cancer | 1.291 | 8.3e-08 |
| oligodendroglioma | 2.300 | 8.1e-03 |
| ovarian cancer | 2.000 | 1.2e-04 |
| pituitary cancer | 1.400 | 1.4e-02 |
| primitive neuroectodermal tumor | 2.300 | 1.8e-05 |
| psoriasis | -1.100 | 5.6e-04 |
MAIATSTQLARALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPANRVKLLPAGP 1 - 70 APKPSLSPASPAQPGSPYPAPDHSNEDQEVYVVPPPARPCPTSGPPAGPCPPSPDLIYKIPRASGTQLAA 71 - 140 PRDALEVYDVPPTALRVPSSGPYDCPASFSHPLTRVAPQPPGEDDAPYDVPLTPKPPAELEPDLEWEGGR 141 - 210 EPGPPIYAAPSNLKRASALLNLYEAPEELLADGEGGGTDEGIYDVPLLGPEAPPSPEPPGALASHDQDTL 211 - 280 AQLLARSPPPPHRPRLPSAESLSRRPLPALPVPEAPSPSPVPSPAPGRKGSIQDRPLPPPPPRLPGYGGP 281 - 350 KVEGDPEGREMEDDPAGHHNEYEGIPMAEEYDYVHLKGMDKAQGSRPPDQACTGDPELPERGMPAPQEAL 351 - 420 SPGEPLVVSTGDLQLLYFYAGQCQSHYSALQAAVAALMSSTQANQPPRLFVPHSKRVVVAAHRLVFVGDT 421 - 490 LGRLAASAPLRAQVRAAGTALGQALRATVLAVKGAALGYPSSPAIQEMVQCVTELAGQALQFTTLLTSLA 491 - 560 P//
