Property Summary

NCBI Gene PubMed Count 37
PubMed Score 120.80
PubTator Score 112.55

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (19)

Disease log2 FC p
malignant mesothelioma -1.300 4.1e-06
psoriasis -2.200 2.7e-05
osteosarcoma 1.299 1.3e-03
posterior fossa group B ependymoma -1.300 2.7e-10
glioblastoma -1.200 2.0e-07
sonic hedgehog group medulloblastoma -1.600 2.5e-07
atypical teratoid / rhabdoid tumor -1.200 2.1e-05
medulloblastoma, large-cell -1.900 4.9e-05
primitive neuroectodermal tumor -1.400 9.5e-05
Duchenne muscular dystrophy -1.056 2.0e-05
juvenile dermatomyositis -1.040 6.3e-07
limb girdle muscular dystrophy 2A -1.070 6.6e-05
pancreatic ductal adenocarcinoma liver m... -1.035 1.0e-02
lung cancer -1.500 1.4e-04
pediatric high grade glioma -1.200 2.5e-05
pilocytic astrocytoma -1.200 3.3e-08
COPD -1.100 3.1e-03
ovarian cancer -1.100 6.7e-07
dermatomyositis -1.400 2.5e-03

MLP Assay (16)

AID Type Active / Inconclusive / Inactive Description
1654 confirmatory 1524 / 0 / 289641 uHTS absorbance assay for the identification of compounds that inhibit VHR1.
1661 summary 1 / 0 / 0 Summary of the absorbance assay for the identification of compounds that inhibit VHR1.
1878 confirmatory 195 / 0 / 853 Fluorescent assay for identification of compounds that inhibit VHR1
1957 confirmatory 36 / 0 / 40 SAR VHR1 Fluorescent Assay for In Vitro dose response studies
1958 confirmatory 26 / 0 / 25 SAR VHR1 absorbance Assay for In Vitro dose response studies.
1992 screening 347 / 0 / 49493 HTS Colorimetric assay for the identification of compounds that inhibit VHR1
2004 confirmatory 21 / 0 / 35 SAR Colorimetric assay for the identification of compounds that inhibit VHR1
2070 confirmatory 30 / 0 / 2 MOA VHR1 Fluorescent secondary assay for identification of redox-state modulating compounds
2074 confirmatory 9 / 0 / 0 SAR Fluorescence Assay for VHR1 Inhibitors using DiFMUP
2684 confirmatory 45 / 0 / 39 SAR VHR1 Fluorescent Assay for In Vitro dose response studies Set 2
More...

Gene RIF (16)

PMID Text
25876765 Our results demonstrate that DUSP3 plays a key and nonredundant role as a regulator of innate immune responses
24901344 Data suggest levels of gene expression of both DUSP3 (dual specificity phosphatase 3) and PSME3 (proteasome activator subunit 3) are associated with susceptibility to Staphylococcus aureus infection/sepsis in humans and in mouse disease model.
24886454 DUSP3 is a pro-angiogenic atypical dual-specificity phosphatase.
24798147 VHR can dimerize inside cells, and that VHR catalytic activity is reduced upon dimerization.
24245651 DUSP3 interacting partners are nucleolar proteins involved in processes related to DNA repair and senescence.
23918168 we report the first successful site-specific incorporation of sulfotyrisine into VHR through the use of expanding genetic code
23322772 Proteins containing the class II motifs are efficient VHR substrates in vitro, suggesting that VHR may act on a novel class of yet unidentified Tyr(P) proteins in vivo.
21921027 Enteric commensal bacteria induce extracellular signal-regulated kinase pathway signaling via formyl peptide receptor-dependent redox modulation of dual specific phosphatase 3
21262974 VHR expression enhances the signaling of ErbB receptors and may be involved in NSCLC pathogenesis.
19010898 VHR has a direct role in the inhibition of JNK-dependent apoptosis in LNCaP cells and may therefore have a role in prostate cancer progression.
18505570 VHR can be considered as a new marker for cancer progression in cervix carcinoma and potential new target for anticancer therapy
18311544 Results highlight the importance of a high intracellular Zn(2+) content and the VHR/ZAP-70/ERK1,2-associated pathways in the modulation of LNCaP prostate cancer cell growth.
17785772 Small dual-specificity phosphatase VHR selectively dephosphorylates tyrosine-phosphorylated interferon-alpha- and beta-activated transcription factor STAT5, leading to the subsequent inhibition of STAT5 function.
17278098 deregulated expression of BRCA1-IRIS is likely to reduce dependence on normal physiological growth stimuli
16604064 VHR is required for cell-cycle progression as it modulates MAP kinase activation in a cell-cycle phase-dependent manner.
12447358 VHR, a Vaccinia virus VH1-related dual-specific protein phosphatase, is phosphorylated at Y138 by ZAP-70.

AA Sequence

MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMH      1 - 70
VNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLM     71 - 140
MRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP                             141 - 185
//

Text Mined References (40)

PMID Year Title
25876765 2015 DUSP3 Genetic Deletion Confers M2-like Macrophage-Dependent Tolerance to Septic Shock.
24901344 2014 Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis.
24886454 2014 DUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase.
24798147 2014 Unnatural amino acid mutagenesis reveals dimerization as a negative regulatory mechanism of VHR's phosphatase activity.
24531476 2014 The family-wide structure and function of human dual-specificity protein phosphatases.
24245651 2013 Proteomic, cellular, and network analyses reveal new DUSP3 interactions with nucleolar proteins in HeLa cells.
23918168 2013 A genetically encoded sulfotyrosine for VHR function research.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
23322772 2013 Specificity profiling of dual specificity phosphatase vaccinia VH1-related (VHR) reveals two distinct substrate binding modes.
22572157 Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip.
21921027 2011 Enteric commensal bacteria induce extracellular signal-regulated kinase pathway signaling via formyl peptide receptor-dependent redox modulation of dual specific phosphatase 3.
21269460 2011 Initial characterization of the human central proteome.
21262974 2011 Vaccinia H1-related phosphatase is a phosphatase of ErbB receptors and is down-regulated in non-small cell lung cancer.
19888758 2009 Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells.
19010898 2008 The mitogen-activated protein kinase phosphatase vaccinia H1-related protein inhibits apoptosis in prostate cancer cells and is overexpressed in prostate cancer.
18505570 2008 Cervix carcinoma is associated with an up-regulation and nuclear localization of the dual-specificity protein phosphatase VHR.
18311544 2008 High intracellular Zn2+ ions modulate the VHR, ZAP-70 and ERK activities of LNCaP prostate cancer cells.
17785772 2007 Cutting edge: selective tyrosine dephosphorylation of interferon-activated nuclear STAT5 by the VHR phosphatase.
17322878 2007 A module of negative feedback regulators defines growth factor signaling.
17278098 2007 BRCA1-IRIS activates cyclin D1 expression in breast cancer cells by downregulating the JNK phosphatase DUSP3/VHR.
16625196 2006 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
16604064 2006 Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15276183 2004 MD-2: the Toll 'gatekeeper' in endotoxin signalling.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12840032 2003 Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12447358 2003 Tyrosine phosphorylation of VHR phosphatase by ZAP-70.
11863439 2002 Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein Phosphatase.
11238845 2001 Vaccinia virus blocks gamma interferon signal transduction: viral VH1 phosphatase reverses Stat1 activation.
11085983 2001 Inhibitory role for dual specificity phosphatase VHR in T cell antigen receptor and CD28-induced Erk and Jnk activation.
10224087 1999 Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway.
8650541 1996 Crystal structure of the dual specificity protein phosphatase VHR.
7961745 1994 The catalytic role of Cys124 in the dual specificity phosphatase VHR.
7876121 1995 The purification and characterization of a human dual-specific protein tyrosine phosphatase.
7874108 1994 The detailed characterisation of a 400 kb cosmid walk in the BRCA1 region: identification and localisation of 10 genes including a dual-specificity phosphatase.
7829094 1994 Confirmation of the assignment of the gene encoding Kv1.3, a voltage-gated potassium channel (KCNA3) to the proximal short arm of human chromosome 1.
7829067 1994 Localization of the VHR phosphatase gene and its analysis as a candidate for BRCA1.
1281549 1992 Expression cloning of a human dual-specificity phosphatase.