| Tchem | Dipeptidyl peptidase 9 |
This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Idiopathic pulmonary fibrosis | 23 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Diabetes mellitus type 2 | 69 |
| Disease | Target Count | P-value |
|---|---|---|
| Polycystic ovary syndrome | 360 | 2.0e-03 |
| diabetes mellitus | 1728 | 7.0e-03 |
| non primary Sjogren syndrome sicca | 891 | 1.5e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| interstitial lung disease | 298 | 0.0 | 3.0 |
| Disease | Target Count |
|---|---|
| Pulmonary Fibrosis, Idiopathic | 12 |
| Disease | log2 FC | p |
|---|---|---|
| diabetes mellitus | -1.100 | 7.0e-03 |
| non primary Sjogren syndrome sicca | 1.100 | 1.5e-02 |
| Polycystic ovary syndrome | -1.072 | 2.0e-03 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| OMA EggNOG | ||
| OMA EggNOG |
teneligliptin
pIC50 6.27
anagliptin
pIC50 7.22
vildagliptin
pKi 7.17
saxagliptin
pKi 7.15
vildagliptin
pIC50 6.17
teneligliptin
pIC50 6.27
saxagliptin
pIC50 6.98
CHEMBL552127
pIC50 6.00
CHEMBL3091488
pIC50 6.00
CHEMBL2333025
pIC50 6.00
CHEMBL1909989
pKi 6.01
CHEMBL2206469
pIC50 6.03
CHEMBL584494
pIC50 6.04
CHEMBL2069856
pIC50 6.05
CHEMBL558452
pIC50 6.06
CHEMBL3330070
pIC50 6.06
CHEMBL3093913
pIC50 6.06
CHEMBL481290
pIC50 6.09
CHEMBL194354
pIC50 6.10
CHEMBL398076
pIC50 6.10
CHEMBL480914
pIC50 6.11
CHEMBL223497
pIC50 6.13
CHEMBL471960
pIC50 6.14
CHEMBL388111
pIC50 6.15
CHEMBL2069858
pIC50 6.18
CHEMBL3616889
pIC50 6.18
CHEMBL480154
pIC50 6.19
MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSH 1 - 70 RLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGIT 71 - 140 SYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLW 141 - 210 VANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEV 211 - 280 DESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVE 281 - 350 YIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVW 351 - 420 INVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALT 421 - 490 SGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFV 491 - 560 SHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHA 561 - 630 LQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQV 631 - 700 EIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERY 701 - 770 MDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERH 771 - 840 SIRCPESGEHYEVTLLHFLQEYL 841 - 863 //
