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  6. Dipeptidyl peptidase 9

Tchem Dipeptidyl peptidase 9

Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2.

This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

Ligand Count 214
NCBI Gene PubMed Count 34
PubMed Score 55.76
PubTator Score 44.80

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (5)

Disease Target Count Z-score Confidence
Idiopathic pulmonary fibrosis 23 0.0 0.0
Disease Target Count
Diabetes mellitus type 2 69
Disease Target Count P-value
Polycystic ovary syndrome 360 2.0e-03
diabetes mellitus 1728 7.0e-03
non primary Sjogren syndrome sicca 891 1.5e-02
Disease Target Count Z-score Confidence
interstitial lung disease 298 0.0 3.0
Disease Target Count
Pulmonary Fibrosis, Idiopathic 12

Expression

  Differential Expression (3)

Disease log2 FC p
diabetes mellitus -1.100 7.0e-03
non primary Sjogren syndrome sicca 1.100 1.5e-02
Polycystic ovary syndrome -1.072 2.0e-03

Synonym

Accession Q86TI2 O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8 Q96NT8 Q9BVR3 DP9
Symbols DP9
DPLP9
DPRP2
DPRP-2

Gene

DPP9

PANTHER Protein Class (3)

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (10)

 GO Function (3)

 GO Component (2)

 Compartment GO Term (13)

 IMPC Phenotype (8)

 MGI Phenotype (2)

 GWAS Trait (1)

 HCA RNA Cell Line (56)

See all...

Pathway (1)

Protein-protein Interaction (5)

KEAP1   DPP8   ABRAXAS2   APOL2   BABAM2  

Drug (4)

Structure of teneligliptin

teneligliptin
pIC50 6.27

Structure of anagliptin

anagliptin
pIC50 7.22

Structure of vildagliptin

vildagliptin
pKi 7.17

Structure of saxagliptin

saxagliptin
pKi 7.15

Ligand (206)

Structure of CHEMBL552127

CHEMBL552127
pIC50 6.00

Structure of CHEMBL3091488

CHEMBL3091488
pIC50 6.00

Structure of CHEMBL2333025

CHEMBL2333025
pIC50 6.00

Structure of CHEMBL1909989

CHEMBL1909989
pKi 6.01

Structure of CHEMBL2206469

CHEMBL2206469
pIC50 6.03

Structure of CHEMBL584494

CHEMBL584494
pIC50 6.04

Structure of CHEMBL2069856

CHEMBL2069856
pIC50 6.05

Structure of CHEMBL558452

CHEMBL558452
pIC50 6.06

Structure of CHEMBL3330070

CHEMBL3330070
pIC50 6.06

Structure of CHEMBL3093913

CHEMBL3093913
pIC50 6.06

Structure of CHEMBL481290

CHEMBL481290
pIC50 6.09

Structure of CHEMBL194354

CHEMBL194354
pIC50 6.10

Structure of CHEMBL398076

CHEMBL398076
pIC50 6.10

Structure of CHEMBL480914

CHEMBL480914
pIC50 6.11

Structure of CHEMBL223497

CHEMBL223497
pIC50 6.13

Structure of CHEMBL471960

CHEMBL471960
pIC50 6.14

Structure of CHEMBL388111

CHEMBL388111
pIC50 6.15

Structure of CHEMBL2069858

CHEMBL2069858
pIC50 6.18

Structure of CHEMBL3616889

CHEMBL3616889
pIC50 6.18

Structure of CHEMBL480154

CHEMBL480154
pIC50 6.19

Gene RIF (24)

AA Sequence 

MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSH      1 - 70
RLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGIT     71 - 140
SYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLW    141 - 210
VANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEV    211 - 280
DESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVE    281 - 350
YIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVW    351 - 420
INVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALT    421 - 490
SGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFV    491 - 560
SHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHA    561 - 630
LQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQV    631 - 700
EIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERY    701 - 770
MDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERH    771 - 840
SIRCPESGEHYEVTLLHFLQEYL                                                   841 - 863
//

Text Mined References (39)

PMID Year Title