| Tdark | Dynein light chain 4, axonemal |
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity).
This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. [provided by RefSeq, Dec 2014]
This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. [provided by RefSeq, Dec 2014]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| oligodendroglioma | 2849 | 9.0e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Situs Inversus | 52 | 4.267 | 2.1 |
| Disease | Target Count |
|---|---|
| Mirror movements 3 | 1 |
| PMID | Text | |
|---|---|---|
| 25236653 | No mutation in DNAL4 in Congenital mirror movements. | |
| 25098561 | DNAL4 may play a role in the cytoplasmic dynein complex for netrin-1-directed retrograde transport, and in commissural neurons of the corpus callosum in particular. This could lead to faulty cross-brain wiring, resulting in Mirror movements (MRMV). |
| PMID | Year | Title | |
|---|---|---|---|
| 25416956 | 2014 | A proteome-scale map of the human interactome network. | |
| 25236653 | 2014 | Congenital mirror movements: no mutation in DNAL4 in 17 index cases. | |
| 25098561 | 2014 | Identification of a homozygous splice site mutation in the dynein axonemal light chain 4 gene on 22q13.1 in a large consanguineous family from Pakistan with congenital mirror movement disorder. | |
| 23382691 | 2013 | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. | |
| 21516116 | 2011 | Next-generation sequencing to generate interactome datasets. | |
| 18029348 | 2008 | Toward a confocal subcellular atlas of the human proteome. | |
| 16189514 | 2005 | Towards a proteome-scale map of the human protein-protein interaction network. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 15461802 | 2004 | A genome annotation-driven approach to cloning the human ORFeome. | |
| 15454493 | 2005 | Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model. | |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | |
| 12529303 | 2003 | Reevaluating human gene annotation: a second-generation analysis of chromosome 22. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 11157096 | 2001 | Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor. | |
| 10591208 | 1999 | The DNA sequence of human chromosome 22. | |
| 8125298 | 1994 | Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |
