Property Summary

NCBI Gene PubMed Count 33
PubMed Score 43.07
PubTator Score 49.86

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (28)

Disease log2 FC p
psoriasis 2.300 9.0e-13
glioblastoma 4.000 1.5e-05
posterior fossa group A ependymoma 2.800 7.0e-07
sonic hedgehog group medulloblastoma 5.000 1.4e-12
atypical teratoid / rhabdoid tumor 4.500 1.3e-13
medulloblastoma, large-cell 4.700 9.6e-09
primitive neuroectodermal tumor 4.500 4.6e-07
Atopic dermatitis 2.100 8.3e-04
adrenocortical carcinoma 2.153 7.9e-04
non-small cell lung cancer 3.783 1.0e-34
intraductal papillary-mucinous carcinoma... 3.400 1.4e-04
intraductal papillary-mucinous neoplasm ... 4.100 1.1e-03
lung cancer 3.600 3.1e-05
active Crohn's disease 1.070 2.7e-02
pancreatic cancer 1.800 3.3e-06
breast carcinoma 1.500 7.4e-34
Breast cancer 3.600 2.2e-02
interstitial cystitis 1.500 1.5e-02
lung adenocarcinoma 2.500 4.4e-08
pediatric high grade glioma 3.800 1.3e-07
pilocytic astrocytoma 1.300 9.7e-05
primary Sjogren syndrome 1.100 4.0e-02
nasopharyngeal carcinoma 1.200 3.6e-03
Endometriosis 1.997 1.2e-02
ductal carcinoma in situ 2.400 1.0e-03
invasive ductal carcinoma 3.000 1.0e-04
ulcerative colitis 1.100 1.1e-03
ovarian cancer 3.100 5.2e-06

Gene RIF (18)

PMID Text
25289861 Aurora-A/HURP relays cell transforming signal to NF-kappaB, and the HURP/NF-kappaB complex is engaged in the regulation of cyclin E1 expression.
24375315 Detection of urinary HURP RNA is a useful for early detection of bladder cancer and bilharzial bladder cancer.
24349376 expression of DLG7, a hypoxia-controlled gene, holds prognostic potential in high-risk CaP; this also demonstrates that variation of oxygen tension may constitute a tool for identification of novel biomarkers for CaP.
24324629 The expression of DLGAP5 is regulated by methylation; the up-regulation of DLGAP5 contributes to hepatocellular carcinoma tumorigenesis by promoting cell proliferation.
24183881 RNA purification using functionalized MNPs was 97%. CONCLUSIONS: The developed colorimetric HURP RNA AuNP assay is sensitive, simple, and can aid noninvasive diagnosis of bladder cancer
23610398 HURP is a substrate of Aurora kinase A, which plays a crucial role in the stabilization of kinetochore fiber
22230478 Knockdown of HURP inhibits the proliferation of hepacellular carcinoma cells via downregulation of gankyrin and accumulation of p53.
22048964 DLGAP5-PINK1 and BUB1B-PINK1 were strong predictors of disease-free survival and overall survival, respectively, among adult patients with ACT.
22022601 Hepatocellular carcinoma patients can be separated into three prognosis-distinguishable groups by use of a risk score that is based upon HURP expression.
21924616 HURP regulates Kif18A localization and dynamics at the plus end of kinetochore microtubules.
19139432 Combined expression of DLG7 and PINK1 was the best predictor of disease free survival in malignant adrenal cortex neoplasms.
18321990 Phosphorylation of HURP by Aurora A provides a regulatory mechanism for the control of spindle assembly and function.
17322106 Dlg7 has a role in stem cell survival, in maintaining stem cell properties, and in carcinogenesis.
16769820 HURP controls spindle stability and dynamics to achieve efficient kinetochore capture at prometaphase, timely chromosome congression to the metaphase plate, and proper interkinetochore tension for anaphase initiation.
15987997 HURP is a potential oncogenic target of Aurora-A.
15340842 KIAA0008 expression is associated with invasiveness of HCC; overexpression of KIAA0008 leads to a more invasive phenotype of HCC cell lines.
15145941 Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis is regulated by Fbx7 and the SCF complex
12527899 results strongly suggest that HURP is a potential novel cell cycle regulator that may play a role in the carcinogenesis of human cancer cells

AA Sequence

MSSSHFASRHRKDISTEMIRTKIAHRKSLSQKENRHKEYERNRHFGLKDVNIPTLEGRILVELDETSQGL      1 - 70
VPEKTNVKPRAMKTILGDQRKQMLQKYKEEKQLQKLKEQREKAKRGIFKVGRYRPDMPCFLLSNQNAVKA     71 - 140
EPKKAIPSSVRITRSKAKDQMEQTKIDNESDVRAIRPGPRQTSEKKVSDKEKKVVQPVMPTSLRMTRSAT    141 - 210
QAAKQVPRTVSSTTARKPVTRAANENEPEGKVPSKGRPAKNVETKPDKGISCKVDSEENTLNSQTNATSG    211 - 280
MNPDGVLSKMENLPEINTAKIKGKNSFAPKDFMFQPLDGLKTYQVTPMTPRSANAFLTPSYTWTPLKTEV    281 - 350
DESQATKEILAQKCKTYSTKTIQQDSNKLPCPLGPLTVWHEEHVLNKNEATTKNLNGLPIKEVPSLERNE    351 - 420
GRIAQPHHGVPYFRNILQSETEKLTSHCFEWDRKLELDIPDDAKDLIRTAVGQTRLLMKERFKQFEGLVD    421 - 490
DCEYKRGIKETTCTDLDGFWDMVSFQIEDVIHKFNNLIKLEESGWQVNNNMNHNMNKNVFRKKVVSGIAS    491 - 560
KPKQDDAGRIAARNRLAAIKNAMRERIRQEECAETAVSVIPKEVDKIVFDAGFFRVESPVKLFSGLSVSS    561 - 630
EGPSQRLGTPKSVNKAVSQSRNEMGIPQQTTSPENAGPQNTKSEHVKKTLFLSIPESRSSIEDAQCPGLP    631 - 700
DLIEENHVVNKTDLKVDCLSSERMSLPLLAGGVADDINTNKKEGISDVVEGMELNSSITSQDVLMSSPEK    701 - 770
NTASQNSILEEGETKISQSELFDNKSLTTECHLLDSPGLNCSNPFTQLERRHQEHARHISFGGNLITFSP    771 - 840
LQPGEF                                                                    841 - 846
//

Text Mined References (43)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
25289861 2015 The involvement of nuclear factor-?appaB in the nuclear targeting and cyclin E1 upregulating activities of hepatoma upregulated protein.
24375315 2014 Evaluation of urinary HURP mRNA as a marker for detection of bladder cancer: relation to bilharziasis.
24349376 2013 Prognostic value of discs large homolog 7 transcript levels in prostate cancer.
24324629 2013 Silencing of DLGAP5 by siRNA significantly inhibits the proliferation and invasion of hepatocellular carcinoma cells.
24183881 2014 Direct detection of unamplified hepatoma upregulated protein RNA in urine using gold nanoparticles for bladder cancer diagnosis.
23610398 2013 Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23056639 2012 A genome-wide association study of circulating galectin-3.
22230478 2012 Knockdown of HURP inhibits the proliferation of hepacellular carcinoma cells via downregulation of gankyrin and accumulation of p53.
22048964 2012 Combined expression of BUB1B, DLGAP5, and PINK1 as predictors of poor outcome in adrenocortical tumors: validation in a Brazilian cohort of adult and pediatric patients.
22022601 2011 HURP expression-assisted risk scores identify prognosis distinguishable subgroups in early stage liver cancer.
21924616 2011 HURP regulates chromosome congression by modulating kinesin Kif18A function.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21269460 2011 Initial characterization of the human central proteome.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
19139432 2009 Gene expression profiling reveals a new classification of adrenocortical tumors and identifies molecular predictors of malignancy and survival.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
18321990 2008 Aurora A regulates the activity of HURP by controlling the accessibility of its microtubule-binding domain.
18220336 2008 Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
17322106 2007 Gene expression analysis of hematopoietic progenitor cells identifies Dlg7 as a potential stem cell gene.
17081983 2006 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
16964243 2006 A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
16769820 2006 HURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture.
16565220 2006 Phosphoproteome analysis of the human mitotic spindle.
16341674 2005 Transcriptome analysis of human gastric cancer.
16189514 2005 Towards a proteome-scale map of the human protein-protein interaction network.
15987997 2005 Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A.
15561729 2005 Proteome analysis of the human mitotic spindle.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15340842 2004 KIAA0008 gene is associated with invasive phenotype of human hepatocellular carcinoma--a functional analysis.
15302935 2004 Large-scale characterization of HeLa cell nuclear phosphoproteins.
15145941 2004 Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region.
14729942 2004 Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14699157 2004 Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells.
12527899 2003 Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma.
12508121 2003 The DNA sequence and analysis of human chromosome 14.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11543626 2001 Characterization of a novel human cell-cycle-regulated homologue of Drosophila dlg1.
9179496 1997 Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins.
7584028 1994 Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement).
7584026 1994 Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.