| Tbio | Dehydrogenase/reductase SDR family member 2, mitochondrial |
Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members of this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative promoter use and alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members of this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative promoter use and alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 1.5e-33 |
| lung cancer | 4740 | 2.3e-05 |
| breast carcinoma | 1638 | 6.7e-04 |
| cystic fibrosis | 1696 | 1.9e-03 |
| non-small cell lung cancer | 2890 | 3.2e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 1.3e-02 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 2.7e-02 |
| pancreatic cancer | 2398 | 4.2e-02 |
| adrenocortical carcinoma | 1428 | 4.3e-02 |
| interstitial cystitis | 2312 | 4.4e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Mastoiditis | 8 | 3.569 | 1.8 |
| Hepatitis A | 11 | 3.079 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical carcinoma | 1.150 | 4.3e-02 |
| breast carcinoma | 1.300 | 6.7e-04 |
| cystic fibrosis | -1.468 | 1.9e-03 |
| interstitial cystitis | -3.500 | 4.4e-02 |
| intraductal papillary-mucinous adenoma (... | -2.300 | 1.3e-02 |
| lung cancer | 2.700 | 2.3e-05 |
| non-small cell lung cancer | 1.067 | 3.2e-03 |
| pancreatic cancer | -1.200 | 4.2e-02 |
| pancreatic ductal adenocarcinoma liver m... | -1.105 | 2.7e-02 |
| psoriasis | -3.000 | 1.5e-33 |
MLSAVARGYQGWFHPCARLSVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQ 1 - 70 QNVDRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDK 71 - 140 ILSVNVKSPALLLSQLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRV 141 - 210 NCVVPGIIKTDFSKVFHGNESLWKNFKEHHQLQRIGESEDCAGIVSFLCSPDASYVNGENIAVAGYSTRL 211 - 280 //
