| Tbio | DENN domain-containing protein 2D |
Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| Astrocytoma, Pilocytic | 3081 | 1.6e-08 |
| osteosarcoma | 7950 | 2.9e-06 |
| glioblastoma | 5792 | 3.7e-05 |
| adult high grade glioma | 3801 | 6.6e-05 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 2.8e-04 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 3.2e-04 |
| ovarian cancer | 8520 | 4.9e-04 |
| Atopic dermatitis | 952 | 9.9e-04 |
| lung cancer | 4740 | 3.9e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 4.6e-03 |
| cutaneous lupus erythematosus | 1057 | 1.4e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 1.600 | 6.6e-05 |
| Astrocytoma, Pilocytic | 1.400 | 1.6e-08 |
| Atopic dermatitis | 1.100 | 9.9e-04 |
| cutaneous lupus erythematosus | 1.100 | 1.4e-02 |
| glioblastoma | 1.100 | 3.7e-05 |
| intraductal papillary-mucinous adenoma (... | 1.400 | 2.8e-04 |
| intraductal papillary-mucinous carcinoma... | 1.900 | 3.2e-04 |
| intraductal papillary-mucinous neoplasm ... | 1.700 | 4.6e-03 |
| lung cancer | -1.800 | 3.9e-03 |
| osteosarcoma | -3.293 | 2.9e-06 |
| ovarian cancer | 1.500 | 4.9e-04 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| OMA EggNOG |
MEGQVVGRVFRLFQRRLLQLRAGPPQDNSGEALKEPERAQEHSLPNFAGGQHFFEYLLVVSLKKKRSEDD 1 - 70 YEPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNEWASLTEYPRETFSFVLTNVDGSRKIGYCRR 71 - 140 LLPAGPGPRLPKVYCIISCIGCFGLFSKILDEVEKRHQISMAVIYPFMQGLREAAFPAPGKTVTLKSFIP 141 - 210 DSGTEFISLTRPLDSHLEHVDFSSLLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYP 211 - 280 FSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKDILPPKL 281 - 350 QDDILDSLGQGINELKTAEQINEHVSGPFVQFFVKIVGHYASYIKREANGQGHFQERSFCKALTSKTNRR 351 - 420 FVKKFVKTQLFSLFIQEAEKSKNPPAGYFQQKILEYEEQKKQKKPREKTVK 421 - 471 //
