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  5. Carnitine O-palmitoyltransferase 1, muscle isoform

Tchem Carnitine O-palmitoyltransferase 1, muscle isoform

The protein encoded by this gene, a member of the carnitine/choline acetyltransferase family, is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-chain fatty acyl-CoAs from the cytoplasm into the mitochondria. Multiple transcript variants encoding different isoforms have been found for this gene, and read-through transcripts are expressed from the upstream locus that include exons from this gene. [provided by RefSeq, Jun 2009]

 Comments

Property Summary

Ligand Count 50
NCBI Gene PubMed Count 48
PubMed Score 211.91
PubTator Score 183.92

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (4)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.7
Disease Target Count Z-score Confidence
Narcolepsy 72 4.104 2.1

Expression

Synonym

Accession Q92523 B7Z4U4 B7Z5T8 E9PCP2 Q13389 Q99655 Q9BY90 CPT1-M
Symbols CPTI
CPT1M
MCPT1
CPT1-M
CPTI-M
M-CPT1
MCCPT1

Gene

CPT1B

PANTHER Protein Class (2)

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (14)

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 GO Function (1)

 GO Component (3)

 GO Process (2)

 Compartment GO Term (31)

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 MGI Phenotype (2)

 GWAS Trait (1)

 HCA RNA Cell Line (56)

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Pathway (20)

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Ligand (50)

Structure of CHEMBL3431507

CHEMBL3431507
pIC50 6.00

Structure of CHEMBL3431624

CHEMBL3431624
pIC50 6.00

Structure of CHEMBL3431548

CHEMBL3431548
pIC50 6.01

Structure of CHEMBL3431889

CHEMBL3431889
pIC50 6.02

Structure of CHEMBL3431686

CHEMBL3431686
pIC50 6.02

Structure of CHEMBL3431661

CHEMBL3431661
pIC50 6.03

Structure of CHEMBL3431924

CHEMBL3431924
pIC50 6.04

Structure of CHEMBL3431642

CHEMBL3431642
pIC50 6.04

Structure of CHEMBL3431879

CHEMBL3431879
pIC50 6.07

Structure of CHEMBL3431721

CHEMBL3431721
pIC50 6.07

Structure of CHEMBL3431635

CHEMBL3431635
pIC50 6.08

Structure of CHEMBL3431920

CHEMBL3431920
pIC50 6.09

Structure of CHEMBL3431623

CHEMBL3431623
pIC50 6.10

Structure of CHEMBL3431679

CHEMBL3431679
pIC50 6.10

Structure of CHEMBL3431549

CHEMBL3431549
pIC50 6.12

Structure of CHEMBL3431511

CHEMBL3431511
pIC50 6.13

Structure of CHEMBL3431512

CHEMBL3431512
pIC50 6.13

Structure of CHEMBL3431601

CHEMBL3431601
pIC50 6.13

Structure of CHEMBL3431890

CHEMBL3431890
pIC50 6.15

Structure of CHEMBL3431926

CHEMBL3431926
pIC50 6.16

Gene RIF (32)

AA Sequence 

MAEAHQAVAFQFTVTPDGVDFRLSREALKHVYLSGINSWKKRLIRIKNGILRGVYPGSPTSWLVVIMATV      1 - 70
GSSFCNVDISLGLVSCIQRCLPQGCGPYQTPQTRALLSMAIFSTGVWVTGIFFFRQTLKLLLCYHGWMFE     71 - 140
MHGKTSNLTRIWAMCIRLLSSRHPMLYSFQTSLPKLPVPRVSATIQRYLESVRPLLDDEEYYRMELLAKE    141 - 210
FQDKTAPRLQKYLVLKSWWASNYVSDWWEEYIYLRGRSPLMVNSNYYVMDLVLIKNTDVQAARLGNIIHA    211 - 280
MIMYRRKLDREEIKPVMALGIVPMCSYQMERMFNTTRIPGKDTDVLQHLSDSRHVAVYHKGRFFKLWLYE    281 - 350
GARLLKPQDLEMQFQRILDDPSPPQPGEEKLAALTAGGRVEWAQARQAFFSSGKNKAALEAIERAAFFVA    351 - 420
LDEESYSYDPEDEASLSLYGKALLHGNCYNRWFDKSFTLISFKNGQLGLNAEHAWADAPIIGHLWEFVLG    421 - 490
TDSFHLGYTETGHCLGKPNPALAPPTRLQWDIPKQCQAVIESSYQVAKALADDVELYCFQFLPFGKGLIK    491 - 560
KCRTSPDAFVQIALQLAHFRDRGKFCLTYEASMTRMFREGRTETVRSCTSESTAFVQAMMEGSHTKADLR    561 - 630
DLFQKAAKKHQNMYRLAMTGAGIDRHLFCLYLVSKYLGVSSPFLAEVLSEPWRLSTSQIPQSQIRMFDPE    631 - 700
QHPNHLGAGGGFGPVADDGYGVSYMIAGENTIFFHISSKFSSSETNAQRFGNHIRKALLDIADLFQVPKA    701 - 770
YS                                                                        771 - 772
//

Text Mined References (49)

PMID Year Title