Tchem Carnitine O-palmitoyltransferase 1, muscle isoform

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The protein encoded by this gene, a member of the carnitine/choline acetyltransferase family, is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-chain fatty acyl-CoAs from the cytoplasm into the mitochondria. Multiple transcript variants encoding different isoforms have been found for this gene, and read-through transcripts are expressed from the upstream locus that include exons from this gene. [provided by RefSeq, Jun 2009]

Comments

Property Summary

Ligand Count	50
NCBI Gene PubMed Count	48
PubMed Score	211.91

PubTator Score	183.92

Knowledge Summary

Patent

No data available

TINX Plot

Disease (4)

Disease	Target Count	Z-score	Confidence
Cardiomegaly	116	0.0	0.0
Diabetes Mellitus, Experimental	108	0.0	0.0
Liver neoplasms	130	0.0	0.0
Myocardial Ischemia	169	0.0	0.0

Disease	Target Count	Z-score	Confidence
Carcinoma	11493	0.0	0.7

Disease	Target Count	Z-score	Confidence
Narcolepsy	72	4.104	2.1

Disease	Target Count	Z-score	Confidence
Carnitine palmitoyltransferase II deficiency	14	3.745	1.9
Obesity	678	3.69	1.8
Osteomyelitis	42	3.474	1.7

Testis 18,518

Heart - Atrial Appendage 17,896

Muscle - Skeletal 17,778

Brain - Cerebellum 17,983

Thyroid 18,024

Brain - Cerebellar Hemisphere 18,015

Heart - Left Ventricle 18,006

Spleen 17,614

Pituitary 18,147

Cells - EBV-transformed lymphocytes 18,186

Prostate 18,213

Nerve - Tibial 18,007

Small Intestine - Terminal Ileum 17,954

Breast - Mammary Tissue 18,103

Esophagus - Muscularis 18,017

Esophagus - Mucosa 18,076

Whole Blood 17,439

Uterus 17,618

Vagina 17,834

Adipose - Visceral (Omentum) 17,937

Skin - Not Sun Exposed (Suprapubic) 18,081

Kidney - Cortex 17,329

Esophagus - Gastroesophageal Junction 18,000

Liver 18,071

Brain - Spinal cord (cervical c-1) 17,973

Adipose - Subcutaneous 18,110

Lung 18,057

Skin - Sun Exposed (Lower leg) 17,968

Colon - Transverse 17,825

Adrenal Gland 18,071

Brain - Nucleus accumbens (basal ganglia... 18,024

Brain - Cortex 18,039

Minor Salivary Gland 18,005

Brain - Hypothalamus 18,169

Colon - Sigmoid 18,089

Brain - Caudate (basal ganglia) 18,001

Artery - Coronary 17,949

Ovary 17,971

Brain - Putamen (basal ganglia) 17,863

Brain - Frontal Cortex (BA9) 18,069

Stomach 17,879

Pancreas 18,123

Brain - Substantia nigra 17,981

Brain - Anterior cingulate cortex (BA24) 17,989

Brain - Hippocampus 18,011

Brain - Amygdala 18,006

Artery - Aorta 17,896

Artery - Tibial 17,631

Cells - Transformed fibroblasts 17,577

Fetal Heart 9,228

Adult Heart 6,506

Adult Testis 10,836

Adult Ovary 10,192

Adult Adrenal 8,475

Platelets 6,131

Fetal Ovary 9,118

Fetal Testis 7,955

CD8 Cells 9,840

NK Cells 8,475

Adult Liver 9,113

Monocytes 7,422

Adult Esophagus 4,936

CD4 Cells 7,773

Fetal Liver 8,402

B Cells 9,086

Fetal Gut 8,640

Adult Kidney 6,723

Adult Spinal Cord 7,594

Adult Rectum 8,022

Adult Colon 7,915

Adult Prostate 8,952

Adult Frontal Cortex 9,048

Adult Urinary Bladder 7,592

Adult Retina 10,115

Adrenal gland

Blood platelet

Brain

Colon

Frontal lobe

Gall bladder

Gut

Heart

Kidney

Liver

B-lymphocyte

Monocyte

Natural killer cell

Esophagus

Ovary

Pancreas

Placenta 6,083

Prostate gland

Rectum

Retina

Spinal cord

Testis

Urinary bladder

BTO:0004410

BTO:0005453

adipose tissue 15,837

adrenal gland 15,963

appendix 16,247

bone marrow 14,571

breast 16,063

cerebral cortex 16,630

cervix, uterine 15,871

colon 15,959

duodenum 15,975

endometrium 16,349

epididymis 15,863

esophagus 15,898

fallopian tube 16,245

gallbladder 16,333

heart muscle 14,972

kidney 15,917

liver 14,587

lung 16,312

lymph node 15,833

ovary 15,408

pancreas 14,070

parathyroid gland 14,769

placenta 15,937

prostate 16,460

rectum 15,705

salivary gland 14,981

seminal vesicle 15,918

skeletal muscle 14,011

skin 16,206

small intestine 16,154

smooth muscle 15,857

spleen 15,972

stomach 16,099

testis 17,936

thyroid gland 15,959

tonsil 15,400

urinary bladder 15,814

Liver and Pancreas 16,750

Digestive Tract 17,369

Urinary Tract 16,678

Endocrine System 18,159

Blood and immune system 16,909

Respiratory system 16,393

Female tissues 17,400

Male tissues 17,142

Skin and soft tissues 17,230

Nervous System 16,725

Cardiovascular System 15,192

Heart 583

Skeletal muscle 549

Tongue 470

See source...

Muscle 1,170

Osteoblast 180

Liver 1,045

gl6 6

See source...

Synonym

Accession	Q92523 B7Z4U4 B7Z5T8 E9PCP2 Q13389 Q99655 Q9BY90 CPT1-M
Symbols	CPTI CPT1M MCPT1 CPT1-M CPTI-M M-CPT1 MCCPT1

Gene

CPT1B

PANTHER Protein Class (2)

transferase 625

acetyltransferase 68

Ortholog (10)

Species	Source	Disease
Chimp 14,140	OMA EggNOG
Macaque 12,761	OMA EggNOG
Mouse 16,570	Inparanoid OMA EggNOG
Rat 15,117	Inparanoid OMA EggNOG
Dog 15,073	Inparanoid OMA EggNOG
Horse 14,252	Inparanoid OMA EggNOG
Cow 15,320	Inparanoid OMA EggNOG
Pig 10,168	Inparanoid EggNOG
Opossum 12,230	Inparanoid OMA EggNOG
Xenopus 10,468	Inparanoid OMA

UniProt Keyword (14)

Complete proteome 20,231

Polymorphism 12,194

Reference proteome 20,231

Alternative splicing 10,528

Membrane 7,361

Transmembrane 5,228

Transmembrane helix 5,207

Fatty acid metabolism 124

Lipid metabolism 432

Transferase 1,782

See all...

GO Function (1)

carnitine O-palmitoyltransferase activit... 4

GO Component (3)

integral component of membrane 3,665

mitochondrial outer membrane 163

mitochondrion 1,281

GO Process (2)

fatty acid beta-oxidation 42

carnitine shuttle 11

Compartment GO Term (31)

Bounding membrane of organelle 1,956

Cell 16,178

Cell part 16,177

Cytoplasm 10,983

Cytoplasmic part 9,247

GO:0031975 1,150

Integral component of membrane 5,331

Intracellular 14,109

Intracellular membrane-bounded organelle 10,341

Intracellular organelle 12,025

Intracellular organelle part 8,783

Intracellular part 13,972

Intrinsic component of membrane 5,458

Membrane 8,531

Membrane part 6,554

See all...

MGI Phenotype (2)

homeostasis-metabolism phenotype 4,747

mortality-aging 5,018

GWAS Trait (1)

Narcolepsy 7

HCA RNA Cell Line (56)

A-431 16,131

A549 15,174

AF22 16,160

AN3-CA 15,648

ASC TERT1 14,842

BEWO 16,726

BJ 15,448

BJ hTERT+ 15,353

BJ hTERT+ SV40 Large T+ 15,609

BJ hTERT+ SV40 Large T+ RasG12V 15,493

See all...

Pathway (20)

Fatty acid metabolism 48

Adipocytokine signaling pathway 69

Thermogenesis 232

Fatty acid degradation 44

PPAR signaling pathway 72

Glucagon signaling pathway 105

Insulin resistance 107

AMPK signaling pathway 120

http://pathwaycommons.org/pc2/Pathway_eb... 45

Signal Transduction 2,657

See all...

Ligand (50)

CHEMBL3431507
pIC50 6.00

CHEMBL3431624
pIC50 6.00

CHEMBL3431548
pIC50 6.01

CHEMBL3431889
pIC50 6.02

CHEMBL3431686
pIC50 6.02

CHEMBL3431661
pIC50 6.03

CHEMBL3431924
pIC50 6.04

CHEMBL3431642
pIC50 6.04

CHEMBL3431879
pIC50 6.07

CHEMBL3431721
pIC50 6.07

CHEMBL3431635
pIC50 6.08

CHEMBL3431920
pIC50 6.09

CHEMBL3431623
pIC50 6.10

CHEMBL3431679
pIC50 6.10

CHEMBL3431549
pIC50 6.12

CHEMBL3431511
pIC50 6.13

CHEMBL3431512
pIC50 6.13

CHEMBL3431601
pIC50 6.13

CHEMBL3431890
pIC50 6.15

CHEMBL3431926
pIC50 6.16

See all 50 ligands...

Gene RIF (32)

AA Sequence

MAEAHQAVAFQFTVTPDGVDFRLSREALKHVYLSGINSWKKRLIRIKNGILRGVYPGSPTSWLVVIMATV      1 - 70
GSSFCNVDISLGLVSCIQRCLPQGCGPYQTPQTRALLSMAIFSTGVWVTGIFFFRQTLKLLLCYHGWMFE     71 - 140
MHGKTSNLTRIWAMCIRLLSSRHPMLYSFQTSLPKLPVPRVSATIQRYLESVRPLLDDEEYYRMELLAKE    141 - 210
FQDKTAPRLQKYLVLKSWWASNYVSDWWEEYIYLRGRSPLMVNSNYYVMDLVLIKNTDVQAARLGNIIHA    211 - 280
MIMYRRKLDREEIKPVMALGIVPMCSYQMERMFNTTRIPGKDTDVLQHLSDSRHVAVYHKGRFFKLWLYE    281 - 350
GARLLKPQDLEMQFQRILDDPSPPQPGEEKLAALTAGGRVEWAQARQAFFSSGKNKAALEAIERAAFFVA    351 - 420
LDEESYSYDPEDEASLSLYGKALLHGNCYNRWFDKSFTLISFKNGQLGLNAEHAWADAPIIGHLWEFVLG    421 - 490
TDSFHLGYTETGHCLGKPNPALAPPTRLQWDIPKQCQAVIESSYQVAKALADDVELYCFQFLPFGKGLIK    491 - 560
KCRTSPDAFVQIALQLAHFRDRGKFCLTYEASMTRMFREGRTETVRSCTSESTAFVQAMMEGSHTKADLR    561 - 630
DLFQKAAKKHQNMYRLAMTGAGIDRHLFCLYLVSKYLGVSSPFLAEVLSEPWRLSTSQIPQSQIRMFDPE    631 - 700
QHPNHLGAGGGFGPVADDGYGVSYMIAGENTIFFHISSKFSSSETNAQRFGNHIRKALLDIADLFQVPKA    701 - 770
YS                                                                        771 - 772
//

Text Mined References (49)

Summary
Details

	PMID	Year	Title

Tchem Carnitine O-palmitoyltransferase 1, muscle isoform Add to cart View Collections Empty Collection

Property Summary

Knowledge Summary

Patent

No data available

TINX Plot

Disease (4)

Expression

Synonym

Gene

PANTHER Protein Class (2)

Ortholog (10)

UniProt Keyword (14)

GO Function (1)

GO Component (3)

GO Process (2)

Compartment GO Term (31)

MGI Phenotype (2)

GWAS Trait (1)

HCA RNA Cell Line (56)

Pathway (20)

Ligand (50)

Gene RIF (32)

AA Sequence

Text Mined References (49)

Tchem Carnitine O-palmitoyltransferase 1, muscle isoform

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