| Tbio | Cytoplasmic polyadenylation element-binding protein 2 |
May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity). Required for cell cycle progression, specifically for the transition from metaphase to anaphase (PubMed:26398195).
The protein encoded by this gene is highly similar to cytoplasmic polyadenylation element binding protein (CPEB), an mRNA-binding protein that regulates cytoplasmic polyadenylation of mRNA as a trans factor in oogenesis and spermatogenesis. Studies of the similar gene in mice suggested a possible role of this protein in transcriptionally inactive haploid spermatids. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is highly similar to cytoplasmic polyadenylation element binding protein (CPEB), an mRNA-binding protein that regulates cytoplasmic polyadenylation of mRNA as a trans factor in oogenesis and spermatogenesis. Studies of the similar gene in mice suggested a possible role of this protein in transcriptionally inactive haploid spermatids. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 1.4e-12 |
| Amyotrophic lateral sclerosis | 451 | 1.1e-06 |
| acute quadriplegic myopathy | 1158 | 6.4e-06 |
| atypical teratoid / rhabdoid tumor | 5112 | 6.7e-06 |
| Pick disease | 1894 | 2.5e-04 |
| medulloblastoma, large-cell | 6241 | 1.6e-03 |
| mucosa-associated lymphoid tissue lymphoma | 484 | 6.4e-03 |
| glioblastoma | 5792 | 1.3e-02 |
| progressive supranuclear palsy | 676 | 1.4e-02 |
| astrocytic glioma | 2597 | 1.5e-02 |
| group 3 medulloblastoma | 4104 | 1.9e-02 |
| spina bifida | 1074 | 2.3e-02 |
| gastric carcinoma | 807 | 3.3e-02 |
| acute myeloid leukemia | 783 | 4.2e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 4.6e-02 |
| Disease | log2 FC | p |
|---|---|---|
| acute myeloid leukemia | 1.400 | 4.2e-02 |
| acute quadriplegic myopathy | 1.483 | 6.4e-06 |
| Amyotrophic lateral sclerosis | 1.300 | 1.1e-06 |
| astrocytic glioma | -1.800 | 1.5e-02 |
| atypical teratoid / rhabdoid tumor | -2.300 | 6.7e-06 |
| gastric carcinoma | -1.100 | 3.3e-02 |
| glioblastoma | -1.100 | 1.3e-02 |
| group 3 medulloblastoma | -1.200 | 1.9e-02 |
| intraductal papillary-mucinous neoplasm ... | 1.300 | 4.6e-02 |
| medulloblastoma, large-cell | -3.200 | 1.6e-03 |
| mucosa-associated lymphoid tissue lympho... | 1.127 | 6.4e-03 |
| non-small cell lung cancer | -1.097 | 1.4e-12 |
| Pick disease | -1.100 | 2.5e-04 |
| progressive supranuclear palsy | -1.100 | 1.4e-02 |
| spina bifida | -1.616 | 2.3e-02 |
MPPPSPDSENGFYPGLPSSMNPAFFPSFSPVSPHGCTGLSVPTSGGGGGGFGGPFSATAVPPPPPPAMNI 1 - 70 PQQQPPPPAAPQQPQSRRSPVSPQLQQQHQAAAAAFLQQRNSYNHHQPLLKQSPWSNHQSSGWGTGSMSW 71 - 140 GAMHGRDHRRTGNMGIPGTMNQISPLKKPFSGNVIAPPKFTRSTPSLTPKSWIEDNVFRTDNNSNTLLPL 141 - 210 QVRSSLQLPAWGSDSLQDSWCTAAGTSRIDQDRSRMYDSLNMHSLENSLIDIMRAEHDPLKGRLSYPHPG 211 - 280 TDNLLMLNGRSSLFPIDDGLLDDGHSDQVGVLNSPTCYSAHQNGERIERFSRKVFVGGLPPDIDEDEITA 281 - 350 SFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQEESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRP 351 - 420 WNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFS 421 - 490 NQQSYIAAISARFVQLQHGDIDKRVEVKPYVLDDQMCDECQGARCGGKFAPFFCANVTCLQYYCEFCWAN 491 - 560 IHSRAGREFHKPLVKEGADRPRQIHFRWN 561 - 589 //
