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  6. Cyclic nucleotide-gated olfactory channel

Tchem Cyclic nucleotide-gated olfactory channel

Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.

The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010]

 Comments

Property Summary

Ligand Count 3
NCBI Gene PubMed Count 11
PubMed Score 61.20
PubTator Score 24.93

Knowledge Summary

Patent (1,725)

TINX Plot

  Disease (5)

Disease Target Count
Congenital anosmia 1
Disease Target Count P-value
diabetes mellitus 1728 1.0e-03
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 1.0
ENSP00000256078 30 0.0 0.5
Disease Target Count
ANIC 1

Expression

  Differential Expression (1)

Disease log2 FC p
diabetes mellitus 1.200 1.0e-03

Synonym

Accession Q16280 A0AVD0
Symbols CNCA
CNG2
CNCA1
OCNC1
OCNCa
OCNCALPHA

Gene

CNGA2

  Ortholog (12)

Species Source Disease
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA
OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG

 UniProt Keyword (18)

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 GO Function (3)

 GO Component (4)

 GO Process (3)

 Compartment GO Term (42)

See all...

 MGI Phenotype (6)

 HCA RNA Cell Line (4)

Pathway (7)

Protein-protein Interaction (2)

CNGA4   CNGB1  

Drug (1)

Structure of dequalinium

dequalinium
- 5.60

Ligand (2)

Structure of L-(cis)-diltiazem

L-(cis)-diltiazem
2.12

Structure of IUPHAR2350

all-trans-retinal
4.57

Gene RIF (2)

AA Sequence 

MTEKTNGVKSSPANNHNHHAPPAIKANGKDDHRTSSRPHSAADDDTSSELQRLADVDAPQQGRSGFRRIV      1 - 70
RLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGEDKGTKKKFELFVLDPAGDWY     71 - 140
YCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRLRTGFLEQGLLVKDTKK    141 - 210
LRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVL    211 - 280
YILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEY    281 - 350
LFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNK    351 - 420
KTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKE    421 - 490
MYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAV    491 - 560
TEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQEKLGQLETNMETLYTRFGRLLAEYTGAQQKLK    561 - 630
QRITVLETKMKQNNEDDYLSDGMNSPELAAADEP                                        631 - 664
//

Text Mined References (12)

PMID Year Title