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Tbio Centrosomal protein of 192 kDa

Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication.

 Comments

Property Summary

NCBI Gene PubMed Count 29
PubMed Score 13.33
PubTator Score 14.84

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 1.2
Kidney cancer 2613 0.0 0.7
Disease Target Count Z-score Confidence
Microcephaly 166 3.376 1.7

Expression

  Differential Expression (13)

Disease log2 FC p
glioblastoma 1.100 3.0e-05
group 3 medulloblastoma 1.600 2.9e-04
intraductal papillary-mucinous adenoma (... 1.200 2.4e-02
intraductal papillary-mucinous carcinoma... 1.200 1.3e-02
intraductal papillary-mucinous neoplasm ... 1.500 1.5e-02
malignant mesothelioma 1.300 6.5e-07
nasopharyngeal carcinoma 1.100 3.7e-04
osteosarcoma -1.797 2.2e-04
ovarian cancer -1.300 2.2e-04
Pick disease -1.100 6.1e-05
pituitary cancer 1.100 1.1e-05
posterior fossa group B ependymoma 1.200 5.1e-05
progressive supranuclear palsy -1.100 1.4e-02

Synonym

Accession Q8TEP8 A0A060A9S4 B7ZMF0 E9PF99 Q8WYT8 Q9H0F4 Q9NW27 Cep192
Symbols PPP1R62

Gene

CEP192

PDB

4N7Z  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (10)

 GO Function (1)

 GO Component (4)

 GO Process (6)

 Compartment GO Term (27)

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 GWAS Trait (1)

 HCA RNA Cell Line (56)

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Pathway (17)

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Gene RIF (13)

AA Sequence 

MKTSDLVPSFGYFIRSPEKREPIALIRKSDVSRGNLEKEMAHLNHDLYSGDLNEQSQAQLSEGSITLQVE      1 - 70
AVESTSQVDENDVTLTADKGKTEDTFFMSNKPQRYKDKLPDSGDSMLRISTIASAIAEASVNTDPSQLAA     71 - 140
MIKALSNKTRDKTFQEDEKQKDYSHVRHFLPNDLEKSNGSNALDMEKYLKKTEVSRYESALENFSRASMS    141 - 210
DTWDLSLPKEQTTQDIHPVDLSATSVSVRAPEENTAAIVYVENGESENQESFRTINSSNSVTNRENNSAV    211 - 280
VDVKTCSIDNKLQDVGNDEKATSISTPSDSYSSVRNPRITSLCLLKDCEEIRDNRENQRQNECVSEISNS    281 - 350
EKHVTFENHRIVSPKNSDLKNTSPEHGGRGSEDEQESFRPSTSPLSHSSPSEISGTSSSGCALESFGSAA    351 - 420
QQQQPPCEQELSPLVCSPAGVSRLTYVSEPESSYPTTATDDALEDRKSDITSELSTTIIQGSPAALEERA    421 - 490
MEKLREKVPFQNRGKGTLSSIIQNNSDTRKATETTSLSSKPEYVKPDFRWSKDPSSKSGNLLETSEVGWT    491 - 560
SNPEELDPIRLALLGKSGLSCQVGSATSHPVSCQEPIDEDQRISPKDKSTAGREFSGQVSHQTTSENQCT    561 - 630
PIPSSTVHSSVADMQNMPAAVHALLTQPSLSAAPFAQRYLGTLPSTGSTTLPQCHAGNATVCGFSGGLPY    631 - 700
PAVAGEPVQNSVAVGICLGSNIGSGWMGTSSLCNPYSNTLNQNLLSTTKPFPVPSVGTNCGIEPWDSGVT    701 - 770
SGLGSVRVPEELKLPHACCVGIASQTLLSVLNPTDRWLQVSIGVLSISVNGEKVDLSTYRCLVFKNKAII    771 - 840
RPHATEEIKVLFIPSSPGVFRCTFSVASWPCSTDAETIVQAEALASTVTLTAIAESPVIEVETEKKDVLD    841 - 910
FGDLTYGGWKALPLKLINRTHATVPIRLIINANAVAWRCFTFSKESVRAPVEVAPCADVVTRLAGPSVVN    911 - 980
HMMPASYDGQDPEFLMIWVLFHSPKKQISSSDILDSAEEFSAKVDIEVDSPNPTPVLRSVSLRARAGIAR    981 - 1050
IHAPRDLQTMHFLAKVASSRKQHLPLKNAGNIEVYLDIKVPEQGSHFSVDPKNLLLKPGEEHEVIVSFTP   1051 - 1120
KDPEACEERILKIFVQPFGPQYEVVLKGEVISSGSKPLSPGPCLDIPSILSNKQFLAWGGVPLGRTQLQK   1121 - 1190
LALRNNSASTTQHLRLLIRGQDQDCFQLQNTFGSEQRLTSNCEIRIHPKEDIFISVLFAPTRLSCMLARL   1191 - 1260
EIKQLGNRSQPGIKFTIPLSGYGGTSNLILEGVKKLSDSYMVTVNGLVPGKESKIVFSVRNTGSRAAFVK   1261 - 1330
AVGFKDSQKKVLLDPKVLRIFPDKFVLKERTQENVTLIYNPSDRGINNKTATELSTVYLFGGDEISRQQY   1331 - 1400
RRALLHKPEMIKQILPEHSVLQNINFVEAFQDELLVTEVYDLPQRPNDVQLFYGSMCKIILSVIGEFRDC   1401 - 1470
ISSREFLQPSSKASLESTSDLGASGKHGGNVSLDVLPVKGPQGSPLLSRAARPPLDQLASEEPWTVLPEH   1471 - 1540
LILVAPSPCDMAKTGRFQIVNNSVRLLRFELCWPAHCLTVTPQHGCVAPESKLQILVSPNSSLSTKQSMF   1541 - 1610
PWSGLIYIHCDDGQKKIVKVQIREDLTQVELLTRLTSKPFGILSPVSEPSVSHLVKPMTKPPSTKVEIRN   1611 - 1680
KSITFPTTEPGETSESCLELENHGTTDVKWHLSSLAPPYVKGVDESGDVFRATYAAFRCSPISGLLESHG   1681 - 1750
IQKVSITFLPRGRGDYAQFWDVECHPLKEPHMKHTLRFQLSGQSIEAENEPENACLSTDSLIKIDHLVKP   1751 - 1820
RRQAVSEASARIPEQLDVTARGVYAPEDVYRFRPTSVGESRTLKVNLRNNSFITHSLKFLSPREPFYVKH   1821 - 1890
SKYSLRAQHYINMPVQFKPKSAGKFEALLVIQTDEGKSIAIRLIGEALGKN                      1891 - 1941
//

Text Mined References (38)

PMID Year Title