Property Summary

NCBI Gene PubMed Count 17
PubMed Score 1.49
PubTator Score 18.65

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count
Hypertensive disease 193
Disease Target Count Z-score Confidence
Exocrine pancreatic insufficiency 21 3.495 1.7

Expression

Gene RIF (3)

PMID Text
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
16247445 analysis of regulation of hELA2 gene expression suggests transcriptional effects of AML1-ETO are more complex than simple DNA binding and repression via recruitment of corepressors

AA Sequence

MIRTLLLSTLVAGALSCGDPTYPPYVTRVVGGEEARPNSWPWQVSLQYSSNGKWYHTCGGSLIANSWVLT      1 - 70
AAHCISSSRTYRVGLGRHNLYVAESGSLAVSVSKIVVHKDWNSNQISKGNDIALLKLANPVSLTDKIQLA     71 - 140
CLPPAGTILPNNYPCYVTGWGRLQTNGAVPDVLQQGRLLVVDYATCSSSAWWGSSVKTSMICAGGDGVIS    141 - 210
SCNGDSGGPLNCQASDGRWQVHGIVSFGSRLGCNYYHKPSVFTRVSNYIDWINSVIANN               211 - 269
//

Text Mined References (18)

PMID Year Title
20932654 2010 Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20179351 2010 Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
16327289 2006 Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans.
16247445 2006 ELA2 is regulated by hematopoietic transcription factors, but not repressed by AML1-ETO.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15342556 2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11729383 2001 Identification of disease-specific genes in chronic pancreatitis using DNA array technology.
10620133 2000 Human elastase 1: evidence for expression in the skin and the identification of a frequent frameshift polymorphism.
3646943 1987 Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas.
3427074 1987 Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA.
2834346 1987 Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2.
2307232 1990 Further studies on the human pancreatic binary complexes involving procarboxypeptidase A.