Tbio CEACAM16 Carcinoembryonic antigen-related cell adhesion molecule 16

Protein Summary

Description

Required for proper hearing, it may play a role in maintaining the integrity of the tectorial membrane. The protein encoded by this gene is a secreted glycoprotein that in mouse interacts with tectorial membrane proteins in the inner ear. The encoded adhesion protein is found in cochlear outer hair cells and appears to be important for proper hearing over an extended frequency range. Defects in this gene likely are a cause of non-syndromic autosomal dominant hearing loss. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• Q2WEN9
• A7LI12

Gene Name

• CEACAM16

Ensembl ID

• ENST00000405314
• ENSP00000385576
• ENSG00000213892
• ENST00000587331
• ENSP00000466561

Symbol

• CEAL2
• CEAL2
• DFNA4B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
cell line	0.64
cell type or tissue	0.63
tissue	0.48
disease	0.4

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.67   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 112   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.67   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0