Property Summary

NCBI Gene PubMed Count 7
PubMed Score 11.10
PubTator Score 9.14

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (4)

Disease Target Count Z-score Confidence
Alzheimer's disease 644 0.0 2.0
Disease Target Count Z-score Confidence
Nonsyndromic deafness 121 4.063 2.0
Disease Target Count
DEAFNESS, AUTOSOMAL DOMINANT 4B 1
Disease Target Count
Deafness, autosomal dominant, 4B 1

Expression

Synonym

Accession Q2WEN9 A7LI12
Symbols CEAL2
DFNA4B

Gene

  Ortholog (8)

Gene RIF (4)

PMID Text
26497080 Results confirm that CEACAM6 promoted cell proliferation mediated by cyclin D1/CDK4.
25589040 Data indicate that a heterozygous missense mutation, c.505G>A (p.G169R) in exon 3 of the CEACAM16 gene (carcinoembryonic antigen-related cell adhesion molecule 16) was identified in autosomal dominant nonsyndromic hearing loss family.
22544735 CEACAM16 can probably form higher order structures with other tectorial membrane proteins such as alpha-tectorin and beta-tectorin and influences the physical properties of the tectorial membrane
21368133 data identify CEACAM16 as an alpha-tectorin-interacting protein that concentrates at the point of attachment of the TM to the stereocilia and, when mutated, results in ADNSHL at the DFNA4 locus

AA Sequence

MALTGYSWLLLSATFLNVGAEISITLEPAQPSEGDNVTLVVHGLSGELLAYSWYAGPTLSVSYLVASYIV      1 - 70
STGDETPGPAHTGREAVRPDGSLDIQGILPRHSGTYILQTFNRQLQTEVGYGHVQVHEILAQPTVLANST     71 - 140
ALVERRDTLRLMCSSPSPTAEVRWFFNGGALPVALRLGLSPDGRVLARHGIRREEAGAYQCEVWNPVSVS    141 - 210
RSEPINLTVYFGPERVAILQDSTTRTGCTIKVDFNTSLTLWCVSRSCPEPEYVWTFNGQALKNGQDHLNI    211 - 280
SSMTAAQEGTYTCIAKNTKTLLSGSASVVVKLSAAAVATMIVPVPTKPTEGQDVTLTVQGYPKDLLVYAW    281 - 350
YRGPASEPNRLLSQLPSGTWIAGPAHTGREVGFPNCSLLVQKLNLTDTGRYTLKTVTVQGKTETLEVELQ    351 - 420
VAPLG                                                                     421 - 425
//

Text Mined References (9)

PMID Year Title
26497080 2016 Cell motility and spreading promoted by CEACAM6 through cyclin D1/CDK4 in human pancreatic carcinoma.
25589040 2015 Exome sequencing identifies a novel CEACAM16 mutation associated with autosomal dominant nonsyndromic hearing loss DFNA4B in a Chinese family.
23565137 2013 SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.
22544735 2012 Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies.
21368133 2011 Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4).
16139472 2005 Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15057824 2004 The DNA sequence and biology of human chromosome 19.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.