| Tbio | CD83 antigen |
May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.
The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Arsenic Poisoning | 62 | 0.0 | 0.0 |
| Arthritis, Juvenile | 126 | 0.0 | 0.0 |
| Arthritis, Rheumatoid | 174 | 0.0 | 0.0 |
| Liver Cirrhosis, Experimental | 769 | 0.0 | 0.0 |
| Skin Diseases | 71 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Dermatologic disorders | 93 |
| Juvenile arthritis | 126 |
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 3.9e-86 |
| non-small cell lung cancer | 2890 | 4.6e-18 |
| lung carcinoma | 2843 | 6.2e-12 |
| malignant mesothelioma | 3232 | 1.1e-08 |
| pituitary cancer | 1972 | 7.3e-06 |
| lung adenocarcinoma | 2716 | 7.5e-06 |
| lung cancer | 4740 | 3.7e-05 |
| ovarian cancer | 8520 | 5.3e-05 |
| ulcerative colitis | 1819 | 1.1e-04 |
| chronic lymphosyte leukemia | 204 | 3.1e-04 |
| hepatocellular carcinoma | 547 | 8.1e-04 |
| cutaneous lupus erythematosus | 1057 | 1.6e-03 |
| interstitial cystitis | 2312 | 8.8e-03 |
| gastric cancer | 459 | 1.3e-02 |
| ependymoma | 4679 | 1.3e-02 |
| acute myeloid leukemia | 783 | 2.5e-02 |
| Waldenstrons macroglobulinemia | 765 | 3.5e-02 |
| mucosa-associated lymphoid tissue lymphoma | 484 | 4.6e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Rheumatoid arthritis | 1191 | 0.0 | 3.0 |
| Disease | log2 FC | p |
|---|---|---|
| acute myeloid leukemia | 1.300 | 2.5e-02 |
| chronic lymphosyte leukemia | -1.100 | 3.1e-04 |
| cutaneous lupus erythematosus | 1.900 | 1.6e-03 |
| ependymoma | -1.100 | 1.3e-02 |
| gastric cancer | -1.200 | 1.3e-02 |
| hepatocellular carcinoma | -1.700 | 8.1e-04 |
| interstitial cystitis | 1.500 | 8.8e-03 |
| lung adenocarcinoma | -1.190 | 7.5e-06 |
| lung cancer | -4.000 | 3.7e-05 |
| lung carcinoma | -1.700 | 6.2e-12 |
| malignant mesothelioma | 3.100 | 1.1e-08 |
| mucosa-associated lymphoid tissue lympho... | 1.296 | 4.6e-02 |
| non-small cell lung cancer | -2.101 | 4.6e-18 |
| ovarian cancer | 1.300 | 5.3e-05 |
| pituitary cancer | 1.600 | 7.3e-06 |
| psoriasis | 1.400 | 3.9e-86 |
| ulcerative colitis | 1.700 | 1.1e-04 |
| Waldenstrons macroglobulinemia | 1.128 | 3.5e-02 |
