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  6. C-C chemokine receptor
  7. C-C chemokine receptor-like 2

Tchem C-C chemokine receptor-like 2

Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.

This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

Ligand Count 93
NCBI Gene PubMed Count 19
PubMed Score 18.92
PubTator Score 100.50

Knowledge Summary

Patent (50,713)

TINX Plot

  Disease (5)

Disease Target Count Z-score Confidence
Arsenic Poisoning 62 0.0 0.0
Skin Diseases 71 0.0 0.0
Disease Target Count
Dermatologic disorders 93
Disease Target Count Z-score Confidence
Acquired immunodeficiency syndrome 197 0.0 0.7
Disease Target Count Z-score Confidence
Molluscum contagiosum 8 3.032 1.5

Expression

  Differential Expression (11)

Disease log2 FC p
cutaneous lupus erythematosus 2.600 1.4e-04
intraductal papillary-mucinous adenoma (... 1.500 1.4e-03
intraductal papillary-mucinous carcinoma... 1.400 3.5e-03
lung adenocarcinoma -1.203 9.3e-07
lung cancer -2.400 1.1e-02
lung carcinoma -1.700 3.0e-19
malignant mesothelioma -1.800 4.2e-07
mucosa-associated lymphoid tissue lympho... 1.012 1.7e-02
non-small cell lung cancer -1.883 5.3e-18
osteosarcoma -3.257 3.5e-05
tuberculosis -4.000 1.2e-08

Synonym

Accession O00421 B4DKQ8 O75307 Q4VBB0 Q6IPX0 Q7KYQ9 Q96KP5 Q9UPG0
Symbols HCR
CKRX
CRAM
ACKR5
CRAM-A
CRAM-B

Gene

CCRL2

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (13)

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 GO Function (3)

 GO Component (2)

 GO Process (3)

 Compartment GO Term (12)

 MGI Phenotype (4)

 GWAS Trait (5)

 HCA RNA Cell Line (42)

See all...

Pathway (8)

Protein-protein Interaction (5)

AMY1C   FITM2   IGHA1   CST1   CST4  

Ligand (93)

Structure of CHEMBL3704126

CHEMBL3704126
pIC50 7.00

Structure of CHEMBL3704044

CHEMBL3704044
pIC50 7.00

Structure of CHEMBL3704129

CHEMBL3704129
pIC50 7.01

Structure of CHEMBL3704134

CHEMBL3704134
pIC50 7.04

Structure of CHEMBL3704076

CHEMBL3704076
pIC50 7.04

Structure of CHEMBL3704108

CHEMBL3704108
pIC50 7.05

Structure of CHEMBL3659058

CHEMBL3659058
pIC50 7.07

Structure of CHEMBL3704128

CHEMBL3704128
pIC50 7.08

Structure of CHEMBL3704127

CHEMBL3704127
pIC50 7.09

Structure of CHEMBL3704121

CHEMBL3704121
pIC50 7.09

Structure of CHEMBL3704059

CHEMBL3704059
pIC50 7.11

Structure of CHEMBL3704107

CHEMBL3704107
pIC50 7.13

Structure of CHEMBL3704055

CHEMBL3704055
pIC50 7.13

Structure of CHEMBL3659054

CHEMBL3659054
pIC50 7.14

Structure of CHEMBL3704142

CHEMBL3704142
pIC50 7.14

Structure of CHEMBL3704053

CHEMBL3704053
pIC50 7.14

Structure of CHEMBL3704045

CHEMBL3704045
pIC50 7.14

Structure of CHEMBL3704119

CHEMBL3704119
pIC50 7.17

Structure of CHEMBL3704041

CHEMBL3704041
pIC50 7.19

Structure of CHEMBL3704070

CHEMBL3704070
pIC50 7.19

Gene RIF (11)

AA Sequence 

MANYTLAPEDEYDVLIEGELESDEAEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVVLILVKYKGLK      1 - 70
RVENIYLLNLAVSNLCFLLTLPFWAHAGGDPMCKILIGLYFVGLYSETFFNCLLTVQRYLVFLHKGNFFS     71 - 140
ARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLPADETFWKHFLTLKMNISVLV    141 - 210
LPLFIFTFLYVQMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSYNLDK    211 - 280
SVHITKLIATTHCCINPLLYAFLDGTFSKYLCRCFHLRSNTPLQPRGQSAQGTSREEPDHSTEV          281 - 344
//

Text Mined References (22)

PMID Year Title