| Tchem | C-C chemokine receptor-like 2 |
This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Arsenic Poisoning | 62 | 0.0 | 0.0 |
| Skin Diseases | 71 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Dermatologic disorders | 93 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 3.0e-19 |
| non-small cell lung cancer | 2890 | 5.3e-18 |
| tuberculosis | 2010 | 1.2e-08 |
| malignant mesothelioma | 3232 | 4.2e-07 |
| lung adenocarcinoma | 2716 | 9.3e-07 |
| osteosarcoma | 7950 | 3.5e-05 |
| cutaneous lupus erythematosus | 1057 | 1.4e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 1.4e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 3.5e-03 |
| lung cancer | 4740 | 1.1e-02 |
| mucosa-associated lymphoid tissue lymphoma | 484 | 1.7e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Acquired immunodeficiency syndrome | 197 | 0.0 | 0.7 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Molluscum contagiosum | 8 | 3.032 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| cutaneous lupus erythematosus | 2.600 | 1.4e-04 |
| intraductal papillary-mucinous adenoma (... | 1.500 | 1.4e-03 |
| intraductal papillary-mucinous carcinoma... | 1.400 | 3.5e-03 |
| lung adenocarcinoma | -1.203 | 9.3e-07 |
| lung cancer | -2.400 | 1.1e-02 |
| lung carcinoma | -1.700 | 3.0e-19 |
| malignant mesothelioma | -1.800 | 4.2e-07 |
| mucosa-associated lymphoid tissue lympho... | 1.012 | 1.7e-02 |
| non-small cell lung cancer | -1.883 | 5.3e-18 |
| osteosarcoma | -3.257 | 3.5e-05 |
| tuberculosis | -4.000 | 1.2e-08 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
CHEMBL3704126
pIC50 7.00
CHEMBL3704044
pIC50 7.00
CHEMBL3704129
pIC50 7.01
CHEMBL3704134
pIC50 7.04
CHEMBL3704076
pIC50 7.04
CHEMBL3704108
pIC50 7.05
CHEMBL3659058
pIC50 7.07
CHEMBL3704128
pIC50 7.08
CHEMBL3704127
pIC50 7.09
CHEMBL3704121
pIC50 7.09
CHEMBL3704059
pIC50 7.11
CHEMBL3704107
pIC50 7.13
CHEMBL3704055
pIC50 7.13
CHEMBL3659054
pIC50 7.14
CHEMBL3704142
pIC50 7.14
CHEMBL3704053
pIC50 7.14
CHEMBL3704045
pIC50 7.14
CHEMBL3704119
pIC50 7.17
CHEMBL3704041
pIC50 7.19
CHEMBL3704070
pIC50 7.19
MANYTLAPEDEYDVLIEGELESDEAEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVVLILVKYKGLK 1 - 70 RVENIYLLNLAVSNLCFLLTLPFWAHAGGDPMCKILIGLYFVGLYSETFFNCLLTVQRYLVFLHKGNFFS 71 - 140 ARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLPADETFWKHFLTLKMNISVLV 141 - 210 LPLFIFTFLYVQMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSYNLDK 211 - 280 SVHITKLIATTHCCINPLLYAFLDGTFSKYLCRCFHLRSNTPLQPRGQSAQGTSREEPDHSTEV 281 - 344 //
