| Tchem | C-C chemokine receptor-like 2 |
This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count |
|---|---|
| Arsenic Poisoning | 59 |
| Dermatologic disorders | 65 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2844 | 2.98304577962885E-19 |
| non-small cell lung cancer | 2798 | 5.29008666757428E-18 |
| tuberculosis | 1563 | 1.20563677711963E-8 |
| malignant mesothelioma | 3163 | 4.21351485057346E-7 |
| lung adenocarcinoma | 2714 | 9.2925473384295E-7 |
| osteosarcoma | 7933 | 3.50019868068269E-5 |
| cutaneous lupus erythematosus | 1056 | 1.41056734172758E-4 |
| intraductal papillary-mucinous adenoma (IPMA) | 2956 | 0.00140145597847179 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2988 | 0.00345439384059798 |
| lung cancer | 4473 | 0.010859101256455 |
| mucosa-associated lymphoid tissue lymphoma | 480 | 0.0189385389898567 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Molluscum contagiosum | 8 | 3.145 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| malignant mesothelioma | -1.800 | 0.000 |
| cutaneous lupus erythematosus | 2.600 | 0.000 |
| osteosarcoma | -3.257 | 0.000 |
| tuberculosis | -4.000 | 0.000 |
| non-small cell lung cancer | -1.883 | 0.000 |
| intraductal papillary-mucinous adenoma (... | 1.500 | 0.001 |
| intraductal papillary-mucinous carcinoma... | 1.400 | 0.003 |
| lung cancer | -2.400 | 0.011 |
| lung adenocarcinoma | -1.203 | 0.000 |
| lung carcinoma | -1.700 | 0.000 |
| mucosa-associated lymphoid tissue lympho... | 1.086 | 0.019 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Opossum | OMA EggNOG Inparanoid |
| Platypus | OMA EggNOG |
CHEMBL3704126
pIC50 7.00
CHEMBL3704044
pIC50 7.00
CHEMBL3704129
pIC50 7.01
CHEMBL3704134
pIC50 7.04
CHEMBL3704076
pIC50 7.04
CHEMBL3704108
pIC50 7.05
CHEMBL3659058
pIC50 7.07
CHEMBL3704128
pIC50 7.08
CHEMBL3704127
pIC50 7.09
CHEMBL3704121
pIC50 7.09
CHEMBL3704059
pIC50 7.11
CHEMBL3704107
pIC50 7.13
CHEMBL3704055
pIC50 7.13
CHEMBL3659054
pIC50 7.14
CHEMBL3704142
pIC50 7.14
CHEMBL3704053
pIC50 7.14
CHEMBL3704045
pIC50 7.14
CHEMBL3704119
pIC50 7.17
CHEMBL3704041
pIC50 7.19
CHEMBL3704070
pIC50 7.19
| PMID | Text |
|---|---|
| 26563945 | in breast cancer, CRAM-A becomes specifically upregulated under inflammatory stimuli and may serve as a potential marker of immune response. |
| 26487662 | CCRL2 inhibited the growth of breast cancer cells in vitro and in vivo. |
| 24162774 | HIV-1 gp120 upregulates the expression of chemokine (C-C motif) receptor-like 2 (CCRL2) in human B cells |
| 23142225 | these results suggest for the first time that elevated CCRL2 in glioma promotes cell migration and invasion. |
| 22046140 | Considering the newly defined role of CCRL2 in lung dendritic cell trafficking, this atypical chemokine receptor may affect pneumocystis pneumonia through immune regulation and inducing inflammation. |
| 20677014 | Observational study of gene-disease association. (HuGE Navigator) |
| 20056178 | Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 20002784 | demonstration that the homeostatic chemokine CCL19 is a specific ligand for CRAM |
| 18794339 | Results identify chemerin as a natural nonsignaling protein ligand for both human and mouse CCRL2. |
| 15188357 | CCRL2 expression is up-regulated on synovial neutrophils of rheumatoid arthritis patients |
MANYTLAPEDEYDVLIEGELESDEAEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVVLILVKYKGLK 1 - 70 RVENIYLLNLAVSNLCFLLTLPFWAHAGGDPMCKILIGLYFVGLYSETFFNCLLTVQRYLVFLHKGNFFS 71 - 140 ARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLPADETFWKHFLTLKMNISVLV 141 - 210 LPLFIFTFLYVQMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSYNLDK 211 - 280 SVHITKLIATTHCCINPLLYAFLDGTFSKYLCRCFHLRSNTPLQPRGQSAQGTSREEPDHSTEV 281 - 344 //
| PMID | Year | Title |
|---|---|---|
| 26563945 | 2015 | CRAM-A indicates IFN-?-associated inflammatory response in breast cancer. |
| 26487662 | 2015 | The human chemokine receptor CCRL2 suppresses chemotaxis and invasion by blocking CCL2-induced phosphorylation of p38 MAPK in human breast cancer cells. |
| 25340798 | 2014 | Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation. |
| 23142225 | 2012 | Elevated chemokine CC-motif receptor-like 2 (CCRL2) promotes cell migration and invasion in glioblastoma. |
| 22046140 | 2011 | Role of exonic variation in chemokine receptor genes on AIDS: CCRL2 F167Y association with pneumocystis pneumonia. |
| 21502085 | 2011 | Genome-wide association study implicates PARD3B-based AIDS restriction. |
| 20677014 | 2010 | An approach based on a genome-wide association study reveals candidate loci for narcolepsy. |
| 20190752 | 2010 | Multiple common variants for celiac disease influencing immune gene expression. |
| 20056178 | 2010 | Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. |
| 20002784 | 2010 | CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B. |
| More... |
