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Tdark CDK5 and ABL1 enzyme substrate 2

Unknown. Probably involved in G1-S cell cycle transition.

 Comments

Property Summary

NCBI Gene PubMed Count 8
PubMed Score 0.95
PubTator Score 1.90

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count
Colorectal Cancer 62
Disease Target Count P-value
osteosarcoma 7933 4.3e-04
invasive ductal carcinoma 2950 6.0e-04
subependymal giant cell astrocytoma 2287 1.2e-02

Expression

  Differential Expression (3)

Disease log2 FC p
osteosarcoma -1.427 4.3e-04
subependymal giant cell astrocytoma -1.475 1.2e-02
invasive ductal carcinoma 1.100 6.0e-04

Synonym

Accession Q9BTV7 Q5JWL0 Q9BYK0
Symbols ik3-2
C20orf150
dJ908M14.2

Gene

CABLES2

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (7)

 GO Process (3)

 Compartment GO Term (3)

 GWAS Trait (1)

 HCA RNA Cell Line (56)

See all...

Pathway (3)

Gene RIF (2)

PMID Text
20056645 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
14637168 We thus identified ik3-2 as a proapoptotic factor involved in both p53-mediated and p53-independent apoptotic pathways.

AA Sequence 

MAAAAAGGAPGPAPGPAGPPPPAAPTSAARAPPQALRRRGDSRRRQAALFFLNNISLDGRPPSLGPGGEK      1 - 70
PPPPPAEAREPPAPPPPEPPTGLPARTPAPQGLLSPTQVPTGLGLDGQRQRKRVTSQRCSLEFLEDAVGC     71 - 140
APAQRTKHTSGSPRHKGLKKTHFIKNMRQYDTRNSRIVLICAKRSLCAAFSVLPYGEGLRISDLRVDSQK    141 - 210
QRHPSGGVSVSSEMVFELEGVELGADGKVVSYAKFLYPTNALVTHKSDSHGLLPTPRPSVPRTLPGSRHK    211 - 280
PAPTKSAPASTELGSDVGDTLEYNPNLLDDPQWPCGKHKRVLIFASYMTTVIEYVKPSDLKKDMNETFRE    281 - 350
KFPHVKLTLSKIRSLKREMRSLSEECSLEPVTVAMAYVYFEKLVLQGKLSKQNRKLCAGACVLLAAKISS    351 - 420
DLRKSGVTQLIDKLEERFRFNRRDLIGFEFTVLVALELALYLPENQVLPHYRRLTQQF                421 - 478
//

Text Mined References (11)

PMID Year Title
24737748 2014 Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.
23535732 2013 Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
20056645 2010 Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19369195 2009 Large-scale proteomics analysis of the human kinome.
18691976 2008 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14637168 2003 ik3-2, a relative to ik3-1/Cables, is involved in both p53-mediated and p53-independent apoptotic pathways.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11955625 2002 ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl.
11780052 2001 The DNA sequence and comparative analysis of human chromosome 20.