Property Summary

NCBI Gene PubMed Count 13
PubMed Score 210.30
PubTator Score 38.79

Knowledge Summary


No data available


  Differential Expression (2)

Disease log2 FC p
active Crohn's disease -1.987 3.2e-03
ulcerative colitis -2.300 3.9e-06


Accession P43166 Q541F0 Q86YU0
Symbols CAVII



PANTHER Protein Class (2)


3MDZ   3ML5  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

Gene RIF (5)

25885898 Our results indicate that decreased expression of CA7 correlates with disease progression and predicts poor prognosis in CRC, especially for patients with early stage tumors.
23851572 native hCA VII can protect cells from oxidative damage by preventing the apoptosis cascade and that cysteines play a leading role in this process
20493921 conclude that the full-length CA VII is a predominant active form in human brain and also in other tissues. In addition to the brain, CA VII is expressed in several other organs including the stomach, duodenum, colon, liver, and skeletal muscle
15686895 these data furnish further evidence that hCA VII is the isozyme responsible for the anticonvulsant/antiepileptic activity of sulfonamides and sulfamates
15528236 GABAergic transmission is influenced by the neuronal expression of carbonic anhydrase cavii--REVIEW

AA Sequence


Text Mined References (20)

PMID Year Title
25885898 2015 Prognostic value of carbonic anhydrase VII expression in colorectal carcinoma.
23851572 2013 Human carbonic anhydrase VII protects cells from oxidative damage.
22020285 2011 Image-based genome-wide siRNA screen identifies selective autophagy factors.
20493921 2010 Analysis of a shortened form of human carbonic anhydrase VII expressed in vitro compared to the full-length enzyme.
19206230 2009 Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors.
19186056 2009 A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.
17705204 2007 Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste.
17314045 2007 Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.
17127057 2007 Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV.
16807956 2006 Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme.
16686544 2006 Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design.
15686895 2005 Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.
15528236 2005 Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12417987 2002 A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis.
11875253 2001 The cellular physiology of carbonic anhydrases.
10493829 1999 Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.
7574487 1995 Human carbonic anhydrases and carbonic anhydrase deficiencies.
1783392 1991 Characterization of the human gene for a newly discovered carbonic anhydrase, CA VII, and its localization to chromosome 16.