Property Summary

NCBI Gene PubMed Count 7
PubMed Score 3.95
PubTator Score 1.81

Knowledge Summary


No data available


  Differential Expression (17)

Disease log2 FC p
malignant mesothelioma 2.300 2.6e-08
astrocytoma 1.500 2.0e-24
ependymoma 1.900 9.6e-03
oligodendroglioma 1.900 6.5e-03
psoriasis -1.600 1.4e-09
cutaneous lupus erythematosus -1.100 1.6e-03
glioblastoma 1.300 5.2e-05
osteosarcoma -2.612 1.7e-08
group 3 medulloblastoma 2.300 1.2e-03
atypical teratoid / rhabdoid tumor 1.400 1.7e-03
primitive neuroectodermal tumor 2.100 1.1e-04
cystic fibrosis -1.400 2.1e-04
pediatric high grade glioma 1.100 4.1e-03
pilocytic astrocytoma 1.100 2.7e-03
inflammatory breast cancer -1.100 1.5e-05
Pick disease 1.400 2.6e-04
ovarian cancer -1.600 1.8e-07


Accession Q2NKX9 B4DT10 Q4G0J7 Q6ZVA6
Symbols HCRCN81


  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

Gene RIF (4)

26607374 hcrcn81 might promote carcinogenesis and progression through regulation of the Wnt/beta-catenin signaling pathway and plays an important role in the carcinogenesis of colorectal cancer.
25023051 c2orf68 expression correlates with the pathogenesis of colorectal cancer through PI3K/Akt/mTOR pathway.
23404111 Observations of the current study indicate that hcrcn81 may play a role in tumorigenesis by regulating the mTOR signaling pathway.
21874238 The mRNA levels of NM_001013649.3 are significantly down-regulated in colorectal adenocarcinoma tissue, and this down-regulation is most likely correlated with the differentiation status of the cancer.

AA Sequence

TPLDPPMREALKLRIQEEIAKRQSQH                                                141 - 166

Text Mined References (8)

PMID Year Title
26607374 2016 hcrcn81 promotes cell proliferation through Wnt signaling pathway in colorectal cancer.
25023051 2014 The role of c2orf68 and PI3K/Akt/mTOR pathway in human colorectal cancer.
23404111 2013 Hcrcn81 is upregulated by rapamycin treatment in human colorectal adenocarcinoma cells.
21874238 NM_001013649.3 gene is down-regulated in human colorectal adenocarcinoma.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15146197 2004 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.