Property Summary

NCBI Gene PubMed Count 22
PubMed Score 12.18
PubTator Score 27.20

Knowledge Summary


No data available


  Disease (1)


  Differential Expression (6)

Disease log2 FC p
Waldenstrons macroglobulinemia 1.057 3.1e-03
Multiple myeloma 1.014 4.9e-03
lung cancer 1.500 1.5e-04
diabetes mellitus -1.200 1.3e-03
Breast cancer 2.600 2.5e-02
ovarian cancer -1.900 5.0e-07

Gene RIF (9)

26905879 C14orf166 promotes bladder cancer cell proliferation and can be a novel prognostic biomarker for patients with bladder cancer.
26883017 C14orf166 could be a novel prognostic biomarker of breast cancer, it also contributes to cell proliferation by regulating G1/S transition.
25964093 Overexpression of chromosome 14 open reading frame 166 correlates with disease progression in nasopharyngeal carcinoma.
24608264 hCLE/C14orf166 associates with DDX1, HSPC117, and FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.
22174317 HIV-1 Rev interacting protein, chromosome 14 open reading frame 166 (C14orf166), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with C14orf166 is increased by RRE
21900157 Silencing of CLE causes reduction of influenza A virus polymerase activity, viral RNA transcription and replication, virus titer, and viral particle production.
21823664 spatial interactions of hnRNPH1, NF45, and C14orf166 with HCVc174 likely modulate HCV or cellular functions during acute and chronic HCV infection
19152423 c14orf166 was identified asa novel metastasis-associated protein, and the roles of radixin, moesin and c14orf166 in pancreatic cancer metastasis deserve further investigations.
15147888 A novel protein CGI-99 is isolated, which may be involved in the functional regulation of human ninein in the centrosome structure and may also be important in brain development and tumorigenesis.

AA Sequence

ELRELQTKINEAIVAVQAIIADPKTDHRLGKVGR                                        211 - 244

Text Mined References (26)

PMID Year Title
26905879 2016 C14orf166 is a high-risk biomarker for bladder cancer and promotes bladder cancer cell proliferation.
26883017 2016 C14orf166 overexpression correlates with tumor progression and poor prognosis of breast cancer.
26219895 2016 C14ORF166 overexpression is associated with pelvic lymph node metastasis and poor prognosis in uterine cervical cancer.
25964093 2015 Overexpression of chromosome 14 open reading frame 166 correlates with disease progression and poorer prognosis in human NPC.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25416956 2014 A proteome-scale map of the human interactome network.
24870230 2014 Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors.
24608264 2014 hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
22658674 2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
21994455 2011 Generation and comprehensive analysis of an influenza virus polymerase cellular interaction network.
21900157 2011 Cellular human CLE/C14orf166 protein interacts with influenza virus polymerase and is required for viral replication.
21823664 2011 Identification of hnRNPH1, NF45, and C14orf166 as novel host interacting partners of the mature hepatitis C virus core protein.
21311021 2011 HSPC117 is the essential subunit of a human tRNA splicing ligase complex.
21269460 2011 Initial characterization of the human central proteome.
19608861 2009 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19152423 2009 Proteomic profiling in pancreatic cancer with and without lymph node metastasis.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
16950395 2006 hCLE/CGI-99, a human protein that interacts with the influenza virus polymerase, is a mRNA transcription modulator.
15635413 2005 Nucleolar proteome dynamics.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15147888 2004 A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11507205 2001 PA subunit from influenza virus polymerase complex interacts with a cellular protein with homology to a family of transcriptional activators.
10810093 2000 Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.
1602151 1992 Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.