| Tbio | Protein DEPP1 |
Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS.
The expression of this gene is induced by fasting as well as by progesterone. The protein encoded by this gene contains a t-synaptosome-associated protein receptor (SNARE) coiled-coil homology domain and a peroxisomal targeting signal. Production of the encoded protein leads to phosphorylation and activation of the transcription factor ELK1. [provided by RefSeq, Jul 2008]
The expression of this gene is induced by fasting as well as by progesterone. The protein encoded by this gene contains a t-synaptosome-associated protein receptor (SNARE) coiled-coil homology domain and a peroxisomal targeting signal. Production of the encoded protein leads to phosphorylation and activation of the transcription factor ELK1. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count |
|---|---|
| Lipoidosis | 19 |
| Mammary Neoplasms | 425 |
| Disease | Target Count | P-value |
|---|---|---|
| lung adenocarcinoma | 2716 | 4.2e-15 |
| Breast cancer | 3578 | 2.4e-12 |
| non-small cell lung cancer | 2890 | 1.1e-11 |
| malignant mesothelioma | 3232 | 9.6e-07 |
| acute quadriplegic myopathy | 1158 | 1.7e-06 |
| lung carcinoma | 2843 | 1.8e-06 |
| ductal carcinoma in situ | 1745 | 4.2e-05 |
| posterior fossa group B ependymoma | 416 | 1.0e-04 |
| invasive ductal carcinoma | 2951 | 9.7e-04 |
| breast carcinoma | 1638 | 1.1e-03 |
| psoriasis | 6694 | 1.3e-03 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.7e-03 |
| pituitary cancer | 1972 | 2.7e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 3.5e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 3.5e-03 |
| adrenocortical carcinoma | 1428 | 5.0e-03 |
| fibroadenoma | 559 | 5.8e-03 |
| ovarian cancer | 8520 | 5.9e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 7.3e-03 |
| medulloblastoma | 720 | 8.0e-03 |
| lung cancer | 4740 | 1.5e-02 |
| gastric carcinoma | 807 | 1.5e-02 |
| glioblastoma | 5792 | 2.5e-02 |
| active ulcerative colitis | 764 | 3.1e-02 |
| medulloblastoma, large-cell | 6241 | 3.8e-02 |
| Disease | log2 FC | p |
|---|---|---|
| active ulcerative colitis | 2.053 | 3.1e-02 |
| acute quadriplegic myopathy | 1.560 | 1.7e-06 |
| adrenocortical carcinoma | -1.491 | 5.0e-03 |
| atypical teratoid / rhabdoid tumor | -1.800 | 1.7e-03 |
| Breast cancer | -2.200 | 2.4e-12 |
| breast carcinoma | -1.600 | 1.1e-03 |
| ductal carcinoma in situ | -2.000 | 4.2e-05 |
| fibroadenoma | -2.100 | 5.8e-03 |
| gastric carcinoma | 1.100 | 1.5e-02 |
| glioblastoma | 1.900 | 2.5e-02 |
| intraductal papillary-mucinous adenoma (... | -1.100 | 3.5e-03 |
| intraductal papillary-mucinous carcinoma... | -1.200 | 3.5e-03 |
| intraductal papillary-mucinous neoplasm ... | -2.100 | 7.3e-03 |
| invasive ductal carcinoma | -1.600 | 9.7e-04 |
| lung adenocarcinoma | -2.600 | 4.2e-15 |
| lung cancer | -1.200 | 1.5e-02 |
| lung carcinoma | -1.500 | 1.8e-06 |
| malignant mesothelioma | -2.100 | 9.6e-07 |
| medulloblastoma | -1.300 | 8.0e-03 |
| medulloblastoma, large-cell | -1.900 | 3.8e-02 |
| non-small cell lung cancer | -1.606 | 1.1e-11 |
| ovarian cancer | 1.500 | 5.9e-03 |
| pituitary cancer | -1.700 | 2.7e-03 |
| posterior fossa group B ependymoma | -2.000 | 1.0e-04 |
| psoriasis | -1.200 | 1.3e-03 |
