Tbio | Protein DEPP1 |
Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS.
The expression of this gene is induced by fasting as well as by progesterone. The protein encoded by this gene contains a t-synaptosome-associated protein receptor (SNARE) coiled-coil homology domain and a peroxisomal targeting signal. Production of the encoded protein leads to phosphorylation and activation of the transcription factor ELK1. [provided by RefSeq, Jul 2008]
The expression of this gene is induced by fasting as well as by progesterone. The protein encoded by this gene contains a t-synaptosome-associated protein receptor (SNARE) coiled-coil homology domain and a peroxisomal targeting signal. Production of the encoded protein leads to phosphorylation and activation of the transcription factor ELK1. [provided by RefSeq, Jul 2008]
Comments
Disease | Target Count |
---|---|
Lipoidosis | 19 |
Mammary Neoplasms | 425 |
Disease | Target Count | P-value |
---|---|---|
lung adenocarcinoma | 2716 | 4.2e-15 |
Breast cancer | 3578 | 2.4e-12 |
non-small cell lung cancer | 2890 | 1.1e-11 |
malignant mesothelioma | 3232 | 9.6e-07 |
acute quadriplegic myopathy | 1158 | 1.7e-06 |
lung carcinoma | 2843 | 1.8e-06 |
ductal carcinoma in situ | 1745 | 4.2e-05 |
posterior fossa group B ependymoma | 416 | 1.0e-04 |
invasive ductal carcinoma | 2951 | 9.7e-04 |
breast carcinoma | 1638 | 1.1e-03 |
psoriasis | 6694 | 1.3e-03 |
atypical teratoid / rhabdoid tumor | 5112 | 1.7e-03 |
pituitary cancer | 1972 | 2.7e-03 |
intraductal papillary-mucinous adenoma (IPMA) | 2955 | 3.5e-03 |
intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 3.5e-03 |
adrenocortical carcinoma | 1428 | 5.0e-03 |
fibroadenoma | 559 | 5.8e-03 |
ovarian cancer | 8520 | 5.9e-03 |
intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 7.3e-03 |
medulloblastoma | 720 | 8.0e-03 |
lung cancer | 4740 | 1.5e-02 |
gastric carcinoma | 807 | 1.5e-02 |
glioblastoma | 5792 | 2.5e-02 |
active ulcerative colitis | 764 | 3.1e-02 |
medulloblastoma, large-cell | 6241 | 3.8e-02 |
Disease | log2 FC | p |
---|---|---|
active ulcerative colitis | 2.053 | 3.1e-02 |
acute quadriplegic myopathy | 1.560 | 1.7e-06 |
adrenocortical carcinoma | -1.491 | 5.0e-03 |
atypical teratoid / rhabdoid tumor | -1.800 | 1.7e-03 |
Breast cancer | -2.200 | 2.4e-12 |
breast carcinoma | -1.600 | 1.1e-03 |
ductal carcinoma in situ | -2.000 | 4.2e-05 |
fibroadenoma | -2.100 | 5.8e-03 |
gastric carcinoma | 1.100 | 1.5e-02 |
glioblastoma | 1.900 | 2.5e-02 |
intraductal papillary-mucinous adenoma (... | -1.100 | 3.5e-03 |
intraductal papillary-mucinous carcinoma... | -1.200 | 3.5e-03 |
intraductal papillary-mucinous neoplasm ... | -2.100 | 7.3e-03 |
invasive ductal carcinoma | -1.600 | 9.7e-04 |
lung adenocarcinoma | -2.600 | 4.2e-15 |
lung cancer | -1.200 | 1.5e-02 |
lung carcinoma | -1.500 | 1.8e-06 |
malignant mesothelioma | -2.100 | 9.6e-07 |
medulloblastoma | -1.300 | 8.0e-03 |
medulloblastoma, large-cell | -1.900 | 3.8e-02 |
non-small cell lung cancer | -1.606 | 1.1e-11 |
ovarian cancer | 1.500 | 5.9e-03 |
pituitary cancer | -1.700 | 2.7e-03 |
posterior fossa group B ependymoma | -2.000 | 1.0e-04 |
psoriasis | -1.200 | 1.3e-03 |