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  7. STKR Type 1 subfamily
  8. Bone morphogenetic protein receptor type-1A

Tchem Bone morphogenetic protein receptor type-1A

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

Ligand Count 8
NCBI Gene PubMed Count 124
PubMed Score 211.01
PubTator Score 133.33

Knowledge Summary

Patent (20,298)

TINX Plot

  Disease (6)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.9

Expression

  Differential Expression (7)

Disease log2 FC p
astrocytoma 1.100 2.6e-15
Astrocytoma, Pilocytic 1.200 2.1e-04
atypical teratoid / rhabdoid tumor 1.200 1.3e-04
osteosarcoma 1.441 9.5e-04
ovarian cancer -1.400 1.2e-07
posterior fossa group A ependymoma 1.100 8.9e-05
psoriasis -1.100 5.2e-07

Synonym

Accession P36894 A8K6U9 Q8NEN8 BMP type-1A receptor
Symbols ALK3
SKR5
CD292
ACVRLK3
10q23del

Gene

BMPR1A

PANTHER Protein Class (4)

  Ortholog (11)

Species Source Disease
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA

 UniProt Keyword (20)

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 GO Function (9)

 GO Component (6)

 GO Process (57)

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 Compartment GO Term (32)

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 OMIM Phenotype (3)

 MGI Phenotype (23)

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 HCA RNA Cell Line (56)

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Pathway (32)

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PDB (11)

Ligand (8)

Structure of CHEMBL2385579

CHEMBL2385579
pIC50 7.98

Structure of CHEMBL511563

CHEMBL511563
pIC50 8.17

Structure of CHEMBL3818173

CHEMBL3818173
pIC50 8.62

Structure of compound 13a [PMID: 23639540]

compound 13a [PMID: 23639540]
pIC50 7.98

Structure of compound 13d [PMID: 23639540]

compound 13d [PMID: 23639540]
pIC50 8.30

Structure of compound 13r [PMID: 23639540]

compound 13r [PMID: 23639540]
pIC50 8.30

Structure of LDN-214117

LDN-214117
pIC50 5.93

Structure of ML347

ML347
pIC50 4.97

Gene RIF (79)

AA Sequence 

MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDD      1 - 70
AINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPP     71 - 140
VVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSISSRRRYNRDLEQDEAFIPVGESLKDLI    141 - 210
DQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQT    211 - 280
VLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIY    281 - 350
GTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKN    351 - 420
HFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSD    421 - 490
ECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI                                491 - 532
//

Text Mined References (128)

PMID Year Title