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Tbio
BCL11B
B-cell lymphoma/leukemia 11B

Protein Summary
Description
Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucle ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345514
  • ENSP00000280435
  • ENSG00000127152
  • ENST00000357195
  • ENSP00000349723

Symbol
  • CTIP2
  • RIT1
  • ATL1
  • RIT1
  • CTIP2
  • IMD49
  • CTIP-2
  • IDDFSTA
  • ZNF856B
  • ATL1-beta
  • ATL1-alpha
  • ATL1-delta
  • ATL1-gamma
  • hRIT1-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.93
PubMedID
0.88
molecular function
0.86
microRNA
0.78
transcription factor binding site profile
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 278.77   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 278.77   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0