| Tchem | Gamma-butyrobetaine dioxygenase |
This gene encodes gamma butyrobetaine hydroxylase which catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthetic pathway. Carnitine is essential for the transport of activated fatty acids across the mitochondrial membrane during mitochondrial beta-oxidation. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Liver Cirrhosis, Experimental | 769 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| Breast cancer | 3578 | 5.7e-26 |
| astrocytoma | 1146 | 1.7e-09 |
| pituitary cancer | 1972 | 9.5e-09 |
| glioblastoma multiforme | 142 | 2.0e-07 |
| group 3 medulloblastoma | 4104 | 1.5e-05 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.0e-05 |
| medulloblastoma, large-cell | 6241 | 2.1e-05 |
| posterior fossa group A ependymoma | 468 | 2.6e-04 |
| breast carcinoma | 1638 | 2.7e-04 |
| oligodendroglioma | 2850 | 1.0e-03 |
| cystic fibrosis | 1696 | 2.4e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 1.1e-02 |
| nephrosclerosis | 333 | 1.7e-02 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 1.9e-02 |
| esophageal adenocarcinoma | 737 | 2.0e-02 |
| primitive neuroectodermal tumor | 3035 | 2.9e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Opitz-GBBB syndrome | 18 | 5.477 | 2.7 |
| Mulibrey nanism | 13 | 5.29 | 2.6 |
| Familial Mediterranean fever | 13 | 3.664 | 1.8 |
| Vertebrobasilar insufficiency | 9 | 3.357 | 1.7 |
| Cancer | 2499 | 3.102 | 1.6 |
| Hypospadias | 53 | 3.042 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytoma | 1.400 | 1.7e-09 |
| atypical teratoid / rhabdoid tumor | -3.400 | 2.0e-05 |
| Breast cancer | -5.400 | 5.7e-26 |
| breast carcinoma | -2.000 | 2.7e-04 |
| cystic fibrosis | -1.100 | 2.4e-03 |
| esophageal adenocarcinoma | -2.100 | 2.0e-02 |
| glioblastoma multiforme | 1.100 | 2.0e-07 |
| group 3 medulloblastoma | -3.100 | 1.5e-05 |
| intraductal papillary-mucinous adenoma (... | -2.100 | 1.1e-02 |
| intraductal papillary-mucinous carcinoma... | -2.100 | 1.9e-02 |
| medulloblastoma, large-cell | -3.600 | 2.1e-05 |
| nephrosclerosis | -2.336 | 1.7e-02 |
| oligodendroglioma | 1.100 | 1.0e-03 |
| pituitary cancer | -3.500 | 9.5e-09 |
| posterior fossa group A ependymoma | 1.200 | 2.6e-04 |
| primitive neuroectodermal tumor | -2.300 | 2.9e-02 |
CHEMBL51085
pIC50 6.08
CHEMBL3234348
pIC50 6.09
CHEMBL3234352
pIC50 6.22
CHEMBL3234373
pIC50 6.28
CHEMBL3234372
pIC50 6.28
CHEMBL3234354
pIC50 6.31
CHEMBL3234364
pIC50 6.59
CHEMBL3234371
pIC50 7.00
CHEMBL3234384
pIC50 7.05
MACTIQKAEALDGAHLMQILWYDEEESLYPAVWLRDNCPCSDCYLDSAKARKLLVEALDVNIGIKGLIFD 1 - 70 RKKVYITWPDEHYSEFQADWLKKRCFSKQARAKLQRELFFPECQYWGSELQLPTLDFEDVLRYDEHAYKW 71 - 140 LSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFYGHTWQVQDKIDANNVAYTTGKLSFHTDYPALHH 141 - 210 PPGVQLLHCIKQTVTGGDSEIVDGFNVCQKLKKNNPQAFQILSSTFVDFTDIGVDYCDFSVQSKHKIIEL 211 - 280 DDKGQVVRINFNNATRDTIFDVPVERVQPFYAALKEFVDLMNSKESKFTFKMNPGDVITFDNWRLLHGRR 281 - 350 SYEAGTEISRHLEGAYADWDVVMSRLRILRQRVENGN 351 - 387 //
