| Tdark | Rho GTPase-activating protein 36 |
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| pituitary cancer | 1972 | 3.5e-09 |
| Breast cancer | 3578 | 2.1e-08 |
| Duchenne muscular dystrophy | 601 | 5.4e-08 |
| acute quadriplegic myopathy | 1158 | 3.0e-07 |
| Amyotrophic lateral sclerosis | 451 | 6.7e-07 |
| juvenile dermatomyositis | 1187 | 5.5e-06 |
| psoriasis | 6694 | 3.8e-05 |
| sonic hedgehog group medulloblastoma | 467 | 1.1e-04 |
| limb girdle muscular dystrophy 2A | 213 | 4.2e-04 |
| autosomal dominant Emery-Dreifuss muscular dystrophy | 510 | 4.5e-04 |
| Becker muscular dystrophy | 191 | 9.4e-04 |
| aldosterone-producing adenoma | 665 | 9.4e-03 |
| Disease | log2 FC | p |
|---|---|---|
| acute quadriplegic myopathy | 2.364 | 3.0e-07 |
| aldosterone-producing adenoma | -4.152 | 9.4e-03 |
| Amyotrophic lateral sclerosis | 2.484 | 6.7e-07 |
| autosomal dominant Emery-Dreifuss muscul... | 1.689 | 4.5e-04 |
| Becker muscular dystrophy | 1.170 | 9.4e-04 |
| Breast cancer | -2.900 | 2.1e-08 |
| Duchenne muscular dystrophy | 2.021 | 5.4e-08 |
| juvenile dermatomyositis | 1.843 | 5.5e-06 |
| limb girdle muscular dystrophy 2A | 1.235 | 4.2e-04 |
| pituitary cancer | -7.600 | 3.5e-09 |
| psoriasis | -1.500 | 3.8e-05 |
| sonic hedgehog group medulloblastoma | -1.900 | 1.1e-04 |
MGGCIPFLKAARALCPRIMPPLLLLSAFIFLVSVLGGAPGHNPDRRTKMVSIHSLSELERLKLQETAYHE 1 - 70 LVARHFLSEFKPDRALPIDRPNTLDKWFLILRGQQRAVSHKTFGISLEEVLVNEFTRRKHLELTATMQVE 71 - 140 EATGQAAGRRRGNVVRRVFGRIRRFFSRRRNEPTLPREFTRRGRRGAVSVDSLAELEDGALLLQTLQLSK 141 - 210 ISFPIGQRLLGSKRKMSLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVV 211 - 280 LDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKA 281 - 350 LHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHYVASVNVVRAMID 351 - 420 NWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPVETSAEARAAVLAQS 421 - 490 KPSDEGSSEEPAVPSGTARSHDDEEGAGNPPIPEQDRPLLRVPREKEAKTGVSYFFP 491 - 547 //
