Tbio ARHGAP11A Rho GTPase-activating protein 11A

Protein Summary

Description

This gene encodes a member of the Rho GTPase activating protein family. In response to DNA damage, the encoded protein interacts with the p53 tumor suppressor protein and stimulates its tetramerization, which results in cell-cycle arrest and apoptosis. A chromosomal deletion that includes this gene is one cause of Prader-Willi syndrome, and an intronic variant of this gene may be associated with sleep duration in children. This gene is highly expressed in colon cancers and in a human basal-like breast cancer cell line. This gene also produces a ARHGAP11A-SCG5 readthrough transcript and ARHGAP11A-SCG5 protein. [provided by RefSeq, Feb 2019]

Uniprot Accession IDs

• Q6P4F7
• B4DZN9
• Q6PI96
• Q9Y3S6

Gene Name

• ARHGAP11A

Ensembl ID

• ENST00000361627
• ENSP00000355090
• ENSG00000198826
• ENST00000543522
• ENSP00000440073
• ENST00000565905
• ENSP00000455754
• ENST00000567348
• ENSP00000454575
• ENST00000611363
• ENSP00000480085
• ENSG00000275568
• ENST00000619401
• ENSP00000479117
• ENST00000622253
• ENSP00000481011
• ENST00000633634
• ENSP00000488640
• ENSG00000282168

Symbol

• KIAA0013
• GAP (1-12)

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.78
transcription factor binding site profile	0.74
kinase perturbation	0.71
microRNA	0.67
cell line	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.9   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 72   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.9   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0