Property Summary

NCBI Gene PubMed Count 10
PubMed Score 2.22
PubTator Score 1.42

Knowledge Summary


No data available


  Disease (1)

Disease Target Count P-value
osteosarcoma 7933 1.2e-07
psoriasis 6685 1.8e-04
astrocytoma 1493 6.3e-03


  Differential Expression (3)

Disease log2 FC p
psoriasis -1.200 1.8e-04
osteosarcoma -2.111 1.2e-07
astrocytoma -1.200 6.3e-03


Accession P60006 G3V1Q3 Q9CXK2 Q9Y269 APC15
Symbols APC15



4UI9   5A31   5G04   5G05   5LCW  

  Ortholog (1)

Species Source Disease
Macaque OMA EggNOG Inparanoid

Protein-protein Interaction (10)

Gene RIF (2)

23007861 APC15 is required for anaphase-promoting complex/cyclosome-bound mitotic checkpoint complex-dependent CDC20 autoubiquitylation and degradation and for timely anaphase initiation.
21926987 Anaphase promoting complex subunit 15(APC15) mediates the constant turnover of CDC20 and mitotic checkpoint protein complexes, allowing the spindle checkpoint assembly to respond to the attachment state of kinetochores.

AA Sequence


Text Mined References (13)

PMID Year Title
25043029 2014 Molecular architecture and mechanism of the anaphase-promoting complex.
23007861 2012 APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.
21926987 2011 APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
16554811 2006 Human chromosome 11 DNA sequence and analysis including novel gene identification.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15146197 2004 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11256614 2000 Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.
11230166 2001 Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
11042152 2000 Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
8125298 1994 Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.