| Tbio | Aldehyde dehydrogenase family 3 member B2 |
Oxidizes medium and long chain aldehydes into non-toxic fatty acids.
This gene encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene of this particular family member is over 10 kb in length. Altered methylation patterns at this locus have been observed in spermatozoa derived from patients exhibiting reduced fecundity. [provided by RefSeq, Aug 2017]
This gene encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene of this particular family member is over 10 kb in length. Altered methylation patterns at this locus have been observed in spermatozoa derived from patients exhibiting reduced fecundity. [provided by RefSeq, Aug 2017]
Comments
| Disease | Target Count |
|---|---|
| Alcoholic Intoxication, Chronic | 289 |
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 1.4e-13 |
| nasopharyngeal carcinoma | 1058 | 4.9e-05 |
| cystic fibrosis | 1696 | 4.7e-04 |
| psoriasis | 6694 | 5.1e-04 |
| ductal carcinoma in situ | 1745 | 8.4e-04 |
| ovarian cancer | 8520 | 2.2e-03 |
| invasive ductal carcinoma | 2951 | 1.7e-02 |
| esophageal adenocarcinoma | 737 | 1.9e-02 |
| interstitial cystitis | 2312 | 4.1e-02 |
| Disease | log2 FC | p |
|---|---|---|
| cystic fibrosis | 1.300 | 4.7e-04 |
| ductal carcinoma in situ | 3.400 | 8.4e-04 |
| esophageal adenocarcinoma | -1.900 | 1.9e-02 |
| interstitial cystitis | -1.200 | 4.1e-02 |
| invasive ductal carcinoma | 2.600 | 1.7e-02 |
| nasopharyngeal carcinoma | -1.300 | 4.9e-05 |
| non-small cell lung cancer | 2.168 | 1.4e-13 |
| ovarian cancer | 1.500 | 2.2e-03 |
| psoriasis | 2.200 | 5.1e-04 |
MKDEPRSTNLFMKLDSVFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLA 1 - 70 EVLPQYLDQSCFAVVLGGPQETGQLLEHKLDYIFFTGSPRVGKIVMTAATKHLTPVTLELGGKNPCYVDD 71 - 140 NCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGHIINQKQF 141 - 210 QRLRALLGCSRVAIGGQSNESDRYIAPTVLVDVQETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKP 211 - 280 LALYAFSNSSQVVNQMLERTSSGSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLLA 281 - 350 PSGLEKLKEIHYPPYTDWNQQLLRWGMGSQSCTLL 351 - 385 //
